Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges [0.03%]
人体健康和疾病中的乳酸介导的乳酸化修饰：进展与挑战
Xue-Ting Hu,Xiao-Feng Wu,Jin-Yi Xu et al.
Xue-Ting Hu et al.
Background: Lactate was once considered as metabolic waste for a long time. In 2019, Professor Zhao Yingming's team from the University of Chicago found that lactate could also be used as a substrate to induce histone lac...
Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms [0.03%]
脑靶向自身免疫与长新冠及其慢性疲劳综合症和情感症状密切相关
Abbas F Almulla,Michael Maes,Bo Zhou et al.
Abbas F Almulla et al.
Introduction: Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ...
Endothelial NMMHC IIA dissociation from PAR1 activates the CREB3/ARF4 signaling in thrombin-mediated intracerebral hemorrhage [0.03%]
血栓素介导的脑出血中内皮NMMHC IIA从PAR1解离激活CREB3 / ARF4信号通路
Yujie Dai,Liangying Bao,Juan Huang et al.
Yujie Dai et al.
Introduction: There is an urgent need for cerebroprotective interventions to improve the suboptimal outcomes with intracerebral hemorrhage (ICH). Despite the important role of nonmuscle myosin heavy chain IIA (NMMHC IIA) ...
Increased Rab1a accelerates osteoarthritis by inhibiting autophagy via activation of the mTORC1-S6K pathway [0.03%]
Rab1a通过激活mTORC1-S6K通路抑制自噬从而加速骨关节炎的发展
Ze Chen,Mingze Tang,Zewei Wu et al.
Ze Chen et al.
Introduction: Cartilage degradation is a critical alteration in the progression of osteoarthritis (OA) due to the disorder of chondrocyte metabolic homeostasis. Autophagy plays an important role in maintaining intracellul...
Advanced machine learning schemes for prediction CO2 flux based experimental approach in underground coal fire areas [0.03%]
基于实验方法预测地下煤火区二氧化碳通量的先进机器学习方案
Yongjun Wang,Mingze Guo,Hung Vo Thanh et al.
Yongjun Wang et al.
Introduction: Underground coal fires pose significant environmental and health risks due to releasing CO2 emissions. Predicting surface CO2 flux accurately in underground coal fire areas is crucial for understanding the d...
Akt-FoxO signaling drives co-adaptation to insecticide and host plant stresses in an herbivorous insect [0.03%]
Akt-FoxO信号驱动食植害虫适应杀虫剂和寄主植物胁迫的协同进化
Huihui Zhang,Haoli Gao,Xumin Lin et al.
Huihui Zhang et al.
Introduction: Ongoing interactions between host and herbivorous insect trigger a co-evolutionary arms race. Genetic diversity within insects facilitates their adaptation to phytochemicals and their derivatives, including ...
Pan-genome analysis reveals genomic variations during enoki mushroom domestication, with emphasis on genetic signatures of cap color and stipe length [0.03%]
全基因组分析揭示了金针菇驯化过程中的基因组变异，并重点强调了菌盖颜色和菌柄长度的遗传标志
Fei Liu,Xin-Bin Ma,Bei Han et al.
Fei Liu et al.
Introduction: The domestication of edible mushrooms, including Flammulina filiformis, offers valuable insights into the genetic changes driven by artificial selection. Understanding these changes is crucial for uncovering...
Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer [0.03%]
四氢姜黄素靶向TRIP13介导三阴性乳腺癌细胞c-FLIP泛素化降解的作用及机制研究
Yu-Jie Sun,Qiang Zhang,Shi-Jie Cao et al.
Yu-Jie Sun et al.
Introduction: Triple-negative breast cancer (TNBC) has a high mortality rate and limited treatment options. Tetrahydrocurcumin (THC), a major metabolite of curcumin, has potential antitumor activities. However, the antitu...
Kaempferol alleviates myocardial ischemia injury by reducing oxidative stress via the HDAC3-mediated Nrf2 signaling pathway [0.03%]
山柰酚通过HDAC3介导的Nrf2信号通路减少氧化应激从而缓解心肌缺血损伤
Zejun Yue,Yirong Zhang,Wei Zhang et al.
Zejun Yue et al.
Introduction: Kaempferol (KAE) is a flavonoid found in various plants. Recent studies showed that high dietary intake of KAE was associated with a lower risk of myocardial infarction; however, the cardioprotective mechani...
A molecular perspective on the role of FERONIA in root growth, nutrient uptake, stress sensing and microbiome assembly [0.03%]
FERONIA在根系生长、养分吸收、胁迫感知及微生物群组装作用的分子机制研究进展
Sajad Ali,Anshika Tyagi,Suvin Park et al.
Sajad Ali et al.
Background: Roots perform multifaceted functions in plants such as movement of nutrients and water, sensing stressors, shaping microbiome, and providing structural support. How roots perceive and respond above traits at t...