Hippocampal Hap1 downregulation exacerbates Alzheimer's disease-related neuropathology through impairment of glucocorticoid receptor nuclear translocation in APP/PS1 mice [0.03%]
APP/PS1小鼠海马体中Hap1下调通过影响糖皮质激素受体核转位加重阿尔茨海默病相关性神经病理损伤
Taiqi Huang,Meiyu Zhang,Yanyu Zhang et al.
Taiqi Huang et al.
Although impaired nuclear translocation of glucocorticoid receptor (GR) contributes to hippocampal vulnerability in Alzheimer's disease (AD), its regulatory mechanisms remain poorly understood.Here, we identify Huntingtin-associated protein...
ZBP1 Promotes RIPK1-Dependent Apoptosis in Aristolochic Acid Nephropathy [0.03%]
小分子结合蛋白1通过促进RIPK1依赖性凋亡介导 Aristolochic 酸肾病发生发展
Zhenhuan Zou,Keng Ye,Fengbin Chen et al.
Zhenhuan Zou et al.
Aristolochic acid nephropathy (AAN) is a progressive form of kidney disease marked by acute tubular injury and interstitial fibrosis, ultimately leading to end-stage renal disease (ESRD). Despite regulatory restrictions, aristolochic acid (...
Tubulin hyperglutamylation causes retinal degeneration by impairing the structural integrity of cilia and protein mistrafficking [0.03%]
角蛋白过度谷氨酰胺化通过损害纤毛的结构完整性和蛋白质分拣错误导致视网膜变性
Hao-Lin Wang,Ting Wang,Fang-Yuan Zhen et al.
Hao-Lin Wang et al.
Tubulins undergo various posttranslational modifications (PTMs) that confer diverse functions to microtubules. Tubulin polyglutamylation is dynamically regulated by glutamylation and deglutamylation. AGBL5 is a deglutamylase that specifical...
Phylogenomic analysis of Cervidae provides insights into antler origin and evolution [0.03%]
鹿科的泛基因组分析为角的起源和演化提供了启示
Zhenyu Zhong,Zihe Li,Zhili Zuo et al.
Zhenyu Zhong et al.
Antlers represent the only known example of complete annual organ regeneration in mammals. Despite this unique regenerative capacity, the genetic mechanisms driving antler origin and morphological diversification across Cervidae remain poor...
Multiple etiological agents associated with the deaths of trafficked pangolins [0.03%]
与走私穿山甲死亡相关联的多种病原体
Xian-Dan Lin,Shuo-Wei Quan,Jia-Xin Lv et al.
Xian-Dan Lin et al.
Pangolins represent the most heavily trafficked mammal globally and harbor diverse microorganisms, raising the concern that illegal trade increases their susceptibility to infectious diseases and facilitates the spread of zoonotic pathogens...
Epigenetic editing of marine medaka ( Oryzias melastigma) fgf2 using CRISPR/dCas9-Tet1CD [0.03%]
CRISPR/dCas9-Tet1CD技术在拟斑姑鱼（Oryzias melastigma）fgf2表观基因编辑中的应用研究
Lei Lin,Jing-Jing Zhang,Bing-Hua Liu et al.
Lei Lin et al.
CRISPR/dCas9-mediated epigenetic editing offers a versatile approach for transcriptional regulation without introducing DNA strand breaks. Although this strategy has been explored in a limited number of species, its application in aquatic v...
Establishment of mouse endometrial assembloids with luminal epithelial-like structures in vitro [0.03%]
体外建立具有腔上皮样结构的小鼠子宫内膜组装体
Xiao-Yan Qiu,Jing-Yi Tu,Jie Yang et al.
Xiao-Yan Qiu et al.
Embryo implantation requires coordinated interactions between the embryo and the maternal endometrium. Endometrial organoids (EOs) have emerged as promising in vitro models for studying this process. At present, however, mouse-derived EOs (...
Peptides derived from exocrine secretions of venomous animals used as traditional Chinese "worm" medicines [0.03%]
来源于有毒动物外分泌物的用于传统中国“驱虫”药物的多肽
Shian Lai,Jinwei Chai,Yongtao Luo et al.
Shian Lai et al.
The term "worm medicines" (Chong Yao) in Traditional Chinese Medicine encompasses a diverse category of small animal-derived therapeutics, including arthropods, amphibians, and reptiles, rather than strictly vermiform organisms. Many of the...
Emerging technologies for advancing molecular and cellular research in bats [0.03%]
新兴技术助力蝙蝠的分子与细胞研究
Peng Chen,Zhen-Na Zhang,Rong-Song Luo et al.
Peng Chen et al.
Bats represent a remarkable mammalian lineage, distinguished by the evolution of powered flight, sophisticated echolocation, exceptional longevity, and robust resistance to viral infections. These adaptations have contributed to their rapid...
Bacterial defense systems: Mechanisms, homology to eukaryotic immune systems, and applications [0.03%]
细菌防御系统：机制、同源性与应用及其对真核生物免疫系统的启示
Guan-Zong Li,Zhi-Qing Liang,Chu-Ying Liang et al.
Guan-Zong Li et al.
Bacteria, as fundamental members of the microbial biosphere, are under constant threat from mobile genetic elements (MGEs), including bacteriophages and plasmids. In response, diverse molecular defense strategies have emerged to detect, neu...