Mechanistic Study of Isotactic Poly(propylene oxide) Synthesis using a Tethered Bimetallic Chromium Salen Catalyst [0.03%]
拴系双金属铬Salen催化剂合成等规聚丙烯氧化物的机理研究
Bryce M Lipinski,Katherine L Walker,Naomi E Clayman et al.
Bryce M Lipinski et al.
Initial catalyst dormancy has been mitigated for the enantioselective polymerization of propylene oxide using a tethered bimetallic chromium(III) salen complex. A detailed mechanistic study provided insight into the species responsible for ...
Structural diversification of hapalindole and fischerindole natural products via cascade biocatalysis [0.03%]
通过级联生物催化作用使hapalindole和fischerindole类天然产物的结构多样化
Robert M Hohlman,Sean A Newmister,Jacob N Sanders et al.
Robert M Hohlman et al.
Hapalindoles and related compounds (ambiguines, fischerindoles, welwitindolinones) are a diverse class of indole alkaloid natural products. They are typically isolated from the Stigonemataceae order of cyanobacteria and possess a broad scop...
Phenanthroline-Catalyzed Stereoselective Formation of α-1,2- cis 2-Deoxy-2-Fluoro Glycosides [0.03%]
菲恩蓝催化立体选择性合成α-1,2-反式-2-脱氧-2-氟糖苷
Paul M DeMent,Chenlu Liu,Joseph Wakpal et al.
Paul M DeMent et al.
Phenanthroline is a heterocyclic aromatic organic compound and commonly used in coordination chemistry acting as a bidentate ligand. The C4 and C7 positions of phenanthroline can often be substituted to change the binding capabilities of th...
Iron-Catalyzed Vinylsilane Dimerization and Cross-Cycloadditions with 1,3-Dienes: Probing the Origins of Chemo- and Regioselectivity [0.03%]
铁催化下烯丙基硅烷的二聚反应和与1,3-丁二烯的交叉环加成反应：探索化学选择性和区域选择性的起源
C Rose Kennedy,Matthew V Joannou,Janelle E Steves et al.
C Rose Kennedy et al.
The selective, intermolecular, homodimerization and cross-cycloaddition of vinylsilanes with unbiased 1,3-dienes, catalyzed by a pyridine-2,6-diimine (PDI) iron complex is described. In the absence of a diene coupling partner, vinylsilane h...
Kinetic Evidence for an Induced Fit Mechanism in the Binding of the Substrate Camphor by Cytochrome P450cam [0.03%]
细胞色素P450cam结合底物莰烯的诱导契合机制的动力学证据
F Peter Guengerich,Stella A Child,Ian R Barckhausen et al.
F Peter Guengerich et al.
Bacterial cytochrome P450 (P450) 101A1 (P450cam) has served as a prototype among the P450 enzymes and has high catalytic activity towards its cognate substrate, camphor. X-ray crystallography and NMR and IR spectroscopy have demonstrated th...
Methylene Oxidation of Alkyl Sulfates by Cytochrome P450BM-3 and a Role for Conformational Selection in Substrate Recognition [0.03%]
细胞色素P450 BM-3催化的硫酸酯类底物的亚甲基氧化反应及底物识别中的构象选择性作用
F Peter Guengerich,Mostafa I Fekry
F Peter Guengerich
Cytochrome P450BM-3 (P450BM-3) is a flavoprotein reductase-heme fusion protein from the bacterium Bacillus megaterium that has been well-characterized in many biophysical aspects. Although the enzyme is known to catalyze the hydroxylation o...
Iterative Supervised Principal Component Analysis Driven Ligand Design for Regioselective Ti-Catalyzed Pyrrole Synthesis [0.03%]
迭代监督主成分分析驱动配体设计用于区域选择性钛催化吡咯合成
Xin Yi See,Xuelan Wen,T Alexander Wheeler et al.
Xin Yi See et al.
The rational design of catalysts remains a challenging endeavor within the broader chemical community owing to the myriad variables that can affect key bond-forming events. Designing selective catalysts for any reaction requires an efficien...
Structural basis for peptide substrate specificities of glycosyltransferase GalNAc-T2 [0.03%]
糖基转移酶GalNAc-T2底物特异性的结构基础
Sai Pooja Mahajan,Yashes Srinivasan,Jason W Labonte et al.
Sai Pooja Mahajan et al.
The polypeptide N-acetylgalactosaminyl transferase (GalNAc-T) enzyme family initiates O-linked mucin-type glycosylation. The family constitutes 20 isoenzymes in humans. GalNAc-Ts exhibit both redundancy and finely tuned specificity for a wi...
From Hydrogenation to Transfer Hydrogenation to Hydrogen Auto-Transfer in Enantioselective Metal-Catalyzed Carbonyl Reductive Coupling: Past, Present, and Future [0.03%]
手性金属催化羰基还原偶联反应中的氢化、转移氢化和氢自传递：过去、现在与未来
Catherine Gazolla Santana,Michael J Krische
Catherine Gazolla Santana
Atom-efficient processes that occur via addition, redistribution or removal of hydrogen underlie many large volume industrial processes and pervade all segments of chemical industry. Although carbonyl addition is one of the oldest and most ...
Elucidating the Mechanism of Ambient-Temperature Aldol Condensation of Acetaldehyde on Ceria [0.03%]
在氧化铈上甲醛环境条件下缩合反应机制的研究
Suman Bhasker-Ranganath,Md Saeedur Rahman,Chuanlin Zhao et al.
Suman Bhasker-Ranganath et al.
Using in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS) and density functional theory (DFT) calculations, we conclusively demonstrate that acetaldehyde (AcH) undergoes aldol condensation when flown over ceria octa...