Genomic and Epigenomic Landscapes of Sarcopenia: From Molecular Etiology to Precision Interventions [0.03%]
sarcopenia的基因组和表观基因组景观：从分子病因学到精准干预措施
Ji-Yong Sung,Jung Woo Lee
Ji-Yong Sung
Sarcopenia-the age-related loss of skeletal muscle mass and strength-is a major contributor to frailty, disability, and mortality in the elderly. Once considered a physiological consequence of aging, sarcopenia is now recognized as a comple...
Hanin Shakeel,Dana Jin,Kunlin Jin
Hanin Shakeel
Chronological age is an inadequate proxy for the biological processes that drive disease risk, progression, and treatment response in older adults. This editorial advocates for a minimal standard in age-related disease research: the inclusi...
Editorial
Aging and disease. 2026 Jan 9. DOI:10.14336/AD.2026.0108 2026
Mortality among Older Adults Across Multimorbidity Categories and Lifestyle Patterns [0.03%]
不同多病种分类和生活方式模式下的老年人死亡率
Rafael Ogaz-González,Qian Zou,Javier Maroto-Rodriguez et al.
Rafael Ogaz-González et al.
Multimorbidity is common in older adults, and certain combinations of chronic conditions may confer higher mortality risk. Unhealthy lifestyle behaviours are also linked to shorter life expectancy. This study examined whether lifestyle patt...
Mengqi Chen,Xiangyu Zhu,Lejia Hang et al.
Mengqi Chen et al.
Aging is a major risk factor for a wide range of chronic diseases. Elucidating the molecular mechanisms underlying aging-associated disorders is essential for developing effective preventive and therapeutic strategies. Recent research has u...
Expanding on Gut Microbiota Insights in Sarcopenia and Osteoporosis [0.03%]
肠道微生物组在肌少症和骨质疏松症中的作用机制及其应用前景展望
Lei Chen,Cong Hong,Yu Xie
Lei Chen
NPM1 in Aging-Related Multi-System Diseases: Molecular Mechanisms and Therapeutic Implications [0.03%]
NPM1在衰老相关多系统疾病中的分子机制和治疗意义
Jiayao Li,Jiaqi Jin,Xinyu Yang et al.
Jiayao Li et al.
The prevalence of aging-related diseases, including tumors, cardiovascular and cerebrovascular diseases, and fibrotic diseases, has been consistently increasing in the aging population. In these conditions, nucleolar stress response mechani...
USP3 Promotes Glioma Progression by Stabilizing PLK1 through Deubiquitination [0.03%]
USP3通过去泛素化稳定PLK1促进胶质瘤进展
Feng Yan,Yongzhi Shan,Yaming Wang et al.
Feng Yan et al.
Glioma is an aggressive primary brain tumor with high morbidity and mortality, and it requires novel therapeutic targets. Ubiquitination and deubiquitination pathways regulate tumor progression. USP3, a deubiquitinating enzyme, and PLK1, a ...
Mitochondrial Dysfunction in Alzheimer's disease: Focus on Dynamics and Electron Transport Chain [0.03%]
阿尔茨海默病中的线粒体功能障碍：侧重于动力学和电子传递链
Jiehui Li,Gajendra Kumar,Yuqing Yan et al.
Jiehui Li et al.
Alzheimer's disease (AD) is a progressive neurological disease characterized by a decline in cognitive abilities and memory loss. Mitochondrial dysfunction is a major factor in early pathological changes; however, its precise pathogenic mec...
Admission Neutrophil-to-Lymphocyte Ratio Predicts Short- and Long-Term Mortality in Hospitalized Older Adults: A Retrospective Multicenter Study [0.03%]
中性粒细胞与淋巴细胞比值可预测住院老年患者的短期和长期死亡率：一项回顾性多中心研究
Luca Antognoli,Jacopo Sabbatinelli,Mirko Di Rosa et al.
Luca Antognoli et al.
The neutrophil-to-lymphocyte ratio (NLR) is an inexpensive biomarker of systemic inflammation. Although widely studied in acute and chronic conditions, evidence on long-term outcomes in hospitalized older adults is limited. We assessed whet...
Comprehensive Review of Therapeutic Efficacy and Underlying Mechanisms of Various Exercise Modalities in Treating Osteoporosis [0.03%]
多种运动方式治疗骨质疏松症的疗效及机制综合述评
Yangzheng Xie,Suyi Xu,Rushi Dai et al.
Yangzheng Xie et al.
Osteoporosis (OP) is a major public health challenge affecting over 200 million individuals worldwide. While pharmacological interventions represent mainstream treatment, concerns regarding long-term side effects and patient compliance have...