The deficiency of circSLC8A1 fosters tubular partial EMT-induced renal fibrosis through upregulating Annexin A2 signaling [0.03%]
Lei Wei,Peng He,Limin Liu et al.
Lei Wei et al.
Background: Chronic kidney disease (CKD) progression to renal fibrosis is primarily driven by maladaptive partial epithelial-mesenchymal transition (pEMT) in tubular epithelial cells (TECs), a process lacking effective th...
Min Joung Lee,Young Eun Kim,Hee Jin Chang et al.
Min Joung Lee et al.
Background: Normal pressure hydrocephalus (NPH), which is characterized by gait disturbances, cognitive impairment, and urinary incontinence, is a distinct subtype of hydrocephalus that predominantly affects older adults....
Natural flavonoids inhibit plasmid conjugation via iron chelation and zinc-responsive envelope stress [0.03%]
Bingqing Yang,Miao Zhang,Shuyao Zhu et al.
Bingqing Yang et al.
Introduction: Plasmid-mediated bacterial conjugation is a major driver of horizontal gene transfer (HGT) via direct cell-to-cell contact, significantly accelerating the dissemination of antimicrobial resistance (AMR). Giv...
Yusi Fan,Tian Wang,Zhiying Yan et al.
Yusi Fan et al.
Introduction: Feature selection plays a crucial role in improving predictive performance and interpretability in high-dimensional machine learning tasks. However, it is an NP-hard combinatorial optimization problem. Conve...
Muscone promotes remyelination and alleviates Parkinson's disease by targeting FKBP5 in MPTP-induced mouse model [0.03%]
Jiatian Zhang,Yulin Xiao,Anyao Li et al.
Jiatian Zhang et al.
Introduction: The side effects and limited efficacy of existing dopaminergic treatments for Parkinson's disease (PD) underscore the urgent need for novel therapeutic strategies. Promoting myelin renewal might be one promi...
High throughput screening identifies sanguinarine chloride as a multi-faceted therapeutic agent for PRCC-TFE3 rRCC by targeting lactylation-driven VEGFB-VEGFR2 signaling and PMN-MDSC infiltration [0.03%]
Xuwentai Liu,Yi Chen,Wujia Liu et al.
Xuwentai Liu et al.
Introduction: PRCC-TFE3 rearranged renal cell carcinoma (PRCC-TFE3 rRCC) is a highly malignant renal malignancy with limited therapeutic options, underscoring the urgent need for novel treatment strategies. ...
LncRNA HCP5 remodels G6PD dual post-translational modification to mediate metabolic adaptations driving osimertinib resistance in lung adenocarcinoma [0.03%]
长链非编码RNA HCP5 通过重塑G6PD双重翻译后修饰介导代谢适应以诱导肺腺癌对奥希替尼耐药性
Wei Xu,Xi Chen,Qianqian Zhang et al.
Wei Xu et al.
Introduction: Osimertinib represents the standard treatment for EGFR-mutant lung adenocarcinoma (LUAD); however, acquired resistance limits its clinical efficacy. Elucidating the underlying mechanisms of resistance is cru...
PCSK9 promotes prostate cancer via facilitating intratumoral cholesterol accumulation and enhancing immunosuppressive tumor microenvironment [0.03%]
PCSK9通过促进瘤内胆固醇积累和增强免疫抑制性肿瘤微环境来促进前列腺癌发展
Yan Gu,Fengxiang Wei,Ying Dong et al.
Yan Gu et al.
Introduction: Cholesterol plays critical roles in prostate cancer (PCa) proliferation, immune evasion, and androgen signaling. PCSK9 regulates cholesterol metabolism. Its role in PCa remains unclear. ...
LPCAT3 deficiency Drives phospholipid remodeling and mitochondrial oxidative dysfunction to accelerate MASH-HCC development [0.03%]
LPCAT3缺陷通过磷脂重塑和线粒体氧化损伤加速MASH-HCC的发展
Gaoxuan Shao,Chenhao Ye,Chenceng Sun et al.
Gaoxuan Shao et al.
Introduction: Metabolic dysfunction-associated steatohepatitis (MASH) represents a severe subtype of metabolic dysfunction-associated fatty liver disease (MAFLD), characterized by hepatic steatosis, chronic inflammation, ...
Brain-heart interaction: direct and indirect circuits in health and diseases [0.03%]
脑-心交互作用：健康与疾病中的直接和间接环路
Yi Wang,Lele Liu,Tianai Zhang et al.
Yi Wang et al.
Background: Epidemiological data indicate a significant global increase in both comorbidity and mutually induced rates between cardiovascular and neurological diseases. Among these, cardiovascular and cerebrovascular dise...