Xingyi Chen,Chaoran Shi,Meihui He et al.
Xingyi Chen et al.
The endoplasmic reticulum (ER) functions as a quality-control organelle for protein homeostasis, or "proteostasis". The protein quality control systems involve ER-associated degradation, protein chaperons, and autophagy. ER stress is activa...
RBFOX2: a key factor in suppressing PDAC metastasis through regulation of alternative splicing events [0.03%]
RBFOX2通过调控可变剪接事件抑制胰腺癌转移
Laura Urbach,Shiv K Singh
Laura Urbach
MDIG-mediated H3K9me3 demethylation upregulates Myc by activating OTX2 and facilitates liver regeneration [0.03%]
MDIG介导的H3K9me3去甲基化通过激活OTX2上调Myc以促进肝再生
Jinpeng Du,Wenwei Liao,Haichuan Wang et al.
Jinpeng Du et al.
The mineral dust-induced gene (MDIG) comprises a conserved JmjC domain and has the ability to demethylate histone H3 lysine 9 trimethylation (H3K9me3). Previous studies have indicated the significance of MDIG in promoting cell proliferation...
Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge [0.03%]
从最早的新冠肺炎康复者中获得的广谱中和抗体可保护小鼠免受新冠病毒变种的攻击
Qianyun Liu,Haiyan Zhao,Zhiqiang Li et al.
Qianyun Liu et al.
Coronavirus disease 2019 (COVID-19) was first reported three years ago, when a group of individuals were infected with the original SARS-CoV-2 strain, based on which vaccines were developed. Here, we develop six human monoclonal antibodies ...
Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study [0.03%]
基因型式对FLT3-ITD阳性急性髓系白血病患者异基因造血干细胞移植后索拉非尼疗效影响的多中心队列研究
Ruoyang Shao,Yu Zhang,Jinping He et al.
Ruoyang Shao et al.
Sorafenib therapy improves overall survival (OS) in patients with FLT3 internal tandem duplication (ITD) acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation. We explored the efficacy of sorafenib thera...
Skeletal muscle-directed gene therapy: hijacking the fusogenic properties of muscle cells [0.03%]
肌细胞融合特性在骨骼肌定向基因治疗中的应用
Hildegard Büning,Michael Morgan,Axel Schambach
Hildegard Büning
Zhe-Nan Ling,Yi-Fan Jiang,Jun-Nan Ru et al.
Zhe-Nan Ling et al.
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function. Amino acid metabolism disorders have been linked with a numbe...
RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation [0.03%]
RNA结合蛋白TIAR通过调节pgRNA的翻译水平来调控HBV复制
Ting Zhang,Huiling Zheng,Danjuan Lu et al.
Ting Zhang et al.
The pregenomic RNA (pgRNA) of hepatitis B virus (HBV) serves not only as a bicistronic message RNA to translate core protein (Cp) and DNA polymerase (Pol), but also as the template for reverse transcriptional replication of viral DNA upon p...
Oit3, a promising hallmark gene for targeting liver sinusoidal endothelial cells [0.03%]
具有潜力作为靶向肝窦状内皮细胞标志物的Oit3基因
Zhi-Wen Li,Bai Ruan,Pei-Jun Yang et al.
Zhi-Wen Li et al.
Liver sinusoidal endothelial cells (LSECs) play a pivotal role in maintaining liver homeostasis and influencing the pathological processes of various liver diseases. However, neither LSEC-specific hallmark genes nor a LSEC promoter-driven C...
CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability [0.03%]
CBX4缺失通过诱导基因组不稳定性促进KrasG12D背景下的肿瘤发生
Fangzhen Chen,Wulei Hou,Xiangtian Yu et al.
Fangzhen Chen et al.
Chromobox protein homolog 4 (CBX4) is a component of the Polycomb group (PcG) multiprotein Polycomb repressive complexes 1 (PRC1), which is participated in several processes including growth, senescence, immunity, and tissue repair. CBX4 ha...