Discovery of pyrazole derivative IHMT-140 as a pancreatic cancer therapeutic agent via dual mechanisms DDR1 inhibition and methuosis induction [0.03%]
发现双机制DDR1抑制剂和甲基诱导剂吡唑衍生物IHMT-140作为胰腺癌治疗药物
Beilei Wang,Wenwen Ma,Fengming Zou et al.
Beilei Wang et al.
Introduction: Pancreatic cancer continues to be among the most lethal malignancies. The distinct tumor microenvironment (TME) not only facilitates tumor cell proliferation, invasion, and metastasis but also establishes a ...
The FAP transcription factor affects the fruiting body development and toughness of Flammulina filiformis by regulating the ROS signaling [0.03%]
FAP转录因子通过调节ROS信号影响金针菇子实体分化和硬度
Faqin Li,Hao Fan,Siyi Wang et al.
Faqin Li et al.
Introduction: High toughness in Flammulina filiformis fruiting bodies severely restricts consumption. Mechanical strength shows a significant positive correlation with chitin content in cell walls, and understanding the r...
ADR, an optimized combination of ASIV, DLA, and R1, ameliorates blood-brain barrier disruption following rtPA thrombolysis at 4.5 h after stroke onset in mice via multitarget regulation [0.03%]
一种优化的ASIV、DLA和R1组合（即ADR）可通过多靶点调节改善卒中后4.5小时重组组织型纤溶酶原激活物溶栓引起的血脑屏障破坏小鼠模型中的血液-大脑屏障损伤
Yi Zhang,Fan-Kai Chen,Shan-Shan Yue et al.
Yi Zhang et al.
Introduction: Administration of recombinant tissue plasminogen activator (rtPA) beyond 4.5 h after ischemic stroke exacerbates blood-brain barrier (BBB) disruption, leading to vasogenic cerebral edema and hemorrhage. Howe...
A 3D-bioprinted osteogenic niche model reveals bone microenvironment-driven malignant phenotypes in prostate cancer [0.03%]
基于三维生物打印的骨微环境模型揭示前列腺癌恶化表型
Chengyi Zhong,Mingchang Pang,Hang Sun et al.
Chengyi Zhong et al.
Introduction: Prostate cancer (PCa) is one of the most prevalent malignancies in men and frequently progresses to bone metastasis. Understanding the interactions between PCa cells and the bone microenvironment, as well as...
Engineered extracellular vesicles derived from sweet potato loaded with siPOLD1 for targeted therapy of glioma [0.03%]
加载siPOLD1的工程甘薯胞外囊泡针对胶质瘤的治疗研究
Zhiyong Jin,Shan Jiang,Liujie Yuan et al.
Zhiyong Jin et al.
Introduction: Glioma is the most common malignant tumor of the central nervous system, with high malignancy and poor prognosis, necessitating the development of novel targeted therapies. DNA polymerase delta catalytic sub...
The Wnt signaling regulator Dkk3 improves neural-activity homeostasis to prevent stress-induced anxiety disorder [0.03%]
Wnt信号调节因子Dkk3可通过改善神经元活性稳态来预防压力引起的焦虑障碍
Xiao Chen,Ruojing Guo,Changmin Wang et al.
Xiao Chen et al.
Objectives: The medial prefrontal cortex (mPFC) is a cortical brain region that involved in various emotional disorder. Neuroinflammation and oxidative stress are reported to associated with the pathogenesis of anxiety, b...
Complement C3 as a marker for blood-brain barrier leakage after burn injury [0.03%]
补体C3作为烧伤后血脑屏障渗漏的标志物
Hongyu Li,Jie Yang,Yitong Li et al.
Hongyu Li et al.
Background: Burns can lead to blood-brain barrier (BBB) disruption, triggering severe neurological complications. However, not all patients with mild thermal injury develop BBB leakage, and reliable peripheral biomarkers ...
Targeting FBXO48 with BC1618 promotes axon regeneration and alleviates symptoms of Parkinson's disease [0.03%]
靶向FBXO48的化合物BC1618促进轴突再生并缓解帕金森病症状
Yong-Quan Sun,Pei-Pei Liu,Chang-Ping Li et al.
Yong-Quan Sun et al.
Introduction: Neurons depend on the ubiquitin system to maintain proteostasis, which plays crucial roles in processes of neuronal death and axon regeneration after injuries and diseases. Developing druggable targets withi...
Bioorthogonal epigenetic anchoring of heterochromatin to the nuclear lamina reverses senescence and osteoarthritis [0.03%]
用于生物正交异染色质锚定的分子使衰老和骨关节炎逆转
Xunshan Ren,Huangming Zhuang,Junming Zhu et al.
Xunshan Ren et al.
Introduction: An increase in the number of senescent cells with advancing age is a major predisposing factor for aging-related osteoarthritis (OA). However, effective intervention strategies targeting cellular senescence ...
The gut microbiota metabolite IAA modulates gut-brain axis to alleviate reproductive endocrine dysfunction in PCOS [0.03%]
肠道微生物代谢物IAA通过调节肠-脑轴缓解PCOS的生殖内分泌功能障碍
Yifan Wu,Juanjuan Yu,Jiangshuang He et al.
Yifan Wu et al.
Background: Circadian rhythm disruption (CD) and gut microbiota dysbiosis are emerging drivers of the polycystic ovary syndrome (PCOS). However, the specific microbial metabolites mediating the gut-brain-ovary axis remain...