Phyllosphere microbiomes in grassland plants harbor a vast reservoir of novel antimicrobial peptides and biosynthetic diversity [0.03%]
草地植物叶球微生物组富含新型抗菌肽和生物合成多样性资源
Hongzhang Zhou,Gao,Baiyila Wu et al.
Hongzhang Zhou et al.
Introduction: The phyllosphere microorganisms colonizing plant surface harbor capacities to synthesize diverse specialized metabolites that mediate communication and interactions with environment and host. However, most k...
Grain proteins ameliorate glucose metabolism disorders by activating intestinal AhR and the hepatic NLK/FOXO1 pathway via gut microbiota-derived indole metabolites [0.03%]
肠道微生物来源吲哚衍生物通过改善肠道AhR和肝脏NLK/FOXO1通路来缓解谷物蛋白引起的糖代谢紊乱
Zijian Dai,Xin Bao,Hua Jiang et al.
Zijian Dai et al.
Introduction: Consumption of gran proteins has been associated with lower risk of type 2 diabetes (T2D), but the underlying mechanisms remain unclear. Gut microbiota plays a key role in glucose metabolism, and dietary pro...
Essential function of Nr4a2 in subicular development and social novelty [0.03%]
Nr4a2在副嗅脑发育及社交行为中的重要作用
Xi-Yue Liu,Yun-Chao Tao,Qiong Zhang et al.
Xi-Yue Liu et al.
Introduction: The subicular regions are a major output hub of the hippocampus. Recent studies have shown that subicular neurons are highly diverse in their gene expression patterns, neural circuitry, and electrophysiologi...
RNA m6A-binding protein YTHDF2 regulates neoblast proliferation in planarian regeneration by targeting ASTACIN Signaling [0.03%]
RNA m6A结合蛋白YTHDF2通过靶向ASTACIN信号调节计划海绵再生中的新生细胞增殖
Hanxue Zheng,Du Wang,Linfeng Li et al.
Hanxue Zheng et al.
Introduction: Planarians exhibit remarkable notable regenerative capacity, through the self-renewal of the neoblast stem cells. The RNA N6-methyladenosine (m6A)-binding protein YTHDF2 recognizes m6A modified regions on th...
Combinatorial genome engineering of pseudorabies virus Bartha by developing a reverse genetic system based on three overlapping genomic segments [0.03%]
基于三个重叠的基因组片段建立伪狂犬病病毒Bartha反向遗传学系统及组合基因组工程技术
Hengxing Yuan,Yulu Zhang,Long Tan et al.
Hengxing Yuan et al.
Introduction: The 138-kilobase genome of pseudorabies virus vaccine strain Bartha K61 harbors many nonessential genes for replication and exhibits remarkable capacity for incorporating foreign genes for therapeutic applic...
A chitosan-based aerogel with radially aligned structure for cushioning and antimicrobial packaging of fruits [0.03%]
一种具有径向对齐结构的壳聚糖基气凝胶用于水果缓冲和抗菌包装
Liwen Liang,Xinru Liu,Yiyi Li et al.
Liwen Liang et al.
Introduction: Cushioning materials paly a critical role in protecting delicate fruits against mechanical stress during postharvest handling. To minimize spoilage, these materials must combine impact absorption with antimi...
Arsenic exposure, arsenic metabolism, and plasma lipidome in relation to type 2 diabetes and glycemic traits: a lipidome-wide association study [0.03%]
砷暴露、砷代谢与血浆脂质组在2型糖尿病及血糖特征方面的关联：一项关于脂质组的全范围关联研究
Yongfang Zhang,Jiahao Song,Shuhui Wan et al.
Yongfang Zhang et al.
Introduction: Both arsenic exposure and lipid metabolism disturbances are implicated in type 2 diabetes (T2D), whereas arsenic-associated lipidomic alterations and their contributions to T2D remain unclear. ...
High-throughput screening identifies FDA approved drug mitiglinide as a novel pyroptosis inhibitor and therapeutic agent for osteoarthritis [0.03%]
高通量筛选发现FDA批准药物米格列奈是一种新型的焦亡抑制剂和治疗骨关节炎的有效药物
Hanwen Zhang,Tanxin Yu,Nanfang Zhuo et al.
Hanwen Zhang et al.
Introduction: Osteoarthritis (OA), a leading cause of joint dysfunction, is characterized by progressive cartilage degradation linked to chondrocyte pyroptosis, yet disease-modifying therapies remain elusive. In this stud...
Noninvasive detection and differentiation of gastric malignancy using cell-free DNA biomarkers [0.03%]
基于细胞游离DNA的胃癌无创检出与分类研究
Hengzhen Li,Meng Chen,Ying Liu et al.
Hengzhen Li et al.
Introduction: Gastric cancer remains a major global health burden, with high mortality driven by late-stage diagnoses that limit treatment options and reduce survival. Current diagnostic methods such as endoscopy and biop...
Extracellular matrix-inspired multi-morphology microspheres harness osteogenic-prone stem cells to recruit and reprogram adjacent stem cells for synergistic bone regeneration [0.03%]
受细胞外基质启发的多形态微球募集和重编程周围干细胞实现协同骨再生
Huixin Lv,Yihan Wang,Jingxia Chen et al.
Huixin Lv et al.
Governed by epigenetic regulation, distinct types of adult stem cells exhibit lineage-specific differentiation biases. Osteogenic-prone stem cells might recruit, proliferate, and induce osteogenesis in adjacent osteogenic-weak stem cells, c...