Predicting assembly mode of membraneless organelles by a FRET-based crowding sensor [0.03%]
基于FRET的分子拥挤传感器预测无膜细胞器组装模式
Feng Chen,Siyuan Shen,Xu Cao et al.
Feng Chen et al.
Dicoumarol is an effective post-exposure prophylactic for SARS-CoV-2 Omicron infection in human airway epithelium [0.03%]
dicoumarol可有效预防omicron感染人呼吸道上皮细胞
Yang Peng,Shi-Ying Chen,Zhao-Ni Wang et al.
Yang Peng et al.
Repurposing existing drugs to inhibit SARS-CoV-2 infection in airway epithelial cells (AECs) is a quick way to find novel treatments for COVID-19. Computational screening has found dicoumarol (DCM), a natural anticoagulant, to be a potentia...
A Kaposi's sarcoma-associated herpes virus-encoded microRNA contributes to dilated cardiomyopathy [0.03%]
卡波西肉瘤相关疱疹病毒的一种内源性微型RNARNA对扩张型心肌病有贡献作用
Yanru Zhao,Huaping Li,Hengzhi Du et al.
Yanru Zhao et al.
Dilated cardiomyopathy (DCM) is the leading cause of heart transplantation. By microRNA (miRNA) array, a Kaposi's sarcoma-associated herpes virus (KSHV)-encoded miRNA, kshv-miR-K12-1-5p, was detected in patients with DCM. The KSHV DNA load ...
Xia Li,Chentao Li,Wanying Zhang et al.
Xia Li et al.
Aging is characterized by systemic chronic inflammation, which is accompanied by cellular senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the multidimensional complexity of aging, there is an urgent need for...
Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection [0.03%]
新冠病毒感染引起的代谢改变及潜在的抗冠状病毒治疗靶点
Peiran Chen,Mandi Wu,Yaqing He et al.
Peiran Chen et al.
The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2 infection has become a global pandemic due to the high viral transmissibility and pathogenesis, bringing enormous burden to our society. Most patients infected by SARS...
Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits [0.03%]
成年产生的神经元通过局部异常兴奋性环路在关键时期维持海马区癫痫发作
Liying Chen,Yingwei Xu,Heming Cheng et al.
Liying Chen et al.
Temporal lobe epilepsy (TLE), one common type of medically refractory epilepsy, is accompanied with altered adult-born dentate granule cells (abDGCs). However, the causal role of abDGCs in recurrent seizures of TLE is not fully understood. ...
A new treatment for sarcoma extracted from combination of miRNA deregulation and gene association rules [0.03%]
基于组合的微核糖核酸异常表达及其基因关联规则的新恶性肉瘤治疗方法
José Manuel García-Heredia,Marco Pérez,Eva M Verdugo-Sivianes et al.
José Manuel García-Heredia et al.
CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors [0.03%]
由γ-分泌酶切割生成的CNTNAP2胞内结构域(CICD)可改善自闭症相关行为
Jing Zhang,Fang Cai,Renbin Lu et al.
Jing Zhang et al.
As the most prevalent neurodevelopmental disorders in children, autism spectrum disorders (ASD) are characterized by deficits in language development, social interaction, and repetitive behaviors or inflexible interests. Contactin associate...
Murine studies and expressional analyses of human cardiac pericytes reveal novel trajectories of SARS-CoV-2 Spike protein-induced microvascular damage [0.03%]
小鼠研究和人类心脏周细胞表达分析揭示了SARS-CoV-2刺突蛋白诱导的微血管损伤的新轨迹
Elisa Avolio,Prashant K Srivastava,Jiahui Ji et al.
Elisa Avolio et al.