Activating Sigma1R by fluoxetine suppresses neuronal ferroptosis in epilepsy by inhibiting MDM2-mediated GPX4 ubiquitination [0.03%]
氟西汀通过抑制MDM2介导的GPX4泛素化激活Sigma1R抑制癫痫神经元铁死亡
Yuxiang Li,Cong Wang,Mengying Huang et al.
Yuxiang Li et al.
Introduction: Epilepsy affects more than 70 million individuals worldwide, contributing to early mortality, disability, and cognitive impairment. Antidepressants have been explored for epilepsy treatment, although their e...
Mouse models of aortic aneurysm and dissection: pathophysiological insights and translational perspectives [0.03%]
主动脉瘤和夹层的鼠类模型：病理生理学见解与转化视角
Chenyang He,Hiromi Yanagisawa,Tzung K Hsiai et al.
Chenyang He et al.
Background: Aortic aneurysm (AA) and aortic dissection (AD) are catastrophic aortic disorders characterized by progressive structural weakening or acute medial tearing, often resulting in rupture and high mortality. Their...
Spatiotemporal-specific DNA methylation and small RNAs are involved to regulate cell cycle progression and organ development of cucumber (Cucumis sativus L.) [0.03%]
时空特异性的DNA甲基化和小RNA通过调控黄瓜细胞周期进程参与器官建成调节
Xiaotao Ding,Yueying Mao,Yongxue Zhang et al.
Xiaotao Ding et al.
Introduction: Cucumber fruits, with a relatively high rate of fruit expansion, are harvested at an early developmental stage once moderately expanded. Although DNA methylation regulating fruit ripening has been well studi...
Immune cell dynamics in myocardial infarction: mechanisms, therapeutic targets, and translational Perspectives [0.03%]
心肌梗死中的免疫细胞动态变化：机制、治疗靶点和转化视角
Yue Ran,Yuexin Luo,Yumo Chen et al.
Yue Ran et al.
Background: Myocardial infarction (MI) triggers a complex and dynamic immune response involving both innate and adaptive immune cells. Among these, macrophages (Mφ), neutrophils, dendritic cells, and mast cells play esse...
Cisplatin-induced ecDNA enhances tumor malignancy and accelerates chemoresistance acquire in gastric cancer [0.03%]
顺铂诱导的生态DNA增强胃癌恶性程度并加速耐药产生
Huanbo Zhu,Lian Chen,Longtao Huangfu et al.
Huanbo Zhu et al.
Background: Extrachromosomal DNA (ecDNA), as a dynamic genetic vector, enables tumor cells to exhibit enhanced adaptability under chemotherapeutic stress. However, its functional role in tumor malignancy and the developme...
Discovery of pyrazole derivative IHMT-140 as a pancreatic cancer therapeutic agent via dual mechanisms DDR1 inhibition and methuosis induction [0.03%]
发现双机制DDR1抑制剂和甲基诱导剂吡唑衍生物IHMT-140作为胰腺癌治疗药物
Beilei Wang,Wenwen Ma,Fengming Zou et al.
Beilei Wang et al.
Introduction: Pancreatic cancer continues to be among the most lethal malignancies. The distinct tumor microenvironment (TME) not only facilitates tumor cell proliferation, invasion, and metastasis but also establishes a ...
The FAP transcription factor affects the fruiting body development and toughness of Flammulina filiformis by regulating the ROS signaling [0.03%]
FAP转录因子通过调节ROS信号影响金针菇子实体分化和硬度
Faqin Li,Hao Fan,Siyi Wang et al.
Faqin Li et al.
Introduction: High toughness in Flammulina filiformis fruiting bodies severely restricts consumption. Mechanical strength shows a significant positive correlation with chitin content in cell walls, and understanding the r...
ADR, an optimized combination of ASIV, DLA, and R1, ameliorates blood-brain barrier disruption following rtPA thrombolysis at 4.5 h after stroke onset in mice via multitarget regulation [0.03%]
一种优化的ASIV、DLA和R1组合（即ADR）可通过多靶点调节改善卒中后4.5小时重组组织型纤溶酶原激活物溶栓引起的血脑屏障破坏小鼠模型中的血液-大脑屏障损伤
Yi Zhang,Fan-Kai Chen,Shan-Shan Yue et al.
Yi Zhang et al.
Introduction: Administration of recombinant tissue plasminogen activator (rtPA) beyond 4.5 h after ischemic stroke exacerbates blood-brain barrier (BBB) disruption, leading to vasogenic cerebral edema and hemorrhage. Howe...
A 3D-bioprinted osteogenic niche model reveals bone microenvironment-driven malignant phenotypes in prostate cancer [0.03%]
基于三维生物打印的骨微环境模型揭示前列腺癌恶化表型
Chengyi Zhong,Mingchang Pang,Hang Sun et al.
Chengyi Zhong et al.
Introduction: Prostate cancer (PCa) is one of the most prevalent malignancies in men and frequently progresses to bone metastasis. Understanding the interactions between PCa cells and the bone microenvironment, as well as...
Engineered extracellular vesicles derived from sweet potato loaded with siPOLD1 for targeted therapy of glioma [0.03%]
加载siPOLD1的工程甘薯胞外囊泡针对胶质瘤的治疗研究
Zhiyong Jin,Shan Jiang,Liujie Yuan et al.
Zhiyong Jin et al.
Introduction: Glioma is the most common malignant tumor of the central nervous system, with high malignancy and poor prognosis, necessitating the development of novel targeted therapies. DNA polymerase delta catalytic sub...