Noninvasive detection and differentiation of gastric malignancy using cell-free DNA biomarkers [0.03%]
基于细胞游离DNA的胃癌无创检出与分类研究
Hengzhen Li,Meng Chen,Ying Liu et al.
Hengzhen Li et al.
Introduction: Gastric cancer remains a major global health burden, with high mortality driven by late-stage diagnoses that limit treatment options and reduce survival. Current diagnostic methods such as endoscopy and biop...
Extracellular matrix-inspired multi-morphology microspheres harness osteogenic-prone stem cells to recruit and reprogram adjacent stem cells for synergistic bone regeneration [0.03%]
受细胞外基质启发的多形态微球募集和重编程周围干细胞实现协同骨再生
Huixin Lv,Yihan Wang,Jingxia Chen et al.
Huixin Lv et al.
Governed by epigenetic regulation, distinct types of adult stem cells exhibit lineage-specific differentiation biases. Osteogenic-prone stem cells might recruit, proliferate, and induce osteogenesis in adjacent osteogenic-weak stem cells, c...
Rational engineering of an antifreeze-based biomaterial with dual-enhanced ice-binding and delivery for high-efficiency cryopreservation [0.03%]
基于理性的抗冻基生物材料的工程改造及其高效冷冻保存性能及运输冰能力的双重增强
Yishan Fu,Yangyang Li,Fei Pan et al.
Yishan Fu et al.
Introduction: Reliable cell cryopreservation is essential for biomedical research and cell-based therapies. Although dimethyl sulfoxide (DMSO) is widely used as a cryoprotectant, its cytotoxicity and clinical incompatibil...
Discovery of FBP1 as novel therapeutic target and asiatic acid-hydrogen sulfide donors accelerate diabetic wound healing [0.03%]
FBP1被发现是新的治疗靶点及总冠字第ⅹ号巴西酸-氢 sulfide供体可加速糖尿病伤口愈合
Shenglin Wang,Tongtong Ye,Lihao Shi et al.
Shenglin Wang et al.
Introduction: Wound healing impairment is highly prevalent in diabetes and frequently progresses to serious complications, including refractory ulcers and necessitated amputations. RNA sequencing in methylglyoxal (MGO)-in...
c-Myc-PANK3-EMT axis regulates the structure and function of intestinal barrier in ulcerative colitis c-Myc-PANK3-EMT axis regulates UC intestinal barrier integrity [0.03%]
c-Myc-PANK3-EMT轴调控溃疡性结肠炎肠道屏障结构和功能
Shize Zhang,Yuang Chen,Nan Aa et al.
Shize Zhang et al.
Introduction: The repair of structural damage of the intestinal barrier is critical to rescue ulcerative colitis (UC), but there lacks effective targets currently. ...
Butylphthalide enhances neurorestoration following ischemic stroke by restructuring microvasculature through vimentin modulation [0.03%]
丁苯酞通过调节波形蛋白重构脑血管单元促进缺血性卒中后神经功能恢复
Haiyan Xiao,Haochen Xie,Meng Qin et al.
Haiyan Xiao et al.
Introduction: Ischemic stroke severely threatens human health. Rapid restoration of cerebral blood flow (CBF) in ischemic microvessels is significant as it enhances neurovascular function, prevents neuronal death, and min...
Aromatic short peptide-metal nanoassemblies in smart hydrogel sensors for real-time food freshness monitoring [0.03%]
用于实时监控食品新鲜度的智能水凝胶传感器中的芳香短肽-金属纳米组件
Xuecheng Zhu,Jing Su,Yuzhen Wang et al.
Xuecheng Zhu et al.
Introduction: The accumulation of volatile biogenic amines (BAs) during food spoilage constitutes a global economic and public health burden. Conventional BA detection methods based on chromatography and electrochemistry ...
Modulation of the tumor microenvironment through BMAL1-LHX8 axis augments the sensitivity of ameloblastoma to vemurafenib [0.03%]
通过BMAL1-LHX8轴调节肿瘤微环境可增强成釉细胞瘤对维莫非尼的敏感性
Shujin Li,Eun-Jung Kim,Hyun-Yi Kim et al.
Shujin Li et al.
Introduction: Ameloblastoma (AM) frequently develops resistance to the BRAF inhibitor vemurafenib, primarily mediated by ameloblastoma-associated fibroblasts (AMFs). However, the potential contribution of the circadian cl...
Unique molecular architecture of N-glycosylated TM4SF5 dimer highlights evolutionary and structural divergence among small four-transmembrane protein families [0.03%]
N-糖基化TM4SF5二聚体的独特分子结构凸显了小四次跨膜蛋白家族的进化和结构差异
Yoonji Lee,Ji Eon Kim,Wonsik Kim et al.
Yoonji Lee et al.
Introduction: Membrane proteins, including small four-transmembrane proteins, play roles in membrane organization and signal transduction. Generally, they share capacities for protein-protein association and subcellular t...
From waste to resource: development of selenium-enhanced iron-carbon galvanic materials from landfill leachate for efficient mercury and thallium detoxification in contaminated waters [0.03%]
从垃圾渗滤液中开发硒增强型铁碳电化学材料用于污染水体的高效除汞和铊毒害化研究
Dongping Song,Tao Huang,Jialin Cui et al.
Dongping Song et al.
Landfill leachate, characterized by high concentrations of organic pollutants, ammonia nitrogen (NH3-N), and heavy metals (HMs), impacts ecosystems and human health threats. Conventional treatment technologies exhibit significant efficiency...