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Copper ionophore complex ES-Cu synergizes with quercetin to target FDX1, promote cuproptosis, and reverse lenvatinib resistance in hepatocellular carcinoma cells

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Introduction: Lenvatinib resistance remains a major challenge in hepatocellular carcinoma (HCC) treatment, highlighting the need for novel therapeutic strategies. Cuproptosis, a copper-dependent form of cell death, has been incre... ...