Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy [0.03%]
肿瘤再播种细胞来源的微颗粒通过级联放大化疗诱导的抗肿瘤免疫来增强抗PD-1疗法
Nana Bie,Tuying Yong,Zhaohan Wei et al.
Nana Bie et al.
Immune checkpoint blockade (ICB) therapy, particularly antibodies targeting the programmed death receptor 1 (PD-1) and its ligand (PD-L1), has revolutionized cancer treatment. However, its efficacy as a standalone therapy remains limited. A...
Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase [0.03%]
通过真核起始因子2激酶控制CD4+t细胞以抑制炎症性疾病发生发展
Hao-Yun Peng,Liqing Wang,Jugal Kishore Das et al.
Hao-Yun Peng et al.
CD4+ T cells, particularly IL-17-secreting helper CD4+ T cells, play a central role in the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor 2 Kinase (eEF2K) is pivotal in CD8+ T cells and has important im...
Real-world effectiveness of an intranasal spray A8G6 antibody cocktail in the post-exposure prophylaxis of COVID-19 [0.03%]
针对新冠暴露后预防的鼻用抗体鸡尾酒A8G6的现实世界有效性研究
Xiaosong Li,Pai Peng,Haijun Deng et al.
Xiaosong Li et al.
Previously, we identified an antibody combination A8G6 that showed promising efficacy in COVID-19 animal models and favorable safety profile in preclinical models as well as in a first-in-human trial. To evaluate the real-word efficacy of A...
Controlled Clinical Trial
Signal transduction and targeted therapy. 2023 Oct 23;8(1):403. DOI:10.1038/s41392-023-01656-5 2023
Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease [0.03%]
Fe65工程神经外泌体递送 Corynoxine B 改善阿尔茨海默病认知和病理表型
Ashok Iyaswamy,Abhimanyu Thakur,Xin-Jie Guan et al.
Ashok Iyaswamy et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neurofibrillary tangles in the bra...
B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy [0.03%]
B细胞免疫检查点TIM-1：肿瘤免疫治疗的潜在靶标
Xinyu Tian,Xiangyun Zheng,Dong Tian
Xinyu Tian
Astragaloside IV derivative HHQ16 ameliorates infarction-induced hypertrophy and heart failure through degradation of lncRNA4012/9456 [0.03%]
Astragaloside IV 衍生物 HHQ16通过降解 lncRNA4012/9456 改善心梗诱导的心室肥大和心力衰竭
Jingjing Wan,Zhen Zhang,Chennan Wu et al.
Jingjing Wan et al.
Reversing ventricular remodeling represents a promising treatment for the post-myocardial infarction (MI) heart failure (HF). Here, we report a novel small molecule HHQ16, an optimized derivative of astragaloside IV, which effectively rever...
From signalling pathways to targeted therapies: unravelling glioblastoma's secrets and harnessing two decades of progress [0.03%]
从信号通路到靶向治疗：揭开胶质母细胞瘤的秘密并利用二十年的研究成果
Brittany Dewdney,Misty R Jenkins,Sarah A Best et al.
Brittany Dewdney et al.
Glioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients alike. Despite advancements in brain cancer resear...
Anti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer [0.03%]
装备抗PD-1抗体的γδT细胞在卵巢癌中的抗癌效果增强效应
Yue Wang,Jingyi Han,Dongdong Wang et al.
Yue Wang et al.
γδ T cells have the unique ability to detect a wide range of tumors with low mutation burdens, making them attractive candidates for CAR-T-cell therapy. Unlike αβ T cells and other immune cells, γδ T cells are superior in MHC non-rest...
Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy [0.03%]
单细胞转录组分析揭示了COVID-19相关儿童脑病的系统性免疫失调
Yi Wang,Laurence Don Wai Luu,Shuang Liu et al.
Yi Wang et al.
Unraveling the molecular mechanisms for COVID-19-associated encephalopathy and its immunopathology is crucial for developing effective treatments. Here, we utilized single-cell transcriptomic analysis and integrated clinical observations an...
Neo-intline: integrated pipeline enables neoantigen design through the in-silico presentation of T-cell epitope [0.03%]
Neo-intline：集成化流程通过T细胞表位的计算机模拟呈递设计新生抗原
Bingyu Li,Ping Jing,Genhui Zheng et al.
Bingyu Li et al.
Neoantigen vaccines are one of the most effective immunotherapies for personalized tumour treatment. The current immunogen design of neoantigen vaccines is usually based on whole-genome sequencing (WGS) and bioinformatics prediction that fo...