VDAC1 protein derived from extracellular vesicles promotes paclitaxel resistance in gastric cancer through autophagy and mitophagy [0.03%]
胃癌细胞来源的外泌体VDAC1蛋白通过自噬和线粒体自噬促进紫杉醇耐药性
Yanna Bi,Sisi Wei,Zhe Zhang et al.
Yanna Bi et al.
Objective: Paclitaxel (PTX), a conventional second-line therapeutic agent for advanced gastric cancer (GC), exhibits compromised clinical efficacy due to acquired chemoresistance in patients, the molecular mechanisms of w...
Coordinated DNA methyltransferase 3A and methyltransferase-like 7A activity reprograms the tumor microenvironment through discoidin domain receptor 1 signaling [0.03%]
DNA甲基转移酶3A和类似甲基转移酶7A的协同活性通过盘状结构域受体1信号对肿瘤微环境进行重新编程
Zhengyang Bai,Dan Yang,Jiayi Li et al.
Zhengyang Bai et al.
Objective: Breast cancer is the most common malignancy in women and is characterized by a high recurrence rate that severely impacts patient survival. Regulatory T cells (Tregs) in the tumor microenvironment (TME) promote...
Antitumor effects of STING agonists on nervous system tumors via tumor-intrinsic STING-STAT1-mediated HMGN2 expression [0.03%]
STING激动剂通过肿瘤内在的STING-STAT1-HMGN2轴对神经系统肿瘤产生抗肿瘤作用
Zijian Lv,Tiance Wang,Runjia Fan et al.
Zijian Lv et al.
Objective: Clinical use of stimulator of interferon genes (STING) agonists has challenges due to poor responsiveness and variable efficacy. Therefore, identifying tumor types that are sensitive to these agents and clarify...
CD4+ T cells in cancer: dual roles, exhaustion, and therapeutic breakthroughs [0.03%]
CD4+T细胞在肿瘤免疫中的双重角色、耗竭及治疗突破
Yangyang Zhang,Jingli Xu,Siwei Pan et al.
Yangyang Zhang et al.
In recent years the crucial role of CD4+ T cells in tumor immunomodulation has garnered increasing recognition. While conventional cancer immunotherapy research has predominantly focused on the cytotoxic function of CD8+ T cells, emerging e...
Beyond origin: multimodal AI synthesis to resolve cancers of unknown primary [0.03%]
超越起源：多模态AI合成技术破解原发不明癌症难题
Hongru Shen,Xiangchun Li
Hongru Shen
SARS-CoV-2 infection in brain tumors and the association with alterations in the tumor immune microenvironment [0.03%]
脑肿瘤中SARS-CoV-2感染及其对肿瘤免疫微环境改变的影响关系研究
Weikang Chen,Haojie Bai,Maoling Tian et al.
Weikang Chen et al.
Objective: Recent clinical evidence indicates that persistent reservoirs of SARS-CoV-2 in human brain tissue are associated with various neurologic symptoms. While brain tumors have unique vascular abnormalities and immun...
Blood-based prediction and early detection of pancreatic cancer recurrence after tumor resection [0.03%]
基于血液的胰腺癌术后复发预测和早期检测
Fawaz N Al-Shaheri,Teresa Colbatzky,Andrea S Bauer et al.
Fawaz N Al-Shaheri et al.
Pan-KRAS inhibition: unlocking broad-spectrum targeted therapy for KRAS-mutant cancers [0.03%]
泛KRAS抑制：针对KRAS突变癌症的广谱靶向治疗解锁
Juanjuan Feng,Xuanzheng Xiao,Zhengke Lian et al.
Juanjuan Feng et al.
Gut microecology empowers cancer immunotherapy: commensal microbiota-mediated mechanisms and translational prospects of PD-1/PD-L1 therapy [0.03%]
肠道微生态助力癌症免疫治疗：PD-1/PD-L1疗法共生微生物介导的机制与转化前景
Sifan Li,Chang Che,Yelu Zhou et al.
Sifan Li et al.
Anti-programmed cell death protein 1 (PD-1) or its ligand (PD-L1) are immune checkpoint inhibitors (ICIs) that have revolutionized cancer therapy. However, the efficacy of anti-PD-1 and anti-PD-L1 is limited by resistance and inter-individu...