Unbalanced replication as a major source of genetic instability in cancer cells [0.03%]
染色体不分离是癌细胞中遗传不稳定的主要来源
Daniel Corcos
Daniel Corcos
The origin of genetic instability in tumors is a matter of debate: while the prevailing model postulates a mutator phenotype resulting from an alteration in a caretaker gene as a prerequisite for genetic alterations leading to tumor formati...
Chih-Chien Tsai,Tu-Lai Yew,Der-Chi Yang et al.
Chih-Chien Tsai et al.
Cultivation of cells is usually performed under atmospheric oxygen tension; however, such a condition does not replicate the hypoxic conditions of normal physiological or pathological status in the body. Recently, the effects of hypoxia on ...
Quality of life and physicians' perception in myelodysplastic syndromes [0.03%]
骨髓增生异常综合征患者的生活质量和医生的认知差异
Esther Natalie Oliva,Carlo Finelli,Valeria Santini et al.
Esther Natalie Oliva et al.
To detect factors associated with quality of life (QOL) of patients with myelodysplastic syndrome (MDS) and to compare the MDS patients' self-assessed QOL with that perceived by their physicians. In an observational, non-interventional, pro...
Time and temperature stability of T-cell subsets evaluated by a dual-platform method [0.03%]
双平台方法评估T细胞亚群的时间和温度稳定性
Horatiu Olteanu,Bernard C Schur,Alexandra M Harrington et al.
Horatiu Olteanu et al.
Introduction: T-cell subset enumeration in HIV patients is routinely performed for monitoring infection stage and response to antiretroviral therapy. Studies have examined the effect of specimen refrigeration and age for ...
The involvement of Galectins in the modulation of the JAK/STAT pathway in myeloproliferative neoplasia [0.03%]
半乳糖凝集素通过调节JAK/STAT信号传导途径参与骨髓增殖性肿瘤发生发展的机制研究
Suzanne M Koopmans,Freek J Bot,Harry C Schouten et al.
Suzanne M Koopmans et al.
Background: In patients with myeloproliferative neoplasia (MPN) the development of fibrosis and increased vessel density correlate with poor prognosis. The JAK2(V617F) mutation constitutively activates JAK2, which phospho...
Subtle bone marrow involvement by large B-cell lymphoma with pronormoblast-like morphology and prominent but not exclusive sinusoidal distribution [0.03%]
伴有类似原始幼粒细胞形态和以淋巴窦分布为主但非独有分布的大B细胞淋巴瘤的细微骨髓受侵
Christine G Roth,Kaaren K Reichard
Christine G Roth
Primary bone marrow presentation of diffuse large B-cell lymphoma (DLBCL) is unusual, and appreciation of the diffuse growth pattern may be difficult in cases with low-level involvement. In particular, subtle sinusoidal and interstitial bon...
Detection of minimal residual disease in hematopoietic progenitor cell harvests: lack of predictive value of peripheral blood and bone marrow analysis in mantle cell and indolent lymphoma [0.03%]
造血祖细胞移植中微小残留病灶的检测：外周血及骨髓分析对套细胞淋巴瘤和惰性淋巴瘤预后意义的缺乏
Michele Magni,Massimo Di Nicola,Carmelo Carlo-Stella et al.
Michele Magni et al.
Elimination of neoplastic cells from peripheral blood progenitor cells (PBPCs) is an important issue in transplantation-based high-dose chemotherapy in non Hodgkin's lymphoma (NHL). The capacity to reliably assess the presence of residual l...
A long road of T-cells to cure cancer: from adoptive immunotherapy with unspecific cellular products to donor lymphocyte infusions and transfer of engineered tumor-specific T-cells [0.03%]
漫谈T细胞的抗癌之路：从非特异性过继免疫疗法到供者淋巴细胞移植及肿瘤特异性工程化T细胞转移
Alexandros Spyridonidis,Maria Liga
Alexandros Spyridonidis
The notion that immunocompetent cells, contained within adult bone marrow or peripheral blood, are capable of mediating an antitumor effect was first validated experimentally in 1957. T-cell immunotherapy for malignant disease is now routin...
Advances and application of radioimmunotherapy in non-Hodgkin lymphoma [0.03%]
非霍奇金淋巴瘤放射免疫治疗的新进展及应用展望
Patrick L Stevens,Olalekan Oluwole,Nishitha Reddy
Patrick L Stevens
The activity of radio-immuno conjugate in Non-Hodgkin Lymphoma (NHL) has resulted in FDA approval of two antibodies, Y(90) Ibritumomab tiuxetan and I(131) tositumomab. Both these agents target CD20, a receptor widely expressed in B-Cell NHL...
Bim is required for T-cell allogeneic responses and graft-versus-host disease in vivo [0.03%]
Bim对体内T细胞异基因反应和移植物抗宿主病是必需的
Yu Yu,Jing Yu,Cristina Iclozan et al.
Yu Yu et al.
Bim, a BH3-only Bcl-2-family protein, is essential for T-cell negative selection in the thymus as well as for the death of activated T cells in the periphery. The role of Bim has been extensively studied in T-cell responses to self-antigens...