Mechanical force activates KCNN4 to regulate the NLRP3 inflammasome in periodontal ligament cells during orthodontic tooth movement [0.03%]
机械力通过活化KCNN4调节牙周膜细胞移动过程中的NLRP3炎性小体
Fu Zheng,Feifei Wang,Peng Chen et al.
Fu Zheng et al.
Introduction: Orthodontic tooth movement (OTM) relies on mechanical force that triggers inflammatory responses in periodontal tissue, orchestrating alveolar bone remodeling. Potassium (K+) efflux plays a key role in infla...
Band selection framework for hyperspectral images based on discriminability-oriented optimization mechanism [0.03%]
基于区分度优化机制的高光谱图像波段选择框架
Ximei Ma,Dong Zhao,Qier Kang et al.
Ximei Ma et al.
Introduction: Hyperspectral images suffer from high dimensionality, inter-band redundancy, and noise interference, increasing computational cost and degrading classification performance. Conventional band selection method...
PhaseOM: an integrated multi-task framework for phase separation analysis and key residue detection [0.03%]
PhaseOM：一个集成的多任务框架用于液-液相分离分析和关键残基检测
Liping Xu,Shengming Zhou,Zixu Ran et al.
Liping Xu et al.
Introduction: Liquid-liquid phase separation (LLPS) drives cellular organization through scaffold proteins that initiate condensate formation and client proteins that partition into them. Current computational tools lack ...
Discovery of modifiable factors associated with Pan-Cancer Risk: An Exposome-Wide analysis [0.03%]
泛癌风险的可改变因素的发现： exposome水平的研究分析
Wen Liu,Shuai Xiang,Yiwei Liu et al.
Wen Liu et al.
Introduction: Hypothesis-driven studies have identified many modifiable cancer risk factors, but research focusing on single exposures overlooks their complex interactions. ...
Targeting a candidate stromal immune checkpoint: a cellular senescence signature identifies COMP⁺ cancer-associated fibroblasts associated with CD8⁺ T-cell exclusion via a predicted COMP-CD47 axis in colorectal cancer [0.03%]
靶向候选间质免疫检查点：一种细胞衰老特征识别出一组COMP+癌相关成纤维细胞，该细胞通过预测的COMP-CD47轴排除Colorectal Cancer中CD8+T细胞
Yingying Chen,Ying Zhang,Chi Lv
Yingying Chen
Introduction: Resistance to immunotherapy in colorectal cancer (CRC) is closely linked to an immunosuppressive tumour microenvironment (TME), in which cancer-associated fibroblasts (CAFs) are key regulators. Cellular sene...
Protective monoclonal antibody targeting mycobacterial HBHA blocks the interaction with the novel attachment co-receptor NRP1 to inhibit Mycobacterium bovis entry [0.03%]
靶向结核分枝杆菌HBHA的保护性单克隆抗体可通过阻断与新鉴定到的附着辅助受体NRP1相互作用来抑制牛型结核分枝杆菌侵入宿主细胞
Mengjin Qu,Xiangmei Zhou,Xianfeng Zhang et al.
Mengjin Qu et al.
Introduction: The immune protection conferred by Bacillus Calmette-Guérin (BCG) is insufficient, underscoring the urgent need for novel strategies to control tuberculosis (TB). Although antibody-mediated responses target...
Corrigendum to "Orthosteric-allosteric dual inhibitors of PI5P4Kγ with potent antitumor activity in non-small cell lung cancer" [J. Adv. Res. 84 (2026) 1105-1126] [0.03%]
“PI5P4Kγ正则异位双抑制剂的抗肿瘤活性研究”一文的勘误[1105-1126]
Liang Xiong,Lei Tang,Wenfeng Zhao et al.
Liang Xiong et al.
Engineered marbled meat through EPA-mediated co-differentiation of porcine muscle and fat progenitors without conventional hormonal induction [0.03%]
通过EPA介导的肌肉和脂肪谱系共同分化培养肌间脂肪干细胞而无需使用传统激素诱导工程化大理石化肌肉
Xin Gu,Shiyuan Hua,Teresa G Valencak et al.
Xin Gu et al.
Introduction: Intramuscular fat, known as "snowflake" pattern in pork, critically determines meat tenderness, juiciness, flavor, and overall consumer preference. Cultured meat has emerged as a promising solution to addres...
Nutraceutical and functional food: efficacy against metabolic disorders and underlying mechanistic insights [0.03%]
营养药和功能性食品：对抗代谢紊乱的疗效及潜在机制透视
Qihui Yang,Yuxin Pei,Luyao Zhao et al.
Qihui Yang et al.
Background: The growing global emphasis on health consciousness has significantly increased demand for traditional and complementary medicine products, including functional foods, nutraceuicals, and medicine and food homo...
A dual-target modulator of STK11 and PP2Acα from the flowers of Chrysanthemum indicum mitigates drug-induced liver injury [0.03%]
一朵野菊花中的小分子化合物通过靶向STK11和PP2Acα缓解药物性肝损伤
Fei Zhou,Yu Liu,Haoyu Zhao et al.
Fei Zhou et al.
Introduction: Hormesis, characterized by low-dose stimulation and high-dose inhibition, is a biphasic regulatory phenomenon, and its underlying mechanisms remain elusive. Drug-induced liver injury (DILI) can progress to l...