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Bim is required for T-cell allogeneic responses and graft-versus-host disease in vivo

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Bim, a BH3-only Bcl-2-family protein, is essential for T-cell negative selection in the thymus as well as for the death of activated T cells in the periphery. The role of Bim has been extensively studied in T-cell responses to self-antigens and viral infection... ...