Global landscape and temporal trends in lifetime risk of colorectal cancer in 185 countries: a population-based study [0.03%]
全球185个国家结直肠癌终生发病风险的时空变化趋势：基于人群的流行病学研究
Li Li,Kexin Sun,Xiang Li et al.
Li Li et al.
Objective: Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer-related mortality worldwide. This study was aimed at estimating regional and national variations in lifetime CRC ri...
Anogenital human papillomavirus infection patterns by anatomical site and sexual orientation in Chinese men: a national multi-center study [0.03%]
中国男性不同解剖部位和性取向的人乳头瘤病毒感染模式：一项全国多中心研究
Shangying Hu,Huan Yang,Jinyu Zhang et al.
Shangying Hu et al.
FDX1 expression promotes DSF/Cu-induced cuproptosis in gastric cancer cells [0.03%]
FDX1表达促进胃癌细胞中DSF/Cu诱导的铜依赖性细胞死亡(Cuproptosis)
Qirong Li,Yi Guo,Jiahuan Yuan et al.
Qirong Li et al.
Objective: Gastric cancer (GC) is a prevalent malignant tumor that warrants the development of drugs and therapeutic targets. Cuproptosis has emerged as a promising mechanism by which to inhibit tumors because copper home...
Myeloid cell reprogramming combined with zoledronic acid effectively suppresses bone metastasis [0.03%]
联合唑来膦酸进行髓系细胞重编程可有效抑制骨转移
Yuting Luo,Yiran Cai,Zizheng Jiang et al.
Yuting Luo et al.
Objective: Bone metastases are refractory to current therapies, primarily owing to the immunosuppressive metastasis tumor microenvironment (TME), which is dominated by myeloid cells. However, the function and regulatory m...
From chemical compounds to herbal interventions: a transfer learning-based perturbational transcriptome prediction framework for cancer drug discovery [0.03%]
从化学化合物到草药干预：一种基于迁移学习的癌症药物发现的扰动转录组预测框架
Qingyuan Liu,Boyang Wang,Shao Li
Qingyuan Liu
Objective: Transcriptomic perturbation profiles from tumor cell lines serve as the core molecular basis for cancer drug discovery and mechanism of action (MOA) analysis. Traditional Chinese medicine (TCM) holds great anti...
Global patterns, temporal trends and socioeconomic inequalities in the burden of breast cancer: a population-based study across 185 countries [0.03%]
全球模式、时间趋势和乳腺癌社会经济负担的不平等：覆盖185个国家的基于人口的研究
Weijia Kong,Hengna Lin,Jie Li et al.
Weijia Kong et al.
Objective: Breast cancer is the most frequently diagnosed cancer among women worldwide and is a leading cause of cancer-related deaths. Comparative assessments of breast cancer lifetime risks across populations are limite...
Next-generation CAR immunotherapy for neuroblastoma: expanding the role of immune cell platforms [0.03%]
下一代CAR免疫治疗在神经母细胞瘤中的应用：扩大免疫平台的作用
Ke-En Tan,Kok Siong Yeo,Yat-Yuen Lim et al.
Ke-En Tan et al.
Neuroblastoma (NB) is a pediatric cancer that develops from immature nerve cells in the peripheral sympathetic nervous system. NB is remarkably heterogeneous, ranging from spontaneous regression to aggressive progression, and is characteriz...
Kexin Feng,Jun Wang,Shuai Wang et al.
Kexin Feng et al.
Lung cancer is a fatal and the most common malignancy globally. Despite the significant therapeutic benefits of immune checkpoint inhibitors (ICIs), 60%-80% of patients respond poorly to immunotherapy. The identification of reliable predict...
Apatinib enhances targeted immunotherapy via the IL-6-gp130-PI3K pathway in HER2-positive gastric cancer [0.03%]
阿帕替尼通过IL-6-gp130-PI3K途径增强HER2阳性胃癌的靶向免疫治疗
Ruoxi Tian,Ziyue Sha,Shasha Zhang et al.
Ruoxi Tian et al.
Objective: We aimed to evaluate chemotherapy-free apatinib-based immunotherapy regimens for patients with human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) who were chemotherapy-intolerant or de...
Genetic susceptibility, environmental risk factors, and incident gastric cancer risk among individuals with different Helicobacter pylori infection status: a population-based study [0.03%]
遗传易感性、环境危险因素及不同幽门螺杆菌感染状态个体的新发胃癌发病风险：一项基于人群的研究
Hengmin Xu,Hui Ma,Yuxin Wang et al.
Hengmin Xu et al.