Zasp52 in Drosophila melanogaster indirect flight muscles can serve as a model system to investigate the function of clinical variants causing myopathies [0.03%]
果蝇飞行肌中的Zasp52蛋白可用于研究与肌肉病相关的临床变异功能模型系统
José Medina-Quintana,Bijan Akbari-Gakieh,Marie-Pier Lalonde et al.
José Medina-Quintana et al.
The sarcomere is the basic contractile unit of muscle fibers, bordered by Z-discs. In Drosophila, Z-disc structure and maintenance rely on actinin and the Z band alternatively spliced PDZ-motif protein 52 (Zasp52), a member of the Alp/Enigm...
The Lipid-binding PX Domain of RRC-1 (ARHGAP32/33) is Required for Optimal Assembly and Function of Integrin Adhesion Complexes at the Muscle Cell Boundary in C. elegans [0.03%]
秀丽隐杆线虫肌肉细胞边界整合素粘附复合物的最优装配和功能需要RRC-1（ARHGAP32/33）的脂质结合PX结构域
Sara Sagadiev,Isabel Martin,Nahum Arefeayne et al.
Sara Sagadiev et al.
Integrin adhesion complexes (IACs) are a network of many proteins that serve as anchors of the cell to the extracellular matrix (ECM). In muscle, IACs located at costameres, also serve to transmit the force of muscle contraction to the outs...
Multimodal genomic prediction is not a buzzword: why modern plant breeding must integrate genomics, enviromics, and phenomics [0.03%]
多模态基因组预测并非一个噱头——现代植物育种必须整合基因组学、环境组学和表型组学的原因分析
José Crossa,Abelardo Montesinos-López,Jaime Cuevas et al.
José Crossa et al.
Plant breeding has entered a new era, transitioning from a predominantly unimodal, genomics-focused paradigm to one defined by multimodal data integration. Dense genomic markers, long-term environmental datasets, physiological and omics mea...
diempy: fast and reference-free genome polarisation and chromosome painting [0.03%]
DiEmpy：快速且无需参考的基因组极化和染色体着色
Derek Setter,Konrad Lohse,Stuart J E Baird
Derek Setter
Most ancestry inference methods rely on putatively pure reference panels to define ancestry informative variants. This approach is often unrealistic and can bias inference. The genome polarization algorithm diem, introduced previously by ba...
MKado: a toolkit for McDonald-Kreitman tests of natural selection [0.03%]
MKado：用于自然选择的McDonald-Kreitman检验工具包
Angel G Rivera-Colón,Clara T Rehmann,Andrew D Kern
Angel G Rivera-Colón
MKado is a Python toolkit for performing McDonald-Kreitman (MK) tests of natural selection from aligned coding sequences. It implements the standard MK test as well as a wide variety of its extensions and related statistics, including a num...
FLInt 2.0: Robust and customizable single shot integration in C. elegans [0.03%]
FLint 2.0：线虫中的稳健且可自定义的一步集成法
Nawaphat Malaiwong,Porhathai Malaiwong,Chloe Kim et al.
Nawaphat Malaiwong et al.
Transgenesis in Caenorhabditis elegans has revolutionized biological research by enabling the precise control of expression of both endogenous and exogenous genes. FLInt (Fluorescent Landmark Interference) was developed to integrate transge...
Haplotype-phased genomes of the barley leaf rust pathogen reveal evidence of repeat element expansion and somatic hybridization [0.03%]
大麦叶锈菌的单倍体型基因组揭示了重复元件扩张和体细胞杂交的证据
Rebecca Spanner,Eric S Nazareno,Eva C Henningsen et al.
Rebecca Spanner et al.
Barley leaf rust disease, caused by Puccinia hordei, leads to substantial yield losses and diminished malting quality of barley across temperate growing regions worldwide. To address the paucity of high-resolution genomic resources for this...
New annotations for three pea aphid genome assemblies allow comparative analyses of duplication and gene family evolution [0.03%]
三种豌豆蚜基因组注释的补充使得重复序列和基因家族演化的比较分析成为可能
Kevin D Deem,Jennifer A Brisson
Kevin D Deem
Reliable genome annotation is crucial for analyses of gene function, conservation, duplication, and evolution. Factors such as the sequencing technology used to create the assembly, as well as duplication and rearrangements within the genom...
Multi-metric Evaluation and Parametric Optimization of Stochastic Gradient Boosting Machines for Genomic Prediction and Selection in Wheat (Triticum aestivum) Breeding [0.03%]
基于随机梯度提升机的基因组预测和选择在小麦育种中的多指标评价与参数优化
Henry Newton Munroe,Bright Enogieru Osatohanmwen,Ahmad Reza Sharifi
Henry Newton Munroe
Machine learning (ML) models with stochastic and non-deterministic characteristics are increasingly used for genomic prediction in plant breeding, but evaluation often neglects important aspects like prediction stability and ranking perform...
A haplotype-resolved, chromosome-scale genome assembly and annotation for Carya glabra (pignut hickory; Juglandaceae) [0.03%]
用于Carya glabra（猪坚壳斗树；榆绿木科）的单倍体型解析、染色体规模基因组组装和注释
Shengchen Shan,Edgardo M Ortiz,Baylee Klein et al.
Shengchen Shan et al.
Carya glabra (2n = 4x = 64), also known as pignut hickory, is a widely distributed species in the walnut family (Juglandaceae). Native to the central and eastern United States and southeastern Canada, C. glabra plays an important ecological...