T-cell epitope supplementation enhanced cross-protection against H7N9 AIV in chickens via upregulated HA epitope-specific T cell and CD4 T cell-mediated help [0.03%]
T细胞表位补充通过上调HA表位特异性T细胞和CD4T细胞的辅助作用来增强鸡对H7N9禽流感病毒的交叉保护作用
Xiaoli Hao,Xinjie Yuan,Jiongjiong Wang et al.
Xiaoli Hao et al.
The continuous circulation of H7N9 avian influenza viruses (AIVs) in poultry poses a significant public health threat. T cell-mediated immunity favors enhanced and broad protection against viruses. However, it remains challenging to exploit...
The MaEIL9-MaZIP5-MaSCL8 module integrates MaBEL1 and synergistically modulates banana fruit ripening [0.03%]
MaEIL9-MaZIP5-MaSCL8模块整合MaBEL1并协同调节香蕉果实成熟过程
Fan Liu,Xueli Sun,Ou Sheng et al.
Fan Liu et al.
Introduction: Fruit ripening is a genetically predetermined developmental process that is governed by a complex multilevel regulatory network requiring the orchestration of spatiotemporal expression of many genes and prot...
Rejuvenation of THY1+ nucleus pulposus-derived stem cells promotes intervertebral disc regeneration through FGF10-FGFR1-CREB pathway and mitochondrial fission [0.03%]
THY1+椎间盘干细胞的年轻化通过FGF10-FGFR1-CREB通路和线粒体分裂促进椎间盘再生
Haoxin Zhai,Zexin Wang,Shaoyi Wang et al.
Haoxin Zhai et al.
Introduction: Intervertebral disc degeneration (IVDD), a major cause of low back pain, is primarily characterized by compromised regeneration ability of nucleus pulposus-derived stem cells (NPSCs) owing to their senescenc...
DHA ameliorates GDM placental angiogenesis by regulating HAMP-mediated iron imbalance [0.03%]
DHA通过调节HAMP介导的铁稳态失衡改善GDM胎盘血管生成
Zihao Huang,Shijian Zhou,Zhijuan Cui et al.
Zihao Huang et al.
Introduction: Iron metabolism imbalance is closely associated with gestational diabetes mellitus (GDM), but the underlying mechanisms of its contribution to placental endothelial dysfunction and effective interventions re...
Species-specific tryptophan metabolism drives bioactivity divergence in Apis cerana and Apis mellifera honeys [0.03%]
天冬酰胺特异性色氨酸代谢驱动Apis cerana和Apis mellifera蜂蜜的生物活性分歧
Yan Liu,Yunyun Hu,Qian Luo et al.
Yan Liu et al.
Introduction: The honeys produced by Apis mellifera ligustica Spinola (A. mellifera) and Apis cerana cerana Fabricius (A. cerana) are the two predominant varieties in terms of global yield, each recognized for its distinc...
Indoor aerosols induced blood-brain barrier leakiness and β-amyloid1-42 aggregation [0.03%]
室内气溶胶可引起血脑屏障通透性和β淀粉样蛋白1-42聚集现象
Jinping Wang,Baoteng Wang,Kunpeng Zhu et al.
Jinping Wang et al.
Introduction: Exposure to indoor aerosols that include fine particulate matter 2.5 (PM2.5) and microorganisms has been implicated in various health issues, including neurodegenerative diseases. ...
Microglia Dld-K127 lactylation promotes Parkinson's disease via regulating the metabolism of lactate-pyruvate transformation [0.03%]
小胶质细胞丙酮酸乳酸互变代谢调控的低丰度赖氨酸127-乳酰化促进帕金森病发病进展
Guoqing Wang,Guichun Gong,Xinxing Yang et al.
Guoqing Wang et al.
Introduction: Microglial activation represents a central pathological hallmark of Parkinson's disease (PD), characterized by a distinct metabolic reprogramming from oxidative phosphorylation toward glycolysis during pro-i...
Temporal dynamic and GhGLR4.8-mediated reorganization of 3D chromatin architecture during Fusarium oxysporum f. Sp. Vasinfectum infection in cotton [0.03%]
棉花枯萎病菌侵染下三维基因组动态变化及鬼笔环肽酰基转移酶GhGLR4.8介导的染色质高级结构重编程
Shiming Liu,Xianhui Huang,Xiaojun Zhang et al.
Shiming Liu et al.
Introduction: Plants evolve sophisticated strategies to rapidly regulate gene expression in response to environmental stress. Epigenetic regulation and highly dynamic three-dimensional (3D) chromatin reorganization are cr...
Dynamic impact of intermittent fasting and refeeding on metabolic health and microbiome-metabolome signatures in cynomolgus monkeys [0.03%]
断食和再进食对食蟹猴代谢健康及微生物群-代谢组标志物的动态影响
Libing Xu,Liying Guo,Qunchao Su et al.
Libing Xu et al.
Introduction: Dietary intervention has emerged as a promising approach for improving metabolic health across species; however, its systemic effects in non-human primates (NHPs) remain insufficiently characterized. ...
Co-delivery nanoparticle targeting CAF for simultaneous activating T cell plus NKT cell attack in solid tumor [0.03%]
一种协同输送型纳米粒子，用于靶向实体肿瘤中的癌症相关成纤维细胞以激活T细胞和NKT细胞的联合攻击
Yucheng Xiang,Lie Zhang,Jing Ye et al.
Yucheng Xiang et al.
Introduction: Tumor fibrosis promotes immunosuppression by creating physical barrier that limits immune cell infiltration, posing challenges for immunotherapy. Therefore, it is essential to design a reasoned therapeutic s...