Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines [0.03%]
针对SARS-CoV-2 S2亚单位的设计靶点以开发泛冠状病毒融合抑制剂和疫苗元件
Liyan Guo,Sheng Lin,Zimin Chen et al.
Liyan Guo et al.
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused devastating impacts on the public health and the global economy. Rapid viral antigenic ev...
Signaling pathways in cancer metabolism: mechanisms and therapeutic targets [0.03%]
癌症代谢信号通路：机制和治疗靶点
Mengshu You,Zhuolin Xie,Nan Zhang et al.
Mengshu You et al.
A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can be sensed by specific sensors, then trigger a series of signal transduction pathways and affect the expression levels of genes in epigenetics, whic...
SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication [0.03%]
SARS-CoV-2 N蛋白通过增强MCL-1的抗凋亡活性来促进病毒复制
Pan Pan,Weiwei Ge,Zhiwei Lei et al.
Pan Pan et al.
Viral infection in respiratory tract usually leads to cell death, impairing respiratory function to cause severe disease. However, the diversity of clinical manifestations of SARS-CoV-2 infection increases the complexity and difficulty of v...
A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors [0.03%]
预测非BRCAness肿瘤新合成致死性的核糖体基因谱系
Chao Zhang,Qiang Guo,Lifeng Chen et al.
Chao Zhang et al.
Poly (ADP-ribose) polymerase (PARP) inhibitors are one of the most exciting classes of targeted therapy agents for cancers with homologous recombination (HR) deficiency. However, many patients without apparent HR defects also respond well t...
Konstantin M J Sparrer,Frank Kirchhoff
Konstantin M J Sparrer
Spatial TIME landscape and its prognostic value in the lung and brain tumor: location matters [0.03%]
空间TIME景观及其在肺癌和脑瘤中的预后价值：位置很重要
Yunke Wang,Anne E Geller,Jun Yan
Yunke Wang
Cell-cycle dependent nuclear gene delivery enhances the effects of E-cadherin against tumor invasion and metastasis [0.03%]
细胞周期依赖的核基因传递增强E-钙黏蛋白对肿瘤侵袭和转移的作用
Liting Xie,Jieqiong Wang,Liming Song et al.
Liting Xie et al.
Gene delivery is the process by which foreign DNA is transferred to host cells, released from intracellular vesicles, and transported to the nuclei for transcription. This process is frequently inefficient and difficult to control spatiotem...
Retraction Note: Dickkopf-1 contributes to hepatocellular carcinoma tumorigenesis by activating the Wnt/β-catenin signaling pathway [0.03%]
撤回 notice: dickkopf-1通过激活Wnt / β-catenin信号通路促进肝细胞癌的发生发展
Rui Zhang,Hao-Ming Lin,Ruth Broering et al.
Rui Zhang et al.
Retraction of Publication
Signal transduction and targeted therapy. 2023 May 5;8(1):181. DOI:10.1038/s41392-023-01475-8 2023
Comparing T- and B-cell responses to COVID-19 vaccines across varied immune backgrounds [0.03%]
比较不同免疫背景下的COVID-19疫苗诱导的T细胞和B细胞免疫反应
Zhen Cui,Wenxin Luo,Ruihong Chen et al.
Zhen Cui et al.
The emergence of adapted variants of the SARS-CoV-2 virus has led to a surge in breakthrough infections worldwide. A recent analysis of immune responses in people who received inactivated vaccines has revealed that individuals with no prior...
Carbon nanotube promotes contraction and electrical activity of neonatal cardiomyocytes by targeting sodium/calcium exchanger NCX1 [0.03%]
碳纳米管通过作用钠钙交换体NCX1促进心肌细胞收缩及电生理活动
Xiao Zhang,Yuan Shen,Zhen Cao et al.
Xiao Zhang et al.