Genetic variation in innate immune gene expression influences mortality after traumatic brain injury in Drosophila [0.03%]
果蝇先天免疫基因表达的遗传多态性影响创伤性脑损伤后的死亡率
Rebeccah J Katzenberger,Nathaniel P Sharp,Barry Ganetzky et al.
Rebeccah J Katzenberger et al.
Traumatic brain injury (TBI) is a leading cause of disability and death, with outcome severity varying widely even among individuals with comparable injuries. A major challenge is to identify pathways that underlie this variation and could ...
Manual validation finds ultra-long-read sequencing best enables faithful, population-level structural variant calling in Drosophila melanogaster euchromatin with nanopore [0.03%]
手动验证发现，与纳米孔测序相比，超长读测序最适合在Drosophila melanogaster euchromatin中准确地进行结构变异的种群水平呼叫
James A Hemker,Hannah R Gellert,Jessica A Smiley-Rhodes et al.
James A Hemker et al.
The increasing accessibility of long-read sequencing and the rapid development of automated variant callers are promoting the generation of population-level structural variation data. However, the effect of the length of long-reads on autom...
Genetic analysis of triplicated genes affecting sex-specific skeletal deficits in Down syndrome model mice [0.03%]
关于唐氏综合症模型小鼠性别特异性骨骼缺陷的基因分析
Kourtney Sloan,Kristina M Piner,Pathum Randunu Nawarathna Kandedura Arachchige et al.
Kourtney Sloan et al.
Down syndrome (DS) is caused by the triplication of human chromosome 21 (Hsa21), resulting in skeletal insufficiency (low bone mineral density) and altered bone development. DS mouse models recapitulate these deficits, including sexual dimo...
A chromosome-scale genome assembly for Clark's Nutcracker (Nucifraga columbiana) [0.03%]
一种美洲山雀（Nucifraga columbiana）的染色体级基因组组装
Peter Innes,Matthew D Carling,Ethan Linck
Peter Innes
Focal and intelligent passerine songbirds, corvids (Aves: Corvidae) have served as models for research on the genomics of hybridization and cognition. Clark's Nutcracker (Nucifraga columbiana), the sole North American member of its genus, i...
Compound effector genes suppress malaria parasite infections in gene-drive population modification strains of the African malaria mosquitoes, Anopheles gambiae and Anopheles coluzzii [0.03%]
复合效应基因可抑制冈比亚疟蚊和科鲁兹疟蚊基因驱动品系的疟原虫感染
Rebeca Carballar-Lejarazú,Yuemei Dong,Thai Binh Pham et al.
Rebeca Carballar-Lejarazú et al.
Malaria remains a major global health burden and is caused by protozoan parasites in the genus Plasmodium. Parasites are transmitted to humans during blood feeding by anopheline mosquitoes, and members of the Anopheles gambiae species compl...
Mutational Basis of Ceftazidime-Borrelidin A Collateral Sensitivity in Escherichia coli [0.03%]
关于大肠杆菌头孢他啶和博来霉素侧向敏感性的突变基础研究
Laura L Phillips,Arianna Carrasco,Jonathan Weiss et al.
Laura L Phillips et al.
The rapid emergence of antimicrobial resistance in bacterial pathogens threatens the efficacy of nearly all available antibiotics. One evolution-informed strategy to limit the emergence of resistance is the exploitation of collateral sensit...
Three Muscle-Specific DAF-16/FOXO Transcriptional Targets Activated by Reduced Insulin/IGF-1 Signaling [0.03%]
三条肌肉特异的DAF-16/FOXO转录途径靶基因在胰岛素/IGF-1信号减弱时被激活
Shifei Wu,Jinghua Gao,Yan Li et al.
Shifei Wu et al.
C. elegans insulin/insulin-like growth factor 1 signaling, IIS, affects diverse physiological processes through the DAF-16/FOXO transcription factor. Despite its ubiquitous presence in somatic cells, DAF-16's effects exhibit prevalent tissu...
Haplotype-resolved genome assemblies for the New World screwworm, Cochliomyia hominivorax (Diptera: Calliphoridae), using the trio binning approach [0.03%]
利用三体分类方法进行美洲新世界隧蜂蝇（双翅目肉蝇科）的单倍型基因组解析及拼接
Paul V Hickner,Sheina B Sim,David Luecke et al.
Paul V Hickner et al.
The New World screwworm, Cochliomyia hominivorax, is an obligate parasite of warm-blooded animals and a major pest of livestock and wildlife in the Americas. The first genome assembly for C. hominivorax enabled substantial progress in key a...
Chromosome-level assembly and phylophenetic insights of Cladosporium oxysporum A3.I.1, a fungus with the ability to degrade polyurethane polymers [0.03%]
一种具有降解聚氨酯聚合物能力的Cladosporium oxysporum A3.I.1真菌的染色体水平基因组及其表型系统发育学研究
Ayixon Sánchez-Reyes,Itzayana Chavarría-Quintanilla,Martín Vargas-Suárez et al.
Ayixon Sánchez-Reyes et al.
Notwithstanding the ecological significance of the Cladosporium genus, which includes several cosmopolitan fungi reported as saprobes, plant pathogens, and causes of allergic and cutaneous diseases in humans, only 41 genomes have been repor...
Swatantra Neupane,Michael E Pfrender,Li Wang et al.
Swatantra Neupane et al.
CRISPR-Cas9 has established itself as a robust tool for conducting loss of function gene research in emerging model species including the freshwater zooplankton Daphnia. However, sensitive detection of mutations, especially in genetic mosai...