Crafting an innovative one health-aligned machine learning framework for neglected tropical diseases elimination [0.03%]
一种创新的一体化机器学习框架在被忽视的热带病消除中的应用
Ziyu Zhao,Liying Wang,Robert Bergquist et al.
Ziyu Zhao et al.
Introduction: Strategic investment in new interventions is crucial for controlling and eliminating NTDs. However, selecting the optimal intervention combination is challenging, especially with limited resources and urgent...
Identification of Bruceine A as a novel HSP90AB1 inhibitor for suppressing hepatocellular carcinoma growth [0.03%]
布鲁欣A是一种新型HSP90AB1抑制剂可抑制肝癌细胞生长
Weijun Peng,Dazun Shi,Die Xu et al.
Weijun Peng et al.
Introduction: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with limited therapeutic options available. Natural compounds, such as Bruceine A (BRA), derived from Brucea java...
SIRT7 facilitates ferroptosis resistance of melanocytes via activating the SMAD3-ATF3-GPX4 signaling pathway in vitiligo [0.03%]
SIRT7通过激活SMAD3-ATF3-GPX4信号通路促进白癜风中黑素细胞的铁死亡抵抗作用
Lili Wu,Weinan Guo,Hao Wang et al.
Lili Wu et al.
Introduction: Vitiligo is a hypopigmentation disorder characterized by epidermal melanocyte loss. Endogenous and exogenous oxidative stress causes the regulated cell death (RCD) of melanocytes in vitiligo. Recent studies ...
Kaempferol drives genotype-specific microbiota Bacillaceae to enhance nitrogen acquisition in rapeseed [0.03%]
芸苔素介导的大豆专属肠道菌芽孢杆菌科微生物氮素吸收作用的研究
Youqiang Wang,Donglin Zhao,Zhe Li et al.
Youqiang Wang et al.
Introduction: Host genotype is a key driver in shaping plant microbiome in response to dynamic changes in soil nitrogen (N) availability. However, the effects of rapeseed (Brassica napus) genotypes with different N use ef...
Podocyte TLR4 deletion alleviates diabetic kidney disease through prohibiting PKCδ/SHP-1-dependent ER stress and relieving podocyte damage and inflammation [0.03%]
TLR4敲除抑制PKCδ/SHP-1依赖性内质网应激，缓解糖尿病肾病中足细胞损伤和炎症
Zongze Li,Di Tan,Jiangong Lin et al.
Zongze Li et al.
Introduction: Toll-like receptor 4 (TLR4) has emerged as a crucial factor in the pathogenesis of various kidney disease including diabetic kidney disease (DKD), whereas its intricate role in the complex pathophysiology of...
Flavonoid-mediated modulation of ferroptosis: therapeutic potential in gastrointestinal cancers [0.03%]
黄酮介导的铁死亡调控在胃肠道肿瘤治疗中的潜力研究
Ruqaia Shoheeduzzaman,Elizabeth Varghese,Samson Mathews Samuel et al.
Ruqaia Shoheeduzzaman et al.
Background: The incidence of early-onset gastrointestinal cancer in individuals under 50 has been rising at an alarming rate in recent years. A major challenge in standard therapeutic interventions is the ability of cance...
Dexmedetomidine improves sleep quality and alleviates emotional dysfunction by attenuating α-synuclein deposition in mice with sepsis-associated encephalopathy [0.03%]
右美托咪啶通过减轻全身炎症反应综合征相关性脑病小鼠α-突触核蛋白沉积改善睡眠质量及情感障碍
Qi Jia,Lin Yang,Jiajia Wang et al.
Qi Jia et al.
Introduction: Most septic patients have severe sleep disorders that are closely related to poor prognoses, and some patients with sepsis-associated encephalopathy (SAE) experience severe cerebral inflammatory reactions si...
Hyodeoxycholic acid relieves neuropathic pain by activating farnesoid X receptor signaling [0.03%]
熊去氧胆酸通过激活法尼醇X受体信号通路缓解神经病理性疼痛
Jiaqi Lin,Xuejiao Zeng,Zehua Su et al.
Jiaqi Lin et al.
Background: Neuropathic pain, is a chronic condition stemming from nervous system injuries. The farnesoid X receptor (FXR), primarily expressed in the liver and intestines, plays a crucial role in regulating bile acids an...
Direct pharmacological targeting of Piezo1 by Paeoniflorin: a novel therapeutic approach for renal fibrosis [0.03%]
芍药甘草素直接药理作用于Piezo1：肾纤维化的新治疗策略
Run Li,Jikai Xia,Chunru Shi et al.
Run Li et al.
Background: Renal fibrosis-characterized by microcirculatory disturbances and endothelial-mesenchymal transition (EndMT)-is a major pathological feature of chronic kidney disease (CKD) and remains a significant therapeuti...
Insomnia: the gut microbiome connection, prospects for probiotic and postbiotic therapies, and future directions [0.03%]
失眠与肠菌的关系、益生菌和后生素疗法的前景及未来发展方向
Qiong Wu,Guangqi Gao,Lai-Yu Kwok et al.
Qiong Wu et al.
Background: The gut microbiota is influenced by a complex interplay of factors including the host's genetics, diet, and lifestyle. It plays a crucial role in regulating metabolic processes and is linked to various disease...