METTL4 enhances GLI1 translation through m6Am modification to promote tumor progression as a therapeutic target for hepatocellular carcinoma [0.03%]
METTL4通过m6Am修饰增强GLI1翻译，促进肝细胞癌进展并作为治疗靶点
Weijie Sun,Weiqi Dai,Chaobo Chen et al.
Weijie Sun et al.
Introduction: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality. Epigenetic dysregulation, particularly through methyltransferase METTL4, plays a critical role in HCC progression. METTL4 is known...
Tetrapeptides derived from black bean enhance osteogenesis and alleviate ovariectomy-induced bone loss via activation of BMP-2/Smad signaling [0.03%]
从黑豆中提取的四肽通过激活BMP-2/Smad信号通路增强成骨作用并缓解卵巢切除术引起的骨质流失
Yan Zhang,Chong Chen,Chibuike C Udenigwe et al.
Yan Zhang et al.
Introduction: Osteoporosis, a "silent killer" among the elderly, is marked by progressive bone loss and microstructural deterioration. Oligopeptides derived from black bean, particularly tetrapeptides, have shown notable ...
Fructooligosaccharides and ellagic acid synergistically enhance muscular endurance via targeting gut microbial urolithin A biosynthesis [0.03%]
益生元低聚果糖和Ellagic酸通过靶向肠道微生物催化产生Urolithin A增强小鼠肌肉耐力的协同作用机制研究
Laiming Zhang,Zengliang Jiang,Donghong Liu et al.
Laiming Zhang et al.
Introduction: Sarcopenia, characterized by the progressive loss of muscle mass and function, may be alleviated by ellagic acid (EA) through its microbial metabolite urolithin A (Uro-A). However, the low in vivo conversion...
BnaGRP3 mediates salt tolerance via Na+/K+ homeostasis and BnaPIPs interactions in Brassica napus [0.03%]
盐 tolerance通过Na+/K+ 家园斯和BnaPIPs相互作用在油菜中.mediatemediates鹽_tolerance通过Na+/K+ 家园斯和BnaPIPs相互作用在油菜中的介导物质BnaGRP3
Ouqi Li,Min Zou,Xianfei Hou et al.
Ouqi Li et al.
Introduction: Rapeseed (Brassica napus L.) is a major oilseed crop with considerable potential for improving saline-alkali soils, yet the molecular mechanisms underlying its salt tolerance remain unclear. ...
Spatial heterogeneity of viral communities across the gastrointestinal tracts of ruminants [0.03%]
反刍动物胃肠病毒群的空间异质性分布
Shizhe Zhang,Qiushuang Li,Yongyi Peng et al.
Shizhe Zhang et al.
Introduction: Viruses are abundant biological entities within the gastrointestinal tract (GIT) of ruminants. Current understanding is extensive for bacterial and archaeal communities, but limited for viral communities. ...
High-fat diet score reveals total and cardiovascular mortality and identifies protein biomarkers in large cohorts [0.03%]
高脂肪饮食评分可揭示大量人群中的总死亡率和心血管死亡率并识别蛋白质生物标志物
Xiaomin Li,Xiangju Kong,Shanpeng Liu et al.
Xiaomin Li et al.
Introduction: The high-fat diet (HFD) has complex health implications, shaped by the composition of macronutrients and food sources. However, existing dietary assessment tools lack the precision required for effective ris...
Corrigendum to "CDK4/6 inhibitor PD-0332991 suppresses hepatocarcinogenesis by inducing senescence of hepatic tumor-initiating cells" [J. Adv. Res. 73 (2025) 357-373] [0.03%]
“CDK4/6抑制剂PD-0332991通过诱导肝肿瘤起始细胞衰老来抑制肝癌发生”一文的勘误[J.Adv.Res.73(2025)357-373]
Miaomiao Chen,Wenjian Chen,Shiwen Sun et al.
Miaomiao Chen et al.
Genotype-driven variations in lncRNA expression underlie predisposition to high-grade serous ovarian cancer [0.03%]
基因型驱动的长链非编码RNA表达变化是高级别浆液性卵巢癌易感性的基础
Mingming Lu,Yanan Chu,Ziwei Zhu et al.
Mingming Lu et al.
Introduction: New effective early diagnosis strategies and therapeutic targets are desperately needed for high-grade serous ovarian cancer (HGSOC). Previous functional interpretation of HGSOC genome-wide association studi...
Gut microbiota dysbiosis transmits deoxynivalenol toxicity and triggers liver inflammation [0.03%]
肠道菌群失调可传递脱氧雪腐镰刀菌烯醇毒性并引发肝炎
Jing Jin,Fangfang Li,Yafan Hu et al.
Jing Jin et al.
Introduction: Deoxynivalenol (DON), a mycotoxin produced by Fusarium species, is known to compromise gut barrier integrity and induce systemic inflammation. ...
Guaianolide dimer KGA-1002 targets GRP94 and triggers unfolded protein response-associated degradation of SKP2/AKT axis as a novel antihepatoma agent [0.03%]
瓜内酯二聚体KGA-1002靶向GRP94并触发未折叠蛋白反应相关SKP2/AKT轴的降解作为新型抗肝癌制剂
Qi-Hao Li,Tian-Ze Li,Yong-Cui Wang et al.
Qi-Hao Li et al.
Introduction: Hepatocellular carcinoma (HCC) remains a highly lethal malignant tumor with limited treatment options. The guaianolide dimer KGA-1002 exhibited significant inhibitory effects on HCC cells, but the specific t...