Enantioselective Synthesis of Chiral Amines via Biocatalytic Carbene N-H Insertion [0.03%]
手性胺的不对称合成——通过生物催化卡宾N-H插入反应实现
Viktoria Steck,Daniela M Carminati,Nathan R Johnson et al.
Viktoria Steck et al.
Optically active amines represent highly valuable building blocks for the synthesis of advanced pharmaceutical intermediates, drug molecules, and biologically active natural products. Hemoproteins have recently emerged as promising biocatal...
Interfacial Water Structure as a Descriptor for Its Electro-Reduction on Ni(OH)2-Modified Cu(111) [0.03%]
Ni(OH)₂改性的Cu(111)表面上水电解还原反应的界面水结构描述符研究
Andrea Auer,Francisco J Sarabia,Daniel Winkler et al.
Andrea Auer et al.
The hydrogen evolution reaction (HER) has been crucial for the development of fundamental knowledge on electrocatalysis and electrochemistry, in general. In alkaline media, many key questions concerning pH-dependent structure-activity relat...
Manganese-Pincer-Catalyzed Nitrile Hydration, α-Deuteration, and α-Deuterated Amide Formation via Metal Ligand Cooperation [0.03%]
锰-夹环-催化的腈类水合、α-氘化和α-重氮化酰胺的形成及金属配体协同作用
Quan-Quan Zhou,You-Quan Zou,Sayan Kar et al.
Quan-Quan Zhou et al.
A simple and efficient system for the hydration and α-deuteration of nitriles to form amides, α-deuterated nitriles, and α-deuterated amides catalyzed by a single pincer complex of the earth-abundant manganese capable of metal-ligand coo...
Sara Blomberg,Uta Hejral,Mikhail Shipilin et al.
Sara Blomberg et al.
Performing fundamental operando catalysis studies under realistic conditions is a key to further develop and increase the efficiency of industrial catalysts. Operando X-ray photoelectron spectroscopy (XPS) experiments have been limited to p...
On the Metal-Aided Catalytic Mechanism for Phosphodiester Bond Cleavage Performed by Nanozymes [0.03%]
纳米酶催化的金属辅助切断磷酯键机制研究
Adam Pecina,Daniele Rosa-Gastaldo,Laura Riccardi et al.
Adam Pecina et al.
Recent studies have shown that gold nanoparticles (AuNPs) functionalized with Zn(II) complexes can cleave phosphate esters and nucleic acids. Remarkably, such synthetic nanonucleases appear to catalyze metal (Zn)-aided hydrolytic reactions ...
Catalytic Cyclopropanol Ring Opening for Divergent Syntheses of γ-Butyrolactones and δ-Ketoesters Containing All-Carbon Quaternary Centers [0.03%]
用于合成含全碳季碳中心的γ-丁内酯和δ-酮酸酯的环丙醇催化开环反应
Zhishi Ye,Xinpei Cai,Jiawei Li et al.
Zhishi Ye et al.
Catalytic ring opening cross coupling reactions of strained cyclopropanols have been useful for the syntheses of various β-substituted carbonyl products. Among these ring opening cross coupling reactions, the formation of α,β-unsaturated...
Biocatalytic, Stereoselective Deuteration of α-Amino Acids and Methyl Esters [0.03%]
生物催化立体选择性氨基酸及甲酯的轻度氘化反应
Stephanie W Chun,Alison R H Narayan
Stephanie W Chun
α-2H amino acids are valuable precursors toward labeled pharmaceutical agents and tools for studying biological systems; however, these molecules are costly to purchase and challenging to synthesize in a site- and stereoselective manner. H...
Mechanistic Studies of Pd(II)-Catalyzed E/ Z Isomerization of Unactivated Alkenes: Evidence for a Monometallic Nucleopalladation Pathway [0.03%]
钯(II)催化未活化的烯烃的E/Z异构化机理研究：单金属核 palladacycle路径的证据
Rei Matsuura,Malkanthi K Karunananda,Mingyu Liu et al.
Rei Matsuura et al.
Pd(II)-catalyzed E/Z isomerization of alkenes is a common process-yet its mechanism remains largely uncharacterized, particularly with non-conjugated alkenes. In this work, the mechanism of Pd(II)-catalyzed E/Z isomerization of unactivated ...
Selective Hydrolysis of Aryl Esters under Acidic and Neutral Conditions by a Synthetic Aspartic Protease Mimic [0.03%]
一种天冬氨酸蛋白酶模拟物在酸性和中性条件下对芳基酯的选择性水解作用
Ishani Bose,Yan Zhao
Ishani Bose
Aspartic proteases use a pair of carboxylic acids to activate water molecules for nucleophilic attack. Here we report a nanoparticle catalyst with a similar catalytic motif capable of generating a hydroxide ion in its active site even under...
Nikita Kvasovs,Valeriia Iziumchenko,Vitalii Palchykov et al.
Nikita Kvasovs et al.
A visible light-induced palladium-catalyzed oxidative C-H alkylation of oximes has been developed. This mild protocol allows for an efficient atom economical C-C bond construction of alkyl-substituted oximes. A broad range of primary, secon...