The loss of epigenetic information: not only consequences but a cause of mammalian aging [0.03%]
表观遗传信息的丢失：不仅是哺乳动物衰老的结果，也是其原因
Chen Pan,Fangfang Zhou,Long Zhang
Chen Pan
Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure [0.03%]
心力衰竭分泌的心肌细胞外泌体抑制肿瘤的铁死亡敏感性
Ye Yuan,Zhongting Mei,Zhezhe Qu et al.
Ye Yuan et al.
Heart failure (HF) patients in general have a higher risk of developing cancer. Several animal studies have indicated that cardiac remodeling and HF remarkably accelerate tumor progression, highlighting a cause-and-effect relationship betwe...
Pathogenesis of allergic diseases and implications for therapeutic interventions [0.03%]
过敏病的发病机理及其对治疗干预的意义
Ji Wang,Yumei Zhou,Honglei Zhang et al.
Ji Wang et al.
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD), food allergy (FA), and eczema are systemic diseases caused by an impaired immune system. Accompanied by high recurrence rates, the steadily ris...
Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review [0.03%]
肥胖和糖尿病相关胰腺癌发病机制：全面系统综述
Rexiati Ruze,Jianlu Song,Xinpeng Yin et al.
Rexiati Ruze et al.
Research on obesity- and diabetes mellitus (DM)-related carcinogenesis has expanded exponentially since these two diseases were recognized as important risk factors for cancers. The growing interest in this area is prominently actuated by t...
Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia [0.03%]
伊马替尼通过阻断Smad4的酪氨酸磷酸化恢复TGF-β在BCR-ABL1阳性白血病中的生长抑制作用
Lijing Wang,Shuchen Gu,Fenfang Chen et al.
Lijing Wang et al.
Loss of TGF-β-mediated growth suppression is a major contributor to the development of cancers, best exemplified by loss-of-function mutations in genes encoding components of the TGF-β signaling pathway in colorectal and pancreatic cancer...
To metabolomics and beyond: a technological portfolio to investigate cancer metabolism [0.03%]
从代谢组学迈向更广阔的研究领域：用于探究癌症代谢的技术组合
Federica Danzi,Raffaella Pacchiana,Andrea Mafficini et al.
Federica Danzi et al.
Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed activities include a complete rewiring of the bioenerge...
Stellettin B renders glioblastoma vulnerable to poly (ADP-ribose) polymerase inhibitors via suppressing homology-directed repair [0.03%]
Stellettin B通过抑制同源重组修复使胶质母细胞瘤易受聚ADP核糖聚合酶抑制剂的影响
Xin Peng,Yingying Wang,Shaolu Zhang et al.
Xin Peng et al.
TGF-β changes cyto/mito-ribosome balance to target respiratory chain complex V biogenesis in pulmonary fibrosis therapy [0.03%]
TGF-β通过改变细胞质/线粒体核糖体平衡来靶向呼吸链复合物V的生物发生以治疗肺纤维化
Na Zhang,Zunling Zhao,Yin Zhao et al.
Na Zhang et al.
Promotion of liquid-to-solid phase transition of cGAS by Baicalein suppresses lung tumorigenesis [0.03%]
黄芩素促进cGAS液固相变抑制肺肿瘤生成
Tiansheng Zheng,Haipeng Liu,Yifan Hong et al.
Tiansheng Zheng et al.
FXR inhibition: an innovative prophylactic strategy against SARS-CoV-2 infection [0.03%]
法尼醇受体抑制：预防SARS-CoV-2感染的创新策略
Zhe Li,Shuai Wang,Fangfang Zhou
Zhe Li