Irisin alleviates obesity-induced bone loss by inhibiting interleukin 6 expression via TLR4/MyD88/NF-κB axis in adipocytes [0.03%]
irisin通过TLR4/MyD88/NF-κB轴抑制脂肪细胞中IL-6的表达缓解肥胖引起的骨质流失
Yuanshu Zhang,Xu He,Kai Wang et al.
Yuanshu Zhang et al.
Introduction: Obesity-induced bone loss affects the life quality of patients all over the world. Irisin, one of the myokines, plays an essential role in bone and fat metabolism. ...
CircHIPK3 targets DRP1 to mediate hydrogen peroxide-induced necroptosis of vascular smooth muscle cells and atherosclerotic vulnerable plaque formation [0.03%]
Circular RNA CircHIPK3通过靶向DRP1介导血管平滑肌细胞氢氧根诱导的坏死性凋亡及动脉粥样易损斑块形成
Xiaolu Li,Yanyan Yang,Zhibin Wang et al.
Xiaolu Li et al.
Introduction: Necroptosis triggered by H2O2 is hypothesized to be a critical factor in the rupture of atherosclerotic plaques, which may precipitate acute cardiovascular events. Nevertheless, the specific regulatory molec...
Interplay between lipid dysregulation and ferroptosis in chondrocytes and the targeted therapy effect of metformin on osteoarthritis [0.03%]
脂质代谢紊乱与软骨细胞铁死亡的相互作用及二甲双胍靶向治疗膝骨关节炎的效果研究
Zhi Zou,Wenhui Hu,Fei Kang et al.
Zhi Zou et al.
Introduction: Osteoarthritis (OA) is a devastating whole-joint disease affecting a large population worldwide; the role of lipid dysregulation in OA and mechanisms underlying targeted therapy effect of lipid-lowering metf...
Tanshinone IIA destabilizes SLC7A11 by regulating PIAS4-mediated SUMOylation of SLC7A11 through KDM1A, and promotes ferroptosis in breast cancer [0.03%]
丹参酮IIA通过KDM1A调节PIAS4介导的SLC7A11SUMO化来 Destabilizing SLC7A11并促进乳腺癌铁死亡发生
Na Luo,KeJing Zhang,Xin Li et al.
Na Luo et al.
Introduction: Breast cancer (BC) is the most common malignancy in women with unfavorite prognosis. Objectives: Tanshinone IIA (Tan IIA)...
Urolithin A inhibits breast cancer progression via activating TFEB-mediated mitophagy in tumor macrophages [0.03%]
尿石素A通过激活肿瘤巨噬细胞中的TFEB介导的线粒体自噬抑制乳腺癌进展
Bowen Zheng,Yuying Wang,Baian Zhou et al.
Bowen Zheng et al.
Introduction: Urolithin A (UA) is a naturally occurring compound that is converted from ellagitannin-like precursors in pomegranates and nuts by intestinal flora. Previous studies have found that UA exerts tumor-suppressi...
Integrative analysis of senescence-related genes identifies robust prognostic clusters with distinct features in hepatocellular carcinoma [0.03%]
整合分析与衰老相关的基因，识别肝细胞癌中具有不同特征的稳健预后簇群
Sicheng Liu,Yang Meng,Yaguang Zhang et al.
Sicheng Liu et al.
Introduction: Senescence refers to a state of permanent cell growth arrest and is regarded as a tumor suppressive mechanism, whereas accumulative evidence demonstrate that senescent cells play an adverse role during cance...
The CsTM alters multicellular trichome morphology and enhances resistance against aphid by interacting with CsTIP1;1 in cucumber [0.03%]
CsTM通过与黄瓜CsTIP1;1互作改变多细胞腺体形态并提高其对蚜虫的抗性
Songlin Yang,Shudan Xue,Li Shan et al.
Songlin Yang et al.
The multicellular trichomes of cucumber (Cucumis sativus L.) serve as the primary defense barrier against external factors, whose impact extends beyond plant growth and development to include commercial characteristics of fruits. The aphid ...
Punicalagin attenuates hyperuricemia via restoring hyperuricemia-induced renal and intestinal dysfunctions [0.03%]
Punicalagin通过恢复高尿酸诱导的肾脏和肠道功能障碍来缓解高尿酸血症
Qing-Qing Han,Qi-Dong Ren,Xu Guo et al.
Qing-Qing Han et al.
Introduction: It is estimated that 90% of hyperuricemia cases are attributed to the inability to excrete uric acid (UA). The two main organs in charge of excreting UA are the kidney (70%) and intestine (30%). Previous stu...
Enhanced LRP8 expression induced by Helicobacter pylori drives gastric cancer progression by facilitating β-Catenin nuclear translocation [0.03%]
Helicobacter pylori通过促进β-连环素核转位来驱动胃癌进展的机制研究
Bin Liu,Ihtisham Bukhari,Fazhan Li et al.
Bin Liu et al.
Introduction: Helicobacter pylori (H. pylori) infection has been associated with gastric carcinogenesis. However, the precise involvement of LRP8, the low-density lipoprotein receptor-related protein 8, in H. pylori patho...
FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis [0.03%]
成纤维细胞生长因子21通过自噬/HIF-1α轴限制促炎性巨噬细胞活化从而改善脓毒症肝损伤
Junjie Zhu,Zhouxiang Jin,Jie Wang et al.
Junjie Zhu et al.
Introduction: Sepsis, a systemic immune syndrome caused by severe trauma or infection, poses a substantial threat to the health of patients worldwide. The progression of sepsis is heavily influenced by septic liver injury...