Cx26 heterozygous mutations: role in hyperacusis and vulnerability to noise [0.03%]
CX26杂合子突变在噪声过度敏感和听力损失中的作用
Karen Tawk,Mehdi Abouzari
Karen Tawk
Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants [0.03%]
定义高度保守的隐蔽表位以识别SARS-CoV-2变异毒株的抗体
Aihua Hao,Wenping Song,Cheng Li et al.
Aihua Hao et al.
Meng Fang,Hong-Kun Wu,Yumeng Pei et al.
Meng Fang et al.
Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers. In particular, the dysregulation of ubiquitination-dependen...
Adverse effects of tyrosine kinase inhibitors in cancer therapy: pathophysiology, mechanisms and clinical management [0.03%]
致癌治疗的酪氨酸激酶抑制剂不良反应：病理生理学、机制和临床管理
Sunitha Shyam Sunder,Umesh C Sharma,Saraswati Pokharel
Sunitha Shyam Sunder
Since their invention in the early 2000s, tyrosine kinase inhibitors (TKIs) have gained prominence as the most effective pathway-directed anti-cancer agents. TKIs have shown significant utility in the treatment of multiple hematological mal...
TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases [0.03%]
瞬时受体电位(TRP)离子通道家族：结构、生物学功能及其疾病治疗干预措施研究
Miao Zhang,Yueming Ma,Xianglu Ye et al.
Miao Zhang et al.
Transient receptor potential (TRP) channels are sensors for a variety of cellular and environmental signals. Mammals express a total of 28 different TRP channel proteins, which can be divided into seven subfamilies based on amino acid seque...
Traumatic brain injury stimulates sympathetic tone-mediated bone marrow myelopoiesis to favor fracture healing [0.03%]
创伤性脑损伤通过交感神经介导的骨髓髓系细胞生成促进骨折修复
Weijian Liu,Wei Chen,Mao Xie et al.
Weijian Liu et al.
Traumatic brain injury (TBI) accelerates fracture healing, but the underlying mechanism remains largely unknown. Accumulating evidence indicates that the central nervous system (CNS) plays a pivotal role in regulating immune system and skel...
Chemotherapy induces cell plasticity; controlling plasticity increases therapeutic response [0.03%]
化疗会诱导细胞的可塑性；控制可塑性会提高治疗效果
Francisco J Iborra,Cristina Martí,Virtu Calabuig-Navarro et al.
Francisco J Iborra et al.
Structure of human NCC: insights into the inhibition mechanism of thiazides [0.03%]
人NCC结构：噻嗪类抑制机制的见解
Livia de Souza Goncalves,Pattareeya Yottasan,Onur Cil
Livia de Souza Goncalves
SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence [0.03%]
SIRT6通过抑制炎症和衰老表观遗传学上抑制胸主动脉瘤发生发展的作用机制研究
Yang-Nan Ding,Ting-Ting Wang,Shuang-Jie Lv et al.
Yang-Nan Ding et al.
Thoracic aortic aneurysms (TAAs) develop asymptomatically and are characterized by dilatation of the aorta. This is considered a life-threating vascular disease due to the risk of aortic rupture and without effective treatments. The current...
Author Correction: GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer [0.03%]
作者更正：GPR162 通过激活新的抑癌和放疗增敏的 STING 依赖性 DNA 损伤通路发挥作用
Yao Long,Jiaxing Guo,Jielin Chen et al.
Yao Long et al.