Robustness Evaluation of a Legacy N-Glycan Profiling Method for a Therapeutic Antibody Under ICH Q14 Lifecycle Principles [0.03%]
ICH Q14生命周期原则下的抗体类药物治疗性N-糖链图谱的稳健性评估
Ming-Ching Hsieh,Chao Richard Li,Margaret A Velardo et al.
Ming-Ching Hsieh et al.
Background: This study assesses the robustness of a legacy N-glycan profiling method for the therapeutic antibody MAB1 with different Peptide-N-glycosidase F (PNGase F) enzyme sources, solid phase extraction (SPE) cartrid...
Paraneoplastic Neurological Syndromes: Advances and Future Perspectives in Immunopathogenesis and Management [0.03%]
肿瘤相关神经系统综合征：免疫病理机制及治疗策略的研究进展与未来趋势
Stoimen Dimitrov,Mihael Tsalta-Mladenov,Plamena Kabakchieva et al.
Stoimen Dimitrov et al.
Paraneoplastic neurological syndromes (PNSs) are immune-mediated disorders caused by an antitumor response that cross-reacts with the nervous system, leading to severe and often irreversible neurological disability. Once considered exceedin...
Autoantibodies as Precision Tools in Connective Tissue Diseases: From Epiphenomenon to Endophenotype [0.03%]
自身抗体在结缔组织病中的精准应用：从伴随现象到内在标志物
Muhammad Soyfoo,Julie Sarrand
Muhammad Soyfoo
Autoantibodies have long been regarded as passive reflections of immune dysregulation in connective tissue diseases (CTDs). Recent advances in systems immunology and molecular pathology have fundamentally redefined them as active molecular ...
Oral Immunotherapy-Induced Changes in IgE, IgG, and IgA: A Review of Antibody Isotype Shifts and Their Clinical Relevance in Food Allergy [0.03%]
口服免疫治疗引起的IgE、IgG和IgA的变化：对食物过敏中抗体类别转换及其临床意义的回顾
Giovanni Lasagni,Laura Vetrugno,Chiara Maria Maggiore et al.
Giovanni Lasagni et al.
Background: Food allergy is a growing public health concern, and oral immunotherapy (OIT) has emerged as a promising approach to induce desensitization and potentially sustained unresponsiveness to allergenic foods. Chang...
Bispecific Antibodies: Strategies Available to Optimize Their Safe Delivery in Patients with Multiple Myeloma [0.03%]
双特异抗体：优化多发性骨髓瘤患者安全用药的策略
Hannah Victoria Giles,Bhuvan Kishore
Hannah Victoria Giles
Bispecific antibodies (BsAbs) have emerged as an important new class drugs for the treatment of multiple myeloma (MM) over the last few years. Currently, BsAbs are only licensed for use as monotherapy in patients with relapsed/refractory MM...
Updates on Antibody Drug Conjugates and Bispecific T-Cell Engagers in SCLC [0.03%]
小细胞肺癌中的抗体偶联药物及双特异性T细胞 engager 的研究进展
Kinsley Wang,Kyle Taing,Robert Hsu
Kinsley Wang
Background/Objectives: Small-cell lung cancer (SCLC) is an aggressive neuroendocrine malignancy characterized by rapid proliferation, early metastasis, and near-universal relapse after initial therapy. While chemo-immunotherapy modestly imp...
Antibody-Based Therapeutics in Breast Cancer: Clinical and Translational Perspectives [0.03%]
乳腺癌的抗体药物：临床和转化视角
Anna Balata,Katarzyna Pogoda
Anna Balata
Breast cancer remains the most common malignancy and one of the leading causes of cancer-related death among women worldwide. Advances in antibody-based therapies have improved outcomes across all biological subtypes: HER2-positive, triple-...
Antibodies Against SARS-CoV-2 Nucleocapsid Protein Possess Autoimmune Properties [0.03%]
抗SARS-CoV-2核衣壳蛋白的抗体具有自身免疫特性
Alexandra Rak,Yana Zabrodskaya,Pei-Fong Wong et al.
Alexandra Rak et al.
Background/objectives: Notwithstanding the declaration by the World Health Organization in May 2023 regarding the conclusion of the COVID-19 pandemic, new cases of this potentially lethal infection continue to be document...
Nanobody Therapeutics in Alzheimer's Disease: From Molecular Mechanisms to Translational Approaches [0.03%]
阿尔茨海默病的纳米抗体治疗：从分子机制到转化方法
Deepika Godugu,Kranthi Gattu,Parul Suri et al.
Deepika Godugu et al.
Nanobodies (single-domain antibodies, VHHs) have emerged as versatile tools for evaluating and treating Alzheimer's disease (AD). They offer distinct engineering benefits compared with traditional antibodies and small molecules, including s...
Enhancement of Structural Stability and IgG Affinity of a Z34C-Derived α-Helical Peptide via Lactam Stapling [0.03%]
通过内酯环亚胺连接增强Z34C衍生α-螺旋肽的结构稳定性和IgG亲和力
Jung Gu Lee,Inseo Lee,Joo-Young Kim et al.
Jung Gu Lee et al.
Background: The Fc region of immunoglobulin G (IgG) is a key target in therapeutic and analytical applications, such as antibody purification and site-specific bioconjugation. Although Protein A exhibits strong Fc-binding...