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PCSK9 in Brain Health and Disease: Liver-Vascular-Brain Interactions in Aging and Disease

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Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of peripheral cholesterol metabolism. Inhibitors of hepatic PCSK9 potently reduce low-density lipoprotein cholesterol (LDL-C) and have become a staple of lipid-lowering therapeutic regime... ...