Diet and Cancer Metabolism [0.03%]
饮食与癌症代谢
Jason W Locasale,Marcus D Goncalves,Maira Di Tano et al.
Jason W Locasale et al.
Diet and exercise are modifiable lifestyle factors known to have a major influence on metabolism. Clinical practice addresses diseases of altered metabolism such as diabetes or hypertension by altering these factors. Despite enormous public...
Katherine C Kurnit,Kunle Odunsi
Katherine C Kurnit
Despite progress in other tumor types, immunotherapy is not yet part of the standard of care treatment for high-grade serous ovarian cancer patients. Although tumor infiltration by T cells is frequently observed in patients with ovarian can...
Retinal Disorders [0.03%]
视网膜疾病
José-Alain Sahel,Eyal Banin,Jean Bennett et al.
José-Alain Sahel et al.
Retinal disorders caused by genetic or environmental factors cause severe visual impairment and often result in blindness. The past ten years have seen rapid progress in our understanding of the biological basis of these conditions, as well...
Prostanoids Regulate Angiogenesis and Lymphangiogenesis in Pathological Conditions [0.03%]
血管生成和淋巴管生成调节的前列腺素病理学研究进展
Masataka Majima,Yasuhiro Matsuda,Shin-Ichi Watanabe et al.
Masataka Majima et al.
Angiogenesis, the formation of new blood vessels from the preexistent microvasculature, is an essential component of wound repair and tumor growth. Nonsteroidal anti-inflammatory drugs that suppress prostanoid biosynthesis are known to supp...
S Jay Olshansky,James L Kirkland
S Jay Olshansky
Why we age and whether our lifespan can be extended have intrigued scientists for centuries. Meanwhile public health advances mean humanity is having to confront the realities of an aging and increasingly frail population. The nascent field...
Natalya N Pavlova,Craig B Thompson
Natalya N Pavlova
A cell committed to proliferation must reshape its metabolism to enable robust yet balanced production of building blocks for the assembly of proteins, lipids, nucleic acids, and other macromolecules, from which two functional daughter cell...
Osteosarcoma through the Lens of Bone Development, Signaling, and Microenvironment [0.03%]
骨发育、信号转导和微环境视角下的骨肉瘤
Elizabeth P Young,Amanda E Marinoff,Eunice Lopez-Fuentes et al.
Elizabeth P Young et al.
In this work, we review the multifaceted connections between osteosarcoma (OS) biology and normal bone development. We summarize and critically analyze existing research, highlighting key areas that merit further exploration. The review add...
Acute Promyelocytic Leukemia, Retinoic Acid, and Arsenic: A Tale of Dualities [0.03%]
急性早幼粒细胞白血病、维甲酸和砷剂：兼论对立统一规律
Domitille Rérolle,Hsin-Chieh Wu,Hugues de Thé
Domitille Rérolle
Acute promyelocytic leukemia (APL) is driven by the promyelocytic leukemia (PML)/retinoic acid receptor α (RARA) fusion oncoprotein. Over the years, it has emerged as a model system to understand how this simple (and sometimes sole) geneti...
Knowledge-Based Therapeutics for Tricarboxylic Acid (TCA) Cycle-Deficient Cancers [0.03%]
基于知识的治疗学在三羧酸循环缺陷型癌症中的应用
Daniel Peled,Ruth Casey,Eyal Gottlieb
Daniel Peled
With the foundation pre-laid, research in the new millennium has readily excavated and expanded upon the architectural framework laid out by Otto Warburg's seminal work in a new wave of "westward expansion," ever widening our understanding ...
Chris B Damoci,Joseph R Merrill,Yanping Sun et al.
Chris B Damoci et al.
The broad application of noninvasive imaging has transformed preclinical cancer research, providing a powerful means to measure dynamic processes in living animals. While imaging technologies are routinely used to monitor tumor growth in mo...