Clinical Relevance of the 516 G>T Polymorphism in CYP2B6 and Its Effects on Efavirenz Concentrations in Patients with HIV and Tuberculosis: A Meta-analysis [0.03%]
CYP2B6 516G＞T多态性与HIV合并结核患者中埃夫替尼浓度关系的meta分析及临床意义
Alexandra Villalpando-Solórzano,Ashley Marieth Ramirez-Díaz,José Giovanni Navarro-Rangel et al.
Alexandra Villalpando-Solórzano et al.
Background and objective: Efavirenz is associated with frequent adverse effects, mainly hepatotoxicity and central nervous system disturbances. The cytochrome P450 enzyme CYP2B6 plays a key role in efavirenz metabolism an...
Toxicity-Tailored Thresholds of Delayed Methotrexate Elimination in Non-Hodgkin Lymphoma: A Population-Based Approach to Therapy Optimization [0.03%]
基于人群的优化治疗：非霍奇金淋巴瘤患者甲氨蝶呤延迟排出阈值的毒性调整模型
Tuan Fauziah,Ganesh Kasinathan,Teng Keat Chew et al.
Tuan Fauziah et al.
Background: High-dose methotrexate (HDMTX) is an essential agent in hematological malignancies, the use of which is complicated by toxicities related to delayed elimination. Existing thresholds to define delayed eliminati...
Protein Binding of Cefazolin is Not Saturated in Human Synovial Fluid After Single-Dose Perioperative Antibiotic Prophylaxis [0.03%]
单剂量围手术期抗生素预防后人滑膜液中头孢唑林蛋白结合未达到饱和状态
Steffen T Ubl,Luc M Arnold,Sophia Krombholz et al.
Steffen T Ubl et al.
Background and objective: Cefazolin is widely used for perioperative antibiotic prophylaxis and exhibits high protein binding. As only the unbound fraction exerts antimicrobial activity, understanding protein binding at t...
Impact of SLCO1B1 Gene Polymorphisms on Vadadustat Pharmacokinetics [0.03%]
SLCO1B1基因多态性对 vadadustat 药代动力学的影响
Satoshi Yokoyama,Michiko Shimada,Junichi Nakagawa et al.
Satoshi Yokoyama et al.
Background and objective: Vadadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, is transported into hepatocytes via OATP1B1, which is encoded by the SLCO1B1 gene. Although interindividual variability ...
PKPD-Based Translational Modeling of Calaspargase Pegol Preclinical Activity in Hepatocellular Carcinoma [0.03%]
基于PKPD的Calaspargase Pegol在肝细胞癌临床前活性的转化模型研究
Eef Hoeben,Vincent Madelain,Chayan Acharya et al.
Eef Hoeben et al.
Background and objective: Calaspargase pegol (CalPEG) is a PEGylated conjugate of L-Asparaginase (L-Asp) and an asparagine specific enzyme approved by the Food and Drug Administration (FDA) as a component of a multi-agent...
JLP-2008 Fixed-Dose Combination Tablet Demonstrates Bioequivalence and Comparable Safety to Separate Dapagliflozin + Pioglitazone in Healthy Participants [0.03%]
2型糖尿病药品达格列净和吡格列酮复方制剂(JLPH-1001)与单方制剂在健康受试者中的生物等效性和安全性比较研究
Woo-Lee Roh,Wonsuk Shin,Hyounggyoon Yoo et al.
Woo-Lee Roh et al.
Background and objectives: To establish pharmacokinetic bioequivalence and assess the safety of a single-dose administration of fixed-dose combination (FDC) tablet containing dapagliflozin 10 mg + pioglitazone 15 mg (JLP-...
Population Pharmacokinetics of Intranasal Amiloride in Healthy Volunteers [0.03%]
健康志愿者鼻内给药amiloride的群体药物代谢动力学研究
Manav Jain,Shaun Kumar,Marco Battaglia et al.
Manav Jain et al.
Background and objective: Amiloride, an acid-sensing ion channel (ASIC) blocking agent with demonstrated anti-panic effects in preclinical models, is a promising candidate for rapid treatment of panic attacks. Intranasal ...
Evaluation of the Effects of Nicardipine on Entrectinib Metabolism in vitro and in Rats [0.03%]
尼卡地平对恩曲替尼代谢影响的体内外评价研究
Peipei Pan,Yating Jiang,Yuxiao Tu et al.
Peipei Pan et al.
Background: Entrectinib, a multi-target tyrosine kinase inhibitor (TKI) against TRK, ROS1, and ALK, is clinically approved for genetically-defined solid tumors. The prevalence of drug-drug interactions (DDIs) with increas...
Pulmonary Pharmacokinetics/Pharmacodynamics of Commonly Used Antibiotics in the Treatment of Community-Acquired Pneumonia [0.03%]
社区获得性肺炎常用抗菌药物肺药代动力学/药效学特征研究进展
Yimin Wang,Jiankang Zhao,Bin Cao
Yimin Wang
Community-acquired pneumonia (CAP) remains a major global health burden, with antibacterial therapy as the primary treatment strategy. In clinical practice, plasma drug concentrations are often used to guide therapy, yet they may not reliab...
Julian Ananyev,Todd M Myers
Julian Ananyev
For over 50 years, ketamine has been approved for anesthesia and indicated for analgesia. In recent years, new clinical uses of ketamine have become increasingly common and continue to emerge. Intramuscular administration is a main route of...