The Dickkopf Protein Family in Non-Neoplastic Disorders: Emerging Roles and Therapeutic Targeting [0.03%]
Dickkopf蛋白家族在非肿瘤性疾病中的作用及靶向治疗研究进展
Juju Zhou,Xiaoqian Zhu,Weihan Chen et al.
Juju Zhou et al.
The Dickkopf (DKK) family of secreted glycoproteins, comprising DKK1-4, serves as a pivotal regulator of the Wnt signaling pathway. Acting as canonical antagonists of the Wnt/β-catenin cascade, these proteins are indispensable for essentia...
Àngela Llop-Hernández,Júlia López,Sara Verdura et al.
Àngela Llop-Hernández et al.
Cellular senescence is a stress response that prevents the proliferation of damaged cells. As senescence has evolved in the near-surface biosphere, where cosmic background radiation (CBR) continuously delivers a low flux of highly penetrati...
Melatonin in Circadian Rhythm and Brain Health: Neuroprotective Effects and Therapeutic Potential [0.03%]
褪黑素与昼夜节律和脑健康：神经保护作用及治疗潜力
Yuxiao Feng,Yanpo Si,Xin Pang et al.
Yuxiao Feng et al.
Melatonin is an indole-like hormone secreted by the pineal gland. It regulates circadian rhythms and exerts antioxidants, anti-inflammatory, immunomodulatory, tumor-suppressing, and sleep-improving effects. With global population aging, neu...
PCSK9 in Brain Health and Disease: Liver-Vascular-Brain Interactions in Aging and Disease [0.03%]
PCSK9在脑健康和疾病中的作用：肝脏-血管-大脑在衰老和疾病中的相互作用
Mengqi Zhang,Neel S Singhal
Mengqi Zhang
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of peripheral cholesterol metabolism. Inhibitors of hepatic PCSK9 potently reduce low-density lipoprotein cholesterol (LDL-C) and have become a staple of lipid-lowerin...
LRRC8A in Aging and Aging-Related Diseases: Emerging Evidence and Therapeutic Potential [0.03%]
LRRC8A与衰老及老年相关疾病：新兴证据和治疗潜力
Yuman Wang,Teding Chang,Anding Liu et al.
Yuman Wang et al.
The aging process is a major risk factor for numerous chronic diseases, and the progressive increase in global life expectancy has intensified the need to understand the molecular mechanisms underlying aging and age-related diseases. Volume...
Jelena Vasilevska,Nelli A Arakelyan,Anastasiya L Kungurtseva et al.
Jelena Vasilevska et al.
Human progeroid syndromes, caused by single-gene mutations, offer unique insights into the genetic determinants of brain development, ageing, and neurodegeneration. However, the link between these mutations and neurological phenotypes remai...
Astrocytic Ferroptosis: An Integrative Hub Linking Metabolic Dyshomeostasis, Glial Crosstalk, and Neurodegeneration in Alzheimer's Disease [0.03%]
星形胶质细胞铁死亡：阿尔茨海默病中代谢失调、胶质通讯和神经退行性病变的综合枢纽
Zhimin Lu,Chang Meng,Xiaoyan Ren et al.
Zhimin Lu et al.
Alzheimer's disease (AD) is a widespread age-related neurodegenerative disorder. Current therapies targeting Aβ plaques and hyperphosphorylated Tau show limited efficacy. The core pathology of AD involves neuroglial metabolic network colla...
Aging Biomarkers in Osteoporosis: A Systematic Review of Molecular Mechanisms, Biological Aging, and Population Evidence [0.03%]
骨质疏松症的衰老生物标志物：分子机制、生物衰老和人群证据的系统评价
Miaosen Liu,Su Yon Jung
Miaosen Liu
While chronological age is an important risk factor for osteoporosis, biological aging measures may better capture nuances in systemic and bone-tissue aging among same-age individuals. This review aims to summarize the associations between ...
Difference between Biological Age and Chronological Age Predicts Mortality and Hospitalization in a Longitudinal Adult Cohort [0.03%]
纵向成人队列中生物学年龄和日历年龄的差异预测死亡率和住院治疗
Abigail Goshen,Evelyne Bischof,Edward H Livingston et al.
Abigail Goshen et al.
Biological age (BA) reflects overall health status and may deviate from chronological age (CA). Whether the magnitude of this difference (Agediff) independently predicts hospitalization and mortality remains unknown. Retrospective longitudi...
Harnessing Neuronal Autophagy: Bridging Mechanistic Breakthroughs to Therapeutic Interventions [0.03%]
利用神经元自噬：从机制突破到治疗干预
Nuzhat Ahsan,Farheen Badrealam Khan,Jhinuk Basu et al.
Nuzhat Ahsan et al.
Autophagy, an essential cellular process that degrades and recycles misfolded proteins, damaged organelles, and intracellular pathogens, is vital for neurons due to their limited capacity for apoptosis. Dysregulation of autophagy and lysoso...