Notch signaling pathway in cancer: from mechanistic insights to targeted therapies [0.03%]
诺瑟信号通路与癌症：从机制研究到靶向治疗
Qingmiao Shi,Chen Xue,Yifan Zeng et al.
Qingmiao Shi et al.
Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue homeostasis across metazoans, is highly conserved throughout evolution. The Notch receptor and its ligands are transmembrane proteins containing e...
DEAD-box helicase 17 (DDX17) protects cardiac function by promoting mitochondrial homeostasis in heart failure [0.03%]
DEAD盒解旋酶17（DDX17）通过促进心力衰竭中的线粒体稳态来保护心脏功能
Mingjing Yan,Junpeng Gao,Ming Lan et al.
Mingjing Yan et al.
DEAD-box helicase 17 (DDX17) is a typical member of the DEAD-box family with transcriptional cofactor activity. Although DDX17 is abundantly expressed in the myocardium, its role in heart is not fully understood. We generated cardiomyocyte-...
Peripheral immune cell-derived matrix metalloprotease 8 (MMP8): brain trafficking promotes depression-like behavior [0.03%]
外周免疫细胞源性基质金属蛋白酶8(MMP8)：脑内递送促进类似抑郁的行为反应
Dietmar Spengler,Theo Rein
Dietmar Spengler
Development of pharmacological immunoregulatory anti-cancer therapeutics: current mechanistic studies and clinical opportunities [0.03%]
药理免疫调节抗癌药物的研发：当前的机制研究及临床应用机遇
Nanhao Yin,Xintong Li,Xuanwei Zhang et al.
Nanhao Yin et al.
Immunotherapy represented by anti-PD-(L)1 and anti-CTLA-4 inhibitors has revolutionized cancer treatment, but challenges related to resistance and toxicity still remain. Due to the advancement of immuno-oncology, an increasing number of nov...
Yue Zhou,Lei Tao,Jiahao Qiu et al.
Yue Zhou et al.
Tumor biomarkers, the substances which are produced by tumors or the body's responses to tumors during tumorigenesis and progression, have been demonstrated to possess critical and encouraging value in screening and early diagnosis, prognos...
Xiang Wei,Fangfang Zhou,Long Zhang
Xiang Wei
DNA double-strand break (DSB) sites that prevent the disjunction of broken DNA ends are formed through poly (ADP-ribose) (PAR) polymerase 1 (PARP1)-DNA co-condensation. The co-condensates apply mechanical forces to hold the DNA ends togethe...
Sintilimab (anti-PD-1 antibody) plus chidamide (histone deacetylase inhibitor) in relapsed or refractory extranodal natural killer T-cell lymphoma (SCENT): a phase Ib/II study [0.03%]
斯鲁利单抗（PD-1抗体）联合希维普替尼（组蛋白脱乙酰酶抑制剂）治疗复发或难治性结外NK/T细胞淋巴瘤患者：Ib/II期临床研究(SCENT)
Yan Gao,Haixia He,Xueping Li et al.
Yan Gao et al.
Anti-PD-1 antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma (RR-ENKTL), however, the complete response (CR) rate and the duration of response (DOR) need to be improved. This phase 1b/2...
Yao Zong,Hao Li,Peng Liao et al.
Yao Zong et al.
Mitochondria, with their intricate networks of functions and information processing, are pivotal in both health regulation and disease progression. Particularly, mitochondrial dysfunctions are identified in many common pathologies, includin...