MyD88 is involved in myeloid as well as lymphoid hematopoiesis independent of the presence of a pathogen
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MyD88 was originally described as a primary response gene up-regulated during myeloid differentiation after IL-6 induction. Later, MyD88 was shown to be a key molecule necessary for IL1, IL18 and Toll-like receptor signaling. Since these receptors recognize ab... ...
