Microsecond Dynamics of Fc-CD16a Recognition: Impact of Mutations, Core Fucosylation, and Fc Asymmetry [0.03%]
微秒级Fc-CD16a识别动力学：变异、核心岩藻糖基化和Fc不对称性的影响
Sébastien Estaran,Bernard Hehlen,Alain Chavanieu
Sébastien Estaran
Background/objectives: Antibody-dependent cellular cytotoxicity relies on the interaction between the Fc region of immunoglobulin G1 (IgG1) and the CD16a receptor. While removal of core fucosylation on Fc and introduction...
Juan Carlos Silva-Espinoza,Mauricio I Rodriguez Rodriguez,Claire Eunise Perucho et al.
Juan Carlos Silva-Espinoza et al.
Background/Objectives: Schlafen (SLFN) 8 and SLFN9 are mouse members of the Schlafen protein family, believed to have arisen through a gene duplication event. The physiological roles of these proteins remain poorly defined, in part due to t...
Analytical Performance of Nanobody-Based Immunoassay and Immunosensing Platforms for Bacteria and Toxin Detection: A Systematic Review [0.03%]
基于纳米抗体的免疫分析和免疫传感平台用于细菌和毒素检测的分析性能系统评价
Aya Jalil,Nadia Touil,Omar Nyabi et al.
Aya Jalil et al.
Background: bacterial pathogens and their toxins present analytical challenges for rapid and specific detection, contributing to over 600 million cases of illness annually and worsening antimicrobial resistance (AMR). Conventional detection...
Transplacental Antibody Transfer: Mechanisms, Pregnancy-Related Disruptions, and Emerging Experimental Models [0.03%]
胎盘抗体转运：机制、妊娠相关障碍及新兴实验模型
Qiqi Li,Zhengyuan Huang,Zainab Saeed et al.
Qiqi Li et al.
The transplacental transfer of maternal immunoglobulin G from the mother to the foetus is central for providing immunity in early life, resulting in full-term newborns having IgG repertoires and levels similar to those of their mothers. The...
Antibody Avidity Profiles as Diagnostic Biomarkers in Differentiating Acute and Chronic Anisakis simplex-Related Allergic Diseases [0.03%]
用于区分由拟东方线虫引起急性期和慢性期相关过敏疾病的抗体亲和力谱型诊断生物标志物研究
Juan González-Fernández,Laura Ullate,Marta Rodero et al.
Juan González-Fernández et al.
Background/objectives: Allergic features of anisakiasis, caused by ingestion of third-stage larvae of Anisakis simplex via raw or undercooked fish, manifest clinically as acute gastroallergic anisakiasis (GAA) or chronic ...
Comparative In Vitro Evaluation of Anti-HIV Immunotoxin, Antibody-Drug Conjugate, and Radioimmunoconjugate Targeted by the Same Antibody [0.03%]
基于相同抗体的抗HIV免疫毒素、抗体偶联药物和放射性免疫缀合物在体外的对比研究
Anne-Sophie Kuhlmann,Tami Peters,Donald K Hamlin et al.
Anne-Sophie Kuhlmann et al.
Background: We are developing cytotoxic immunoconjugates (CICs) to eliminate HIV-infected cells. We investigated the efficacy and kinetics of killing by different forms of CICs targeted by the same monoclonal antibody (mA...
Jilei Wu,Chenghua Liu,Fenghao Peng et al.
Jilei Wu et al.
Background: Shiga toxin (Stx), produced by enterohemorrhagic Escherichia coli (EHEC), is a highly potent exotoxin responsible for severe complications such as hemolytic uremic syndrome (HUS). Among its isoforms, Stx2 exhibits stronger cytot...
Antibodies as Tools for Characterization, Isolation and Production Enhancement of Anti-Cancer Drugs and Steroidal Hormones from Ginsenoside and Solasodine Glycoside: A Review [0.03%]
抗体在抗肿瘤药物和甾体激素研究中的应用：综述甘草皂苷和粗毛子莲皂苷中抗肿瘤药物及皮质甾体激素的表征、分离及增效作用
Yukihiro Shoyama
Yukihiro Shoyama
There are a vast number of monoclonal antibodies (MAbs) against biological components; however, the number for natural products is less than 50. MAbs against ginsenosides, i.e., dammarane triterpene glycosides contained in ginseng, were pre...
Robustness Evaluation of a Legacy N-Glycan Profiling Method for a Therapeutic Antibody Under ICH Q14 Lifecycle Principles [0.03%]
ICH Q14生命周期原则下的抗体类药物治疗性N-糖链图谱的稳健性评估
Ming-Ching Hsieh,Chao Richard Li,Margaret A Velardo et al.
Ming-Ching Hsieh et al.
Background: This study assesses the robustness of a legacy N-glycan profiling method for the therapeutic antibody MAB1 with different Peptide-N-glycosidase F (PNGase F) enzyme sources, solid phase extraction (SPE) cartrid...
Paraneoplastic Neurological Syndromes: Advances and Future Perspectives in Immunopathogenesis and Management [0.03%]
肿瘤相关神经系统综合征：免疫病理机制及治疗策略的研究进展与未来趋势
Stoimen Dimitrov,Mihael Tsalta-Mladenov,Plamena Kabakchieva et al.
Stoimen Dimitrov et al.
Paraneoplastic neurological syndromes (PNSs) are immune-mediated disorders caused by an antitumor response that cross-reacts with the nervous system, leading to severe and often irreversible neurological disability. Once considered exceedin...