Lacticaseibacillus paracasei 36 attenuates D-GalN/LPS-induced acute liver injury in mice via suppressing the TLR4/NF-κB/MAPK pathway and NLRP3 inflammasome activation through modulating the intestinal microbiota [0.03%]
鼠李糖乳杆菌36通过调节肠道微生物群抑制Tlr4/ NF- κB / Mapk通路和NLRP3炎症小体活化从而缓解D-GalN/LPS诱导的急性肝损伤
Fei Wang,Lianchi Wu,Xiang Li et al.
Fei Wang et al.
Introduction: Acute liver injury (ALI) is a severe clinical syndrome with high mortality, often triggered by toxins, viruses, or immune-mediated injury. The gut-liver axis serves as a key mediator in the progression of he...
Electroacupuncture relieves joint pain by weakening the enhanced neuronal CXCR2-TRPA1 signaling in peripheral sensory neurons of a mouse model of acute gouty arthritis [0.03%]
电针可通过减弱急性痛风性关节炎小鼠外周感觉神经元中增强的神经元CXCR2-TRPA1信号来缓解关节疼痛
Chengyu Yin,Peiyi Li,Yufeng Chen et al.
Chengyu Yin et al.
Background: Electroacupuncture (EA) relieves acute gouty arthritis (AGA), but its mechanisms are poorly understood. Our recent work reveals that CXCR2-TRPA1 coupling in dorsal root ganglion (DRG) neurons mediates joint pa...
Effect of platelet-rich plasma in refractory vitiligo by promoting the differentiation of dermal melanocyte progenitors via IGFBP-2/RhoA/YAP pathway [0.03%]
富血小板血浆通过IGFBP-2/RhoA/YAP途径促进真皮黑素细胞前体分化治疗顽固性白癜风的效果研究
Yijian Zhu,Suqing Liu,Chen Wang et al.
Yijian Zhu et al.
Introduction: Vitiligo is an acquired depigmenting disorder. Current repigmentation strategies aim to prevent melanocyte loss and promote regeneration, often by enhancing the differentiation of melanocyte progenitors. How...
Yong-Heng Lu,Xiu-Ping Zhu,Song Li et al.
Yong-Heng Lu et al.
Background: Neurodegenerative disorders impose a growing global burden, yet disease-modifying therapies remain limited. Glial fibrillary acidic protein (GFAP) has shifted from a passive astrocytic marker to an active effe...
Identification of a novel EphB4 inhibitor, Sanguinarine, which attenuates β-catenin signaling to inhibit tumor proliferation and migration in lung cancer [0.03%]
一种新型 EphB4 抑制剂血根碱通过抑制肺癌中β-连环蛋白信号通路来抑制肿瘤增殖和迁移的鉴定研究
Asmat Ullah,Chuanzan Zhou,Wang Xiao et al.
Asmat Ullah et al.
Introduction: EphB4, a receptor tyrosine kinase, is a known promoter of tumor growth and a promising therapeutic target for cancer therapies. However, its contribution to the development and treatment of lung cancer (LC) ...
A novel mechanism of selenium deficiency driving aberrant Th17 cell differentiation via GPX3-targeted PIG3: mitophagy blockade exacerbates mtDNA release [0.03%]
硒通过GPX3靶向PIG3调节异常Th17细胞分化的新机制：线粒体自噬阻断促进mtDNA释放
Tingting Yu,Xu Shi,Yanju Bi et al.
Tingting Yu et al.
Introduction: The biological functions of selenium (Se) are mainly realized through selenoproteins. As the only secreted antioxidant enzyme in the glutathione peroxidase family, the deficiency of glutathione peroxidase 3 ...
The module of PeGLK1-1-PeWRKY111-PePMHA9 orchestrates stomatal aperture to enhance photosynthetic capacity in bamboo [0.03%]
PeGLK1-1-PeWRKY111-PePMHA9模块通过调节气孔开度增强竹子光合能力
Hui Li,Qingnan Wang,Chenglei Zhu et al.
Hui Li et al.
Introduction: Global warming, driven by CO2 emissions, poses a profound threat to the ecosystems and the sustainable development of human society. Bamboo with outstanding carbon sequestration capacity provides natural sol...
Transcriptional repressor IAA15 negatively regulates picloram herbicide resistance by modulating glutathione metabolism in eggplant [0.03%]
transcriptional repressor IAA15通过调节谷胱甘肽代谢负向调控 Eggplant 对草甘膦的抗性
Wenchao Du,Fengqing Cheng,Xusheng Ge et al.
Wenchao Du et al.
Introduction: Auxin/indole acetic acid (Aux/IAA) proteins repress the expression of auxin-responsive genes to mediate environmental abiotic stresses. Distinct auxinic herbicides are differentially involved in the auxin si...
Review of research advances in the cerebral lymphatic system and neurological disorders [0.03%]
脑淋巴系统与神经系统疾病研究进展评述
Zhaoxia Xie,Jiayi Wei,Jue Wang
Zhaoxia Xie
Background: The identification of the central lymphatic system represents a significant advancement in contemporary neuroscientific research. As a vital conduit connecting the central nervous system to the peripheral lymp...
Lactobacillus plantarum AR113 alleviates Western Diet-Induced colitis and liver injury via bidirectional modulation of the Intestinal-Hepatic FXR signaling axis [0.03%]
植物乳杆菌AR113通过肠道-肝脏FXR信号轴的双向调节缓解西方饮食引起的结肠炎和肝损伤
Junlin Shao,Di Zhao,Yongjun Xia et al.
Junlin Shao et al.
Introduction: Bile acids are involved in a variety of diseases in the host. However, the alterations in bile acid enterohepatic circulation during colitis and the pathological mechanisms underlying associated hepatic inju...