miR-7480-5p/SIRT3/GSH axis mediates selenium Deficiency-Exacerbated trimethyltin chloride-induced ferroptosis in chicken thymus [0.03%]
Hongxin Gao,Meichen Gao,Yanwei Liu et al.
Hongxin Gao et al.
Introduction: Trimethyltin chloride (TMT) is a widespread environmental contaminant with significant biotoxicity. Selenium is an essential trace element, and its deficiency can exacerbate pollutant toxicity, with ferropto...
Social determinants of health and female reproductive health: risk score development and cross-national study based on multi-national analysis [0.03%]
Yu Guan,Wenzhu Li,Feng Zhang et al.
Yu Guan et al.
Introduction: Social determinants of health (SDoH) significantly influence female reproductive health. However, existing research has predominantly focused on examining the impact of SDoH on individual reproductive health...
Omics insights into MYBL2-promoted cancer stem-like cells driving ferroptosis resistance in hepatocellular carcinoma [0.03%]
Yuting Chen,Xu Li,Chaochao Luo et al.
Yuting Chen et al.
Introduction: Cancer stem cells are critically involved in the initiation and progression of hepatocellular carcinoma (HCC). Understanding their biological properties and underlying mechanisms is essential for the develop...
Intracellular mitochondrial transfer in ischemic stroke: Mechanisms and therapeutic application [0.03%]
Rong Fu,Yang Zhao,Yayi Li et al.
Rong Fu et al.
Background: Current therapeutic models for ischemic stroke (IS) are shifting from a narrow focus on neuroprotection to a broader concept of cytoprotection. This new paradigm emphasizes rescuing damaged brain cells and mai...
Modulating GRP75 to restore calcium homeostasis: a novel neuroprotective strategy of CRSE6# in Parkinson's disease models [0.03%]
Xiaofang Wang,Shuaibing Li,Xiaohong Xiang et al.
Xiaofang Wang et al.
Introduction: Parkinson's disease (PD) is characterized by dopaminergic neuron loss and α-synuclein (α-syn) aggregation, with no available disease-modifying treatments. Endoplasmic reticulum (ER) stress and consequent m...
The pleiotropic effects of a single transcription factor underpin trade-offs associated with insecticide resistance in whitefly [0.03%]
Mingjiao Huang,Shaonan Liu,Buli Fu et al.
Mingjiao Huang et al.
Introduction: The evolution of insecticide resistance is often accompanied by fitness costs on life-history traits; however, the genetic mechanisms underlying this 'benefit-cost' trade-offs remain limited. ...
Oral Delivery of siSIRPα via Yeast-Derived β-Glucan Particles Enhances Macrophage-Mediated Antitumor Immunity by Blocking the CD47-SIRPα Axis [0.03%]
Liuyang He,Jie Chen,Meng Yuan et al.
Liuyang He et al.
Introduction: The CD47-SIRPα Axis functions as a key innate immune checkpoint that enables tumors to evade phagocytosis and immune surveillance. Blockade of this interaction has emerged as a promising anticancer immunoth...
Jiamin Zhao,Xin Li,Yidan Liang et al.
Jiamin Zhao et al.
Background: Dietary intervention has emerged as a key strategy not only for health control but also for disease treatment. Growing evidence indicates that dietary interventions (including caloric restriction, intermittent...
STING-driven mitochondrial metabolism reverses cisplatin resistance via MDH2 desuccinylation in non-small cell lung cancer [0.03%]
Man Zhu,Xiaoyu Tang,Zeren Zhu et al.
Man Zhu et al.
Introduction: Cisplatin resistance is a major obstacle in the treatment of non-small cell lung cancer (NSCLC) and remains a leading cause of cancer-related deaths worldwide. This resistance substantially reduces the effic...
Smart nano-assembly from traditional Chinese medicine: manganese-enhanced polysaccharide platform for orchestrated cancer chemo-immunotherapy [0.03%]
Zhen Lin,Mingming Rong,Wanyu Tang et al.
Zhen Lin et al.
Introduction: The limitations of conventional cancer therapies have driven the development of precise, low-toxicity strategies. Natural products with bioactivity and self-assembly potential offer a basis for designing mul...