A rapidly fabricated bone marrow enrichment material with a controllable pore size promotes osteogenesis close to autogenous bone graft in clinic [0.03%]
一种可调控孔径的快速制备的骨髓富集材料促进临床异体骨移植近似自体骨移植成骨修复
Qiandong Yang,Bo Yu,Chunyu Liu et al.
Qiandong Yang et al.
Introduction: The shortage of highly osteogenic grafts significantly impacts clinical bone repair and reconstruction in clinic. Selective cell retention technology increases the number of bone marrow (BM)-derived osteogen...
Cinnamic acid derivatives in agrochemicals: current use and future perspective [0.03%]
香豆酸衍生物在农药中的应用：现状与未来展望
Qiong Lei,Wei Zhang,Wang Geng et al.
Qiong Lei et al.
Cinnamic acid (CA) and its derivatives are usual phenylpropanoids including natural products and synthetic compounds, which are widely used in various fields due to their robust and broad-spectrum biological activities, and eco-friendly pro...
Diosgenin activates ERα-dependent PI3K/AKT/GSK3β signaling to enhance brain-derived serotonin and alleviate postmenopausal bone loss [0.03%]
薯蓣皂苷通过激活ERα依赖的PI3K / AKT / GSK3β信号通路增强脑源性血清素的生成并缓解绝经后骨质流失
Xi Chen,MengXue Zhang,Lihui Qian et al.
Xi Chen et al.
Introduction: Postmenopausal osteoporosis (PMOP) stems from estrogen deficiency, which leads to reduced central serotonin (5-HT) levels, induces depressive-like behaviors, enhances sympathetic nervous system (SNS) activit...
A lightweight fully convolutional neural network for efficient and accurate tunnel crack detection [0.03%]
一种用于隧道裂缝高效精准检测的轻量级全卷积网络
Hao Huang,G T S Ho,V Tang et al.
Hao Huang et al.
Introduction: Crack damage is a significant issue in tunnel environments, requiring efficient and reliable detection to ensure structural integrity. Many existing solutions are computationally expensive, making them unsui...
Burden profiles and mortality-attributable risk factors for gastrointestinal cancers: A comprehensive analysis, 1990-2021 [0.03%]
1990-2021年全球胃肠肿瘤疾病负担及归因危险因素的综合分析
Ahui Fan,Chunbaixue Yang,Yangyan Fan et al.
Ahui Fan et al.
Background: Gastrointestinal (GI) cancers accounted for 23.6% of new cancer cases and 34.2% of cancer-related deaths globally. A comprehensive understanding of GI cancer burden and mortality-attributable risk factors is u...
Eravacycline and omadacycline Rescue multidrug-resistant Elizabethkingia anophelis: Triple-Model evaluation across in Vitro, Galleria mellonella, and murine bacteremia systems [0.03%]
依托伐青霉素和奥马潘南治疗耐多药的伊丽莎白菌：在体外、大蜡螟和小鼠菌血症模型中的三重评估
Shaohua Hu,Li Jiang,Hao Xu et al.
Shaohua Hu et al.
Introduction: Elizabethkingia anophelis has emerged as a formidable pathogen causing severe, life-threatening human infections. Treatment remains challenging due to its intrinsic multidrug resistance. ...
The landscape of genitourinary cancer vaccines: clinical advances and future opportunities [0.03%]
泌尿生殖系肿瘤疫苗的研发进展与未来机遇
Ruoxuan Zheng,Yuxin Cai,Weihong Ding et al.
Ruoxuan Zheng et al.
Background: Cancer vaccines have demonstrated potential as a key immunotherapy strategy based on stimulating immune responses targeting tumor-specific antigens and tumor-associated antigens. Therapeutic cancer vaccines ha...
Deciphering the genetic basis of nodule number through integrative analysis of host genotype and endophytes [0.03%]
整合分析宿主基因型和内生菌解析结瘤数的遗传基础
Ruier Zeng,Peiqi Huang,Yunyi Guo et al.
Ruier Zeng et al.
Introduction: Peanut nodule number is determined by the host genotype and endophytes. However, the genetic mechanisms regulating nodule number and the abundance of endophytes significantly associated with nodule number re...
Vessels encapsulating tumor clusters is associated with impaired efficacy of adjuvant immunotherapy in resected hepatocellular carcinoma [0.03%]
血管包裹肿瘤结节与肝细胞癌切除术后辅助免疫治疗疗效不佳相关性研究
Bin Guo,Guangzhen Cai,Jinghan Zhu et al.
Bin Guo et al.
Introduction: Aggressive pathologic features are closely associated with early recurrence of hepatocellular carcinoma (HCC), and the association between vessels encapsulating tumor clusters (VETC) and poor prognosis has r...
Generation of antifungals to combat drug resistance using language models and diffusion models [0.03%]
使用语言模型和扩散模型生成抗真菌药物以对抗耐药性
Yeji Wang,Yuemei Dong,Yi Zheng et al.
Yeji Wang et al.
Introduction: The growing scarcity of effective antifungal agents, coupled with rising drug‑resistance, creates an urgent demand for novel therapeutics. Recent advances in artificial intelligence (AI) have opened new ave...