Plasmids of two novel incompatibility groups IncFIIpPROV114-NR and IncpCHS4.1-3 from Providencia [0.03%]
来自普罗维登菌属的两个新型不相容群质粒IncFIIpPROV114-NR和IncpCHS4.1-3的质粒
Xiuhui Lu,Jiaqi He,Yali Zheng et al.
Xiuhui Lu et al.
This study presents the genetic structure of two incompatibility (Inc) groups found in Providencia: the newly discovered IncFIIpPROV114-NR and the newly designated IncpCHS4.1-3. An extensive genomic comparison was performed on all 14 plasmi...
Soraya Mezouar,Benoit Desnues,Yassina Bechah et al.
Soraya Mezouar et al.
Coxiella burnetii is responsible for Q fever, a zoonosis that mainly manifests as a mild acute infection and may persist in specific individuals causing severe complications, including endocarditis and vascular infections. Transmission main...
Mitochondrial anchor protein Num11 is key to pathogenicity of Candida albicans by affecting mitochondrial function and cell wall masking [0.03%]
线粒体锚蛋白Num11通过影响线粒体功能和细胞壁屏蔽作用是白念珠菌致病性的关键因素
Guangyuan Yang,Xiaojia Niu,Tian Zhuang et al.
Guangyuan Yang et al.
The mitochondrial anchoring protein Num1 directly affects mitochondrial redox function, cell division, and growth in unicellular fungi. However, the functional characterization of Num11, its Candida albicans homolog, remains elusive. Our in...
Human cytomegalovirus UL23 inhibits immune cell migration and blocks antiviral immune cell responses by reducing the expression of chemokines CCL2 and CCL5 [0.03%]
人巨细胞病毒UL23通过降低趋化因子CCL2和CCL5的表达来抑制免疫细胞迁移并阻断抗病毒免疫细胞反应
Hankun Wang,Chunling Zhang,Moran Li et al.
Hankun Wang et al.
Human cytomegalovirus (HCMV) is a typical opportunistic human pathogen, which can endanger the lives of individuals with immune insufficiency or low immune function. One of the most effective immune mechanisms against HCMV in host cells is ...
Bandavirus dabieense: A review of epidemiology, clinical characteristics, pathophysiology, treatment and prevention [0.03%]
丹伯病毒概览：流行病学、临床特征、发病机制、治疗和预防措施综述
Chengcheng Peng,Yujia Hao,Yuge Yuan et al.
Chengcheng Peng et al.
Bandavirus dabieense (commonly known as severe fever with thrombocytopenia syndrome virus, SFTSV) infection leads to severe fever with thrombocytopenia syndrome (SFTS), which is an emerging tick-borne natural focus disease discovered in mid...
Predicting the evolutionary and epidemiological dynamics of SARS-CoV-2 in South Africa [0.03%]
预测南非SARS-CoV-2的进化和流行病动力学
Chaojing Ma,Yantao Yang,Jian Zu
Chaojing Ma
Since the outbreak of coronavirus disease 2019 (COVID-19), the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continuously mutated and evolved, causing several waves of infection. Predicting the evolutionary and epidemiolo...
Prachi Gangil,Manash K Paul,Prathyoosha B et al.
Prachi Gangil et al.
Melioidosis, a fatal tropical disease, presents a wide array of clinical manifestations, including abscesses, pneumonia, septic shock, bacteraemia, osteomyelitis, septic arthritis, and skin infection. The Centers for Disease Control and Pre...
The secreted proteases aur, scpA, sspA and sspB suppress the virulence of Staphylococcus aureus USA300 by shaping the extracellular proteome [0.03%]
分泌蛋白酶aur、scpA、sspA和sspB通过重塑细胞外蛋白质组来抑制金黄色葡萄球菌USA300的毒力
Xiaofang Li,Sandra Maaß,Borja Ferrero-Bordera et al.
Xiaofang Li et al.
Surface-located and secreted virulence factors of the Gram-positive bacterial pathogen Staphylococcus aureus are key drivers for infection of the human host. Proteolytic enzymes may contribute to virulence by breaking primary barriers and h...
Comparative omics analysis of the impact of Mycoplasma synoviae infection on the immune mechanisms of poultry spleen [0.03%]
鸡滑液支原体感染对家禽脾脏免疫机制影响的比较组学分析
Lemiao Zhong,Chunlin Wu,Lvyan Liao et al.
Lemiao Zhong et al.
Mycoplasma synoviae (MS) infection can cause severe inflammatory responses in avian species, evading immune recognition, leading to chronic infection and immune dysfunction. Although the pathogenic mechanisms and immune evasion strategies o...
Comparative Study
Virulence. 2025 Dec;16(1):2507197. DOI:10.1080/21505594.2025.2507197 2025
Enterobacterales use capsules, transporters, mobile genetic elements, and other evolutionary adaptations to survive antibiotics exposure in the absence of resistance genes [0.03%]
肠杆菌目通过荚膜、转运蛋白、可移动遗传元件和其他进化适应在没有抗性基因的情况下存活抗生素暴露
Masego Mmatli,Nontombi Marylucy Mbelle,Bernard Fourie et al.
Masego Mmatli et al.
Methods: Whole-genome sequencing, transcriptomic profiling, and epigenomic analyses were performed. Phenotypic assays were used to evaluate the effects of various inhibitors on antibiotic susceptibility, while bioinformat...