An increase in DNA methylation contributes to anthocyanin biosynthesis in the pericarp as litchi (Litchi chinensis Sonn.) fruit ripens [0.03%]
荔枝(Litchi chinensis Sonn.)果实成熟过程中DNA甲基化水平的升高促进果皮花色苷生物合成
Huiyu Hou,Xiangjin Kong,Jiaqi Xiao et al.
Huiyu Hou et al.
Introduction: Significant progress has been made in uncovering the role of DNA methylation in the development and ripening of fruit. However, whether DNA methylation is involved in litchi fruit ripening and in the corresp...
Qing Lv,Maoping Shao,Mingyan Li et al.
Qing Lv et al.
Background: Microsporidia are a class of obligate intracellular parasitic unicellular eukaryotes that infect almost all animals. Under appropriate environmental stimuli, microsporidia transport the sporoplasm into the hos...
VPA targets Mid1 improves hippocampal neurons retrograde axonal transport function disruption in lithium manganate-induced mice learning and memory dysfunction through the ubiquitin-proteasome pathway [0.03%]
靶向Mid1的VPA改善LiMn诱导的小鼠海马神经元顺行轴浆运输功能障碍及学习记忆功能损伤机制研究：泛素-蛋白酶体通路介导效应
Xinmiao Wang,Yue Chen,Jingqi Chen et al.
Xinmiao Wang et al.
Introduction: Lithium manganate (LMO) is a new type of pollutant that is extensively applied in the manufacture of lithium-ion batteries. Accumulating evidence indicates that both manganese (Mn) and lithium (Li) can cross...
The interactions between rhizobacteria and arbuscular mycorrhizal fungi enhance global soil carbon sequestration in drylands: A global meta-analysis [0.03%]
根际细菌和菌根真菌的相互作用能增强干旱生态系统土壤固碳作用：全球元分析研究
Muhammad Maqsood Ur Rehman,Yun-Li Xiao,Sidra Khattak et al.
Muhammad Maqsood Ur Rehman et al.
Background: Drought is a major constraint in arid and semi-arid regions, leading to a reduction in soil organic carbon (SOC) by suppressing microbial activities and limiting organic matter inputs. The decrease in soil hea...
In silico transcriptome-based drug screening identifies celastrol as a multi-species therapeutic agent against aging-related sarcopenia and mitochondrial dysfunction [0.03%]
基于转录组的药物筛选确定爪蓄素可作为治疗与衰老相关的肌肉减少症和线粒体功能障碍的多物种治疗剂
Bangfu Wu,Jiaxin Liu,Zhaoyu Cui et al.
Bangfu Wu et al.
Introduction: Sarcopenia, characterized by the progressive age-related loss of skeletal muscle mass and function, is a primary driver of ambulatory dysfunction in older adults and lacks approved therapeutics. Although exe...
Neural - adipose crosstalk: Shared genetic architecture of visceral fat and neuropsychiatric disorders [0.03%]
神经与脂肪的相互作用：内脏脂肪和神经精神障碍的共享遗传结构
Jiangwei Xia,Jiajian Li,Siqi Chen et al.
Jiangwei Xia et al.
Introduction: Numerous studies have identified a close association between visceral adipose tissue mass (VAT) and neuropsychiatric disorders (NPDs). Both VAT and NPDs exhibit high heritability, yet their shared genetic ar...
Human milk fat substitutes improve obesity-related NAFLD by enriching LPC 18:2 to activate hepatic GPR119-AMPK signaling [0.03%]
富含油酸甘油脂的人乳脂肪替代品通过激活肝脏GPR119-AMPK信号改善肥胖相关性非酒精性脂肪肝病
Yangzheng He,Jing Li,Zhigang Wen et al.
Yangzheng He et al.
Introduction: Obesity-associated non-alcoholic fatty liver disease (NAFLD) remains a global health burden with limited treatment options. Human milk fat substitutes (HMFS), designed to mimic the triacylglycerol structure ...
Biomimetic and personalized nanovaccines in cancer immunotherapy: Design innovations, translational challenges, and future directions [0.03%]
癌症免疫治疗中的类器官和个性化纳米疫苗：设计创新、转化挑战及未来方向
Suling Xu,Haitao Yang,Boris Minev et al.
Suling Xu et al.
Personalized nanovaccines represent advancing frontier in cancer immunotherapy by integrating patient-specific tumor antigens with biomimetic delivery systems to enhance immune activation, targeting precision and clinical efficacy. Biomimet...
HB023: A glutamine antagonist prodrug boosting antitumor lmmunity via PD-L1 suppression and mitochondrial membrane remodeling [0.03%]
HB023：一种谷氨酰胺拮抗剂前药通过抑制PD-L1和重塑线粒体膜增强抗肿瘤免疫能力
Junyan Zhuang,Ye Chen,Yi Zhang et al.
Junyan Zhuang et al.
Introduction: Glutamine is a key nutrient that supports tumor cell metabolism, biosynthesis, and proliferation. It also shapes the tumor microenvironment and modulates cell death pathways. Glutamine antagonists have emerg...
Screening and identification of a novel PGAM5-specific inhibitor for attenuating multi-organ injury [0.03%]
筛选和鉴定新型PGAM5特异性抑制剂以减轻多器官损伤
Lin Chen,Haibo Li,Qingtain Zhu et al.
Lin Chen et al.
Introduction: The necroptosis regulator PGAM5 drives a pathological cycle of mitochondrial dysfunction and necroptotic signaling, contributing to multi-organ injury and representing a potential therapeutic target. Despite...