Simplified algorithm for genetic subtyping in diffuse large B-cell lymphoma [0.03%]
弥漫性大B细胞淋巴瘤遗传分型的简化算法
Rong Shen,Di Fu,Lei Dong et al.
Rong Shen et al.
Genetic classification helps to disclose molecular heterogeneity and therapeutic implications in diffuse large B-cell lymphoma (DLBCL). Using whole exome/genome sequencing, RNA-sequencing, and fluorescence in situ hybridization in 337 newly...
Viral vectored vaccines: design, development, preventive and therapeutic applications in human diseases [0.03%]
病毒载体疫苗的设计、开发及在人类疾病的预防和治疗中的应用
Shen Wang,Bo Liang,Weiqi Wang et al.
Shen Wang et al.
Human diseases, particularly infectious diseases and cancers, pose unprecedented challenges to public health security and the global economy. The development and distribution of novel prophylactic and therapeutic vaccines are the prioritize...
SARS-CoV-2 N protein induces acute kidney injury in diabetic mice via the Smad3-Ripk3/MLKL necroptosis pathway [0.03%]
S蛋白通过Smad3-Ripk3/MLKL坏死小体途径诱导糖尿病小鼠急性肾损伤
Liying Liang,Wenbiao Wang,Junzhe Chen et al.
Liying Liang et al.
Cdc2-like kinases: structure, biological function, and therapeutic targets for diseases [0.03%]
Cdc2样激酶：结构、生物学功能及其作为疾病治疗靶点的潜力
Mengqiu Song,Luping Pang,Mengmeng Zhang et al.
Mengqiu Song et al.
The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family and play crucial roles in regulating transcript splicing via the phosphorylation of SR proteins (SRSF1-12), catalyzing spliceosome molecular machinery, and mo...
OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2 [0.03%]
OTUB1通过稳定FGFR2促进成骨细胞成骨形成
Qiong Zhu,Yesheng Fu,Chun-Ping Cui et al.
Qiong Zhu et al.
Bone homeostasis is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. Dysregulation of this process leads to multiple diseases, including osteoporosis. However, the underlying molecular mechanis...
tRF-Gln-CTG-026 ameliorates liver injury by alleviating global protein synthesis [0.03%]
tRF-Gln-CTG-026通过抑制整体蛋白质合成从而改善肝损伤作用机制研究
Sunyang Ying,Pengcheng Li,Jiaqiang Wang et al.
Sunyang Ying et al.
tsRNAs (tRNA-derived small RNAs), as products of the stress response, exert considerable influence on stress response and injury regulation. However, it remains largely unclear whether tsRNAs can ameliorate liver injury. Here, we demonstrat...
Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus [0.03%]
新型MST1激酶抑制剂和AMPK激活剂IHMT-MST1-39的发现及其治疗糖尿病的作用机制研究
Junjie Wang,Ziping Qi,Yun Wu et al.
Junjie Wang et al.
Insulin-producing pancreatic β cell death is the fundamental cause of type 1 diabetes (T1D) and a contributing factor to type 2 diabetes (T2D). Moreover, metabolic disorder is another hallmark of T2D. Mammalian sterile 20-like kinase 1 (MS...
Low-dose IL-2 mitigates glucocorticoid-induced Treg impairment and promotes improvement of SLE [0.03%]
小剂量IL-2可改善糖皮质激素所致Tregs功能障碍及促进SLE病情改善
Haotian Zhou,Xiaozhen Zhao,Ruijun Zhang et al.
Haotian Zhou et al.
TCMBank-the largest TCM database provides deep learning-based Chinese-Western medicine exclusion prediction [0.03%]
TCM银行-最大的中药数据库提供基于深度学习的中西药禁忌预测
Qiujie Lv,Guanxing Chen,Haohuai He et al.
Qiujie Lv et al.
Characterization of mesenchymal stem cells in human fetal bone marrow by single-cell transcriptomic and functional analysis [0.03%]
人胎盘骨髓间充质干细胞的单细胞转录组和功能分析鉴定
Ping Zhang,Ji Dong,Xiaoying Fan et al.
Ping Zhang et al.
Bone marrow mesenchymal stromal/stem cells (MSCs) are a heterogeneous population that can self-renew and generate stroma, cartilage, fat, and bone. Although a significant progress has been made toward recognizing about the phenotypic charac...