Safeguarding transcriptional memory: a mitotic bookmarking role for chromatin remodelers [0.03%]
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Godwin Sokpor,Huu Phuc Nguyen,Tran Tuoc
Godwin Sokpor
Artificial sweetener sucralose: a possible modulator of autoimmune diseases [0.03%]
人造甜味剂蔗糖素：可能的自身免疫疾病调节因子
Nicolle Kränkel,Ursula Rauch-Kroehnert
Nicolle Kränkel
Ras homolog family member J (RHOJ): a key regulator of chemoresistance associated with epithelial-mesenchymal transition [0.03%]
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Sijia Liu,Jiang Ren,Long Zhang
Sijia Liu
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease [0.03%]
mTOR（哺乳动物雷帕霉素靶点）信号通路在人类健康和疾病中的多面作用
Vivek Panwar,Aishwarya Singh,Manini Bhatt et al.
Vivek Panwar et al.
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain cellular homeostasis. The mTOR signaling cascade co...
STAT5 promotes PD-L1 expression by facilitating histone lactylation to drive immunosuppression in acute myeloid leukemia [0.03%]
STAT5通过促进组蛋白乳酸化来促进PD-L1表达以驱动急性髓系白血病免疫抑制作用
Ze-Wei Huang,Xue-Ning Zhang,Ling Zhang et al.
Ze-Wei Huang et al.
Immunotherapy is a revolutionized therapeutic strategy for tumor treatment attributing to the rapid development of genomics and immunology, and immune checkpoint inhibitors have successfully achieved responses in numbers of tumor types, inc...
Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study [0.03%]
原发肿瘤与继发肿瘤的基因差异——全基因组对比研究
Lei Zhong,Zhipeng Zhao,Xiaonan Zhang
Lei Zhong
Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions [0.03%]
淋巴结转移在癌症进展中的分子机制、临床意义和治疗干预措施
Haoran Ji,Chuang Hu,Xuhui Yang et al.
Haoran Ji et al.
Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune modulation, and secondary dissemination to distant sites through a series of mechanisms, and it has been proved that lymph node metastasis (LNM) is an essent...
Combined FOLFOX4 with all-trans retinoic acid versus FOLFOX4 with placebo in treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a randomized, double-blind comparative study [0.03%]
联合全反式维甲酸与FOLFOX4对比安慰剂联合FOLFOX4治疗肝细胞癌伴远处转移的疗效：一项随机、双盲临床研究
Juxian Sun,Feifei Mao,Chang Liu et al.
Juxian Sun et al.
The majority of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage. Currently, there are only a few therapeutic methods available for patients with advanced HCC and extrahepatic metastasis (EHM). Systemic chemotherapy, ...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2023 Sep 27;8(1):368. DOI:10.1038/s41392-023-01604-3 2023
Transcriptional-translational conflict: a novel exploitable tumor suppressive mechanism [0.03%]
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Maria Mudryj,Paramita M Ghosh
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Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors [0.03%]
单纯疱疹病毒增效DNA损伤响应抑制剂协同作用杀伤非小细胞肺癌研究
Bopei Cui,Lifang Song,Qian Wang et al.
Bopei Cui et al.
With the continuous in-depth study of the interaction mechanism between viruses and hosts, the virus has become a promising tool in cancer treatment. In fact, many oncolytic viruses with selectivity and effectiveness have been used in cance...