Cellular precision modulation of JAK1: tailoring therapies for allergic lung inflammation [0.03%]
细胞内JAK1精准调控：针对过敏性肺部炎症的个体化治疗
Xiaocheng Yan,Siegfried Ussar
Xiaocheng Yan
Lola Zerbib,Sophia Ladraa,Antoine Fraissenon et al.
Lola Zerbib et al.
Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK, an endothelial transmembrane receptor signaling through PIK3CA. Venous malformations are associated with pain, blee...
DNA of neutrophil extracellular traps promote NF-κB-dependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病中NETs DNA通过cGAS/TLR9信号通路促进NF-κB依赖性的自身免疫反应
Jun Chen,Tao Wang,Xiaoou Li et al.
Jun Chen et al.
Chronic obstructive pulmonary disease (COPD) is characterised by persistent airway inflammation even after cigarette smoking cessation. Neutrophil extracellular traps (NETs) have been implicated in COPD severity and acute airway inflammatio...
Neoadjuvant camrelizumab (an anti-PD-1 antibody) plus chemotherapy or apatinib (a VEGFR-2 inhibitor) for initially unresectable stage II-III non-small-cell lung cancer: a multicentre, two-arm, phase 2 exploratory study [0.03%]
特瑞普利单抗联合化疗或阿帕替尼对比单纯化疗新辅助治疗可切除II-IIIA期非小细胞肺癌的临床研究
Haoran Xia,Han Zhang,Zheng Ruan et al.
Haoran Xia et al.
This multicentre, two-arm, phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II-III non-small-cell lung cancer (NSCLC). Eligible pa...
Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents [0.03%]
非保守表位主导COVID-19康复者的既往存在的T细胞免疫反应
Xin Wang,Jie Zhang,Maoshun Liu et al.
Xin Wang et al.
The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing pandemic. However, the potential function of the nonconserved epitopes in the reverse preexisting cross-reactivity induced by SARS-CoV-2 t...
Beyond the code: the role of histone methylation in cancer resistance and therapy [0.03%]
超越密码：组蛋白甲基化在癌症抗性和治疗中的作用
Daniel Noerenberg,Frederik Damm
Daniel Noerenberg
Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer [0.03%]
用于结直肠癌靶向联合治疗的遗传程序型细胞膜伪装纳米药物
Yun Yang,Qingya Liu,Meng Wang et al.
Yun Yang et al.
Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens, including prolonged circulation in the bloodstream, specific cell recognition and targeting capabilities, and po...
Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein [0.03%]
法尼基转移酶抑制剂lonafarnib通过阻断融合糖蛋白构象变化来抑制呼吸道合胞病毒感染
Qi Yang,Bao Xue,Fengjiang Liu et al.
Qi Yang et al.
Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly. There are currently no approved RSV-specific therapeutic small molecules available. Using high-throughput antiviral scree...
Correction: Anti-lymphangiogenesis for boosting drug accumulation in tumors [0.03%]
关于抗淋巴管生成作用的更正：增强肿瘤内药物蓄积的效果
Chunling Wang,Junchao Xu,Xiaoyu Cheng et al.
Chunling Wang et al.