N-myristoyltransferase-mediated protein myristoylation: molecular mechanisms, pathological roles, and targeted therapeutic strategies [0.03%]
N-myristoy转移酶介导的蛋白质肉豆蔻酰化：分子机制、病理作用和靶向治疗策略
Wenqing Liu,Zhe Chen,Zhen Huang et al.
Wenqing Liu et al.
Background: Protein N-myristoylation, catalyzed by N-myristoyltransferases (NMT1 and NMT2), is a critical lipid modification conferring membrane-binding and conformational plasticity to target proteins. Historically viewe...
HMT + mediated visual motion perception deficits in treatment-resistant depression: a neuroimaging, genomic and neurochemical perspective [0.03%]
难治性抑郁障碍的HMT介导的视运动感知缺陷：神经影像学、基因组和神经化学角度的观点
Shaoyong Ye,Tao Jin,Ruihan Wu et al.
Shaoyong Ye et al.
Background: Visual motion perception (VMP) deficit in depression is mediated by the human middle temporal complex (hMT+). However, the reorganization of neuroactivity-perception in treatment-resistant depression (TRD) and...
Transforming mRNA drug design with AI: From UTR and codon optimization to coordinated design [0.03%]
人工智能变革mRNA药物设计：从调控序列和密码子优化到整体设计
Yuqi Shi,Chuanlong Zeng,Xia Sheng et al.
Yuqi Shi et al.
Background: The design of mRNA drugs involves a complex and high-dimensional optimization of sequence elements to balance stability, translation efficiency, and immunogenicity. Traditional methods, often relying on local ...
Varroa control strategies of different beekeeper groups and corresponding honey bee colony mortality in Central Europe [0.03%]
中欧不同养蜂人群的Varroa控制策略及其相应的蜜蜂群死亡率
Ewa Mazur,Ondřej Biemann,Robert Brodschneider et al.
Ewa Mazur et al.
Introduction: The parasitic mite Varroa destructor remains a major threat to Apis mellifera globally, contributing significantly to high colony losses despite various control interventions. Understanding the range of Varr...
PDZK1 disassembles HER2-HSP90 complexes to promote ubiquitin-mediated HER2 degradation and overcome therapy resistance [0.03%]
PDZK1通过促进泛素介导的HER2降解并克服治疗抵抗性来拆分HER2-HSP90复合物
Xuedi Cao,Chen Qin,Yu Guo et al.
Xuedi Cao et al.
Introduction: Limited therapeutic response and disease recurrence remain major challenges in HER2-positive breast cancer, largely driven by sustained HER2 stabilization and persistent oncogenic signaling mediated by HSP90...
Innovative mucosal nanocarrier systems for enhanced immune response against respiratory pathogens [0.03%]
针对呼吸道病原体增强免疫反应的创新型粘膜纳米载体系统
Zhenzhen Zhang,Rong Chen,Xiang Zhou et al.
Zhenzhen Zhang et al.
Introduction: Effective pulmonary vaccination remains limited by the pulmonary surfactant (PS) barrier and inefficient intracellular delivery of vaccine cargo to alveolar antigen-presenting cells, particularly alveolar ma...
PAD4-mediated citrullination of IGF2BP2 stabilizes MCM mRNAs to drive intrahepatic cholangiocarcinoma progression [0.03%]
PAD4介导的IGF2BP2瓜氨酸化稳定MCM mRNA驱动肝内胆管癌进展
Geng Tian,Lin Zou,Minjie Zhang et al.
Geng Tian et al.
Introduction: Peptidyl arginine deiminase 4 (PAD4) catalyzes the deamination of arginine residues to citrulline, a post-translational modification known as citrullination, which regulates protein structure, function, and ...
ATOX1 deficiency induces memory impairment via promoting cuproptosis in Alzheimer's disease [0.03%]
ATOX1缺乏通过促进铜依赖性细胞死亡加重阿尔茨海默病记忆损伤
Haitao Yu,Haiyan Yi,Dongdong Jia et al.
Haitao Yu et al.
Introduction: Copper homeostasis disturbance has been implicated in Alzheimer's disease (AD), and excess copper exacerbates oxidative damage, protein aggregation and cognitive deficits. Cuproptosis is a new form of cell d...
Efficient large-fragment isogenic sequence replacement in rice via prime editing with engineered reverse transcriptase variants [0.03%]
利用工程化逆转录酶变异体进行高效的大片段同源序列置换水稻原位编辑
Sujie Zhang,Jingqi Du,Guigen Ma et al.
Sujie Zhang et al.
Introduction: Achieving efficient and precise replacement of large genomic fragments with isogenic sequences remains a major challenge in plant genome editing, limiting the exploitation of natural allelic diversity for tr...
Machine learning, bioinformatics analysis and chemical screening streamline target validation by identifying RNA helicase as a druggable essential protein in tobacco mosaic virus [0.03%]
机器学习、生物信息学分析和化学筛选通过识别烟草花叶病毒中的RNA解旋酶作为可成药的必需蛋白从而简化目标验证
Yawen Dong,Danxia Wu,Ji-Yun Zhang et al.
Yawen Dong et al.
Introduction: Plant viruses inflict annual economic losses exceeding $30 billion and pose a significant threat to global food security. Discovering reliable antiviral targets is therefore essential to developing effective...