Amyloid β-based therapy for Alzheimer's disease: challenges, successes and future [0.03%]
基于淀粉样蛋白的阿尔茨海默病疗法：挑战、成功与未来方向
Yun Zhang,Huaqiu Chen,Ran Li et al.
Yun Zhang et al.
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease (AD), and its accumulation has been considered as the molecular driver of Alzheimer's pathogenesis and progression. Aβ has been the prime target for ...
Efficacy, safety and pharmacokinetics of Unecritinib (TQ-B3101) for patients with ROS1 positive advanced non-small cell lung cancer: a Phase I/II Trial [0.03%]
乌纳奇替尼(TQ-B3101)治疗ROS1阳性晚期非小细胞肺癌的疗效、安全性和药代动力学：I/II期临床试验
Shun Lu,Hongming Pan,Lin Wu et al.
Shun Lu et al.
This phase I/II trial characterized the tolerability, safety, and antitumor activities of unecritinib, a novel derivative of crizotinib and a multi-tyrosine kinase inhibitor targeting ROS1, ALK, and c-MET, in advanced tumors and ROS1 inhibi...
Porous insights: IpaH7.8 reveals crystal-clear differences of gasdermins in mice and men [0.03%]
多孔的启示：IpaH7.8揭示了小鼠与人类Gasdermin的晶体清晰的区别
Friedrich Alexander von Samson-Himmelstjerna,Benedikt Kolbrink,Stefan Krautwald
Friedrich Alexander von Samson-Himmelstjerna
Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling [0.03%]
整合素-DDR信号传递介导基质力学压力调控乳腺癌细胞干细胞特性与静息态之间的转换
Cong Li,Shi Qiu,Xiaohan Liu et al.
Cong Li et al.
The extracellular matrix (ECM) serves as signals that regulate specific cell states in tumor tissues. Increasing evidence suggests that extracellular biomechanical force signals are critical in tumor progression. In this study, we aimed to ...
CRISPRing the hypertrophic cardiomyopathy: correcting one pathogenic variant at a time [0.03%]
逐个校正致病突变的肥厚型心肌病的 crispr 编辑疗法
Junaid Afzal,Kshitiz
Junaid Afzal
TRIM28 promotes the escape of gastric cancer cells from immune surveillance by increasing PD-L1 abundance [0.03%]
TRIM28通过增加PD-L1丰度促进胃癌细胞逃逸免疫监视
Xiaoxiao Ma,Shuqin Jia,Gangjian Wang et al.
Xiaoxiao Ma et al.
Immune checkpoint blockade (ICB) offers a new opportunity for treatment for gastric cancer (G.C.). Understanding the upstream regulation of immune checkpoints is crucial to further improve the efficacy of ICB therapy. Herein, using the CRIS...
Xiao Hu,Wei Xu,Yilong Ren et al.
Xiao Hu et al.
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate. The challenges of SCI repair include its complex pathological mechanisms and the difficulties of neural regeneration in the central nervous system. ...
Integrated genetic and epigenetic analysis reveals DNA repair alterations in multifocal hepatocellular carcinoma [0.03%]
整合基因和表观基因组分析揭示了多灶性肝细胞癌中的DNA修复改变
Yi-Hong Ling,Meng-Ni Liu,Yi-Xin Yin et al.
Yi-Hong Ling et al.
Phase separating Rho: a widespread regulatory function of disordered regions in proteins revealed in bacteria [0.03%]
细菌中揭示的蛋白无序区域的一种广泛调节功能：分相Rho蛋白质
Eric Schumbera,Pablo Mier,Miguel A Andrade-Navarro
Eric Schumbera
Cyclin L1 controls cardiomyocyte proliferation and heart repair after injury [0.03%]
Cyclin L1调控心肌细胞增殖及损伤后心脏修复
Rui Gong,Xinlu Gao,Yu Liu et al.
Rui Gong et al.