Traversing the ancient Overland Silk Road: Insights from domestic camel paleogenomics in Xi'an, China [0.03%]
穿越古老的陆上丝绸之路——中国西安家驼古基因组的启示
Jun-Xia Yuan,Dong-Qi Yu,Ji Li et al.
Jun-Xia Yuan et al.
The ancient Overland Silk Road connected distant regions through commerce and movement, enabling large-scale dispersal of domesticated animals alongside goods. However, the evolutionary and demographic trajectories of domestic camels, vital...
Gut microbiota remodeling in HBB-mutant cynomolgus monkeys reveals blood-gut axis disruption associated with β-thalassemia-related gastrointestinal dysfunction [0.03%]
HBB突变食蟹猴肠道菌群重塑揭示血肠轴障碍与β-地中海贫血相关胃肠功能紊乱的关系
Bao-Zhen Liu,Xin-Yuan Zhao,Ze-Wen Sun et al.
Bao-Zhen Liu et al.
Gastrointestinal symptoms frequently accompany anemia caused by HBB mutations, such as β-thalassemia; however, the mechanisms linking disordered hemoglobin biology to intestinal dysfunction remain incompletely understood. In this study, HB...
A miR-305-5p/Nerfin-1/Cyp18a1 cascade fine-tunes 20-hydroxyecdysone degradation to time pupariation in Drosophila [0.03%]
Drosophila中miR-305-5p/Nerfin-1/Cyp18a1级联反应精细调节20-羟基蜕皮酮降解以控制 prepupa形成的时间
Chan Chen,Ze Zhang,Wei Sun
Chan Chen
Steroid hormone pulses provide critical temporal signals that synchronize developmental transitions, yet the mechanisms that restrain hormone clearance and preserve pulse timing remain unclear. Using Drosophila melanogaster metamorphosis, a...
Functional characterization of HR-CATH2, a novel cathelicidin from Hoplobatrachus rugulosus with anti-sepsis activity [0.03%]
HR-CATH2的功能表征：一种具有抗败血症活性的Hoplobatrachus rugulosus新型 Cathelin 家族成员蛋白质
Hang Liao,Shian Lai,Kai Wang et al.
Hang Liao et al.
Cathelicidins are central effectors of innate host immunity against invading microorganisms and represent a promising source of next-generation anti-infective agents. However, current understanding of both antimicrobial activity and immunom...
miR-449a modulates Alzheimer's disease pathology through regulation of Navβ2 [0.03%]
微RNA-miR-449a通过调节Navβ2调控阿尔茨海默病病理变化
Guo-Ji Yan,Xu-Yang Wang,Xin-Ying Shi et al.
Guo-Ji Yan et al.
Progression of Alzheimer's disease (AD) from mild cognitive impairment (MCI) to dementia occurs gradually and remains mechanistically unresolved, limiting development of effective interventions. This study investigated the contribution of N...
First identification of an amphibian-derived peptide with anti-vascular aging activity [0.03%]
首个具有抗血管衰老活性的两栖动物源多肽的鉴定
Xin Liu,Jie Liu,Bin Li et al.
Xin Liu et al.
Vascular aging is a principal driver of cardiovascular morbidity and mortality, and effective prevention of age-related vascular pathologies depends on interventions that target fundamental molecular and cellular aging pathways. The present...
Amphibian-derived peptides as novel therapeutics for skin wound healing: Mechanisms, applications, and challenges [0.03%]
两栖动物源性肽在皮肤伤口愈合中的新治疗作用：机制、应用与挑战
Cheng-Jie Deng,Ying Wang,Xin-Wang Yang
Cheng-Jie Deng
Skin injury disrupts the body's primary barrier against pathogens and environmental insults, often leading to infection, delayed healing, and pathological scarring. Therefore, the development of effective wound-healing therapies remains a m...
Xingyuan Tuo,Chao Cheng,Jun Wen et al.
Xingyuan Tuo et al.
Calcium oxalate (CaOx) stones are the most prevalent form of nephrolithiasis and are characterized by a substantial risk of recurrence. Their pathogenesis arises through distinct etiological pathways, including idiopathic metabolic suscepti...
Integrated transcriptomic analysis reveals lymphatic Icam1-mediated immune dynamics after myocardial infarction [0.03%]
整合转录组分析揭示心肌梗死后淋巴细胞ICAM1介导的免疫动力学变化
Xue-Ting Chen,Bei-Bei Hu,Zhao Zhang et al.
Xue-Ting Chen et al.
Cardiac lymphatic vessels are active regulators of immune surveillance and inflammatory resolution after myocardial injury. Intercellular adhesion molecule-1 (ICAM-1), a cell-surface glycoprotein broadly expressed in endothelial cells, medi...
Knockout of hsd3b1 disrupts steroid hormone homeostasis and compromises gonadal development in zebrafish [0.03%]
斑马鱼中的hsd3b1基因敲除干扰类固醇激素稳态并破坏生殖腺发育
Lijia He,Yaqing Wang,Zhiqin Ren et al.
Lijia He et al.
Steroid hormones are central regulators of gonadal differentiation, endocrine homeostasis, and reproductive function, with impaired steroid biosynthesis leading to metabolic dysfunction and reproductive disease. 3β-Hydroxysteroid dehydroge...