A Poaceae-specific DREB-A6 transcription factor TaDREB26-B regulates ABA responses and enhances drought stress tolerance in wheat [0.03%]
Yufan Zhang,Min Tu,Jiapeng Han et al.
Yufan Zhang et al.
Introduction: Dehydration-responsive element-binding (DREB) transcription factors, members of the AP2/ERF superfamily, are pivotal regulators of stress-responsive gene expression by binding to DRE/CRT cis-elements. They r...
Lipeng Liao,Yuan Meng,Yuhang Shi et al.
Lipeng Liao et al.
Background: Organoids are moving from self-organized three-dimensional (3D) cultures toward engineered living systems with translational intent. Yet most platforms still rely on static, poorly defined matrices and limited...
Mitochondria orchestrated immune microenvironment and response in health and disease-clinically relevant outlook and recommendations [0.03%]
Kai Yang,Junlong Bi,Yu Cao et al.
Kai Yang et al.
Background: The homeostatic balance of the immune microenvironment is key to maintaining bodily health, and its disorder is closely related to the occurrence and development of various major diseases such as cardiovascula...
Spatiotemporal multiomics reveal a default CD4 fate and a stem-like CD8 T cell subset in the thymus [0.03%]
Hanpeng Luo,Xiuping Cui,Yaqin Li et al.
Hanpeng Luo et al.
Background: T cell development in the thymus proceeds through coordinated transcriptional and spatial transitions. While key stages have been described, the precise timing and regulatory logic of lineage bifurcation-such ...
AI-driven multi-scale target analysis of traditional Chinese medicine: From the pharmacological effects of single compounds to the synergistic mechanisms of formulae [0.03%]
Liang Hong,Muyao Teng,Min He et al.
Liang Hong et al.
Background: Traditional Chinese Medicine (TCM) presents a unique therapeutic paradigm characterized by multi-compound, multi-target interventions, yet this complexity impedes mechanistic understanding and standardization....
Ginsenoside Rb1 attenuates diabetic peripheral neuropathy pathology by functioning as a potent activator of isocitrate dehydrogenase 1 [0.03%]
Yujie Huang,Yuxi Wei,Sujie Xie et al.
Yujie Huang et al.
Introduction: Diabetic peripheral neuropathy (DPN) is a severe diabetic complication closely associated with diabetic foot that is a major risk factor for amputation and mortality. Hyperglycemia disrupts the tricarboxylic...
MyD88 inhibitory Peptide-2 (MIP2) improves neurological outcomes and reduces neuroinflammation after intracerebral Hemorrhage-mediated secondary brain injury [0.03%]
Rabeea Siddique,Pingping Guo,Qingli Wang et al.
Rabeea Siddique et al.
Introduction: Intracerebral hemorrhage (ICH) is a highly debilitating brain condition due to the limited availability of treatment options. MyD88 inhibitory peptide-2 (MIP2) is a broad-range TLR-targeting peptide. It prov...
Phytosterol alleviates cholesterol accumulation by influencing intestinal esterification rather than competitive solubilization under dietary MUFA [0.03%]
Tian Zhao,Yansong Zhang,Zhangtie Wang et al.
Tian Zhao et al.
Introduction: Phytosterols (PS) are natural compounds with well-established cholesterol-lowering properties. However, their systemic bioavailability is remarkably low compared to cholesterol. While dietary Monounsaturated...
A Composite interaction Score: Prioritizing cell-cell interactions from single-cell RNA-seq with application to pre-menopausal epithelial barriers [0.03%]
Olha Kholod,Hien M Bui,H Robert Frost et al.
Olha Kholod et al.
Introduction: Cell-cell interactions (CCIs) govern tissue homeostasis, immune regulation, and barrier defense. To study these processes, multiple computational tools have been developed to infer CCIs from single-cell RNA-...
Helminth infection induces malabsorption of dietary fat via STAT6-dependent intestinal MTTP suppression [0.03%]
Chien-Wen Su,Tangyou Mao,Chih-Yu Chen et al.
Chien-Wen Su et al.
Introduction: Epidemiological studies link helminth infections to reduced obesity prevalence, but the mechanisms remain incompletely understood. Objective...