Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex [0.03%]
SARS-CoV-2相分离的核蛋白通过破坏cGAS-G3BP1复合物抑制cGAS-DNA识别
Sihui Cai,Chenqiu Zhang,Zhen Zhuang et al.
Sihui Cai et al.
Currently, the incidence and fatality rate of SARS-CoV-2 remain continually high worldwide. COVID-19 patients infected with SARS-CoV-2 exhibited decreased type I interferon (IFN-I) signal, along with limited activation of antiviral immune r...
Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2 [0.03%]
奈非那韦在感染SARS-CoV-2的恒河猴和人体内的预防及治疗作用
Zhijian Xu,Danrong Shi,Jian-Bao Han et al.
Zhijian Xu et al.
Effective drugs with broad spectrum safety profile to all people are highly expected to combat COVID-19 caused by SARS-CoV-2. Here we report that nelfinavir, an FDA approved drug for the treatment of HIV infection, is effective against SARS...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2023 Apr 24;8(1):169. DOI:10.1038/s41392-023-01429-0 2023
RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis [0.03%]
RBM4通过抑制LKB1-AMPK轴决定食管鳞状细胞癌细胞命运从衰老转向谷氨酰胺成瘾生存路径
Lei Chen,Wenjing Zhang,Dan Chen et al.
Lei Chen et al.
Cellular senescence provides a protective barrier against tumorigenesis in precancerous or normal tissues upon distinct stressors. However, the detailed mechanisms by which tumor cells evade premature senescence to malignant progression rem...
Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions [0.03%]
血管功能和高血压中的信号转导通路：分子机制与治疗干预措施
Jun Ma,Yanan Li,Xiangyu Yang et al.
Jun Ma et al.
Hypertension is a global public health issue and the leading cause of premature death in humans. Despite more than a century of research, hypertension remains difficult to cure due to its complex mechanisms involving multiple interactive fa...
Combination therapy with saxagliptin and vitamin D for the preservation of β-cell function in adult-onset type 1 diabetes: a multi-center, randomized, controlled trial [0.03%]
西格列汀和维生素D联合治疗成人自身免疫性糖尿病以保护β细胞功能的多中心随机对照试验
Xiang Yan,Xia Li,Bingwen Liu et al.
Xiang Yan et al.
Disease modifying therapies aiming to preserve β-cell function in patients with adult-onset autoimmune type 1 diabetes are lacking. Here, we conducted a multi-centre, randomized, controlled trial to assess the β-cell preservation effects ...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2023 Apr 20;8(1):158. DOI:10.1038/s41392-023-01369-9 2023
The chemokine CCL17 is a novel therapeutic target for cardiovascular aging [0.03%]
趋化因子CCL17是心血管衰老的新治疗靶点
Yang Zhang,Xiaoqiang Tang,Zeyuan Wang et al.
Yang Zhang et al.
A bacteria-based system expressing anti-TNF-α nanobody for enhanced cancer immunotherapy [0.03%]
一种基于细菌表达抗TNF-α纳米体的增强型癌症免疫治疗系统
Lina Liu,Xing Liu,Wenjie Xin et al.
Lina Liu et al.
Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants [0.03%]
使用奥密克戎鼻喷新冠疫苗加强剂可对新冠病毒变异株产生广泛黏膜和体液免疫反应
Qian Wang,Chenchen Yang,Li Yin et al.
Qian Wang et al.
The highly contagious SARS-CoV-2 Omicron subvariants severely attenuated the effectiveness of currently licensed SARS-CoV-2 vaccines based on ancestral strains administered via intramuscular injection. In this study, we generated a recombin...
Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma [0.03%]
VHL驱动的透明细胞肾细胞癌转移的肿瘤异质性
Junhui Hu,Ping Tan,Moe Ishihara et al.
Junhui Hu et al.
Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of clear cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this tumor suppressor has been under reported. To study the impac...
Alterations of the oral and gut mycobiome and cytokines during long-term follow-up of COVID-19 convalescents [0.03%]
新冠康复者长期随访期间口腔和肠道真菌群及细胞因子的变化
Zhigang Ren,Shanshuo Liu,Qiong Wang et al.
Zhigang Ren et al.