Differential rumen responses in neonatal ruminants to volatile fatty acids, glucose, and physical stimulation: insights into the drivers of early rumen development [0.03%]
牛羊新生反刍动物瘤胃对挥发性脂肪酸、葡萄糖和物理刺激的差异反应：早期瘤胃发育驱动因素的新见解
Tianrong Chen,Kui Li,Yin Yuyang et al.
Tianrong Chen et al.
Introduction: The transition from milk to solid feed is a critical stage for rumen development in young ruminants; however, the relative contributions of chemical stimuli (such as volatile fatty acids, VFAs) and physical ...
Physical exercise mitigates amyloid beta-driven muscle degeneration in Alzheimer's disease [0.03%]
身体锻炼可缓解阿尔茨海默病患者β淀粉样蛋白驱动的肌肉退化
Ling-Ling Yang,Ya-Xi Luo,Dan Song et al.
Ling-Ling Yang et al.
Introduction: Alzheimer's disease (AD) is increasingly recognized as a systemic disorder, with skeletal muscle dysfunction contributing substantially to frailty and functional decline. Although amyloid-β (Aβ) has been d...
Activation of microglial PPARγ by asperosaponin VI alleviates stress-induced depression and synaptic impairment [0.03%]
asperosaponin VI活化小胶质细胞PPARγ缓解应激诱导的抑郁和突触损伤
Yangyan Ge,Chengyan Yang,Meidan Wang et al.
Yangyan Ge et al.
Background: Depression is a common mental disorder affecting hundreds of millions worldwide. Targeting microglial peroxisome proliferator-activated receptor gamma (PPARγ) is regarded as one of the strategies to improve d...
Human BBB-brain organoid on a millifluidic plate for modeling brain parenchymal pathology-induced barrier dysfunction [0.03%]
基于人脑类器官的微流控芯片人血脑屏障模型在研究脑实质病变诱导的屏障功能障碍中的应用
Lili Zhu,Wen Zhao,Min Shen et al.
Lili Zhu et al.
Introduction: The blood-brain barrier (BBB) maintains brain homeostasis, and its dysfunction is a critical pathological mechanism for many neurological disorders. However, current BBB models lack functional brain parenchy...
Therapeutic potential of ELABELA in alleviating hereditary hypertrophic cardiomyopathy [0.03%]
ELABELA在缓解遗传性肥厚型心肌病中的治疗潜力
Chao Ye,Tao Xu,Hai Yang et al.
Chao Ye et al.
Introduction: Hereditary hypertrophic cardiomyopathy (HCM) is a common genetic heart disease associated with heart failure and sudden cardiac death. Current therapies are limited, and the myosin inhibitor mavacamten is co...
GhLBD18 triggers GhATG18a-dependent autophagy during somatic embryogenesis in cotton [0.03%]
GhLBD18在棉花体细胞胚胎发生过程中触发依赖于GhATG18a的自噬作用
Jiachen Yuan,Xingxing Zhi,Xingxing Liu et al.
Jiachen Yuan et al.
Introduction: Autophagy is well established as a critical mechanism in plant stress responses and sexual reproduction, yet its molecular mechanisms during asexual reproduction remains poorly characterized. Deciphering the...
Sunlight to Plasma: Mimicking nature's light for smarter agriculture and crop production [0.03%]
从阳光到等离子体：模拟自然光以实现更智能的农业和作物生产
Pankaj Attri,Kenji Ishikawa,Kazunori Koga
Pankaj Attri
Background: Over Earth's history, the Sun has continuously released coronal mass ejections of plasma that have flowed toward Earth, generating the need for reactive oxygen and nitrogen species (RONS) for plants. On the ot...
How cotton-specialized aphids hack cucumber plants: DNA methylation reshapes zinc finger protein xFG20-1 regulation for adaptive trade-offs [0.03%]
棉蚜专化危害黄瓜的机制：DNA甲基化重塑锌指蛋白xFG20-1调控以适应颉顽困境
Xueke Gao,Hui Xue,Li Wang et al.
Xueke Gao et al.
Introduction: The cotton-specialized aphid biotype Hap1 cannot survive directly on cucumber but achieves adaptation after several generations via an intermediate zucchini host, epigenetic mechanisms likely mediate this ad...
Cytobiological and molecular mechanisms underlying hybridization fertility differences among albino tea cultivars (Camellia sinensis) [0.03%]
白化茶树品种(Camellia sinensis)杂交生育力差异的细胞生物学和分子机制研究
Xiaohan Xu,Chunju Peng,Anqi Xing et al.
Xiaohan Xu et al.
Camellia sinensis is a perennial economic crop, and albino cultivars ('Baiye No.1' (BY), 'Huangjinya' (HA), 'Huangjinye' (HE)) are valuable for hybrid breeding but exhibit distinct hybridization seed set rates. This study explored these dif...
Yaozhi Zhang,Junyang Huang,Yihang Li et al.
Yaozhi Zhang et al.
Background: Single-cell genetic perturbation screens are increasingly used to study gene function at single-cell resolution. However, their analysis remains difficult because available computational methods differ in assu...