Antimicrobial peptides in anti-infective and immunomodulatory applications: Mechanisms, challenges, and emerging computational design [0.03%]
抗菌肽在抗感染和免疫调节应用中的机制、挑战及新兴计算设计
Yan-Lin Wang,Ya-Qian Yang,Yu-Yang Zhou et al.
Yan-Lin Wang et al.
Antimicrobial Peptides (AMPs) evolutionarily conserved effectors of innate immunity, have emerged as multifunctional agents with broad-spectrum antimicrobial activity, immunomodulatory capabilities, and potential applicability in cancer the...
Dynamic remodeling of membrane proteins for temperature adaptation in oysters [0.03%]
温度适应下牡蛎膜蛋白的动态重建
Ming-Yang Du,Chao-Gang Wang,Mei-Qian Pang et al.
Ming-Yang Du et al.
Rising ocean temperatures due to global warming pose severe threats to marine organism survival. Membrane proteins perform important biological functions and serve as sensitive environmental stress sensors. However, the characterization of ...
Circadian per2 regulates the zebrafish central neuronal Mauthner cell axon regeneration via carboxypeptidase E [0.03%]
视黄酸受体途径调节斑马鱼Mauthner细胞轴突再生中PER2介导的羧肽酶E的作用
Ding-Gang Fan,Ke-Qiang Li,Zi-Ang Zhao et al.
Ding-Gang Fan et al.
Central nervous system (CNS) injuries often result in permanent neurological impairments or fatal outcomes. While circadian regulation is a key pathway affecting the regenerative capacity of peripheral neurons, the role of the intrinsic cir...
Host phylogeny and diet shape gut microbiome and virome in wild small mammals of Gongga Mountain, China [0.03%]
脊柱动物宿主系统发育和饮食对我国贡嘎山野生小型哺乳动物肠道微生物组和病毒组的影响
Le-Wei He,Rui-Xiang Tang,Shao-Ying Liu et al.
Le-Wei He et al.
Gut microbiotas play pivotal roles in host adaptation, yet their composition and function in high-altitude small mammals remain poorly characterized. This study investigated how host phylogeny (order-level) and dietary habits shape the gut ...
DNAJB6a deficiency induces tau pathology through IRE1α-Xbp1-induced mitochondria dysfunction [0.03%]
DNAJB6a缺乏通过IRE1α-Xbp1诱导的线粒体功能障碍诱发tau病理变化
Xiu Chen,Fang-Yuan Qian,Na Zhao et al.
Xiu Chen et al.
Endoplasmic reticulum (ER) stress and mitophagy have been indicated in the early stage of Alzheimer's disease (AD), in which tau hyperphosphorylation is one major pathological alteration. However, the precise mechanism remains unclear. Here...
A non-bactericidal antimicrobial peptide provides protective effect against bacterial sepsis via regulation of antimicrobial immunity and vascular endothelial functions [0.03%]
一种非杀菌性抗菌肽通过调节抗菌免疫和血管内皮功能来对抗细菌感染的保护作用
Yan-Mei He,Ting Lin,Li-Xian Mu et al.
Yan-Mei He et al.
The anti-infective properties of bactericidal antimicrobial peptides (AMPs) have been extensively studied, yet the functions and mechanisms of non-bactericidal AMPs in sepsis remain poorly understood. In this study, a novel β-sheet catheli...
5-HT 2A receptor in medial prefrontal cortex mediates pain-related empathic responses in rats [0.03%]
大鼠中前额叶5-HT₂A受体介导痛相关的同理反应
Wen-Jun Luo,Rui Du,Chun-Li Li et al.
Wen-Jun Luo et al.
Using a dyadic social interaction (DSI) paradigm, we validated a scenario of pain-related empathic responses in rats and mice, during which socially transferred pain was identified in naïve observers spontaneously engaging in caring behavi...
A causal SNP in the promoter of myogenin is essential for lean meat production [0.03%]
肌生成素启动子中的因果SNP是瘦肉生产所必需的
Zhu-Hu Lin,Qing-Shuang Zhou,Xiao-Yu Wang et al.
Zhu-Hu Lin et al.
Single nucleotide polymorphisms (SNPs) widely existing in different breed genomes represent population-specific variations. Under the influence of long-term evolution and artificial selection, there are a large number of SNPs between Wester...
Genome-wide SNVs revealed reticulate evolutionary history of a Eurasian-African songbird radiation ( Saxicola torquatus complex) [0.03%]
横跨欧亚非的戴胜雀类(Saxicola torquatus复合种)基因组重测序解析鸟类辐射进化中的杂交网络事件
Chuan Jiang,Yang Liu,Wen-Wen Zhu et al.
Chuan Jiang et al.
Phylogenomics has the power to reveal complex evolutionary hypotheses across taxa, thereby allowing important glimpses into the evolutionary history, such as incomplete lineage sorting (ILS) and introgression among closely related species. ...
Phylogeographic history of the ring distribution in Malcus flavidipes (Heteroptera: Malcidae) shaped by directional dispersal and island adaptation in the South China Sea region [0.03%]
南中国海地区Malcus flavidipes(Malchiidae: Heteroptera)环状分布的谱系地理格局形成受定向扩散和岛屿适应的影响
Yan-Fei Li,Mei-Qi Guo,Ju-Hong Chen et al.
Yan-Fei Li et al.
The ring distribution pattern offers a unique perspective for analysing the mechanisms of species or population differentiation. The semi-closed South China Sea (SCS) region, with its islands, peninsulas, and continental margins, is ideal f...