Phytosterol alleviates cholesterol accumulation by influencing intestinal esterification rather than competitive solubilization under dietary MUFA [0.03%]
Tian Zhao,Yansong Zhang,Zhangtie Wang et al.
Tian Zhao et al.
Introduction: Phytosterols (PS) are natural compounds with well-established cholesterol-lowering properties. However, their systemic bioavailability is remarkably low compared to cholesterol. While dietary Monounsaturated...
A Composite interaction Score: Prioritizing cell-cell interactions from single-cell RNA-seq with application to pre-menopausal epithelial barriers [0.03%]
Olha Kholod,Hien M Bui,H Robert Frost et al.
Olha Kholod et al.
Introduction: Cell-cell interactions (CCIs) govern tissue homeostasis, immune regulation, and barrier defense. To study these processes, multiple computational tools have been developed to infer CCIs from single-cell RNA-...
Helminth infection induces malabsorption of dietary fat via STAT6-dependent intestinal MTTP suppression [0.03%]
Chien-Wen Su,Tangyou Mao,Chih-Yu Chen et al.
Chien-Wen Su et al.
Introduction: Epidemiological studies link helminth infections to reduced obesity prevalence, but the mechanisms remain incompletely understood. Objective...
Restoring mitochondrial lipid homeostasis with arachidonic acid supplementation to alleviate cognitive impairment in schizophrenia patients [0.03%]
Yan Gao,Dandan Wang,Qian Wang et al.
Yan Gao et al.
Introduction: While mitochondrial dysfunction is implicated in schizophrenia, comprehensive understanding of mitochondrial lipid dysregulation in disease pathogenesis remains limited. ...
Penetration resistance of fiber-reinforced basic magnesium sulfate concrete: Experimental and numerical investigations [0.03%]
Taotao Feng,Chengjun Yue,Hongfa Yu et al.
Taotao Feng et al.
Introduction: Basic magnesium sulfate cement offers significant potential for protective engineering due to its high strength and toughness. Understanding the penetration resistance of fiber-reinforced BMSC (FRBMSC) under...
miR-7480-5p/SIRT3/GSH axis mediates selenium Deficiency-Exacerbated trimethyltin chloride-induced ferroptosis in chicken thymus [0.03%]
Hongxin Gao,Meichen Gao,Yanwei Liu et al.
Hongxin Gao et al.
Introduction: Trimethyltin chloride (TMT) is a widespread environmental contaminant with significant biotoxicity. Selenium is an essential trace element, and its deficiency can exacerbate pollutant toxicity, with ferropto...
Social determinants of health and female reproductive health: risk score development and cross-national study based on multi-national analysis [0.03%]
Yu Guan,Wenzhu Li,Feng Zhang et al.
Yu Guan et al.
Introduction: Social determinants of health (SDoH) significantly influence female reproductive health. However, existing research has predominantly focused on examining the impact of SDoH on individual reproductive health...
Omics insights into MYBL2-promoted cancer stem-like cells driving ferroptosis resistance in hepatocellular carcinoma [0.03%]
Yuting Chen,Xu Li,Chaochao Luo et al.
Yuting Chen et al.
Introduction: Cancer stem cells are critically involved in the initiation and progression of hepatocellular carcinoma (HCC). Understanding their biological properties and underlying mechanisms is essential for the develop...
Intracellular mitochondrial transfer in ischemic stroke: Mechanisms and therapeutic application [0.03%]
Rong Fu,Yang Zhao,Yayi Li et al.
Rong Fu et al.
Background: Current therapeutic models for ischemic stroke (IS) are shifting from a narrow focus on neuroprotection to a broader concept of cytoprotection. This new paradigm emphasizes rescuing damaged brain cells and mai...
Modulating GRP75 to restore calcium homeostasis: a novel neuroprotective strategy of CRSE6# in Parkinson's disease models [0.03%]
Xiaofang Wang,Shuaibing Li,Xiaohong Xiang et al.
Xiaofang Wang et al.
Introduction: Parkinson's disease (PD) is characterized by dopaminergic neuron loss and α-synuclein (α-syn) aggregation, with no available disease-modifying treatments. Endoplasmic reticulum (ER) stress and consequent m...