Post-translational cleavage generates truncated IgY forms in the snake Elaphe taeniura [0.03%]
蛋黄抗体IgY的翻译后剪切作用产生了大王蛇IgY的截短形式
Ming Zhang,Long Hua,Tang-Yuan Xie et al.
Ming Zhang et al.
While variable regions of immunoglobulins are extensively diversified by V(D)J recombination and somatic hypermutation in vertebrates, the constant regions of immunoglobulin heavy chains also utilize certain mechanisms to produce diversity,...
Ribosome-associated pathological TDP-43 alters the expression of multiple mRNAs in the monkey brain [0.03%]
与核糖体结合的异常TDP-43可改变猴脑中多种mRNA的表达水平
Fu-Yu Deng,Gao-Lu Zhu,Kai-Li Ou et al.
Fu-Yu Deng et al.
Cytoplasmic accumulation of TDP-43 is a pathological hallmark of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. While current studies have primarily focused on gene regulation mediated by full-length nuclear TDP-4...
Window to the soul: Pupil dynamics unveil the consolidation of recent and remote memories [0.03%]
灵魂之窗：瞳孔动态揭示最近和远期记忆的巩固过程
Hongyu Chang,Wenbo Tang
Hongyu Chang
Advances and applications of genome-edited animal models for severe combined immunodeficiency [0.03%]
基因组编辑动物模型在联合免疫缺陷研究中的进展及应用
Xiao Zheng,Chun-Hui Huang,Sen Yan et al.
Xiao Zheng et al.
Severe combined immunodeficiency disease (SCID), characterized by profound immune system dysfunction, can lead to life-threatening infections and death. Animal models play a pivotal role in elucidating biological processes and advancing the...
Functional evolution of thyrotropin-releasing hormone neuropeptides: Insights from an echinoderm [0.03%]
垂体激素功能的进化：从棘皮动物中获得的TRH神经肽的新见解
Yingqiu Zheng,Huachen Liu,Xin Dang et al.
Yingqiu Zheng et al.
Feeding behavior is regulated by a complex network of endogenous neuropeptides. In chordates, this role is suggested to be under the control of diverse factors including thyrotropin-releasing hormone (TRH). However, whether this regulatory ...
Elevated CXCL1 triggers dopaminergic neuronal loss in the substantia nigra of C57BL/6J mice: Evaluation of a novel Parkinsonian mouse model [0.03%]
小鼠黑质多巴胺能神经元缺失及一种新的帕金森病动物模型的评价研究CXCL1起到了关键作用
Xi-Zhen Ma,Guo-Rui Jia,Meng-Yu Li et al.
Xi-Zhen Ma et al.
Substantial evidence points to the early onset of peripheral inflammation in the development of Parkinson's disease (PD), supporting the "body-first" hypothesis. However, there remains a notable absence of PD-specific animal models induced ...
Intranasal iron administration induces iron deposition, immunoactivation, and cell-specific vulnerability in the olfactory bulb of C57BL/6 mice [0.03%]
鼻内给铁诱导C57BL/6小鼠嗅球中的铁沉积，免疫激活和细胞特异性脆弱性
Xiao-Qing Mi,Bao-Chen Liu,Le Qu et al.
Xiao-Qing Mi et al.
Iron is the most abundant transition metal in the brain and is essential for brain development and neuronal function; however, its abnormal accumulation is also implicated in various neurological disorders. The olfactory bulb (OB), an early...
Cross-species single-cell transcriptomics reveals neuronal similarities and heterogeneity in amniote pallium [0.03%]
跨物种单细胞转录组揭示羊膜动物皮层中神经元的相似性和异质性
Fu-Bao-Qian Huang,Kuo Liao,Yu-Nong Sun et al.
Fu-Bao-Qian Huang et al.
The amniote pallium, a vital component of the forebrain, exhibits considerable evolutionary divergence across species and mediates diverse functions, including sensory processing, memory formation, and learning. However, the relationships a...
Multi-omics analysis and experimental verification reveal testicular fatty acid metabolism disorder in non-obstructive azoospermia [0.03%]
多组学分析及实验验证发现非梗阻性无精子症患者睾丸脂肪酸代谢紊乱
Zhou Li,Yi-Jian Xiang,Zhi-Chuan Zou et al.
Zhou Li et al.
Increasing evidence implicates disruptions in testicular fatty acid metabolism as a contributing factor in non-obstructive azoospermia (NOA), a severe form of male infertility. However, the precise mechanisms linking fatty acid metabolism t...
sRNA113 regulates Pseudomonas plecoglossicida motility to affect immune response against infection in pearl gentian grouper [0.03%]
sRNA113通过调节假单胞菌动力性影响珍珠杂交 grouper 抗病原感染的免疫反应
Li He,Mei-Qin Mao,Ling-Min Zhao et al.
Li He et al.
Small RNAs (sRNAs) are a class of molecules capable of perceiving environmental changes and exerting post-transcriptional regulation over target gene expression, thereby influencing bacterial virulence and host immune responses. Pseudomonas...