Effector Functions of Conventional and Unconventional Mycobacterium tuberculosis (Mtb)-Specific T Cells [0.03%]
结核分枝杆菌特异性经典和非经典T细胞的效应功能
Sudhasini Panda,Kendall Kearns,Cecilia S Lindestam Arlehamn
Sudhasini Panda
Effector T cells are central to immune defense against Mycobacterium tuberculosis (Mtb), exerting complex and multifaceted roles that contribute to both protection and immunopathology. CD4+ T cells activate macrophages, maintain granulomas,...
Sean Ekins,Thomas R Lane,Jason T Wong
Sean Ekins
There is an urgent need to develop additional treatments for tuberculosis (TB) to complement the small panel of approved drugs and to devise shorter treatment regimens. Within the last 20 years, we have seen an increased focus on using chem...
Pediatric Tuberculosis: Epidemiology, Disease Spectrum, Diagnosis, and Management [0.03%]
儿童结核病的流行病学、疾病谱系、诊断与管理
Ben J Marais,H Simon Schaaf
Ben J Marais
Tuberculosis (TB) is a major cause of disease and death in young children from TB-endemic countries, especially in areas affected by poverty, social disruption, and human immunodeficiency virus (HIV) infection. This article reviews the dise...
From Phagosomes to Niches: Macrophage Biology in Tuberculosis Revisited [0.03%]
从吞噬体到生态位：重新审视结核病中的巨噬细胞生物学
Pierre Dupuy,Sarah C Monard,Olivier Neyrolles et al.
Pierre Dupuy et al.
Mycobacterium tuberculosis thrives inside macrophages by modulating intracellular pathways and adapting to various lung environments. Here, we first describe how the bacillus alters phagosome maturation, endures intracellular pressure, and ...
James M Welch
James M Welch
This article is a requested personal commentary for this project based on my 20+ years of experience working nationally and globally in the advocacy of safe research and the promotion of biosafety and biosecurity. Although neither a scienti...
Oscar J Pundel,Benjamin G Neel
Oscar J Pundel
High-grade serous ovarian carcinoma (HGSC) remains an incompletely understood, highly lethal disease. Historically, a lack of fidelitous in vitro and in vivo models representing HGSC biology and therapy response has been a major barrier to ...
Valina L Dawson,Ted M Dawson
Valina L Dawson
Parkinson's disease (PD) is a complex genetic disorder that is associated with environmental risk factors and aging. Vertebrate genetic models, especially in mice, has aided the study of autosomal-dominant and autosomal-recessive PD. Mice a...
Alexandra Lodge,Julian Agin-Liebes
Alexandra Lodge
α-Synuclein (α-syn) biomarkers show great promise as diagnostic tools for Parkinson's disease (PD). In recent years, a large body of evidence has validated their efficacy as diagnostic tools for PD and other synucleinopathies and has show...
Serge Przedborski,Stanley Fahn
Serge Przedborski
Parkinson's disease (PD), once stigmatized and hidden, is now widely acknowledged by patients and recognized by the public. Yet, fundamental questions about the disease's origins, mechanisms, and progression remain unanswered. The second ed...
Who Are the Space Invaders? Planetary Protection and the Role of Biological Interactions between Extraterrestrial and Terrestrial Biospheres [0.03%]
谁是“太空入侵者”？行星保护与地外生物圈和地球生物圈之间的生物学相互作用的作用
D E Betsy Pugel,John D Rummel
D E Betsy Pugel
Exploring our solar system and returning pieces of it to Earth is a central part of the existential quest to search for life beyond our home planet. Understanding the biosafety and biocontamination implications of landing on a planetary bod...