Metagenomic characterization of the resistome, bacteriome and mobilome in raw milk from intensive farming systems [0.03%]
集约化奶牛场生乳中抗药基因、细菌和可移动基因组元件的元基因组特征分析
Yiping Xu,Jie Zhao,Ningxin Huang et al.
Yiping Xu et al.
Introduction: Intensive farming, as the dominant paradigm in global dairy production, exacerbates antimicrobial resistance (AMR) risks via concentrated animal operations and routine antimicrobial prophylaxis. Nevertheless...
Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD [0.03%]
ITGA3/FAK/YAP轴调节紊乱介导慢性阻塞性肺疾病中II型上皮细胞功能障碍
Li Liu,Suye Zhong,Tengfei Zhou et al.
Li Liu et al.
Introduction: Alveolar regeneration deficiency may lead to persistent emphysematous destruction in chronic obstructive pulmonary disease (COPD), lacking effective treatments to halt disease progression. Dysfunction of alv...
Reactions of N-heterocyclic carbenes with nitrobenzenes: harnessing NHCs as synthetic building blocks [0.03%]
N-杂环卡宾与硝基苯的反应：利用NHC作为合成砌块
Zhiguo Zheng,Youlin Deng,Xiaoqun Yang et al.
Zhiguo Zheng et al.
Introduction: Quinazolin-4-one is a privileged scaffold in drugs with broad clinical applications. Conventionally, an o-amino group was generally needed to be pre-installed on the benzoic acid-derived starting materials f...
Non-traditional lipid-inflammatory parameters estimate the risk of stroke in middle-aged and older Chinese adults: a nationwide prospective cohort study [0.03%]
非传统脂质炎症参数能估算中老年中国人卒中的发病风险——一项全国性前瞻性队列研究
Xiaxuan Huang,Cun Li,Piaorong Zeng et al.
Xiaxuan Huang et al.
Background: Non-traditional lipid parameters demonstrate cardiovascular predictive value, yet their interaction with inflammatory markers in stroke risk assessment remains understudied. This research investigated their in...
Embryo vitrification disturbs the pre-implantation DNA demethylation process and affects hepatic functions to threaten long-term metabolic health in mice [0.03%]
胚胎玻璃化冷冻会干扰小鼠植入前DNA去甲基化过程并影响肝脏功能从而威胁其长期代谢健康
Yue Ying,Yang Yang,Xilin Shen et al.
Yue Ying et al.
Introduction: Embryo vitrification has been linked to an increased incidence of large-for-gestational-age offspring. Investigating how epigenetic regulation transmits vitrification-induced abnormalities to postnatal stage...
IRF1 regulates apoptosis and osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates osteoporosis by activating the PI3K/AKT signaling pathway [0.03%]
IRF1通过激活PI3K/AKT信号通路调节骨髓间充质干细胞的凋亡及成骨分化从而改善骨质疏松症
Menglong Hu,Erfan Wei,Likun Wu et al.
Menglong Hu et al.
Background: Bone marrow mesenchymal stem cells (BMSCs) are a critical cell type for stem cell-based bone regenerative therapy. Promoting osteogenic differentiation of BMSCs is important for the promotion of bone formation...
Spatial multi-omics guides ASCT2-targeted delivery of glycolysis inhibitor for cervical cancer suppression and chemoresistance reversal [0.03%]
空间多组学引导ASCT2靶向递送糖酵解抑制剂以抑制宫颈癌和逆转耐药性
Xiaojiao Li,Xiangchuan Qin,Xiejun Zhao et al.
Xiaojiao Li et al.
Introduction: Cervical carcinoma (CC) mortality remains high due to chemoresistance. Targeting glycolytic reprogramming is promising since CC cells depend on enhanced glycolysis for proliferation and chemoresistance. Howe...
Impacts of trichothecene mycotoxins on human colonic epithelial cells: molecular mechanisms and signaling pathways [0.03%]
单端孢霉烯族毒素对人结肠上皮细胞的影响：分子机制及信号通路研究
Shao-Ji Li,Chun-Min Yang,Shiyi Ou
Shao-Ji Li
Background: Trichothecenes are a family of structurally related mycotoxins typically found in cereal crops, thus threatening the health of human digestive tract. In colonic epithelial cells (CECs), trichothecenes inhibit ...
Peptide IRW upregulates ACE2 in spontaneously hypertensive rats via dopamine/D1R signaling pathway [0.03%]
多巴胺/d₁受体信号通路介导的肽段irw在自发性高血压大鼠中上调ace2的作用
Zihan Wang,Le Luo Guan,Jianping Wu
Zihan Wang
Introduction: The bioactive peptide IRW lowers blood pressure in spontaneously hypertensive rats (SHRs) by upregulating angiotensin-converting enzyme 2 (ACE2), but the underlying mechanisms remain unclear. ...
ZUP1 promotes DNA repair and immune evasion to drive olaparib resistance in triple-negative breast cancer [0.03%]
ZUP1通过促进DNA修复和免疫逃逸驱动三阴性乳腺癌对奥拉帕尼的耐药性
Shanshan Huang,Yu Qiu,Linyu Wu et al.
Shanshan Huang et al.
Introduction: Olaparib resistance limits its therapeutic efficacy in triple-negative breast cancer (TNBC). Exploring the mechanisms underlying olaparib resistance and developing combination strategies are of great clinica...