The main protease of SARS-CoV-2 downregulates innate immunity via a translational repression [0.03%]
SARS-CoV-2主要蛋白酶通过翻译抑制下调固有免疫反应
Weifeng Liang,Ming Gu,Lingxiang Zhu et al.
Weifeng Liang et al.
A thermodynamic model showing that information recording can drive active ion transport [0.03%]
一个热力学模型表明信息记录可以驱动主动离子运输
Xiang Zou,Kun Song,Minbiao Ji et al.
Xiang Zou et al.
Belén Aparicio,Juan J Lasarte,Pablo Sarobe
Belén Aparicio
Patient-derived xenograft models in cancer therapy: technologies and applications [0.03%]
基于患者的肿瘤异种移植模型的技术及应用进展
Yihan Liu,Wantao Wu,Changjing Cai et al.
Yihan Liu et al.
Patient-derived xenograft (PDX) models, in which tumor tissues from patients are implanted into immunocompromised or humanized mice, have shown superiority in recapitulating the characteristics of cancer, such as the spatial structure of ca...
Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors [0.03%]
G1/S期转换的完整调节使食管鳞癌对PI3Kα抑制剂敏感
Xu Zhang,Yuxiang Wang,Xi Zhang et al.
Xu Zhang et al.
Phosphatidylinositol 3-kinase alpha (PI3Kα) inhibitors are currently evaluated for the therapy of esophageal squamous cell carcinoma (ESCC). It is of great importance to identify potential biomarkers to predict or monitor the efficacy of P...
Oncolytic virotherapy: basic principles, recent advances and future directions [0.03%]
溶瘤病毒疗法：基本原理、近期进展和未来发展方向
Danni Lin,Yinan Shen,Tingbo Liang
Danni Lin
Oncolytic viruses (OVs) have attracted growing awareness in the twenty-first century, as they are generally considered to have direct oncolysis and cancer immune effects. With the progress in genetic engineering technology, OVs have been ad...
Diabetic vascular diseases: molecular mechanisms and therapeutic strategies [0.03%]
糖尿病血管病变：分子机制和治疗策略
Yiwen Li,Yanfei Liu,Shiwei Liu et al.
Yiwen Li et al.
Vascular complications of diabetes pose a severe threat to human health. Prevention and treatment protocols based on a single vascular complication are no longer suitable for the long-term management of patients with diabetes. Diabetic panv...
The protective nasal boosting of a triple-RBD subunit vaccine against SARS-CoV-2 following inactivated virus vaccination [0.03%]
针对灭活病毒疫苗受种者的三倍体RBD亚单位疫苗的鼻腔滴注增强免疫效果及其保护作用研究
Jingyi Yang,Mei-Qin Liu,Lin Liu et al.
Jingyi Yang et al.
Control of CAR-T cell activity in space and time: the next level of anti-tumor action [0.03%]
时空控制CAR-T细胞活性：抗癌的下一个水平
Jessica Hoppstädter,Alexandra K Kiemer
Jessica Hoppstädter
Two vs three cycles of neoadjuvant sintilimab plus chemotherapy for resectable non-small-cell lung cancer: neoSCORE trial [0.03%]
二线与三线接受信迪利单抗联合化疗新辅助治疗可切除非小细胞肺癌患者的疗效和安全性：neoSCORE试验
Miner Shao,Jie Yao,Yunke Wang et al.
Miner Shao et al.