Helicase Lymphoid-Specific Enzyme Contributes to the Maintenance of Methylation of SST1 Pericentromeric Repeats That Are Frequently Demethylated in Colon Cancer and Associate with Genomic Damage [0.03%]
解旋酶淋巴细胞特异性酶有助于SST1近端着丝粒重复序列的维持以及甲基化，这种甲基化在结直肠癌中常常丢失并导致基因组损伤
Johanna K Samuelsson,Gabrijela Dumbovic,Cristian Polo et al.
Johanna K Samuelsson et al.
DNA hypomethylation at repetitive elements accounts for the genome-wide DNA hypomethylation common in cancer, including colorectal cancer (CRC). We identified a pericentromeric repeat element called SST1 frequently hypomethylated (>5% demet...
Disruption of Broad Epigenetic Domains in PDAC Cells by HAT Inhibitors [0.03%]
组蛋白乙酰转移酶抑制剂干扰胰腺癌细胞中的广义表观基因域
Diana L Gerrard,Joseph R Boyd,Gary S Stein et al.
Diana L Gerrard et al.
The spreading of epigenetic domains has emerged as a distinguishing epigenomic phenotype for diverse cell types. In particular, clusters of H3K27ac- and H3K4me3-marked elements, referred to as super-enhancers, and broad H3K4me3 domains, res...
Epigenomics of Pancreatic Cancer: A Critical Role for Epigenome-Wide Studies [0.03%]
泛癌症的表观基因组：表观基因组图谱研究的重要作用
Rahul R Singh,Katie M Reindl,Rick J Jansen
Rahul R Singh
Several challenges present themselves when discussing current approaches to the prevention or treatment of pancreatic cancer. Up to 45% of the risk of pancreatic cancer is attributed to unknown causes, making effective prevention programs d...
Application of the High-throughput TAB-Array for the Discovery of Novel 5-Hydroxymethylcytosine Biomarkers in Pancreatic Ductal Adenocarcinoma [0.03%]
高通量TAB阵列在胰腺导管腺癌中新型5羟甲基胞嘧啶生物标志物发现中的应用研究
Chang Zeng,Zhou Zhang,Jun Wang et al.
Chang Zeng et al.
The clinical outcomes of pancreatic ductal adenocarcinoma (PDAC) remain dismal, with an estimated five-year survival rate less than 5%. Early detection and prognostic approaches, including robust biomarkers for PDAC are critical for improvi...
An Orphan CpG Island Drives Expression of a let-7 miRNA Precursor with an Important Role in Mouse Development [0.03%]
一个孤儿CpG岛驱动了一个在小鼠发育中有重要作用的let-7 miRNA前体的表达
Martha V Koerner,Kashyap Chhatbar,Shaun Webb et al.
Martha V Koerner et al.
Most human genes are associated with promoters embedded in non-methylated, G + C-rich CpG islands (CGIs). Not all CGIs are found at annotated promoters, however, raising the possibility that many serve as promoters for transcripts that do n...
Mohammad Alzrigat,Helena Jernberg-Wiklund,Jonathan D Licht
Mohammad Alzrigat
The enhancer of zeste homolog 2 (EZH2) is the enzymatic subunit of the polycomb repressive complex 2 (PRC2) that exerts important functions during normal development as well as disease. PRC2 through EZH2 tri-methylates histone H3 lysine tai...