Fang He,Fenglin Song,Yixuan Xu et al.
Fang He et al.
Introduction: Aging is characterized by progressive, nonlinear decline across organ systems, yet the temporal coordination of multi-organ aging and its relationship with gut microbiota remodeling remain insufficiently def...
SUMOylation-deficient TRPV1 in sensory neurons confers resistance to high-fat diet-induced obesity via enhanced sympathetic adipose innervation [0.03%]
Xiaokun Gu,Weiji Weng,Yang Yang et al.
Xiaokun Gu et al.
Introduction: Sensory neurons have emerged as modulators of adipose metabolism and systemic energy balance, with implications for obesity. TRPV1, a nociceptive ion channel, also participates in metabolic regulation, but i...
Xuejing Zhong,Hanping Bao,Shen Zhang et al.
Xuejing Zhong et al.
Background: Endophytes establish intimate symbioses with their hosts through long-term coevolution. They are known to promote plant growth, enhance stress resistance, and contribute to the biosynthesis of bioactive compou...
Bone marrow mesenchymal stem cells have tissue-specific characteristic in promoting the potential of periodontal ligament stem cells for periodontal regeneration [0.03%]
Fen Liu,Zhifei Zhou,Xiao Sun et al.
Fen Liu et al.
Introduction: Periodontal ligament stem cells (PDLSCs) are commonly used in regenerating damaged periodontal tissues. The regeneration of complex periodontal tissues relies on stem cell crosstalk. Typically, bone marrow m...
Dietary EGCG reshapes metabolic-epigenetic interplay to induce transgenerational host defense [0.03%]
Wenqi Huang,Shiye Lin,Xuanyu Zheng et al.
Wenqi Huang et al.
Introduction: Parental diet is a key determinant of offspring health and immune function, in part through epigenetic regulation. Metabolic and epigenetic networks integrate nutrient sensing with chromatin dynamics to main...
Nanoplastics exposure accelerates the progression of osteoarthritis via lysosomal destabilization-mediated pyroptosis [0.03%]
Tanxin Yu,Hanwen Zhang,Weiqian Sun et al.
Tanxin Yu et al.
Introduction: Nanoplastics (NPs), as emerging environmental pollutants, are increasingly detected in human musculoskeletal tissues, but their impact on osteoarthritis (OA) pathogenesis remains unclear. ...
UHRF1-mediated DNA 5-mC modification drives super-enhancer redistribution and impedes osteogenesis via TGM2-regulated autophagic flux in senile osteoporosis [0.03%]
Peizhuo Pang,Junhua Chen,Qibo Li et al.
Peizhuo Pang et al.
Introduction: Senile osteoporosis (SOP) is an age-related skeletal disorder characterized by progressive bone mineral density loss and deteriorated bone microarchitecture, imposing significant burdens on aging populations...
Time-series single-cell transcriptomics and spatial metabolomics reveal spatiotemporal tobacco leaf response to herbivory [0.03%]
Huan Su,Xiaoxiang Hu,Lijun Meng et al.
Huan Su et al.
Introduction: Plants have evolved complex defense systems to cope with herbivore attack, yet how these defense responses are coordinated across distinct cell types and time scales remains unclear. Understanding the cellul...
Lufeng Yao,Guodun Zheng,Jin Cao et al.
Lufeng Yao et al.
Background: Chronic wounds impose a severe global clinical burden, affecting millions of patients yearly and causing substantial healthcare costs. Commercial dressings are limited by single-functionality. They cannot addr...
Molecular adaptation of sweet potato to Martian soil simulant: insights from mRNA and long non-coding RNA analyses [0.03%]
基于甜薯模拟火星土壤培养的mRNA和长链非编码RNA分子适应性分析
Subramanyam Reddy Chinreddy,Karthik Chinnannan,Purushothaman Natarajan et al.
Subramanyam Reddy Chinreddy et al.
Introduction: Understanding how crops adapt to extraterrestrial environments is essential for sustainable space agriculture. Sweet potato (Ipomoea batatas), a nutritionally rich and stress-resilient crop, is a promising c...