Targeting the bile acid receptor TGR5 with Gentiopicroside to activate Nrf2 antioxidant signaling and mitigate Parkinson's disease in an MPTP mouse model [0.03%]
番泻醇通过活化Nrf2抗氧化信号通路靶向TGR5受体从而缓解MPTP诱导的小鼠帕金森病模型症状的研究
Ying Gao,Xiuling Tang,Jingyue Yao et al.
Ying Gao et al.
Introduction: Parkinson's disease (PD) is a common neurodegenerative disorder characterized by classical symptoms including bradykinesia, rest tremor and rigidity. Oxidative stress and mitochondrial dysfunction are recogn...
Urinary proteins from stone formers promote calcium oxalate crystallization, growth and aggregation via oxidative modifications [0.03%]
结石形成者的尿蛋白通过氧化修饰促进草酸钙结晶、生长和聚集
Sudarat Hadpech,Paleerath Peerapen,Sakdithep Chaiyait et al.
Sudarat Hadpech et al.
Introduction: Various urinary parameters are used for determining kidney stone risk. However, almost all of the widely used lithogenic indices rely on urinary concentrations of small molecules/ions and pH. ...
Fish oil reduces intestinal fat absorption by promoting lacteal junction zippering via GPR120-VEGFR3-MLCK pathway [0.03%]
鱼油通过GPR120-VEGFR3-MLCK通路促进乳糜管上皮“拉链”闭合从而减少肠道脂肪吸收
Junfeng Wang,Liling Cai,Jinhao Liu et al.
Junfeng Wang et al.
Introduction: Diet-induced obesity can be improved by reducing intestinal fat absorption. Fish oil, enriched in n-3 PUFAs such as DHA and EPA, has shown promise in weight reduction. However, the role of fish oil in regula...
Dynamic heterogeneity towards drug resistance in AML cells is primarily driven by epigenomic mechanism unveiled by multi-omics analysis [0.03%]
多组学分析揭示急性髓系白血病细胞的动态异质性主要由表观遗传机制驱动
Yulong Zhang,Yanfang Lu,Liyao Mai et al.
Yulong Zhang et al.
Introduction: Acute myeloid leukemia (AML) is a hematologic malignancy characterized by aggressive proliferation and chemoresistance, leading to poor patient outcomes. Despite advances in chemotherapy, resistance mechanis...
Maternal exposure to urban particulate matter induces cardiac developmental toxicity in zebrafish offspring by disrupting mitochondrial homeostasis [0.03%]
暴露于微粒污染物的母体通过扰乱线粒体稳态诱导斑马鱼后代心脏发育毒性
Shiqian Liu,Ruiyang Ding,Linyuan Huang et al.
Shiqian Liu et al.
Introduction: Urban particulate matter (UPM) is a major air pollutant affecting public health, with maternal exposure potentially leading to cardiac developmental disorders in offspring. However, the exact mechanisms unde...
Aroma compounds with enhanced sweet perception in tea infusions: Screening, characterization, and sweetening mechanism [0.03%]
具有增强甜感的茶汤香气成分筛选、表征及增甜机制研究
Yuming Wei,Ya-Ya Yu,Yuan-Chao Li et al.
Yuming Wei et al.
Introduction: Tea (Camellia sinensis) is globally consumed for its pleasant flavor, with sweetness being a key factor in evaluating tea quality. While taste compounds contribute to this sweetness, aroma also plays a signi...
Ketogenic diet and β-hydroxybutyrate inhibit HDAC1 to preserve vascular smooth muscle cell function in thoracic aortic aneurysm [0.03%]
生酮饮食和β-羟基丁酸通过抑制HDAC1来保持胸主动脉瘤血管平滑肌细胞的功能
Xinyu Weng,Lihong Pan,Xiurui Ma et al.
Xinyu Weng et al.
Background: Thoracic aortic aneurysm (TAA) is a serious condition characterized by dilation of the thoracic aorta, often leading to aortic dissection or rupture. Current treatments involve surgical and pharmacological int...
JAM-C prevents ocular fibrosis by suppressing the TAZ/KLF6 pathway [0.03%]
JAM-C通过抑制TAZ/KLF6途径预防眼部纤维化
Min Chen,Wanhong Li,Yuxiang Du et al.
Min Chen et al.
Introduction: Ocular fibrosis is one of the leading causes of irreversible visual impairment or blindness. Currently, there is no effective drug available for such diseases. Therefore, understanding the underlying mechani...
Clostridium butyricum and its metabolites regulate macrophage polarization through miR-146a to antagonize gouty arthritis [0.03%]
芽孢杆菌及其代谢产物通过调节巨噬细胞极化对抗痛风性关节炎
Siyue Song,Kaiyue Shi,Moqi Fan et al.
Siyue Song et al.
Introduction: Gut microbiota modulation has recently been identified as a prospective avenue for the exploration of novel therapeutic strategies for the management of gout. Nevertheless, the application of a single specif...
Multi-omics analysis of glycolytic reprogramming and ROS dynamics in host-specific responses to Salmonella Typhi infection in mice [0.03%]
小鼠宿主特异性响应伤寒沙门氏菌感染的糖酵解重构及活性氧动态的多组学分析
Yanrui Bai,Wenxiu Liu,Zhiyuan Liu et al.
Yanrui Bai et al.
Introduction: Salmonella Typhi (S. Typhi), a Gram-negative, serves as the etiological agent of typhoid fever. In contrast to other Salmonella serovars, S. Typhi exclusively infects humans. However, the molecular interacti...