Carbon dots and DNA: DNA binding mechanisms and their effect on the cell cycle arrest [0.03%]
碳点和DNA：DNA 结合机制及其对细胞周期阻滞的影响
Jiuyan Chen,Fang Li,Jiawen Yang et al.
Jiuyan Chen et al.
Introduction: Carbon dots (CDs), a type of carbon-based nanoparticles with sizes less than 10 nm, have been widely employed in nucleus-targeted drug delivery for cancer therapy and imaging, and some are capable of binding...
Transforming hosts into nurseries and nutrients: strategic manipulation by endoparasitoid wasps [0.03%]
将宿主转化为养育地和养料：寄生黄蜂的战略操纵手段
Wenxian Wu,Yueyue Liu,Song Chen et al.
Wenxian Wu et al.
Parasitoid wasps, shaped by ecological pressures and interspecific competition, have evolved sophisticated molecular strategies to manipulate host physiology, ensuring successful parasitism and optimal progeny development. Despite substanti...
Fucose-tobramycin sponge-like microparticles to treat pulmonary Pseudomonas aeruginosa infections in a lectin-competitive approach [0.03%]
岩藻糖-妥布霉素海绵状微粒通过竞争受体途径治疗肺铜绿假单胞菌感染
Yuzhen Jin,Jun Chen,Cenfeng Liu et al.
Yuzhen Jin et al.
Introduction: The high incidence of pulmonary infections caused by multidrug-resistant bacteria such as Pseudomonas aeruginosa (PA) poses significant treatment challenges. Dry powder inhaler (DPIs) are an effective treatm...
PRDM15 inhibits responses of Tissue-Resident memory T cells by activating PVR/TIGIT axis to mediate gastric cancer immunosuppression [0.03%]
PRDM15通过激活PVR/TIGIT轴抑制组织驻留记忆T细胞介导胃癌免疫抑制
Xinyao Zhang,Jinsen Zheng,Hantao Guo et al.
Xinyao Zhang et al.
Introduction: Gastric cancer (GC) has shown relatively poor responses to existing immune therapies. The extensive infiltration of tissue-resident memory T cells (TRM) in tumor microenvironment (TME) is associated with bet...
Alveolar macrophage-derived TGF-β promotes acute lung injury recovery by regulating inflammatory monocyte-derived macrophages [0.03%]
肺泡巨噬细胞源TGF-β通过调节炎症单核细胞来源的巨噬细胞促进急性肺损伤修复
Fei Hou,Junjie Xiao,Huan Wang et al.
Fei Hou et al.
Introduction: Acute lung injury (ALI) is a rapidly progressive condition with a high mortality rate and limited treatment options. Alveolar macrophages (AMs) and monocyte-derived macrophages (MDMs) are two types of macrop...
Flavonoid-modulated JAK-STAT signaling mitigates malignant transformation and drug resistance in breast tumors: A clinically relevant 3PM-guided innovation [0.03%]
黄酮调节JAK-STAT信号通路可减轻乳腺肿瘤的恶性转化和药物耐药性：一项具有临床意义的3PM引导创新举措
Peter Kubatka,Mykhailo Huniadi,Andrea Kapinova et al.
Peter Kubatka et al.
Background: Breast cancer (BC) treatment efficacy is often compromised by tumor cell plasticity and multidrug resistance of multi-factorial origin. Among emerging therapeutic agents, flavonoids - a structurally diverse gr...
Hyperuricemia increases susceptibility to chronic kidney injury exacerbation via autophagic flux blockade-mediated ammonia death pathway [0.03%]
高尿酸血症通过自噬流阻断介导的氨死亡途径增加慢性肾脏病恶化风险
Yu-Xin Zhang,Hui Wan,Guan-Yue Shan et al.
Yu-Xin Zhang et al.
Ammonia (NH3), a core toxic byproduct of amino acid metabolism in the body, poses a severe threat to cell survival when its homeostasis is disrupted. Maintaining low systemic ammonia concentrations is crucial. Under physiological conditions...
Multitrophic biodiversity drives soil phosphorus mobilization in subtropical ecosystems [0.03%]
亚热带生态系统的土壤磷释放由多营养级生物多样性驱动
Xionghui Liao,Jie Zhao,Tibor Magura et al.
Xionghui Liao et al.
Introduction: The phosphorus (P) mobilization capacity of plants and microbes is hierarchically constrained by climatic drivers, land-use types, lithological properties, and consumer-mediated trophic cascades. ...
New insights into optimal storage conditions for raw Pu-erh tea: modulating post-fermentation flavor via microbial metabolism under controlled water activity [0.03%]
普洱茶存储条件优化新见解：低湿条件下微生物活性对茶风味代谢影响研究
Bingsong Ma,Longjie Xu,Shuang Liang et al.
Bingsong Ma et al.
Introduction: The post-fermentation storage of raw Pu-erh tea (RPT) is a key process that contributes to the development of its characteristic aged flavor. Microbial activity plays a vital role in this transformation whic...
Andrographolide alleviates type 2 diabetic nephropathy through suppressing PI3K/AKT1/RRM2-triggered oxeiptosis [0.03%]
安格拉醇通过抑制PI3K / AKT1 / RRM2引发的OxER来缓解2型糖尿病肾病
Mingzheng Han,Jingchun Wang,Shuaihao Guo et al.
Mingzheng Han et al.
Type 2 diabetic nephropathy (T2DN) stands as a critical microvascular complication of type 2 diabetes, and current pharmacological interventions remain necessitate refinement and supplement. Through network pharmacology and preliminary scre...