Gerhard Walzl,Delia Goletti,Alimuddin Zumla
Gerhard Walzl
Tuberculosis (TB) remains the leading cause of death from an infectious disease worldwide despite availability of effective treatment. In 2024, an estimated 10.7 million people developed TB disease, including 5.8 million men, 3.7 million wo...
Diagnostic Assays for TB Disease and Drug Resistance Detection-Advances and Latest WHO Recommendations [0.03%]
Paolo Miotto,Francesca Saluzzo,Andrea M Cabibbe et al.
Paolo Miotto et al.
Accurate and timely diagnosis of active tuberculosis (TB) and its drug-resistant forms are essential for effective patient care and global TB disease control. This paper summarizes the latest advances in TB disease diagnostics. We describe ...
Natalie J E Waller,Kyu Y Rhee
Natalie J E Waller
Tuberculosis (TB) chemotherapy was once considered a crowning triumph of modern medicine but has since reemerged as a persisting paradox. While therapeutically still effective in most cases, current frontline treatments for TB remain largel...
Andrea M Cooper,John E Pearl
Andrea M Cooper
The mouse provides a flexible tool to probe the interactions between the immune system and the slow growing and persistent bacterium, Mycobacterium tuberculosis (Mtb). Removal of specific cells or molecules from mice demonstrates the causal...
Jane A Shaw,Gerhard Walzl
Jane A Shaw
Host-derived biomarkers are high-priority targets for development and could play important roles in diagnosis of various states of Mycobacterium tuberculosis (Mtb) infection and disease, prediction of outcomes, and might guide vaccine and d...
Immunodominant Tuberculosis Antigens Recognized by Human CD4+ and CD8+ T Cells [0.03%]
人类CD4+和CD8+t细胞识别的免疫主导性结核杆菌抗原
Deborah A Lewinsohn,Cecilia S Lindestam Arlehamn,Alessandro Sette et al.
Deborah A Lewinsohn et al.
Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis (MTB), represents an important cause of morbidity and mortality worldwide for which an improved vaccine and immunodiagnostics are urgently needed. CD4+ and CD8+ T cells ...
Carl Nathan,John MacMicking
Carl Nathan
Our ability to cope with Mycobacterium tuberculosis (Mtb) infection requires activated macrophages to help confer host defense. The extent to which these cells directly eliminate or restrain Mtb varies not only within different human popula...
Joseph Lipsick
Joseph Lipsick
Research in the 1970s showed that while retroviruses had been a key to identification of oncogenes, they were not actually a major cause of human cancer. Moreover, cells contained additional proto-oncogenes that did not necessarily have vir...
Judith Bruchfeld,Marianne Jansson,Gunilla Källenius
Judith Bruchfeld
Tuberculosis (TB) and acquired immunodeficiency syndrome (AIDS) are the leading causes of death from single infectious agents in low- and middle-income countries. Moreover, in the individual host, the two pathogens, Mycobacterium tuberculos...
Jamshed B Bomanji,Fawziah Alorfi,Sarah Algodayan et al.
Jamshed B Bomanji et al.
Tuberculosis (TB) remains a major global health challenge, with increasing prevalence of multidrug-resistant and extrapulmonary forms complicating diagnosis and management. Imaging plays a pivotal role in the early detection, characterizati...