Trained immunity-primed DLL3-targeted CAR macrophages for the eradication of small cell lung cancer [0.03%]
训练有素的免疫系统-DLL3靶向CAR巨噬细胞根除小细胞肺癌
Hangjie Ying,Yazhou Wang,Na Li et al.
Hangjie Ying et al.
Background: Small cell lung cancer (SCLC) is highly malignant with limited treatment options. Chimeric antigen receptor macrophages (CAR-Ms) show potential for solid tumor therapy due to their phagocytic activity, tissue ...
Structure-guided discovery of quinazoline derivatives as potent FtsZ inhibitors in combating bacterial infections [0.03%]
基于结构的喹唑啉衍生物抗菌剂发现：作为FtsZ抑制剂对抗细菌感染
Linli Yang,Wan Chen,Jingsha Yang et al.
Linli Yang et al.
Introduction: The scarcity of novel antibiotics effective against bacterial infections, coupled with the escalating threat of antibiotic resistance, represents one of the most pressing challenges in global public health a...
Advanced colorectal neoplasia and colorectal cancer in metabolic dysfunction-associated steatotic liver disease [0.03%]
与代谢功能障碍相关性肝脂肪变性疾病中进展期结直肠病变及结直肠癌的风险关系研究
Qin-Fen Chen,Wei Xie,Haojun Cai et al.
Qin-Fen Chen et al.
Background: Although metabolic-associated fatty liver disease (MASLD) is linked to an increased prevalence of colorectal cancer (CRC), large-scale incidence data on its association with advanced colorectal neoplasia (ACN)...
Predicting risk of mental health deterioration using multimodal data from the UK biobank [0.03%]
基于UK生物样本库多模态数据的精神健康恶化风险预测研究
Shuangyu Yang,Xingyu Lv,Bi Huang et al.
Shuangyu Yang et al.
Introduction: Prospective prediction of mental health risk is critical for early intervention to reduce the burden of depression, anxiety, and cognitive disorders. ...
Dysregulated lipid metabolism in hepatocellular carcinoma: a review of molecular networks and therapeutic opportunities [0.03%]
肝细胞癌中失调的脂质代谢：分子网络和治疗机会综述
Hui-Yan Ding,Han Li,Chen-Hang Sun et al.
Hui-Yan Ding et al.
Background: Hepatocellular carcinoma (HCC), characterized by high incidence and mortality rates, is a major global health concern. Most patients are diagnosed at advanced stages, rendering surgical options unfeasible. Cur...
The GSK2-OsHHO3 module antagonistically regulates disease resistance and drought tolerance via interplaying BR and ABA signaling in rice [0.03%]
GSK2-OsHHO3模块通过BR和ABA信号的相互作用拮抗调控水稻的病原菌抗性和干旱耐受性
Kexing Fang,Yapu Cheng,Tiancheng Qiu et al.
Kexing Fang et al.
Introduction: The NIGT1/HHO subfamily of transcription factors in plants plays a crucial role in perceiving and integrating nutrient signals, regulating developmental processes, and mediating stress responses. However, th...
Ca2+ signaling in chronic rhinosinusitis with nasal polyps: Deciphering mechanistic insights and future therapeutic targets [0.03%]
慢性鼻窦炎伴鼻息肉中的钙信号：阐明机制和未来治疗目标的见解
Zaina Kalaji,Iyad Said Hamadi,Ahmad Munzer Al-Waa et al.
Zaina Kalaji et al.
Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a prevalent yet inadequately understood condition characterized by benign lesions originating from inflamed nasal sinuses. It impacts patients by inducing n...
Host-targeted apple pectic oligosaccharides repair intestinal barrier in colitis via HSP90β/miRNA/CORO2A axis [0.03%]
宿主靶向型苹果低聚半乳糖醛酸修复结肠炎小鼠肠道屏障损伤的机制研究
Xiangqi Fan,Xiangjun Xiao,Dayan Tan et al.
Xiangqi Fan et al.
Introduction: While functional oligosaccharides alleviate inflammatory bowel disease (IBD), their mechanisms conventionally attributed to gut microbiota modulation. The direct, host-targeted regulatory pathways of apple p...
Rhein suppresses lactate metabolism and melanoma progression via downregulating LDHA/H3K18 lactylation/PLK1 axis [0.03%]
Rhein通过下调LDHA/H3K18乳酸化/PLK1轴抑制乳酸代谢和黑色素瘤进展
Shuo Zheng,Shang Wang,Jia Zhu et al.
Shuo Zheng et al.
Introduction: An increasing body of evidence suggests that lactate and its associated post-translational modification, lactylation, are critically involved in the aggressive progression of melanoma and represent promising...
Emerging trends in functional chitosan-based composites: applications in environmental remediation, energy storage, and biomedical solutions [0.03%]
基于壳聚糖的功能复合材料的新兴趋势：在环境修复、能量存储和生物医学解决方案中的应用
Abdul Basit,Muhammad Rehan Akhtar,Muhammad Humza et al.
Abdul Basit et al.
Background: Chitosan, derived from marine resources and insects, is biodegradable, non-toxic, and chemically tunable, which makes it a good candidate in green technology. Recent improvements in chitosan composites indicat...