Co-transcriptional modifications of 2'-hydroxyls on synthetic mRNA enhance ribonuclease resistance and lipid nanoparticle thermostability
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The innate fragility of messenger RNA (mRNA) stems from 2'-hydroxyls on the ribose that are responsible for making mRNA sensitive to enzymatic and thermal degradation, posing formidable challenges in efficacy, in vivo stability, global-scale distribution, and... ...
