Decoding strain level interactions between Vibrio cholerae and gut microbiota [0.03%]
解码霍乱弧菌与肠道微生物组的株系间相互作用
Guozhong Chen,Shucheng Li,Qinghua Zhao et al.
Guozhong Chen et al.
Vibrio cholerae is a highly motile, comma-shaped, Gram-negative bacterium, which can cause severe diarrhea, dehydration, and even human death. Accumulating evidence suggests that gut microbiota and their culture supernatants affect the fitn...
Pathogenicity and virulence of Streptococcus suis serotype 2: Emerging insights and persistent knowledge gaps [0.03%]
猪链球菌二型的致病性和毒力：新的研究进展与现存的知识空白
Lihua Fang,Yueru Yao,Jinmei Wu et al.
Lihua Fang et al.
Streptococcus suis serotype 2 is a major zoonotic pathogen causing meningitis, septicemia, streptococcal toxic shock-like syndrome (STSLS) in swine and humans. This review synthesizes discoveries over the past decade, organized around the i...
Emerging infection and nosocomial transmission of carbapenem-resistant Klebsiella pneumoniae harboring blaNDM-21 in a neonatal intensive care unit [0.03%]
新生儿重症监护室中携带blaNDM-21的碳青霉烯耐药肺炎克雷伯菌的院内感染及传播事件
Song Hu,Hua Tan,Rong Ding et al.
Song Hu et al.
Carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a significant threat in neonatal intensive care units (NICU) because of its high antimicrobial resistance and association with increased mortality rates. In our study, we identifi...
Prevalence of bovine endometritis, virulence mechanisms of Escherichia coli, and current therapeutic strategies: A review [0.03%]
牛子宫内膜炎的流行、大肠杆菌的致病机制及当前治疗策略综述
Mengsen Wang,Xiangfu Wen,Xiaohan Li et al.
Mengsen Wang et al.
Dairy cow endometritis is a common postpartum disease influenced by geographic, management, environmental, diagnostic, and socio-economic factors. Escherichia coli (E. coli) was prioritized for its early colonization, frequent detection, an...
Mechanical forces in bacterial pathogenesis: Sensing, tropism, and intervention [0.03%]
细菌致病中的机械力：感应、趋向性和干预措施
Yixin Jiang,Gaixin Xu,Haobo Liang et al.
Yixin Jiang et al.
Bacterial pathogenesis unfolds within mechanically complex host niches, yet physical forces are frequently overlooked as active drivers of virulence. Here, we argue that mechanical cues-shear, confinement, and matrix rheology-serve as essen...
Hematodinium sp. infection alters haemolymph bacteriome composition and function in shore crabs, carcinus maenas [0.03%]
一个未描述的Hematodinium spp.感染改变了Carcinus maenas虾的血淋巴细菌群落结构和功能
Jessica E Thomas,Miguel Lurgi,Charlotte E Davies et al.
Jessica E Thomas et al.
Hematodinium sp. is a parasitic dinoflagellate that infects and causes disease in a large fraction of decapod crustaceans in the Northern Hemisphere. The shore crab Carcinus maenas is susceptible to this parasite in its native range of Euro...
A porcine model of chronic hepatitis E virus (HEV) infection identifies male reproductive glands as sites of viral persistence [0.03%]
猪慢性戊型肝炎病毒(HEV)感染模型鉴定出男性生殖腺是病毒持续存在的部位
Kush K Yadav,Patricia A Boley,Thamonpan Laocharoensuk et al.
Kush K Yadav et al.
Hepatitis E virus (HEV) is an expanding zoonotic viral disease threat. Although HEV causes acute viral hepatitis, it is increasingly being recognized as a systemic pathogen with detection and damage in extrahepatic tissues. The presence of ...
4-aminobenzoic acid attenuates Ralstonia solanacearum virulence by suppressing quorum sensing system [0.03%]
氨基苯甲酸通过抑制群体感应系统削弱Ralstonia solanacearum致病性
Chuanwang Yao,Wanlian Zhang,Zizi Lin et al.
Chuanwang Yao et al.
Quorum sensing (QS) is widely involved in the regulation of the biological functions and pathogenic processes of bacteria in a cell density-dependent manner. The anthranilic acid signal is directly sensed by the receptor RaaR, a transcripti...
HsfA-driven gene transcription regulates fungal morphogenesis and pathogenicity [0.03%]
热休克转录因子HsfA调控真菌形态发生和致病性
Xin-Yi Nie,Guolong Zhu,Bei Qin et al.
Xin-Yi Nie et al.
Aspergillus flavus, a ubiquitous filamentous fungus, severely compromises global food safety and public health by producing carcinogenic aflatoxins. Heat shock factor 1 (HSF1) orchestrates stress responses in eukaryotes, yet the functional ...
Discovery of isokurarinone as an ATCase-engaging lead with potent activity against methicillin-resistant Staphylococcus aureus [0.03%]
异卡瑞林酮作为抗甲氧西林金黄色葡萄球菌的ATCase衔接物先导化合物的发现
Xinyuan Cao,Xiaorong Yang,Lixia Dai et al.
Xinyuan Cao et al.
The global proliferation of methicillin-resistant Staphylococcus aureus (MRSA) persists as a significant contributor to challenging infections, highlighting the urgent necessity for therapies that utilize novel mechanisms. Aspartate transca...