Beyond origin: multimodal AI synthesis to resolve cancers of unknown primary [0.03%]
超越起源：多模态AI合成技术破解原发不明癌症难题
Hongru Shen,Xiangchun Li
Hongru Shen
SARS-CoV-2 infection in brain tumors and the association with alterations in the tumor immune microenvironment [0.03%]
脑肿瘤中SARS-CoV-2感染及其对肿瘤免疫微环境改变的影响关系研究
Weikang Chen,Haojie Bai,Maoling Tian et al.
Weikang Chen et al.
Objective: Recent clinical evidence indicates that persistent reservoirs of SARS-CoV-2 in human brain tissue are associated with various neurologic symptoms. While brain tumors have unique vascular abnormalities and immun...
Blood-based prediction and early detection of pancreatic cancer recurrence after tumor resection [0.03%]
基于血液的胰腺癌术后复发预测和早期检测
Fawaz N Al-Shaheri,Teresa Colbatzky,Andrea S Bauer et al.
Fawaz N Al-Shaheri et al.
Pan-KRAS inhibition: unlocking broad-spectrum targeted therapy for KRAS-mutant cancers [0.03%]
泛KRAS抑制：针对KRAS突变癌症的广谱靶向治疗解锁
Juanjuan Feng,Xuanzheng Xiao,Zhengke Lian et al.
Juanjuan Feng et al.
Gut microecology empowers cancer immunotherapy: commensal microbiota-mediated mechanisms and translational prospects of PD-1/PD-L1 therapy [0.03%]
肠道微生态助力癌症免疫治疗：PD-1/PD-L1疗法共生微生物介导的机制与转化前景
Sifan Li,Chang Che,Yelu Zhou et al.
Sifan Li et al.
Anti-programmed cell death protein 1 (PD-1) or its ligand (PD-L1) are immune checkpoint inhibitors (ICIs) that have revolutionized cancer therapy. However, the efficacy of anti-PD-1 and anti-PD-L1 is limited by resistance and inter-individu...
SPRED2 suppresses the stemness of hepatocellular carcinoma through the p53/miR-506-3p/KLF4 pathway [0.03%]
SPRED2通过p53/miR-506-3p/KLF4通路抑制肝癌干细胞特性
Tong Gao,Sachio Ito,Aye Moh-Moh-Aung et al.
Tong Gao et al.
Objective: We previously reported that endogenous Sprouty-related, EVH1 domain-containing protein 2 (SPRED2), an inhibitor of the Ras/Raf/ERK-MAPK pathway, controls hepatocellular carcinoma (HCC) cell stemness by downregu...
Innovative cross-intervention: copper ions and metabolic pathways in cancer therapy [0.03%]
创新的跨干预措施：铜离子和代谢途径在癌症治疗中的作用
Lili Niu,Wei Su,Lixia Ju et al.
Lili Niu et al.
Copper ions are essential for cellular function but can induce cytotoxic effects when dysregulated. This review explores the multifaceted role of copper in cancer metabolism with a focus on the novel concept of cuproptosis, a regulated form...
Temporal radiomics for non-invasive preoperative prediction of pathologic complete response to neoadjuvant chemoimmunotherapy in non-small cell lung cancer [0.03%]
用于非小细胞肺癌新辅助化疗免疫治疗术前无创预测病理完全缓解的时序影像组学研究
Sunyi Zheng,Shuo Wang,Ziwei Feng et al.
Sunyi Zheng et al.
Objective: This study aimed to develop and validate a temporal radiomics model based on pre- and post-treatment CT scans for the preoperative prediction of pathologic complete response (pCR) in patients with resectable no...
Migration and invasion inhibitory protein inhibits M2 macrophage polarization to suppress colorectal cancer progression through the STING-NFκB2-IL10 axis [0.03%]
迁移和侵袭抑制蛋白通过STING-NFκB2-IL10轴抑制M2型巨噬细胞极化以抑制结直肠癌进展
Shuai Chen,Chenglu Lu,Jiaxin Li et al.
Shuai Chen et al.
Objective: This study aimed to determine the role and mechanism underlying migration and invasion inhibitory protein (MIIP) modulation in M2 macrophages within the tumor microenvironment and the potential of targeting the...