Continuous flow synthesis of Celecoxib from 2-bromo-3,3,3-trifluoropropene
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We describe the total flow synthesis of the widely prescribed anti-inflammatory COX-2 inhibitor Celecoxib from 2-bromo-3,3,3-trifluoropropene, as a convenient and available trifluoromethyl building block, to generate trifluoropropynyl lithium and to trap it im... ...
