Age-Related Epigenetic Drift Shapes Coordinated microRNA Promoter Methylation and Expression in Prostate Cancer [0.03%]
年龄相关的表观遗传漂变影响前列腺癌中多个microRNA启动子的甲基化和表达水平
Fernando Bergez-Hernández,Martín Irigoyen-Arredondo,Lizeth Carolina Flores-Méndez et al.
Fernando Bergez-Hernández et al.
Background: Aging is the strongest risk factor for prostate cancer (PCa). It is accompanied by progressive epigenomic divergence, known as epigenetic drift, particularly affecting DNA methylation at regulatory regions. However, the extent t...
Novel Perspectives on ATP8A2 Regulation: Evidence for Parental Imprinting and Chimeric Transcript Formation [0.03%]
ATP8A2调控的新视角：双亲印记及嵌合转录本形成的证据
Abdelhamid Bouramtane,Badreddine Elmakhzen,Amal Ouskri et al.
Abdelhamid Bouramtane et al.
Background: Parental imprinting plays a crucial role in epigenetic regulation and is increasingly recognized for its involvement in neurodevelopmental disorders. Although ATP8A2 is considered a non-imprinted gene; However, the marked phenot...
Mitochondrial D-Loop Region Methylation Is Not Altered in Children with Autism Spectrum Disorder [0.03%]
自闭症患儿线粒体D环区甲基化水平未发生变化
Andrea Stoccoro,Carmela Serpe,Antonia Parmeggiani et al.
Andrea Stoccoro et al.
Background/Objectives: Although the etiopathogenesis of autism spectrum disorder (ASD) remains incompletely elucidated, current evidence supports a multifactorial model involving genetic and environmental factors that interact to induce a h...
The Many Faces of SetDB1 [0.03%]
SetDB1的多重面孔
Stanislav E Romanov,Dmitry E Koryakov
Stanislav E Romanov
The conserved protein SetDB1 has been identified in various vertebrate and invertebrate groups. It plays key roles in vital processes such as germline and nervous system development, immune response, tumorigenesis, cell cycle progression, a...
Natural Compounds as Epimodulators in Epithelial Ovarian Cancer [0.03%]
表观遗传调控在卵巢癌中的作用及组蛋白修饰调控剂抗肿瘤活性研究进展
Mélida Del Rosario Lizarazo-Taborda,Julio César Villegas-Pineda,Holver Parada et al.
Mélida Del Rosario Lizarazo-Taborda et al.
Epithelial ovarian carcinoma (EOC) is the most common type of ovarian cancer and represents the most lethal gynecologic neoplasm. EOC is usually diagnosed at late stages due to its nonspecific signs and symptoms. Although significant clinic...
Epigenetic Age Feedback as a Catalyst for Sustained Lifestyle Change: One-Year Results from the EU iHelp Study [0.03%]
表观遗传年龄反馈作为持续生活方式改变的催化剂：欧盟iHelp研究的一年结果
Nien-Yu Yang,Yicong Huang,Chaewon Park et al.
Nien-Yu Yang et al.
Background: Sustaining long-term lifestyle change remains a major challenge in preventive health. Epigenetic clocks offer a dynamic, modifiable measure of biological ageing that may enhance motivation when returned to ind...
Hirofumi Sakuma,Satoshi Kawaguchi,Yuya Kobayashi et al.
Hirofumi Sakuma et al.
MicroRNAs (miRNAs) are small non-coding RNAs that play central roles in post-transcriptional gene regulation and cellular homeostasis maintenance. Dysregulation of miRNA expression is increasingly recognized as a key contributor to tissue i...
Epigenetics of Genes Displaying High and Preferential Expression in Myoblasts [0.03%]
肌母细胞高表达和优先表达基因的表观遗传学
Kenneth C Ehrlich,Michelle Lacey,Sriharsa Pradhan et al.
Kenneth C Ehrlich et al.
Background/objectives: Genome-wide studies of differential DNA methylation often focus on its role in turning transcription on or off. Here we report some atypical epigenetic/transcription relationships for 92 genes that ...
Mutant KRAS Heterogeneity Shapes Nuclear Architecture During Pancreatic Cancer Initiation [0.03%]
突变型KRAS异质性在胰腺癌发生过程中的作用及其对细胞核结构的影响
Gareth Pollin,Angela J Mathison,Elise N Leverence et al.
Gareth Pollin et al.
Background/objectives: Pancreatic ductal adenocarcinoma (PDAC) arises predominantly from activating KRAS mutations, yet individual genetic variants differ markedly in signaling output and clinical impact. G12D, the most p...
Changes in Blood DNA CpG Methylation Levels in Response to Methadone Maintenance Treatment: Epigenome-Wide Longitudinal Study [0.03%]
美沙酮维持治疗对血液DNA胞嘧啶-磷基戊糖甲基化水平的影响：表观基因组范围的纵向研究
Orna Levran,Yuli Kim,Justin Li et al.
Orna Levran et al.
Background/objectives: Methadone maintenance treatment (MMT) is one of the major pharmacotherapies for opioid use disorder. The underlying mechanisms of addiction and the treatment response are only partially understood. ...