Ben Patterson,Digby Warner,Robin Wood
Ben Patterson
Despite vast changes in human social structures through evolution-from small hunter-gatherer bands to densely populated megacities-Mycobacterium tuberculosis (Mtb) has persisted within human populations for millennia, underscoring the bacte...
Lucia Pazzagli,Hardik Patel,Stefan H I Kappe et al.
Lucia Pazzagli et al.
The Plasmodium liver stages of infection-initiated when mosquito-transmitted sporozoites invade hepatocytes-are asymptomatic and essential for initial parasite replication and progression to blood stage infection. This paper provides an ove...
The Interaction between Diabetes Mellitus and Tuberculosis: Epidemiology, Screening, and Clinical Management [0.03%]
糖尿病与结核病的相互作用：流行病学、筛查和临床处理
Vijay Viswanathan,Reshma Mirshad
Vijay Viswanathan
Tuberculosis (TB) is usually a preventable and curable disease, yet it remains the leading cause of death due to an infectious agent. Diabetes mellitus (DM) is a chronic metabolic disorder with ∼589 million adults living with it worldwide....
New Malaria Prevention Modalities: Long-Acting Interventions Beyond Vaccines [0.03%]
新的疟疾预防模式：疫苗以外的长效干预措施
Cristina Donini,Richard K Amewu,Benoit Bestgen et al.
Cristina Donini et al.
Malaria prevention is key for protecting high-risk groups, such as children and pregnant women. Existing approaches, including insecticide-based vector control, infant vaccination, and targeted chemoprevention are successful in some context...
From Parasite to Pill: Harnessing Biology for Breakthroughs in Antimalarial Drug Discovery [0.03%]
从寄生虫到药片：利用生物学在抗疟药物发现方面的突破性进展
John G Woodland,Mariana Laureano De Souza,Ferdinand W Ndubi et al.
John G Woodland et al.
The global imperative for malaria eradication demands innovative strategies for antimalarial drug discovery, particularly in the face of growing drug resistance. This article describes how biological insights into Plasmodium parasites and t...
Malaria Parasite Genomics: Decentralization, Diversification, and Development Goals [0.03%]
疟疾寄生虫基因组学：分散化、多样化和发展目标
Alfred Amambua-Ngwa,Daniel E Neafsey,Sarah K Volkman et al.
Alfred Amambua-Ngwa et al.
The practice of malaria parasite genomics has evolved due to changing technology, expanded capacity, shifting funding, and broader applications. What began as a descriptive, discovery-focused field has grown into a global system for routine...
Ibrahim Abubakar,Jeremiah Chakaya,David Hui et al.
Ibrahim Abubakar et al.
Tuberculosis (TB) infection remains the largest reservoir sustaining the global TB epidemic and a critical target for TB elimination. Contemporary evidence has fundamentally reframed TB infection from a static latent state to a dynamic spec...
Graeme Meintjes,Bianca Sossen
Graeme Meintjes
Human immunodeficiency virus (HIV)-associated tuberculosis (TB) is a leading cause of morbidity and mortality, and HIV fuels the TB epidemic in many countries. While there is overlap, there are also critical differences in the diagnosis and...
Dermatophytes: Global Pandemic, Multidrug Resistance, Human-to-Human, and Sexual Transmission [0.03%]
皮肤丝菌：全球大流行、多重耐药性、人传人和性传播
Aditya K Gupta,Tong Wang,Anuradha Chowdhary
Aditya K Gupta
We are witnessing a sea change in the epidemiology of dermatophytosis. While commonly perceived as a mild infection of skin, hair, or nails, new human pathogens have emerged from the zoophilic Trichophyton mentagrophytes complex-Trichophyto...
The Global Epidemiology of Tuberculosis: Burden, Trends, and Determinants [0.03%]
全球结核病流行病学：负担、趋势和决定因素
Gerhard Walzl,Delia Goletti,Alimuddin Zumla
Gerhard Walzl
Tuberculosis (TB) remains the leading cause of death from an infectious disease worldwide despite availability of effective treatment. In 2024, an estimated 10.7 million people developed TB disease, including 5.8 million men, 3.7 million wo...