Dilara Jappar,Jing Wu,Ute Burkard et al.
Dilara Jappar et al.
Background and objectives: Nerandomilast, a preferential phosphodiesterase 4B inhibitor, is approved for idiopathic pulmonary fibrosis and progressive pulmonary fibrosis in some countries. The objective of this study was ...
Factors Affecting Pharmacokinetics and Dosing Strategies of Polymyxin B in Multidrug-resistant Gram-negative Infected Patients with Renal Impairment: A Systematic Review with Expert Opinion [0.03%]
肾功能不全的多重耐药革兰阴性杆菌感染患者多黏菌素B影响药物代谢动力学和给药策略的因素：系统综述与专家意见
Asha K Rajan,Vishal Shanbhag,Muhammed Rashid et al.
Asha K Rajan et al.
Background and objective: Multidrug-resistant (MDR) Gram-negative infections pose significant therapeutic challenges, with limited evidence guiding optimal polymyxin B dosing in patients with renal impairment. This system...
Randomized Study About Influence of Food on the Pharmacokinetics of Disulfiram Metabolites in Healthy Individuals [0.03%]
一项关于食物对受试者体内硫酸酯代谢物药代动力学影响的随机研究
Gabriel P E Silveira,Douglas P Pinto,Luciana F Portela et al.
Gabriel P E Silveira et al.
Background and objective: Disulfiram (DSF) is a substance registered as an adjunct in the treatment of alcoholism, and its repurposing for several different diseases is under investigation. Our study aimed to investigate ...
Pharmacokinetics of Fentanyl and Norfentanyl in a Rat Model of Fixed-Volume Hemorrhagic Shock [0.03%]
家兔恒定失血量性休克模型中的芬太尼与去甲芬太尼的药代动力学变化
Paulina Stach,Kamil Skowron,Sebastian Rojek et al.
Paulina Stach et al.
Background: Hemorrhagic shock (HS) remains a leading cause of trauma-related mortality, primarily due to severe hypovolemia and systemic hypoperfusion. These pathophysiological changes may profoundly affect the pharmacoki...
Population Pharmacokinetic Modeling Study of Glibenclamide in Chinese Healthy Volunteers [0.03%]
中国健康志愿者中格列本脲的群体药代动力学研究
Yaou Liu,Qingyu Yao,Xinhua Cui et al.
Yaou Liu et al.
Background and objective: Type 2 diabetes mellitus (T2DM) is a group of metabolic diseases characterized by chronic hyperglycemia, primarily caused by insulin resistance and/or pancreatic beta cell dysfunction. Glibenclam...
A Relative Bioavailability Study of Vepdegestrant Tablets in Healthy Adult Participants [0.03%]
一项在健康成人受试者中进行的Vepdegestrant片剂相对生物利用度研究
Derek Z Yang,Kyle T Matschke,Jennifer A Kimberly C WintonLee et al.
Derek Z Yang et al.
Background and objective: Vepdegestrant is a selective, oral PROteolysis TArgeting Chimera (PROTAC) estrogen receptor (ER) degrader in development for the treatment of ER-positive/human epidermal growth factor receptor 2-...
Population Pharmacokinetics of Amikacin in Non-Neonatal Pediatric Patients: A Scoping Review [0.03%]
阿米卡星在非早产儿科患者中的药代动力学：一项综述研究
Chin Chiang Toh,Mohd Makmor Bakry,Noraida Mohamed Shah et al.
Chin Chiang Toh et al.
Background: Amikacin remains an important agent in managing severe Gram-negative infections in children. However, its clinical use is limited by a narrow therapeutic index and pronounced pharmacokinetic (PK) variability. ...
Investigating the Impact of Calcium Channel Blockers on the Pharmacokinetics of Lapatinib: Possible Role of Cytochrome P450 Enzymes and P-glycoprotein Efflux Transporters [0.03%]
钙通道阻滞剂对拉帕替尼药代动力学影响的研究：细胞色素P450酶和P-糖蛋白外排转运体的可能作用机制
Mrunal Pradeep Desai,Prajakta Harish Patil,Anithakumari Uttam Singh Rajpurohit et al.
Mrunal Pradeep Desai et al.
Background and objective: Lapatinib, an oral tyrosine kinase inhibitor used to treat breast cancer, is associated with cardiotoxicity. Therefore, cardioprotective agents, including calcium channel blockers, are often co-p...
Clinical Relevance of the 516 G>T Polymorphism in CYP2B6 and Its Effects on Efavirenz Concentrations in Patients with HIV and Tuberculosis: A Meta-analysis [0.03%]
CYP2B6 516G＞T多态性与HIV合并结核患者中埃夫替尼浓度关系的meta分析及临床意义
Alexandra Villalpando-Solórzano,Ashley Marieth Ramirez-Díaz,José Giovanni Navarro-Rangel et al.
Alexandra Villalpando-Solórzano et al.
Background and objective: Efavirenz is associated with frequent adverse effects, mainly hepatotoxicity and central nervous system disturbances. The cytochrome P450 enzyme CYP2B6 plays a key role in efavirenz metabolism an...
Toxicity-Tailored Thresholds of Delayed Methotrexate Elimination in Non-Hodgkin Lymphoma: A Population-Based Approach to Therapy Optimization [0.03%]
基于人群的优化治疗：非霍奇金淋巴瘤患者甲氨蝶呤延迟排出阈值的毒性调整模型
Tuan Fauziah,Ganesh Kasinathan,Teng Keat Chew et al.
Tuan Fauziah et al.
Background: High-dose methotrexate (HDMTX) is an essential agent in hematological malignancies, the use of which is complicated by toxicities related to delayed elimination. Existing thresholds to define delayed eliminati...