Identification of a novel EphB4 inhibitor, Sanguinarine, which attenuates β-catenin signaling to inhibit tumor proliferation and migration in lung cancer [0.03%]
一种新型 EphB4 抑制剂血根碱通过抑制肺癌中β-连环蛋白信号通路来抑制肿瘤增殖和迁移的鉴定研究
Asmat Ullah,Chuanzan Zhou,Wang Xiao et al.
Asmat Ullah et al.
Introduction: EphB4, a receptor tyrosine kinase, is a known promoter of tumor growth and a promising therapeutic target for cancer therapies. However, its contribution to the development and treatment of lung cancer (LC) ...
A novel mechanism of selenium deficiency driving aberrant Th17 cell differentiation via GPX3-targeted PIG3: mitophagy blockade exacerbates mtDNA release [0.03%]
硒通过GPX3靶向PIG3调节异常Th17细胞分化的新机制：线粒体自噬阻断促进mtDNA释放
Tingting Yu,Xu Shi,Yanju Bi et al.
Tingting Yu et al.
Introduction: The biological functions of selenium (Se) are mainly realized through selenoproteins. As the only secreted antioxidant enzyme in the glutathione peroxidase family, the deficiency of glutathione peroxidase 3 ...
The module of PeGLK1-1-PeWRKY111-PePMHA9 orchestrates stomatal aperture to enhance photosynthetic capacity in bamboo [0.03%]
PeGLK1-1-PeWRKY111-PePMHA9模块通过调节气孔开度增强竹子光合能力
Hui Li,Qingnan Wang,Chenglei Zhu et al.
Hui Li et al.
Introduction: Global warming, driven by CO2 emissions, poses a profound threat to the ecosystems and the sustainable development of human society. Bamboo with outstanding carbon sequestration capacity provides natural sol...
Transcriptional repressor IAA15 negatively regulates picloram herbicide resistance by modulating glutathione metabolism in eggplant [0.03%]
transcriptional repressor IAA15通过调节谷胱甘肽代谢负向调控 Eggplant 对草甘膦的抗性
Wenchao Du,Fengqing Cheng,Xusheng Ge et al.
Wenchao Du et al.
Introduction: Auxin/indole acetic acid (Aux/IAA) proteins repress the expression of auxin-responsive genes to mediate environmental abiotic stresses. Distinct auxinic herbicides are differentially involved in the auxin si...
Review of research advances in the cerebral lymphatic system and neurological disorders [0.03%]
脑淋巴系统与神经系统疾病研究进展评述
Zhaoxia Xie,Jiayi Wei,Jue Wang
Zhaoxia Xie
Background: The identification of the central lymphatic system represents a significant advancement in contemporary neuroscientific research. As a vital conduit connecting the central nervous system to the peripheral lymp...
Lactobacillus plantarum AR113 alleviates Western Diet-Induced colitis and liver injury via bidirectional modulation of the Intestinal-Hepatic FXR signaling axis [0.03%]
植物乳杆菌AR113通过肠道-肝脏FXR信号轴的双向调节缓解西方饮食引起的结肠炎和肝损伤
Junlin Shao,Di Zhao,Yongjun Xia et al.
Junlin Shao et al.
Introduction: Bile acids are involved in a variety of diseases in the host. However, the alterations in bile acid enterohepatic circulation during colitis and the pathological mechanisms underlying associated hepatic inju...
SQSTM1/p62-mediated PD-L1 biomolecular condensate formation promotes lung tumorigenesis [0.03%]
SQSTM1/p62介导的PD-L1生物分子凝聚物形成促进肺癌发生发展
Yen-Cheng Lin,Yu-Wei Lin,Rou-Hsin Wang et al.
Yen-Cheng Lin et al.
Introduction: Biomolecular condensates are membraneless organelles functionally involved in diverse processes, including cancer progression. Sequestosome-1 (SQSTM1)/p62 regulates liquid-liquid phase separation to drive bi...
Heterogeneous nuclear ribonucleoprotein L orchestrates alternative splicing critical for primordial follicle formation [0.03%]
异质性核核糖核蛋白L调控原始卵泡形成的关键可变剪接事件
Feng-Jie Hu,Si-Yu Chen,Xiao Chen et al.
Feng-Jie Hu et al.
Introduction: The development of germ cells, from PGCs to the formation of primordial follicles, is tightly regulated by post-transcriptional AS. However, the underlying splicing dynamics, key regulatory factors, and prec...
Bidirectional regulation between bone and vasculature: Mechanisms of osteogenesis and angiogenesis [0.03%]
骨与血管的双向调节：成骨和新生血管生成机制
Tianyue Wang,Hanbing Yao,Feier Jin et al.
Tianyue Wang et al.
Background: The skeletal and vascular systems exhibit critical bidirectional regulation essential for skeletal homeostasis, with distinct mechanisms in intramembranous and endochondral ossification. Disruption of this bal...
Synergistic regulation of SLC7A11 and glucose-6-phosphate dehydrogenase in redox homeostasis governs decidualization: a mechanistic insight into adenomyosis-related infertility [0.03%]
SLC7A11和葡萄糖-6-磷酸脱氢酶在氧化还原稳态中的协同调节支配蜕膜化：子宫腺肌病相关不孕的机制洞察
Yi Zhang,Weijia Gu,Fanxuan Zhao et al.
Yi Zhang et al.
Introduction: Adenomyosis, which affects > 20% of reproductive-age women, is a major cause of infertility. Defective decidualization of endometrial stromal cells (ESCs) is a key pathogenic feature of adenomyosis; however,...