Preventative Cancer Vaccine-Elicited Human Anti-MUC1 Antibodies Have Multiple Effector Functions [0.03%]
预防性癌症疫苗诱发的人类抗MUC1抗体具有多种效应功能
Michelle L McKeague,Jason Lohmueller,Matthew T Dracz et al.
Michelle L McKeague et al.
Background/objectives: Mucin-1 (MUC1) is a transmembrane glycoprotein that is overexpressed and hypoglycosylated in premalignant and malignant epithelial cells compared to normal cells, creating a target antigen for humor...
Laura Inés Klepp,Federico Carlos Blanco,María Mercedes Bigi et al.
Laura Inés Klepp et al.
The development of vaccines and effective diagnostic methods for bovine tuberculosis requires an understanding of the immune response against its causative agent, Mycobacterium bovis. Although this disease is primarily investigated and diag...
Metabolic Engineering of Glycofusion Bispecific Antibodies for α-Dystroglycanopathies [0.03%]
用于α- dystroglycanopathy的代谢工程糖基融合双特异性抗体的研究
Xiaotian Zhong,Guoying Grace Yan,Apurva Chaturvedi et al.
Xiaotian Zhong et al.
Background: α-dystroglycanopathies are congenital muscular dystrophies in which genetic mutations cause the decrease or absence of a unique and complex O-linked glycan called matriglycan. This hypoglycosylation of O-linked matriglycan on t...
Development of a Mammalian Cell Line for Stable Production of Anti-PD-1 [0.03%]
一种稳定生产抗PD-1的哺乳动物细胞系的研发
Erika Csató-Kovács,Pál Salamon,Szilvia Fikó-Lászlo et al.
Erika Csató-Kovács et al.
Background/Objectives: Immune checkpoint blockade, particularly targeting the programmed cell death 1 (PD-1) receptor, is a promising strategy in cancer immunotherapy. The interaction between PD-1 and its ligands, PD-L1 and PD-L2, is crucia...
Measurement of the Memory B Cell Response via Antibodies from Activated Cells [0.03%]
通过活化细胞的抗体测量记忆B细胞反应
Caroline Rockstroh,Katja Hintz,Judith Kannenberg et al.
Caroline Rockstroh et al.
Background/objectives: The body's immune response to infections and vaccination leads to the formation of memory B cells (MBCs), which protect against future infections. MBCs circulate in the blood, and the strength of th...
Insights from Clinical Trials: Evidence-Based Recommendations for Induction Treatment of Newly Diagnosed Transplant-Eligible Multiple Myeloma [0.03%]
移植合格的新诊断多发性骨髓瘤诱导治疗的基于证据的推荐意见：临床试验带来的启示
Olga Lytvynova,Jenna Jwayyed,Daniel Pastel et al.
Olga Lytvynova et al.
Multiple myeloma (MM) is a hematological malignancy and poses significant therapeutic challenges. This review synthesizes evidence from pivotal clinical trials to guide induction treatment for transplant-eligible (TE), newly diagnosed MM (N...
Unveiling GFAP Astrocytopathy: Insights from Case Studies and a Comprehensive Review of the Literature [0.03%]
GFAP星形胶质细胞病的案例研究及文献综述：新的认识和见解
Panagiotis Gklinos,Fotios Athanasopoulos,Vagia Giatrakou et al.
Panagiotis Gklinos et al.
Background: Autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy, which was first identified in 2016, is an immune-mediated inflammatory disorder of the nervous system characterized by antibodies targeting GFA...
SARS-CoV-2 Infection Enhances Humoral Immune Response in Vaccinated Liver Transplant Recipients [0.03%]
肝移植受者中新冠病毒感染增强疫苗诱导的体液免疫反应
Jan Basri Adiprasito,Tobias Nowacki,Richard Vollenberg et al.
Jan Basri Adiprasito et al.
In the spring of 2020, the SARS-CoV-2 pandemic presented a formidable challenge to national and global healthcare systems. Immunocompromised individuals or those with relevant pre-existing conditions were particularly at risk of severe coro...
Residue-Specific Epitope Mapping of the PD-1/Nivolumab Interaction Using X-ray Footprinting Mass Spectrometry [0.03%]
基于X射线足迹质谱的PD-1/纳武单抗相互作用的表位图谱绘制及结合残基特定位点分析
Line G Kristensen,Sayan Gupta,Yan Chen et al.
Line G Kristensen et al.
X-ray footprinting coupled with mass spectrometry (XFMS) presents a novel approach in structural biology, offering insights into protein conformation and dynamics in the solution state. The interaction of the cancer-immunotherapy monoclonal...
Therapeutic Advances in Psoriasis: From Biologics to Emerging Oral Small Molecules [0.03%]
银屑病的治疗进展：从生物制剂到新兴口服小分子药物
Francesco Ferrara,Chiara Verduci,Emanuela Laconi et al.
Francesco Ferrara et al.
Psoriasis is a persistent, inflammatory condition affecting millions globally, marked by excessive keratinocyte proliferation, immune cell infiltration, and widespread inflammation. Over the years, therapeutic approaches have developed sign...