Samuel L Nickels,Ai-Lan Lee,Filipe Vilela
Samuel L Nickels
In recent years, electron donor-acceptor (EDA) complexes have emerged as sustainable, cost-effective, and inherently safer alternatives to traditional transition metal-based photocatalysts in photochemical processes. Formed via the associat...
Multistep non-fouling continuous flow synthesis and PEG-functionalisation of biocompatible iron oxide nanoparticles for magnetic hyperthermia, photothermal heating and antifungal activity [0.03%]
一步除污的连续流动合成及生物相容性铁氧纳米颗粒的PEG功能化用于磁热疗，光热加热和抗真菌活性研究
Sayan Pal,Georgios Gkogkos,Jacopo Piovesan et al.
Sayan Pal et al.
An innovative method for synthesising and functionalising iron oxide nanoparticles (IONPs) with polyethylene glycol (PEG) using a continuous three-phase segmented flow reactor is presented. Integration of synthesis and functionalisation wit...
Straightforward, scalable, solution-phase synthesis of peptide bonds in flow [0.03%]
一种直接的、可放大的溶液相流反应肽键合成方法
Zoe E Wilson,Enol Lopez,Nils J Flodén et al.
Zoe E Wilson et al.
We report the development of simple solution-phase flow conditions for the scalable synthesis of peptides using in-situ activation as mixed anhydrides, contributing to the synthetic toolbox of available solution-phase flow reactions. This a...
Adam T McCormack,John C Stephens
Adam T McCormack
Azo compounds find use in many areas of science, displaying crucial properties for important applications as photoconductive organic pigments, fluorescent quenchers, paints, cosmetics, inks, and in the large and valuable dye industry. Due t...
Rapid plugged flow synthesis of nucleoside analogues via Suzuki-Miyaura coupling and heck Alkenylation of 5-Iodo-2'-deoxyuridine (or cytidine) [0.03%]
通过Suzuki-Miyaura偶联和Heck烯基化方法快速合成5-碘-2'-脱氧尿苷（或胞苷）类似物的研究
Sujeet Gaware,Santosh Kori,Jose Luis Serrano et al.
Sujeet Gaware et al.
Nucleosides modification via conventional cross-coupling has been performed using different catalytic systems and found to take place via long reaction times. However, since the pandemic, nucleoside-based antivirals and vaccines have receiv...
A perspective on automated advanced continuous flow manufacturing units for the upgrading of biobased chemicals toward pharmaceuticals [0.03%]
用于升级生物基化学品面向制药的自动化连续流制造单元的展望
Geoffroy Kaisin,Loïc Bovy,Yoann Joyard et al.
Geoffroy Kaisin et al.
Biomass is a renewable, almost infinite reservoir of a large diversity of highly functionalized chemicals. The conversion of biomass toward biobased platform molecules through biorefineries generally still lacks economic viability. Profitab...
Scaled up and telescoped synthesis of propofol under continuous-flow conditions [0.03%]
连续流动条件下大产量及公斤级苯丙胺的合成
Guilherme M Martins,Maria F A Magalhães,Timothy J Brocksom et al.
Guilherme M Martins et al.
Herein we report a machine-assisted and scaled-up synthesis of propofol, a short-acting drug used in procedural sedation, which is extensively in demand during this COVID-19 pandemic. The continuous-flow protocol proved to be efficient, wit...
Manjinder Singh Phull,Surender Singh Jadav,Chander Singh Bohara et al.
Manjinder Singh Phull et al.
Budesonide, a glucocorticosteroid, is used as anti-asthmatic drug that became generic in 2019. Existing preparation methods of budesonide require utilization of corrosive acids and involve expensive purification process. Thus, a new cost-ef...
3D printed ceramics as solid supports for enzyme immobilization: an automated DoE approach for applications in continuous flow [0.03%]
用于酶固定化的3D打印陶瓷作为固体支撑体：连续流应用中的自动化DoE方法
Alessia Valotta,Manuel C Maier,Sebastian Soritz et al.
Alessia Valotta et al.
In recent years, 3D printing has emerged in the field of chemical engineering as a powerful manufacturing technique to rapidly design and produce tailor-made reaction equipment. In fact, reactors with complex internal geometries can be easi...
Continuous flow synthesis of Celecoxib from 2-bromo-3,3,3-trifluoropropene [0.03%]
从2-溴-3,3,3-三氟丙烯连续流合成立 celecoxib
Maria Ivanova,Julien Legros,Thomas Poisson et al.
Maria Ivanova et al.
We describe the total flow synthesis of the widely prescribed anti-inflammatory COX-2 inhibitor Celecoxib from 2-bromo-3,3,3-trifluoropropene, as a convenient and available trifluoromethyl building block, to generate trifluoropropynyl lithi...