From chemical compounds to herbal interventions: a transfer learning-based perturbational transcriptome prediction framework for cancer drug discovery [0.03%]
从化学化合物到草药干预：一种基于迁移学习的癌症药物发现的扰动转录组预测框架
Qingyuan Liu,Boyang Wang,Shao Li
Qingyuan Liu
Objective: Transcriptomic perturbation profiles from tumor cell lines serve as the core molecular basis for cancer drug discovery and mechanism of action (MOA) analysis. Traditional Chinese medicine (TCM) holds great anti...
Global patterns, temporal trends and socioeconomic inequalities in the burden of breast cancer: a population-based study across 185 countries [0.03%]
全球模式、时间趋势和乳腺癌社会经济负担的不平等：覆盖185个国家的基于人口的研究
Weijia Kong,Hengna Lin,Jie Li et al.
Weijia Kong et al.
Objective: Breast cancer is the most frequently diagnosed cancer among women worldwide and is a leading cause of cancer-related deaths. Comparative assessments of breast cancer lifetime risks across populations are limite...
Next-generation CAR immunotherapy for neuroblastoma: expanding the role of immune cell platforms [0.03%]
下一代CAR免疫治疗在神经母细胞瘤中的应用：扩大免疫平台的作用
Ke-En Tan,Kok Siong Yeo,Yat-Yuen Lim et al.
Ke-En Tan et al.
Neuroblastoma (NB) is a pediatric cancer that develops from immature nerve cells in the peripheral sympathetic nervous system. NB is remarkably heterogeneous, ranging from spontaneous regression to aggressive progression, and is characteriz...
Kexin Feng,Jun Wang,Shuai Wang et al.
Kexin Feng et al.
Lung cancer is a fatal and the most common malignancy globally. Despite the significant therapeutic benefits of immune checkpoint inhibitors (ICIs), 60%-80% of patients respond poorly to immunotherapy. The identification of reliable predict...
Apatinib enhances targeted immunotherapy via the IL-6-gp130-PI3K pathway in HER2-positive gastric cancer [0.03%]
阿帕替尼通过IL-6-gp130-PI3K途径增强HER2阳性胃癌的靶向免疫治疗
Ruoxi Tian,Ziyue Sha,Shasha Zhang et al.
Ruoxi Tian et al.
Objective: We aimed to evaluate chemotherapy-free apatinib-based immunotherapy regimens for patients with human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC) who were chemotherapy-intolerant or de...
Genetic susceptibility, environmental risk factors, and incident gastric cancer risk among individuals with different Helicobacter pylori infection status: a population-based study [0.03%]
遗传易感性、环境危险因素及不同幽门螺杆菌感染状态个体的新发胃癌发病风险：一项基于人群的研究
Hengmin Xu,Hui Ma,Yuxin Wang et al.
Hengmin Xu et al.
Dietary restriction during active cancer therapy is associated with improved treatment response: a systematic review and meta-analysis [0.03%]
癌症治疗期间进行膳食限制与改善治疗反应有关：系统评价和Meta分析
Kajal Agrawal,Dominic Shao Yong Goh,Ee Chern Ng et al.
Kajal Agrawal et al.
The conditional promise of dual-epitope HER2 antibody-drug conjugates in breast cancer [0.03%]
双表位HER2抗体药物偶联物在乳腺癌中的前景展望
Ruoqing Wang,Shuhao Jiang,Qun Zhang et al.
Ruoqing Wang et al.
Vitamin D potentiates STING agonist-induced antitumor immunity in NSCLC [0.03%]
维生素D可增强STING激动剂诱导的非小细胞肺癌抗肿瘤免疫反应
Ke Li,Guichao Liu,Wenhui Yuan et al.
Ke Li et al.
NSAIDs for PI3K-altered head and neck cancer: a biomarker-driven therapeutic opportunity [0.03%]
用于PI3K改变的头颈部癌症的非甾体抗炎药：一种生物标志物驱动的治疗机会
Jovanka Gencel-Augusto,Daniel E Johnson,Jennifer R Grandis
Jovanka Gencel-Augusto
Non-steroidal anti-inflammatory drugs (NSAIDs), primarily aspirin, have long been studied for their anti-cancer properties. Epidemiologic studies have reported diminished rates of several cancers in regular NSAID users. NSAIDs inhibit cyclo...