Sera of Healthy First-Degree Relatives of SLE Patients Contain Autoantibodies to Globular Domains of C1q [0.03%]
狼疮患者一级健康亲属血清中存在抗C1q球区结构域自身抗体
Ginka Cholakova,Alexandra Atanasova,Alexandra Kapogianni et al.
Ginka Cholakova et al.
Background/objectives: The autoimmune disorder Systemic Lupus Erythematosus (SLE) is characterized by increased titers of autoantibodies with different specificities against autoantigens, including the complement proteins...
Natural Versus Vaccine-Induced Immunity Against HPV: A Comparative Review of Antibody Response and Cancer Prevention [0.03%]
自然获得性免疫与疫苗诱导免疫对抗HPV的比较研究——针对抗体应答及癌症预防的一篇综述文章
Bogdan Ghilencea,Bianca Ilinca Moroianu,Ancuța-Iuliana Năstac et al.
Bogdan Ghilencea et al.
Human Papillomavirus (HPV) infection is the leading cause of cervical cancer, presenting a significant global health challenge. While natural infection is widespread, the resulting immune response is often characterized by weak, delayed, an...
The Diagnostic and Clinical Significance of Anti-Mutated Citrullinated Vimentin Antibodies in Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Scoping Review [0.03%]
抗瓜氨酸波形蛋白抗体在类风湿关节炎相关间质性肺病中的诊断和临床意义：系统综述式回顾研究
Christian D&#x;Elia,Giada Santagata,Serena Guiducci et al.
Christian D&#x;Elia et al.
Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is one of the most severe extra-articular manifestations of rheumatoid arthritis (RA), requiring reliable biomarkers for early detection. This scoping review synthesized cur...
A Novel Anti-Cadherin-17 Monoclonal Antibody, Ca17Mab-5, for Multiple Applications [0.03%]
一种新型的抗cadherin-17单克隆抗体Ca17Mab-5及其多种应用
Reina Ito,Hiroyuki Suzuki,Kenichiro Ishikawa et al.
Reina Ito et al.
Background/objectives: Cadherin-17 (CDH17, LI-cadherin) is a non-classical cadherin with an atypical structure and unique functions. CDH17 expression is restricted to normal intestinal epithelium. Furthermore, CDH17 funct...
Beyond the Surface: Antinuclear Antibodies in Rheumatoid Arthritis-Experiences from a Single-Center, Cross-Sectional Observational Study [0.03%]
抗核抗体在类风湿关节炎的表面之下——单中心横断面观察研究的经验教训
Hanna Cholerzyńska,Gabriela Kot,Łukasz Świątek et al.
Hanna Cholerzyńska et al.
Background: Antinuclear antibodies (ANA) can be detected in patients with rheumatoid arthritis (RA) and pose many diagnostic challenges, especially when RA presents an atypical course and requires differentiation from other systemic connect...
Potential Mechanisms of Partial/Transient Response or Resistance to Daratumumab Therapy: A Focus on Anti-Daratumumab Antibodies and Urinary Daratumumab Loss [0.03%]
达托珠单抗治疗部分/暂时性应答或耐药的潜在机制：重点关注抗药物抗体和尿液中排泄的达托珠单抗
Marco Allinovi,Luca Malatesta,Tiziana Biagioli et al.
Marco Allinovi et al.
Daratumumab, a human IgG1 monoclonal antibody targeting CD38, is widely used in multiple myeloma and AL amyloidosis. Despite its clinical success, many patients fail to achieve durable responses or relapse, underscoring the importance of un...
Phage-Selected Clickable Gln-Donor Peptide for Lys-Selective Fab Labeling Using Engineered Microbial Transglutaminase [0.03%]
工程化微生物谷氨酰胺转肽酶选择性标记赖氨酸的点击Gln供体肽的噬菌体展示技术筛选
Eva Agustriana,Koki Murozono,Kosuke Minamihata et al.
Eva Agustriana et al.
Background/Objectives: The use of cross-linking enzymes for site-selective and efficient antibody modification has attracted considerable attention. Microbial transglutaminase (MTG)-mediated labeling of IgG at Gln295 has emerged as a promis...
Aglycosylated Immunoglobulin G1 Fc Stabilized Through Disulfide Bond Addition Exhibits Compositional Homogeneity and Retains Fc γ Receptor IIIa/CD16a Binding [0.03%]
通过二硫键交联稳定的无糖基化免疫球蛋白G1 Fc具有组成均一性并保持与Fcγ受体IIIa/CD16a结合的能力
Anjali Shenoy,Daniel J Falconer,Adam W Barb
Anjali Shenoy
Background: The interaction between human immunoglobulin G (IgG)1 Fc and the Fc gamma receptor (FcγR) IIIa/CD16a elicits protective immune responses. Antibody N-glycosylation stabilizes the FcγR-binding interface and is...
Detection and Identification of Anti-Neutrophil Antibodies in Immune Neutropenia: Integrating Serology, Genotyping and Clinical Interpretation [0.03%]
免疫中性粒细胞减少症中抗中性粒细胞抗体的检测与鉴定：血清学、基因型和临床解释的综合分析
Elyse Moritz,Renato Cerqueira,Juliana Oliveira Martins et al.
Elyse Moritz et al.
Immune-mediated neutropenias comprise a heterogeneous group of disorders characterized by antibody-mediated destruction of neutrophils, in which the detection of anti-neutrophil antibodies remains a significant diagnostic challenge. Human n...
pIgR Stem Zone-Targeted Nanobodies as Apical-to-Basolateral Carriers for Inhaled Biologic Delivery Across Mucosal Barriers [0.03%]
鼻吸入给药的跨黏膜屏障递送生物制剂的靶向nanobody载体研究
Aidong Qiu,Ruiyuan Wang,Yangyingjie Bai et al.
Aidong Qiu et al.
Background: The mucosal barrier presents a significant challenge for non-invasive delivery of macromolecular therapeutics, often requiring administration with poor bioavailability and increased toxicity risks. The polymer...