Modulation of the tumor microenvironment through BMAL1-LHX8 axis augments the sensitivity of ameloblastoma to vemurafenib [0.03%]
通过BMAL1-LHX8轴调节肿瘤微环境可增强成釉细胞瘤对维莫非尼的敏感性
Shujin Li,Eun-Jung Kim,Hyun-Yi Kim et al.
Shujin Li et al.
Introduction: Ameloblastoma (AM) frequently develops resistance to the BRAF inhibitor vemurafenib, primarily mediated by ameloblastoma-associated fibroblasts (AMFs). However, the potential contribution of the circadian cl...
Unique molecular architecture of N-glycosylated TM4SF5 dimer highlights evolutionary and structural divergence among small four-transmembrane protein families [0.03%]
N-糖基化TM4SF5二聚体的独特分子结构凸显了小四次跨膜蛋白家族的进化和结构差异
Yoonji Lee,Ji Eon Kim,Wonsik Kim et al.
Yoonji Lee et al.
Introduction: Membrane proteins, including small four-transmembrane proteins, play roles in membrane organization and signal transduction. Generally, they share capacities for protein-protein association and subcellular t...
From waste to resource: development of selenium-enhanced iron-carbon galvanic materials from landfill leachate for efficient mercury and thallium detoxification in contaminated waters [0.03%]
从垃圾渗滤液中开发硒增强型铁碳电化学材料用于污染水体的高效除汞和铊毒害化研究
Dongping Song,Tao Huang,Jialin Cui et al.
Dongping Song et al.
Landfill leachate, characterized by high concentrations of organic pollutants, ammonia nitrogen (NH3-N), and heavy metals (HMs), impacts ecosystems and human health threats. Conventional treatment technologies exhibit significant efficiency...
Pericyte-myofibroblast transition: a novel mechanism in peritoneal fibrosis and the effect of Asiaticoside [0.03%]
球周细胞肌成纤维细胞转化：腹膜纤维化中的一种新机制及 asiaticoside 的影响
Jun Shi,Lei Tang,Manshu Yu et al.
Jun Shi et al.
Introduction: Peritoneal fibrosis (PF), a major complication of long-term peritoneal dialysis (PD), is characterized by excessive extracellular matrix (ECM) deposition mediated by activated myofibroblasts (MyoFs). While m...
Intratumoral microbiota in colorectal cancer: roles, therapeutic potential, and challenges [0.03%]
结直肠癌瘤内微生物群：作用、治疗潜力和挑战
Xiyu Zhang,Junwen Qi,Chenhua Dong et al.
Xiyu Zhang et al.
Background: Colorectal cancer (CRC) is a multifactorial disease characterized by disruptions in cellular and immune functions, influenced by genetic mutations, environmental factors, and infections. Recent studies have hi...
Paracrine iron activates Hopx+ rectal cancer stem cells to display radioresistance [0.03%]
旁分泌铁激活Hopx+直肠癌干细胞并产生放射耐药性
Xiangjun Liu,Xudan Lei,Jianhua Feng et al.
Xiangjun Liu et al.
Background & aims: The quiescence-activation transition of cancer stem cells regulated by environmental stimuli has been shown to potentially contribute to cancer maintenance and regrowth after therapy. However, little is...
A novel link between enhanced chenodeoxycholic acid synthesis and multi-walled carbon nanotubes-induced proliferation inhibition and apoptosis in human ocular cells [0.03%]
一种关于增强鹅去氧胆酸合成与多壁碳纳米管诱导的人眼细胞增殖抑制和凋亡之间的新联系的研究
Yunxia Liang,Yang Zhou,Dongli Xie et al.
Yunxia Liang et al.
Introduction: The increasing amount of multi-walled carbon nanotubes (MWCNTs) released into the environment due to extensive production and application has raised great concerns for public health. However, there is scarce...
Integrative computational-experimental discovery of α-hederin as a multi-mechanistic, low-toxicity antifungal agent targeting Candida albicans CYP51 [0.03%]
计算与实验整合发现α- Hederin可作为针对白色念珠菌CYP51的多靶点低毒抗真菌剂
Xuan Wang,Yuchun Zhang,Gansukh Sunderiya et al.
Xuan Wang et al.
Introduction: Infections caused by pathogenic fungi such as Candida albicans have led to a continuous increase in disease morbidity and mortality, underscoring the urgent need for safer and more effective antifungal thera...
BMP4 cocktail promotes utricular progenitor reprogramming and vestibular functional recovery in adult mice [0.03%]
BMP4混合物促进成年小鼠耳石腺前体细胞重编程和前庭功能恢复
Dan You,Yunzhong Zhang,Kunkun Wang et al.
Dan You et al.
Introduction: Vestibular hair cells (HCs) are essential for maintaining balance and detecting head movements. In mammals, following vestibular damage HC regeneration derives from epithelial non-hair cells (ENHCs), which p...
Identification of marginal zone B cells cells in head and neck cancer with immunomodulatory characteristics [0.03%]
具有免疫调节特征的头颈部癌症边缘区B细胞的鉴定
Jiantong Bao,Jochen Hess,Annika C Betzler et al.
Jiantong Bao et al.
Introduction: Recently we observed high numbers of marginal zone B cells (MZBs) within murine head and neck squamous cell carcinoma (HNSCC) with immunosuppressive potential. To date, MZBs have not been linked to tumor dev...