Endoplasmic reticulum stress exacerbates ischemia-reperfusion-induced pulmonary endothelial barrier dysfunction by activating TXNDC5 [0.03%]
内质网应激通过激活TXNDC5加重缺血再灌注所致肺血管内皮通透性增高现象
Yu Wang,Pu Chen,Shiqian Huang et al.
Yu Wang et al.
Introduction: Lung ischemia-reperfusion injury (LIRI)-a fatal complication following major surgery, trauma, or shock- is characterized by pulmonary endothelial barrier (PEB) dysfunction. Although thioredoxin domain-contai...
Application of γ-cyclodextrin encapsulation of eugenol and isoeugenol: characterization, stability, and taste impact [0.03%]
γ-环糊精包合姜黄素和异硫氢酸酯的研究：特性、稳定性及风味影响
Ming Lu,ZhaoHong Miao,YunWei Niu et al.
Ming Lu et al.
Introduction: Eugenol and isoeugenol, key flavor isomers, exert distinct effects on sweetness perception but suffer from poor thermal and oxidative stability, as well as rapid aroma volatilization, during food processing ...
Integrated multi-omics unravels solanesol's multi-organ protection mechanisms against insulin resistance in type 2 diabetic mice [0.03%]
整合多组学解开松醇对抗2型糖尿病小鼠胰岛素抵抗的多器官保护机制
Wenji Zhang,Wenli Cheng,Jiaqi Fu et al.
Wenji Zhang et al.
Introduction: Integrated multi-omics analysis has revolutionized the investigation of plant-derived compounds for type 2 diabetes mellitus (T2DM). Solanesol, a bioactive constituent from Solanaceae plants, exhibits high o...
Histone H4 lysine 12 lactylation-driven ZIP14 expression is involved in electroacupuncture therapy against cerebral ischemia/reperfusion injury in mice [0.03%]
组蛋白H4第12位赖氨酸乳酸化调控ZIP14表达介导电针抗小鼠脑缺血再灌注损伤作用机制研究
Feifei Xu,Liwen Shi,Shiquan Wang et al.
Feifei Xu et al.
Introduction: Electroacupuncture (EA) has been demonstrated as an effective therapeutic intervention for cerebral ischemia-reperfusion injury (CIRI); however, the fundamental processes underlying EA therapy remain largely...
Xing Yang,Chunjie Li,Junxian He et al.
Xing Yang et al.
Introduction: Adenomyosis is a prevalent gynaecological disorder affecting women of reproductive age, yet the underlying etiology and cellular-molecular mechanisms driving its pathogenesis remain poorly understood. Gonado...
Parabacteroides goldsteinii mitigates parkinsonism in LRRK2 mutant mice by reducing neuroinflammation through Gut-Brain axis [0.03%]
肠脑轴介导的减少神经炎症作用_parabacteroides goldsteinii通过肠道微生物群在lrrk2突变小鼠中缓解帕金森氏症
Jian-Da Lin,Hsun Li,Chia-Lang Hsu et al.
Jian-Da Lin et al.
Introduction: Alterations in the gut microbiota accompanied by intestinal inflammation are early features of Parkinson's disease (PD). Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene represent a common genetic ...
Whole-genome sequencing identifies genetic diversity and adaptive signatures of hypoxia and ultraviolet radiation in Chinese chickens [0.03%]
全基因组测序鉴定出中国家鸡应对缺氧和紫外线辐射的遗传多样性和适应标记
Semiu Folaniyi Bello,Endashaw Terefe,Haoqiang Ye et al.
Semiu Folaniyi Bello et al.
Introduction: Domestic chickens primarily descended from the wild red junglefowl, play a crucial role in global egg and meat production. China hosts diverse indigenous chicken populations that have adapted to various envi...
A genome-wide CRISPRi screen identifies homologous recombination pathway as potential target for broad-spectrum antibiotic adjuvants [0.03%]
利用CRISPR干扰进行全基因组筛选鉴定同源重组途径作为广谱抗生素增效剂的潜在靶点
Haijie Zhang,Bo Chen,Lina Gu et al.
Haijie Zhang et al.
Introduction: The widespread misuse and overuse of antibiotics have driven the emergence of multidrug-resistant and pan drug-resistant bacteria, constituting a formidable global health threat. Antibiotic adjuvants that po...
Multi-omics analysis of early reperfused ischemic heart reveals ERRβ/γ activation protects against acute myocardial infarction injury [0.03%]
多组学分析揭示早期再灌注的缺血心脏中的ERRβ/γ激活可防止急性心肌梗死损伤
Yun Gao,Fei Huang,Yuan Zhang et al.
Yun Gao et al.
Introduction: Acute myocardial infarction (AMI) is a leading cause of morbidity and mortality globally, with timely percutaneous coronary intervention (PCI) as the standard treatment. Early time reperfusion (ETR) shown to...
Potential biomarkers for human Ascending aortic aneurysm identified through metagenomic and metabolomic analyses: A case-control study [0.03%]
基于元基因组和代谢组分析的升主动脉瘤潜在生物标志物发现：一项病例对照研究
Mingxi Li,Shiqi Gao,Jiale Cheng et al.
Mingxi Li et al.
Introduction: Ascending aortic aneurysm (AsAA) is a high-risk cardiovascular condition; recent research indicates a possible association between gut microbiota, plasma metabolites, and the pathogenesis of AsAA. ...