Rough operators: sphingomyelinase inhibitors spike NK cells to kill cancer [0.03%]
粗糙型操作者：鞘氨醇肌醇酶抑制剂促使自然杀伤细胞杀死癌细胞
Mattias Carlsten,Yenan T Bryceson
Mattias Carlsten
Chemogenetic activation of G12 signaling enhances adipose tissue browning [0.03%]
化学遗传活化G12信号增强脂肪组织褐变
Yuki Ono,Ryo Ito,Kaito Arai et al.
Yuki Ono et al.
Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies [0.03%]
刺猬信号在组织稳态、癌症和靶向治疗中的作用
Junjun Jing,Zhuoxuan Wu,Jiahe Wang et al.
Junjun Jing et al.
The past decade has seen significant advances in our understanding of Hedgehog (HH) signaling pathway in various biological events. HH signaling pathway exerts its biological effects through a complex signaling cascade involved with primary...
Immunotherapy in hematologic malignancies: achievements, challenges and future prospects [0.03%]
血液系统恶性肿瘤的免疫治疗：成就、挑战与未来前景
Lu Tang,Zhongpei Huang,Heng Mei et al.
Lu Tang et al.
The immune-cell origin of hematologic malignancies provides a unique avenue for the understanding of both the mechanisms of immune responsiveness and immune escape, which has accelerated the progress of immunotherapy. Several categories of ...
VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway [0.03%]
VEGF-B通过抑制FGF2/FGFR1通路防止过度血管生成
Chunsik Lee,Rongyuan Chen,Guangli Sun et al.
Chunsik Lee et al.
Although VEGF-B was discovered as a VEGF-A homolog a long time ago, the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different groups. Notwithstanding, drugs that inhibit VEGF-B together with ...
Carolina E Hagberg
Carolina E Hagberg
Shouliang Wang,Haijiao Long,Lianjie Hou et al.
Shouliang Wang et al.
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell death and programmed apoptotic, and are crucial for cell metabolism and survival. Mitophagy serves as a cytoprotective mechanism to remove superf...
CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties [0.03%]
CDK7-YAP-LDHD轴促进D型乳酸消除和铁死亡防御以支持类癌症干细胞特性
Mengzhu Lv,Ying Gong,Xuesong Liu et al.
Mengzhu Lv et al.
Reprogrammed cellular metabolism is essential for maintaining cancer stem cells (CSCs) state. Here, we report that mitochondrial D-lactate catabolism is a necessary initiating oncogenic event during tumorigenesis of esophageal squamous cell...
Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer [0.03%]
二甲双胍通过新型超级增强子激活PTGR1转录程序从而用于前列腺癌的逃逸
Jianheng Ye,Shanghua Cai,Yuanfa Feng et al.
Jianheng Ye et al.
The therapeutic efficacy of metformin in prostate cancer (PCa) appears uncertain based on various clinical trials. Metformin treatment failure may be attributed to the high frequency of transcriptional dysregulation, which leads to drug res...
Envonalkib versus crizotinib for treatment-naive ALK-positive non-small cell lung cancer: a randomized, multicenter, open-label, phase III trial [0.03%]
恩沙替尼对比克唑替尼治疗初治ALK阳性非小细胞肺癌患者：一项随机、开放、多中心III期临床研究
Yunpeng Yang,Jie Min,Nong Yang et al.
Yunpeng Yang et al.
Anaplastic lymphoma kinase (ALK) rearrangements are present in about 5-6% of non-small cell lung cancer (NSCLC) cases and associated with increased risks of central nervous system (CNS) involvement. Envonalkib, a novel ALK inhibitor, demons...