Divergent regulation of DREB1A by ICE1 and ABF4 contributes to distinct cold adaptation in four turfgrass species [0.03%]
ICE1和ABF4对DREB1A的分歧调控贡献了四个草坪草物种中的不同耐冷性
Di Yang,Weiliang Wang,Zhengfu Fang et al.
Di Yang et al.
Introduction: Cold constrains the growth and distribution of turfgrasses, which are divided into cool-season and warm-season types with distinct cold adaptation capacities. However, how different grass species evolved dis...
SpiderMass ambient mass spectrometry and multimodal machine learning enable ex vivo ovarian cancer typing and exploratory immunoscoring [0.03%]
基于小样本的妇科肿瘤质谱和多模态机器学习免疫分型研究
Léa Ledoux,Yanis Zirem,Laurine Lagache et al.
Léa Ledoux et al.
Complete cytoreductive surgery remains one of the strongest determinants of outcome in ovarian cancer, yet surgeons still lack rapid tissue-assessment tools that can be repeated throughout an operation. Here we evaluated whether SpiderMass ...
Genetics of cardiovascular disease: genes and polymorphisms in pathways underlying atherosclerosis and clinical events [0.03%]
心血管疾病的遗传学：动脉粥样硬化及临床事件相关途径中的基因和多态性
Maria Jose Parraga-Viudez,Monica Sanchez-Gutierrez,Alba Quiros-Jimenez et al.
Maria Jose Parraga-Viudez et al.
Background: Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality worldwide and arise from a complex interplay of environmental, metabolic and genetic factors. Over the past decades, advances i...
Injectable Chito-oligosaccharide-hyaluronic acid hydrogels with Fe3+/AMP nano-enzyme promote ROS scavenging and immunomodulation for myocardial infarction repair [0.03%]
具有Fe3+/AMP纳米酶的可注射低聚糖透明质酸水凝胶通过促进ROS清除和免疫调节用于心肌梗死修复
Lin Chen,Sihan Xue,Jinde Zhang et al.
Lin Chen et al.
Introduction: The post-infarction microenvironment, dominated by oxidative stress, hypoxia, and dysregulated inflammation, severely limits cardiac regeneration. Existing injectable hydrogels for myocardial infarction (MI)...
Dynamic bidirectional diffusion-controlled multi-enzyme system for one-pot viral detection [0.03%]
一种用于一次性病毒检测的动力双向扩散控制多酶系统
Jing Zhang,Xuening Shi,Yukun Ding et al.
Jing Zhang et al.
Introduction: Integrating isothermal amplification with CRISPR-based detection in a single reaction vessel holds significant promise for rapid and sensitive point-of-care virus diagnostics. However, conventional one-pot m...
Study of benign prostatic hyperplasia and androgen pathway manipulation on lung cancer survivals [0.03%]
良性前列腺增生与雄激素通路调控对肺癌生存影响的研究
Po-Hsin Lee,Pang-Ting Cheng,Ayse Celik et al.
Po-Hsin Lee et al.
Introduction: Androgens and androgen receptor (AR) signaling may play a role in lung cancer pathophysiology. Patients with benign prostatic hyperplasia (BPH) may represent a population with relatively lower androgen level...
Siyu Wei,Hong Zhang,Yalin Liu et al.
Siyu Wei et al.
Introduction: Arabinoxylan (AX) is a major dietary fiber that is depolymerized and fermented by gut microbiota to produce short-chain fatty acids (SCFAs), thereby influencing host energy harvest and gut homeostasis. Howev...
The Gyro-Top Optimization: A Physics-inspired Metaheuristic for Engineering Optimization and a Case Study of Feature Selection [0.03%]
基于物理的工程优化的新启发式算法：陀螺优化算法及特征选择中的应用研究
Chenliang Huang,Mingjing Wang,Zhilin Wang et al.
Chenliang Huang et al.
This paper proposes Gyro-Top Optimization (GTO), a physics-inspired metaheuristic algorithm motivated by the precession and nutation behaviors of a spinning gyroscope. GTO translates gyroscopic dynamics into a staged search framework, where...
MDH1 K298 succinylation stabilizes redox homeostasis to protect against cardiac ferroptosis in ischemia-reperfusion injury [0.03%]
MDH1 K298琥珀酰化稳定氧化还原稳态以保护心肌缺血再灌注损伤诱导的铁死亡
Haodong Li,Jie Liu,Junting Ren et al.
Haodong Li et al.
Introduction: Lysine succinylation is an emerging post-translational modification critically involved in cardiovascular pathophysiology. Malate dehydrogenase 1 (MDH1), a core enzyme of the malate-aspartate shuttle that ma...
Mapping sarcopenia's causal proteome reveals a leptin-driven inflammatory-mitochondrial axis for early prediction [0.03%]
肌少症因果蛋白质组mapping揭示了早期预测的炎症-线粒体轴(由瘦素驱动)
Jing Sun,Mingchen Yan,Jiang Dan et al.
Jing Sun et al.
Introduction: Sarcopenia, the age-related loss of muscle mass and function, is a major barrier to healthy aging. However, its molecular origins remain obscure, and current clinical tools lack the sensitivity needed to det...