Jie Fu,Xin Zong,Mingliang Jin et al.
Jie Fu et al.
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions in innate immunity, as well as their structure and ...
High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA [0.03%]
高密度脂蛋白通过长链非编码RNA HDRACA调节血管生成
Zhi-Wei Mo,Yue-Ming Peng,Yi-Xin Zhang et al.
Zhi-Wei Mo et al.
Normal high-density lipoprotein (nHDL) can induce angiogenesis in healthy individuals. However, HDL from patients with coronary artery disease undergoes various modifications, becomes dysfunctional (dHDL), and loses its ability to promote a...
A promising small molecule binding pocket in class B GPCRs: expanding potential for drug development [0.03%]
在B类G蛋白偶联受体中具有药物研发潜力的小分子结合位点的发现
Huan Xiao,Qian Sun,Qiu Sun
Huan Xiao
Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils [0.03%]
慢性肺部细菌感染通过募集促肿瘤MHCIIhi中性粒细胞促进乳腺癌肺转移
Teng Ma,Yu Tang,Taolin Wang et al.
Teng Ma et al.
Breast cancer can metastasize to various organs, including the lungs. The immune microenvironment of the organs to be metastasized plays a crucial role in the metastasis of breast cancer. Infection with pathogens such as viruses and bacteri...
Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics [0.03%]
单细胞转录组解析食管鳞癌新辅助治疗耐药机制的全景图
Yushang Yang,Yanguo Li,Haopeng Yu et al.
Yushang Yang et al.
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications [0.03%]
TET（ten-eleven转位）族蛋白：结构、生物学功能及应用
Xinchao Zhang,Yue Zhang,Chaofu Wang et al.
Xinchao Zhang et al.
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3, can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxycytosine ...
Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice [0.03%]
肠道伤口愈合和炎症相关结肠癌的小鼠在老化过程中平滑肌-纤维母细胞转化减少可能会降低肠道伤口愈合和炎症相关结肠癌
Yi Liu,Yanhong Ji,Ruiyi Jiang et al.
Yi Liu et al.
Cancer and impaired tissue wound healing with ageing are closely related to the quality of life of the elderly population. Given the increased incidence of cancer and the population ageing trend globally, it is very important to explore how...
NPRC deletion mitigated atherosclerosis by inhibiting oxidative stress, inflammation and apoptosis in ApoE knockout mice [0.03%]
NPRC缺失通过抑制氧化应激、炎症和凋亡减轻载脂蛋白E基因敲除小鼠的动脉粥样硬化病理损害
Cheng Cheng,Jie Zhang,Xiaodong Li et al.
Cheng Cheng et al.
Previous studies suggested a beneficial effect of natriuretic peptides in animal models of cardiovascular disease, but the role of natriuretic peptide receptor C (NPRC) in the pathogenesis of atherosclerosis (AS) remains unknown. This study...
Predicting the next move: tracking the complexity of lung cancer evolution and metastasis [0.03%]
预测下一步：追踪肺癌演变和转移的复杂性
Carina Lorenz,Axel M Hillmer,Johannes Brägelmann
Carina Lorenz
RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury [0.03%]
RUNX1促进急性肺损伤中的线粒体自噬并缓解肺部炎症
Xiaoju Tang,Lichun Zhong,Xin Tian et al.
Xiaoju Tang et al.