Acute Promyelocytic Leukemia, Retinoic Acid, and Arsenic: A Tale of Dualities
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Acute promyelocytic leukemia (APL) is driven by the promyelocytic leukemia (PML)/retinoic acid receptor α (RARA) fusion oncoprotein. Over the years, it has emerged as a model system to understand how this simple (and sometimes sole) genetic alteration can tra... ...