GhIMP10D, an inositol monophosphatase gene enhancing alkaline stress tolerance in plants [0.03%]
GhIMP10D，一个可增强植物耐碱胁迫的肌醇单磷酸酶基因
Yapeng Fan,Xuke Lu,Xiugui Chen et al.
Yapeng Fan et al.
Introduction: Soil salinization and alkalization are major challenges to global agricultural productivity and food security. Ascorbic acid (AsA) is an essential antioxidant that helps plants mitigate various abiotic stres...
The heterogeneity of dopamine-mediated vasodilation in human intrarenal arteries [0.03%]
人肾内在肾动脉中多巴胺介导的血管扩张的异质性
Xuya Kang,Han Jin,Yaoyao Zheng et al.
Xuya Kang et al.
Introduction: Adequate renal perfusion is critical for maintaining kidney function, and its impairment contributes significantly to acute kidney injury (AKI) and related cardiovascular complications. Dopamine (DA) is clin...
Targeting fibrillin-1 disrupts the fibrogenic niche formation and ameliorates kidney fibrosis [0.03%]
靶向纤维连蛋白-1可破坏促纤维化微环境的形成并改善肾纤维化
Junxin Huang,Zifu Yao,Yuxi Zhang et al.
Junxin Huang et al.
Introduction: Kidney fibrosis is a common pathological pathway of chronic kidney disease (CKD), driven by the formation of fibrogenic niche. Fibroblasts undergo proliferation and activation in this specialized microenviro...
A α-synuclein aggregation inhibitor exerts neuroprotective effects via mitochondrial resilience in Parkinson's disease [0.03%]
α-突触核蛋白聚集抑制剂通过改善帕金森病中的线粒体功能发挥神经保护作用
Ye Peng,Junrui Ye,Hongyun Wang et al.
Ye Peng et al.
Introduction: The pathogenesis of Parkinson's disease (PD) is driven by a vicious cycle of α-synuclein (α-Syn) aggregation and mitochondrial collapse. Breaking this pathogenic loop requires disease-modifying therapeutic...
Differential rumen responses in neonatal ruminants to volatile fatty acids, glucose, and physical stimulation: insights into the drivers of early rumen development [0.03%]
牛羊新生反刍动物瘤胃对挥发性脂肪酸、葡萄糖和物理刺激的差异反应：早期瘤胃发育驱动因素的新见解
Tianrong Chen,Kui Li,Yin Yuyang et al.
Tianrong Chen et al.
Introduction: The transition from milk to solid feed is a critical stage for rumen development in young ruminants; however, the relative contributions of chemical stimuli (such as volatile fatty acids, VFAs) and physical ...
Physical exercise mitigates amyloid beta-driven muscle degeneration in Alzheimer's disease [0.03%]
身体锻炼可缓解阿尔茨海默病患者β淀粉样蛋白驱动的肌肉退化
Ling-Ling Yang,Ya-Xi Luo,Dan Song et al.
Ling-Ling Yang et al.
Introduction: Alzheimer's disease (AD) is increasingly recognized as a systemic disorder, with skeletal muscle dysfunction contributing substantially to frailty and functional decline. Although amyloid-β (Aβ) has been d...
Activation of microglial PPARγ by asperosaponin VI alleviates stress-induced depression and synaptic impairment [0.03%]
asperosaponin VI活化小胶质细胞PPARγ缓解应激诱导的抑郁和突触损伤
Yangyan Ge,Chengyan Yang,Meidan Wang et al.
Yangyan Ge et al.
Background: Depression is a common mental disorder affecting hundreds of millions worldwide. Targeting microglial peroxisome proliferator-activated receptor gamma (PPARγ) is regarded as one of the strategies to improve d...
Human BBB-brain organoid on a millifluidic plate for modeling brain parenchymal pathology-induced barrier dysfunction [0.03%]
基于人脑类器官的微流控芯片人血脑屏障模型在研究脑实质病变诱导的屏障功能障碍中的应用
Lili Zhu,Wen Zhao,Min Shen et al.
Lili Zhu et al.
Introduction: The blood-brain barrier (BBB) maintains brain homeostasis, and its dysfunction is a critical pathological mechanism for many neurological disorders. However, current BBB models lack functional brain parenchy...
Therapeutic potential of ELABELA in alleviating hereditary hypertrophic cardiomyopathy [0.03%]
ELABELA在缓解遗传性肥厚型心肌病中的治疗潜力
Chao Ye,Tao Xu,Hai Yang et al.
Chao Ye et al.
Introduction: Hereditary hypertrophic cardiomyopathy (HCM) is a common genetic heart disease associated with heart failure and sudden cardiac death. Current therapies are limited, and the myosin inhibitor mavacamten is co...
GhLBD18 triggers GhATG18a-dependent autophagy during somatic embryogenesis in cotton [0.03%]
GhLBD18在棉花体细胞胚胎发生过程中触发依赖于GhATG18a的自噬作用
Jiachen Yuan,Xingxing Zhi,Xingxing Liu et al.
Jiachen Yuan et al.
Introduction: Autophagy is well established as a critical mechanism in plant stress responses and sexual reproduction, yet its molecular mechanisms during asexual reproduction remains poorly characterized. Deciphering the...