Genetic and pharmaceutical targeting of Suv39h1 ameliorates renal fibrosis by unlocking CXCL10 transcription [0.03%]
表观遗传调控酶Suv39h1通过解锁CXCL10转录从而缓解肾纤维化遗传和药理学靶向研究
Xiaoyan Wu,Yajun Luo,Caiyi Wu et al.
Xiaoyan Wu et al.
Introduction: Identified as a pathological hallmark of all forms of chronic kidney disease (CKD), renal fibrosis contributes to renal failure when dysregulated. In this process, renal fibroblasts act as the primary source...
R-loop scarlet-RL suppresses scarlet transcription to mediate attraction to plant volatile in migratory locusts [0.03%]
R-loop的scarlet-Rl通过抑制scarlet转录介导飞蝗对植物挥发物的趋化性
Zongyuan Ma,Yajing Sun,Jing Qu et al.
Zongyuan Ma et al.
Introduction: The ABC transporter Scarlet is known for its role in pigment deposition within insect eye pigment granules. However, its extraocular functions remain largely unexplored. ...
Optimizing energy efficiency and occupant comfort in smart buildings using SMOTE-augmented deep learning approaches [0.03%]
基于SMOTE增强深度学习方法的智能建筑能源效率和 occupant comfort优化
Shahid Mahmood,Jinping Guan,Asifa Iqbal et al.
Shahid Mahmood et al.
Introduction: The architecture and construction sector is a major consumer of energy and a significant contributor to greenhouse gas emissions, emphasizing the need for intelligent, energy-efficient, and sustainable build...
Effect of early packed red blood cell transfusion on sepsis-associated acute kidney injury: A target trial emulation [0.03%]
早期输注红细胞对脓毒症相关急性肾损伤的影响：准试验模拟研究
Ting Liu,Weisheng Chen,Xinya Li et al.
Ting Liu et al.
Background: To date, the effects of packed red blood cell (PRBC) transfusion on sepsis-associated acute kidney injury (SA-AKI) have not been reported in the literature. The objective of this study is to conduct a prelimin...
Effect of early packed red blood cell transfusion on sepsis-associated acute kidney injury: A target trial emulation [0.03%]
早期输注红细胞对脓毒症相关急性肾损伤的影响：准实验研究
Ting Liu,Weisheng Chen,Xinya Li et al.
Ting Liu et al.
Background: To date, the effects of packed red blood cell (PRBC) transfusion on sepsis-associated acute kidney injury (SA-AKI) have not been reported in the literature. The objective of this study is to conduct a prelimin...
A biparatopic antibody targeting the Cε2 and Cε3 domains of IgE disrupts IgE-FcεRI interaction [0.03%]
一种靶向IgE的Cε2和Cε3结构域的双结合位点抗体可破坏IgE与FcεRⅠ相互作用
Lixia Zhu,Peiyi Zheng,Qingyu Cheng et al.
Lixia Zhu et al.
Introduction: Therapeutic anti-IgE antibodies that block the interaction between immunoglobulin E (IgE) and its high-affinity receptor (FcεRI) have been a popular direction for the treatment of allergic diseases. ...
From KRAS inhibition to tumor adaptation: mechanistic layers of resistance and therapeutic strategies [0.03%]
从KRAS抑制到肿瘤适应：耐药性的机制层面和治疗策略
Rawan Salih,Fazila Sirajudeen,Mohamed Rahmani
Rawan Salih
Background: KRAS is a central oncogenic driver in multiple solid malignancies, including non-small cell lung cancer, pancreatic ductal adenocarcinoma, and colorectal cancer. Activating KRAS mutations, together with co-mut...
Broad-spectrum light-responsive deep eutectic solvents for ambient microalgae disintegration with intact fractions [0.03%]
广谱光响应深吴溶剂在环境微藻细胞破碎及有效成分保护中的应用研究
Huan Wang,Jianfeng Ma,Bing Song et al.
Huan Wang et al.
Introduction: Rationally integrating microalgae valorization is pivotal to sustainable and cost-competitive biorefineries. However, a trade-off exists between effective disintegration of recalcitrant microalgae and retent...
Dual-functional bacterial extracellular vesicles with therapeutic oligonucleotides for synergistic treatment of ischemia/reperfusion injury in the brain [0.03%]
装载治疗性寡核苷酸的细菌胞外囊泡协同治疗脑缺血再灌注损伤
Kangmin Park,Sung Bin Ahn,Jihun Oh et al.
Kangmin Park et al.
Introduction: Ischemia/reperfusion (I/R) injury refers to secondary damage that occurs following ischemic stroke when reperfusion is achieved using thrombolytic agents. The abrupt restoration of blood flow induces excessi...
Screening cross-injury responses in skin organoids identifies a THBS2-enriched pro-repair fibroblast state during regeneration [0.03%]
在再生过程中筛选皮肤类器官中的交叉损伤反应，鉴定出一种富含THBS2的促修复成纤维细胞状态
Chao Zhang,Xu Guo,Kehao Ren et al.
Chao Zhang et al.
Introduction: Skin injuries impose a substantial global health burden. Conventional wound healing models fail to distinguish evolutionarily conserved regenerative mechanisms from injury specific responses because they can...