Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends [0.03%]
固体瘤免疫检查点疗法的临床困惑与未来趋势
Qian Sun,Zhenya Hong,Cong Zhang et al.
Qian Sun et al.
Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the widespread use of the drug, we must deeply analyze the dilemma of t...
Intestinal eosinophils: characterization of elusive granulocytes as anti-bacterial and immunomodulatory effector cells in colitis [0.03%]
肠嗜酸性粒细胞：难以捉摸的颗粒细胞作为抗细菌和免疫调节效应细胞在结肠炎中的特征化研究
Tim Holland,Jochen Mattner
Tim Holland
Unexpected bonds: Ubiquitin-like conjugation of cGAS/CD-NTases supports their enzymatic activity and antiphage defense [0.03%]
意想不到的联系：cGAS/CD-NTases类泛素连接作用对其酶活性及抗噬菌体防御的支持作用
Katarzyna Andryka-Cegielski,Sofía Soler,Eva Bartok
Katarzyna Andryka-Cegielski
Somatic mutant clone screening: scan for novel NASH target genes in mouse liver [0.03%]
肝脏体细胞突变克隆筛选：寻找NASH小鼠模型新靶基因
Tian Lan,Adrien Guillot,Frank Tacke
Tian Lan
Methylation across the central dogma in health and diseases: new therapeutic strategies [0.03%]
甲基化与健康及疾病中的中心法则的新治疗策略
Ruochen Liu,Erhu Zhao,Huijuan Yu et al.
Ruochen Liu et al.
The proper transfer of genetic information from DNA to RNA to protein is essential for cell-fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone proteins is a reversible post-synthesis modification that...
A20 promotes colorectal cancer immune evasion by upregulating STC1 expression to block "eat-me" signal [0.03%]
A20通过上调STC1表达阻断“吃我”信号促进结直肠癌免疫逃逸
Min Luo,Xueping Wang,Shaocong Wu et al.
Min Luo et al.
Immune checkpoint inhibitors (ICIs) have induced durable clinical responses in a subset of patients with colorectal cancer (CRC). However, the dis-satisfactory response rate and the lack of appropriate biomarkers for selecting suitable pati...
Long Chen,Mengnan Zhou,Hao Li et al.
Long Chen et al.
As key organelles involved in cellular metabolism, mitochondria frequently undergo adaptive changes in morphology, components and functions in response to various environmental stresses and cellular demands. Previous studies of mitochondria...
Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus [0.03%]
呼吸道合胞病毒核壳体类似物的低温电子结构
Yan Wang,Chong Zhang,Yongbo Luo et al.
Yan Wang et al.
Respiratory syncytial virus (RSV) is a nonsegmented, negative strand RNA virus that has caused severe lower respiratory tract infections of high mortality rates in infants and the elderly, yet no effective vaccine or antiviral therapy is av...
Interaction of microglia and T cells: a deadly duo behind Tau-mediated neurodegeneration [0.03%]
小胶质细胞和T细胞的相互作用：Tau介导神经退行性疾病中的“致命组合”
Bilge Askin,Susanne Wegmann
Bilge Askin