Exosomes derived from M1-macrophage promote enteric neuronal injury via MMP8-TGF-β pathway [0.03%]
M1型巨噬细胞来源的外泌体通过MMP8-TGF-β信号通路促进肠神经元损伤
Yuqiong Chen,Kai Song,Yi Zheng et al.
Yuqiong Chen et al.
Introduction: Enteric neuronal injury significantly contributes to gastrointestinal motility disorders. While macrophages are known to interact closely with enteric neurons and modulate intestinal homeostasis, their speci...
Risperidone induces osteoporosis and neuropsychiatric treatment resistance via SMPD1-lysosome-mediated ferroptosis: dual rescue by active vitamin D analog ED-71 [0.03%]
利培酮通过SMPD1-溶酶体介导的铁死亡诱导骨质疏松和治疗抵抗的双重耐药性：由活性维生素D类似物ED-71双重抢救
Yajun Cui,Ke Ma,Lingshuang Li et al.
Yajun Cui et al.
Introduction: Risperidone (RIS), a second-generation antipsychotic for schizophrenia (SZ), is linked to osteoporosis and suboptimal symptom resolution. The shared cellular mechanisms underlying these cross-tissue toxiciti...
Machine learning for food flavor prediction and regulation: models, data integration, and future perspectives [0.03%]
食品风味预测与调控中的机器学习：模型、数据整合及未来展望
Xinyu Ge,Yongjie Zhou,Qing Li et al.
Xinyu Ge et al.
Background: Flavor is a central attribute of food quality, shaping consumer preferences and market performance. Traditional evaluation methods, such as sensory panels and basic assays, are often constrained by subjectivit...
KDM6A/MMP-3 epigenetic axis governs macrophage senescence after spinal cord injury for mediating the regenerative niche to promote neurological repair [0.03%]
KDM6A/MMP-3表观遗传轴调控脊髓损伤后的巨噬细胞衰老，介导再生微环境促进神经功能修复
Jinyun Zhao,Xiaolong Sheng,Yinghe Ding et al.
Jinyun Zhao et al.
Introduction: Spinal cord injury (SCI) stands as the primary cause of disability, still lacking a clear pathogenesis and effective treatment. The role of macrophages is particularly unclear in SCI, especially regarding ce...
Bridging traditional and deep learning methods in H&E histological image normalization: a comprehensive review and introducing a novel framework for comparative analyses [0.03%]
HE染色组织图像归一化中的传统方法与深度学习方法融合：全面综述及介绍一种新的比较分析框架
Behnaz Haji Molla Hoseyni,Sevda Imany,Ahmadreza Iranpour et al.
Behnaz Haji Molla Hoseyni et al.
Background: Histology images are a cornerstone of pathology, which allow automated analysis for disease diagnosis. However, variations in staining and image acquisition processes significantly affect the performance of th...
Preserved ratio impaired spirometry, plasma proteomics, and incident heart failure [0.03%]
肺功能障碍与血浆蛋白质组及心力衰竭事件之间的关系
Yang Geng,Yi Ding,Yalong Pei et al.
Yang Geng et al.
Introduction: Epidemiological evidence suggests the association of preserved ratio impaired spirometry (PRISm) at baseline with the risk of heart failure (HF), however, the associations between transitions of PRISm and in...
Ganoderma lucidum spore powder enhances IFN-α-mediated antiviral capacity of COVID-19 vaccine boosters revealed by single-cell multi-omics sequencing [0.03%]
灵芝孢子粉通过单细胞多组学测序揭示可增强新冠肺炎疫苗加强针的干扰素抗病毒能力
Anyao Li,Xiaoyan Lu,Rongfang Guo et al.
Anyao Li et al.
Introduction: Reduced vaccine efficacy may hinder stable herd immunity. Traditional herbal ingredients, such as Ganoderma lucidum products, have shown potential as safe and effective adjuvants to improve vaccine efficacy....
Postmortem energy metabolism and meat quality development: Advances in basic pathways, endogenous regulatory factors, and exogenous management strategies [0.03%]
肉品可食组织死亡后能量代谢及肉品质形成研究进展：基本生化途径、内源调控因子及外源管理策略的研究进展
Chao Ma,Wangang Zhang,Jian Zhang et al.
Chao Ma et al.
Background: A complex series of biochemical processes is involved during the transformation of muscle into meat, among which postmortem energy metabolism that contributes to adenosine triphosphate regeneration remains par...
Breaking the bottleneck of asthma treatment: the future of omni-targeted therapy [0.03%]
突破哮喘治疗瓶颈：全方位靶向治疗的未来方向
Kuan Li,Huimin Xie,Dongshuai Shen et al.
Kuan Li et al.
Background: Bronchial asthma is a complex, highly heterogeneous disease involving multiple pathological mechanisms and inflammatory pathways. Traditional pharmacotherapies, including glucocorticoids, leukotriene modifiers...
A ventral hippocampus-basolateral amygdala circuit regulates the unconditioned stimulus retrieval-induced reconsolidation of remote fear memory [0.03%]
腹侧海马-基底外侧杏仁核环路调节远程恐惧记忆的未条件刺激提取诱导再巩固作用
Dan Guo,Zhong Wang,Fanglin Liu et al.
Dan Guo et al.
Introduction: Memory is retrieved and updated during reconsolidation, which provides a potential target for therapeutic intervention. Reconsolidation blockade following unconditioned stimulus (US) retrieval has shown incr...