Treatment of severe steroid resistant acute GVHD with mesenchymal stromal cells (MSC) [0.03%]
骨髓基质细胞治疗严重难治性急性移植物抗宿主病
Igor B Resnick,Claudine Barkats,Michael Y Shapira et al.
Igor B Resnick et al.
Background: Several studies revealed that MSC from human bone marrow can downregulate graft-versus-host disease (GVHD) after allogeneic HSCT. Methods: ...
The Epstein-Barr virus microRNA BART11-5p targets the early B-cell transcription factor EBF1 [0.03%]
Epstein-Barr病毒microRNA BART11-5p作用于早期B细胞转录因子EBF1
Nathan Ross,Maher K Gandhi,Jamie P Nourse
Nathan Ross
Epstein-Barr virus (EBV) is a ubiquitous B-cell trophic herpesvirus associated with a variety of histologically diverse B-cell lymphomas, each associated with specific viral-latency gene expression programs. Initial infection drives resting...
Ashraf M Elhefni
Ashraf M Elhefni
Chronic lymphocytic leukemia (CLL) remains an incurable disease, with all patients who require therapy destined to relapse and understanding of the pathophysiology of chronic lymphocytic leukemia has advanced significantly. It is now clear ...
Changes in molecular biology of chronic myeloid leukemia in tyrosine kinase inhibitor era [0.03%]
酪氨酸激酶抑制剂时代慢性粒细胞白血病分子生物学变化
Melda Comert,Yusuf Baran,Guray Saydam
Melda Comert
Chronic myeloid leukemia (CML) is a clonal myeloproliferative disease characterized by a reciprocal translocation between long arms of chromosomes 9 and 22 t(9;22) that generates the BCR-ABL fusion gene. If left untreated, newly diagnosed c...
A rare der(Y)t(Y;1)(q12;q12) in a patient with post-polycythemic myelofibrosis: a case report [0.03%]
报告一例继发于真性红细胞增多症后骨髓纤维化的罕见导管染色体t(Y;1)(q12;q12)异常病例
Masahiro Manabe,Osami Takeda,Junya Okita et al.
Masahiro Manabe et al.
We describe a case of post-polycythemic myelofibrosis harboring der(Y)t(Y;1)(q12;q12). The patient was a 69-year-old man and was initially diagnosed with polycythemia vera. During the clinical course of his condition, the polycythemia devel...
Case Reports
American journal of blood research. 2013 May 5;3(2):186-90. DOI: 2013
Absence of BRAF exon 15 mutations in multiple myeloma and Waldenström's macroglobulinemia questions its validity as a therapeutic target in plasma cell neoplasias [0.03%]
BRAF第15外显子在多发性骨髓瘤和瓦尔登斯特伦巨球蛋白血症中未突变，提示其不应对浆细胞肿瘤进行靶向治疗
Eleftheria Hatzimichael,Samuel Murray,Evangelos Briasoulis
Eleftheria Hatzimichael
Purpose: Recent whole genome and/or exome sequencing in a cohort of 32 Multiple Myeloma (MΜ) patients reported the incidence of BRAF mutations at 4%, while in another exome sequencing study, BRAF mutations were reported ...
Guidelines and diagnostic algorithm for patients with suspected systemic mastocytosis: a proposal of the Austrian competence network (AUCNM) [0.03%]
疑似系统性肥大细胞活化的诊断路径和算法：奥地利系统性肥大细胞病协作网的建议
Peter Valent,Elisabeth Aberer,Christine Beham-Schmid et al.
Peter Valent et al.
Systemic mastocytosis (SM) is a hematopoietic neoplasm characterized by pathologic expansion of tissue mast cells in one or more extracutaneous organs. In most children and most adult patients, skin involvement is found. Childhood patients ...
Refinement of IKZF1 recombination hotspots in pediatric BCP-ALL patients [0.03%]
儿童BCP-ALL患者中IKZF1重组热点的优化研究
Claus Meyer,Udo Zur Stadt,Gabriele Escherich et al.
Claus Meyer et al.
Chromosomal translocations resulting in chimeric fusion genes are prototypic for pediatric leukemia patients. The most known fusions are ETV6-RUNX1 or BCR-ABL1 in B-cell progenitor (BCP)-ALL, and rearrangements of MLL in pediatric ALL and A...
Treatment of older patients with acute myeloid leukemia (AML): a Canadian consensus [0.03%]
急性髓系白血病(AML)老年患者治疗加拿大共识声明
Joseph M Brandwein,Michelle Geddes,Jeannine Kassis et al.
Joseph M Brandwein et al.
Patients over age 60 comprise the majority of those diagnosed with acute myeloid leukemia (AML), but treatment approaches in this population are variable, with many uncertainties and controversies. Our group conducted a literature review to...
MyD88 is involved in myeloid as well as lymphoid hematopoiesis independent of the presence of a pathogen [0.03%]
MYD88独立于病原体参与髓系和淋巴系血液生成
Katja Fiedler,Enikö Kokai,Susanne Bresch et al.
Katja Fiedler et al.
MyD88 was originally described as a primary response gene up-regulated during myeloid differentiation after IL-6 induction. Later, MyD88 was shown to be a key molecule necessary for IL1, IL18 and Toll-like receptor signaling. Since these re...