Kinetic Analysis of Cyclization by the Substrate-Tolerant Lanthipeptide Synthetase ProcM [0.03%]
底物耐受型 lanthipeptide 合酶ProcM催化的环化反应的动力学分析
Emily K Desormeaux,Garrett J Barksdale,Wilfred A van der Donk
Emily K Desormeaux
Lanthipeptides are ribosomally synthesized and post-translationally modified peptides (RiPPs) characterized by the presence of thioether cross-links called lanthionine and methyllanthionine, formed by dehydration of Ser/Thr residues and Mic...
How Do Variants of Residues in the First Coordination Sphere, Second Coordination Sphere, and Remote Areas Influence the Catalytic Mechanism of Non-Heme Fe(II)/2-Oxoglutarate Dependent Ethylene-Forming Enzyme? [0.03%]
第一配位群、第二配位群及远程区域的残基变异如何影响非血红素铁(II)/α-酮戊二酸依赖型乙烯形成酶的催化机制？
Midhun George Thomas,Simahudeen Bathir Jaber Sathik Rifayee,Christo Z Christov
Midhun George Thomas
The ethylene-forming enzyme (EFE) is a Fe(II)/2-oxoglutarate (2OG) and l-arginine (l-Arg)-dependent oxygenase that primarily decomposes 2OG into ethylene while also catalyzing l-Arg hydroxylation. While the hydroxylation mechanism in EFE is...
Lars Longwitz,Marijn D Kamer,Bart Brouwer et al.
Lars Longwitz et al.
Genetically encoded noncanonical amino acids can introduce new-to-nature activation modes into enzymes. While these amino acids can act as catalysts on their own due to their inherent chemical properties, interactions with adjacent residues...
Catalytic Mechanism of SARS-CoV-2 3-Chymotrypsin-Like Protease as Determined by Steady-State and Pre-Steady-State Kinetics [0.03%]
SARS-CoV-2 3-胰凝乳蛋白酶样蛋白酶的催化机制——稳态和预稳态动力学研究
Jiyun Zhu,Alexandria M Kemp,Bala C Chenna et al.
Jiyun Zhu et al.
The 3-chymotrypsin-like protease (3CL-PR; also known as Main protease) of SARS-CoV-2 is a cysteine protease that is the target of the COVID-19 drug, Paxlovid. Here, we report for 3CL-PR, the pH-rate profiles of a substrate, an inhibitor, af...
Csp3-Csp2 Coupling of Isonitriles and (Hetero)arenes through a Photoredox-Catalyzed Double Decyanation Process [0.03%]
通过光氧化还原催化双去氰基过程使异腈和杂芳烃的Csp3-Csp2偶联反应
María Martín,Rafael Martín Romero,Chiara Portolani et al.
María Martín et al.
Herein, we demonstrate the ability of isonitriles to be used as alkyl radical precursors in a photoredox-catalyzed transformation involving selective C-N cleavage and Csp3-Csp2 bond formation. This protocol allows for the preparation of fun...
Disentangling the Pitfalls of Rotating Disk Electrode-Based OER Stability Assessment: Bubble Blockage or Substrate Passivation? [0.03%]
析氧反应催化剂盘状电极测试稳定性的潜在影响因素：气泡遮蔽还是基底失活？
Aline Bornet,Pavel Moreno-García,Abhijit Dutta et al.
Aline Bornet et al.
Oxygen evolution reaction (OER) catalyst stability metrics derived from aqueous model systems (AMSs) prove valuable only if they are transferable to technical membrane electrode assembly (MEA) settings. Currently, there is consensus that st...
Improved Catalyst Performance for the Oxygen Evolution Reaction under a Chiral Bias [0.03%]
手性偏压下氧气析出反应催化剂性能的优化
Aravind Vadakkayil,Wiley A Dunlap-Shohl,Meera Joy et al.
Aravind Vadakkayil et al.
The oxygen evolution reaction (OER) remains an important bottleneck for widespread implementation of a hydrogen economy. While improvements in the OER can be realized by spin polarizing the reaction intermediates, these methods often rely o...
Fe-Doped Ni-Based Catalysts Surpass Ir-Baselines for Oxygen Evolution Due to Optimal Charge-Transfer Characteristics [0.03%]
基于铁掺杂的镍基催化剂通过最优电荷传输特性在析氧反应中超越铱基基准体系
Mai-Anh Ha,Shaun M Alia,Andrew G Norman et al.
Mai-Anh Ha et al.
Ni-based catalysts with Co or Fe can potentially replace precious Ir-based catalysts for the rate-limiting oxygen evolution reaction (OER) in anion-exchange membrane (AEM) electrolyzers. In this study, density functional theory (DFT) calcul...
Expanding the Reaction Network of Ethylene Epoxidation on Partially Oxidized Silver Catalysts [0.03%]
部分氧化银催化剂上乙烯环氧化反应网络的扩展研究
Adhika Setiawan,Tiancheng Pu,Israel E Wachs et al.
Adhika Setiawan et al.
An extended microkinetic model (MKM) for the selective oxidation of ethylene to ethylene oxide (EO) is presented, based on an oxidic representation of the silver (Ag) surface, namely, the p(4 × 4) oxidic reconstruction of the Ag(111) phase...
A Chemoenzymatic Cascade for the Formal Enantioselective Hydroxylation and Amination of Benzylic C-H Bonds [0.03%]
苯基甲基C-H键的正式对映选择性羟基化和胺化的化学酶级联反应
Yuqing Zhang,Chen Huang,Weixi Kong et al.
Yuqing Zhang et al.
We report the synthesis and characterization of an artificial peroxygenase (CoN4SA-POase) with CoN4 active sites by supporting single-atom cobalt on polymeric carbon nitrogen, which exhibits high activity, selectivity, stability, and reusab...