SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread [0.03%]
SARS-CoV-2奥密克戎亚变体BA.2.86：全球传播潜力有限
Xinling Wang,Lu Lu,Shibo Jiang
Xinling Wang
Oncolytic adenoviruses expressing checkpoint inhibitors for cancer therapy [0.03%]
表达检查点抑制剂的溶瘤腺病毒用于癌症治疗
Daoyuan Xie,Yaomei Tian,Die Hu et al.
Daoyuan Xie et al.
Despite the remarkable success of immune checkpoint inhibitors (ICIs), primary resistance to ICIs causes only subsets of patients to achieve durable responses due to the complex tumor microenvironment (TME). Oncolytic viruses (OVs) can over...
Correction: Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L [0.03%]
校正：Eosinophil通过Cathepsin L促进肺基质破坏和肺气肿的发展
Xia Xu,Tao Yu,Lingling Dong et al.
Xia Xu et al.
Jia Guo,Hanyi Zhang,Wenrui Lin et al.
Jia Guo et al.
Psoriasis is a common, chronic, and inflammatory skin disease with a high burden on individuals, health systems, and society worldwide. With the immunological pathologies and pathogenesis of psoriasis becoming gradually revealed, the therap...
Multifunctional mesoporous silica nanoparticles for biomedical applications [0.03%]
用于生物医学应用的多功能介孔二氧化硅纳米粒子
Bolong Xu,Shanshan Li,Rui Shi et al.
Bolong Xu et al.
Mesoporous silica nanoparticles (MSNs) are recognized as a prime example of nanotechnology applied in the biomedical field, due to their easily tunable structure and composition, diverse surface functionalization properties, and excellent b...
γδ T cells: origin and fate, subsets, diseases and immunotherapy [0.03%]
gamma delta T细胞：起源和归宿、亚群、疾病与免疫治疗
Yi Hu,Qinglin Hu,Yongsheng Li et al.
Yi Hu et al.
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential of immune renormalization as a promising strategy in disease treatment. In recent years, our primary focus ...
Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets [0.03%]
缺氧引起的血管信号传导：起因、发病机理及治疗目标
Yongchao Zhao,Weidong Xiong,Chaofu Li et al.
Yongchao Zhao et al.
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent role in cardiovascular diseases. From the research history and milestone events related to ...
Versatile guardians: regenerative regulatory T cells in Parkinson's disease rodent models [0.03%]
多才多艺的守护者：帕金森病啮齿动物模型中的再生调节性T细胞
Chi Wang Ip,Jörg Wischhusen
Chi Wang Ip
Predictive biomarkers of response and survival following immunotherapy with a PD-L1 inhibitor benmelstobart (TQB2450) and antiangiogenic therapy with a VEGFR inhibitor anlotinib for pretreated advanced triple negative breast cancer [0.03%]
预测PD-L1抑制剂巴替利单抗(TQB2450)联合抗血管生成药物安罗替尼治疗三阴乳腺癌患者的疗效及生存的生物标志物研究
Yiqun Han,Jiayu Wang,Tao Sun et al.
Yiqun Han et al.
In our phase Ib trial (ClinialTrials.gov Identifier: NCT03855358), benmelstobart (TQB2450), a novel humanized IgG1 antibody against PD-L1, plus antiangiogenic multikinase inhibitor, anlotinib, demonstrated promising antitumor activities in ...