Emerging technologies for advancing molecular and cellular research in bats [0.03%]
新兴技术助力蝙蝠的分子与细胞研究
Peng Chen,Zhen-Na Zhang,Rong-Song Luo et al.
Peng Chen et al.
Bats represent a remarkable mammalian lineage, distinguished by the evolution of powered flight, sophisticated echolocation, exceptional longevity, and robust resistance to viral infections. These adaptations have contributed to their rapid...
Bacterial defense systems: Mechanisms, homology to eukaryotic immune systems, and applications [0.03%]
细菌防御系统：机制、同源性与应用及其对真核生物免疫系统的启示
Guan-Zong Li,Zhi-Qing Liang,Chu-Ying Liang et al.
Guan-Zong Li et al.
Bacteria, as fundamental members of the microbial biosphere, are under constant threat from mobile genetic elements (MGEs), including bacteriophages and plasmids. In response, diverse molecular defense strategies have emerged to detect, neu...
Nanomaterial strategies for mitigating protein misfolding and neuroinflammation in neurodegenerative diseases [0.03%]
用于缓解神经退行性疾病中蛋白质错误折叠和神经炎症的纳米材料策略
Yu-He Wang,Xiao-Ling Lang,Xiu-Li Qing
Yu-He Wang
Neurodegenerative disorders such as Alzheimer's disease are characterized by pathological protein misfolding, persistent neuroinflammation, and progressive synaptic deterioration. Nanoscale therapeutic platforms offer a versatile strategy f...
Generation of a PKP2 heterozygous knockout pig model of arrhythmogenic cardiomyopathy [0.03%]
PKP2杂合敲除型遗传性心律失常性心肌病猪模型的构建
Hong-Hui Li,Yuan Chang,Tai-Yun Wei et al.
Hong-Hui Li et al.
Arrhythmogenic cardiomyopathy (ACM) confers elevated risk of ventricular arrhythmias and sudden cardiac death, yet limitations in early lesion sampling and model development continue to hinder mechanistic and translational research. Clinica...
Vertebral morphological changes driven by rflna lead to body shape differentiation in carp [0.03%]
rflna诱导脊椎形态变化导致鲤鱼体形分化
Zhou Jiang,Bi-Jun Li,Lin Chen et al.
Zhou Jiang et al.
Body shape evolution in vertebrates frequently involves modifications in vertebral number or patterns of vertebral fusion, with distinct lineages displaying divergent trajectories. This study investigated the morphological and genetic basis...
Molecular divergence of TRPA1 in cetaceans supports lineage-specific adaptation to aquatic life [0.03%]
分子分歧表明TRPA1通道在鲸目中经历了谱系特异性适应以适应水生生活
Tian-Zhen Wu,Xian-Ting Huang,Yu-Qing Deng et al.
Tian-Zhen Wu et al.
Gene loss represents a powerful driver of adaptive evolution. Cetaceans, which underwent a profound transition from terrestrial to fully aquatic life, provide an excellent model for investigating this process. Comparative genomic analysis o...
Diverse mitogenomic variations contribute to population differentiation in Eurasian tree sparrows ( Passer montanus) [0.03%]
多样性的线粒体基因组变异对欧亚树燕的种群分化有贡献（《Passer montanus》）
Cheng-Bin Shan,Ning Wang,Wei Liang et al.
Cheng-Bin Shan et al.
Mitochondrial genomes (mitogenomes) play a crucial role in species adaptation to diverse evolutionary pressures. Although adaptive changes in mitochondrial genes have been reported under extreme conditions, large-scale analyses of mitogenom...
Comparative genomics reveals evolutionary signatures of genes associated with jumping in beetles [0.03%]
比较基因组学揭示了与甲虫跳跃性状进化相关的基因签名
Wei Wang,Le Zong,Jin-Wu He et al.
Wei Wang et al.
Jumping has independently emerged as an effective escape strategy across multiple beetle lineages (order Coleoptera). Characterization of jumping behavior not only informs the development of bioinspired robotic systems but also advances und...
Highly divergent virome in wild rodents of Xinjiang, China: Implications for rodent origin of porcine reproductive and respiratory syndrome virus 1 [0.03%]
中国新疆野生鼠类病毒组高度分化：猪繁殖与呼吸综合征病毒1型起源于啮齿动物的启示
Le Cao,Ying-Ying Ma,Guo-Wu Zhang et al.
Le Cao et al.
Rodents play a pivotal role in the maintenance and transmission of zoonotic viruses. The Yili River Valley, one of the most biodiverse regions in Xinjiang, functions as a critical biogeographic corridor linking China with Central and Wester...
Dynamic single-nucleus transcriptomic profiling of kidney development in Bamaxiang pigs and wild boar [0.03%]
巴马香猪和野猪肾脏发育的单核转录组动态分析
Tian-Xiong Yao,Yang Zhang,Xiao-Yun Chen et al.
Tian-Xiong Yao et al.
Defining developmental periods- and breed-specific cellular features of the porcine kidney is critical for refining donor selection strategies in xenotransplantation. This study utilized single-nucleus RNA sequencing to generate 71 081 high...