Hua Miao,Fei Liu,Yan-Ni Wang et al.
Hua Miao et al.
Accumulated evidence suggested that gut microbial dysbiosis interplayed with progressive chronic kidney disease (CKD). However, no available therapy is effective in suppressing progressive CKD. Here, using microbiomics in 480 participants i...
Mengyuan He,Xiangxiang Zhou,Xin Wang
Mengyuan He
Protein post-translational modification (PTM) is a covalent process that occurs in proteins during or after translation through the addition or removal of one or more functional groups, and has a profound effect on protein function. Glycosy...
Revealing the crucial roles of suppressive immune microenvironment in cardiac myxoma progression [0.03%]
揭示抑制性免疫微环境在心脏黏液瘤进展中的关键作用
Zedong Jiang,Qianlong Kang,Hong Qian et al.
Zedong Jiang et al.
Cardiac myxoma is a commonly encountered tumor within the heart that has the potential to be life-threatening. However, the cellular composition of this condition is still not well understood. To fill this gap, we analyzed 75,641 cells from...
Mechanism insights and therapeutic intervention of tumor metastasis: latest developments and perspectives [0.03%]
肿瘤转移的机制见解和治疗干预：最新进展及展望
Xiaoli Shi,Xinyi Wang,Wentao Yao et al.
Xiaoli Shi et al.
Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-associated mortality. Despite its significance, the mechanisms governing metastasis are not fully elucidated. Contemporary findings in the domain...
Microglial complex I activity: a crucial factor for smoldering inflammation in the central nervous system [0.03%]
小胶质细胞复合物I活性：中枢神经系统阴燃性炎症的关键因素
Jana K Sonner,Christina Mayer,Manuel A Friese
Jana K Sonner
Adhesion G protein-coupled receptor latrophilin 1 (ADGRL1): a novel regulator of glucose and energy homeostasis [0.03%]
黏附G蛋白偶联受体_latrophilin-1（ADGRL1）:葡萄糖稳态和能量稳态的新调控因子
Kavaljit H Chhabra
Kavaljit H Chhabra
Hypoxia-induced nuclear localization of ubiquinol-cytochrome-c reductase complex assembly factor 3 (UQCC3) in hepatocellular carcinoma [0.03%]
缺氧诱导泛醌-细胞色素C还原酶组装因子3(UQCC3)向肝癌细胞核内的转移
Yun Yang,Yinhao Wei,Yiying Sun et al.
Yun Yang et al.
Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts [0.03%]
合成致死效应新机制：PARP抑制剂通过未解决的转录-复制冲突起效
Marina Kolesnichenko,Claus Scheidereit
Marina Kolesnichenko
CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation [0.03%]
CDC7抑製影响肺癌和前列腺肿瘤神经内分泌转化及MYC降解的研究
Alvaro Quintanal-Villalonga,Kenta Kawasaki,Esther Redin et al.
Alvaro Quintanal-Villalonga et al.
Neuroendocrine (NE) transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor prognosis. Up to date, even if patients at high risk of transformation can be identified by the occurre...
Proximity-dependent protein (de)stabilization: screening the human ORFeome for protein degraders and stabilizers [0.03%]
基于距离依赖的蛋白质((去)稳定化):筛选人类ORF蛋白数目用于蛋白降解和稳定
Thomas Hermanns,Kay Hofmann
Thomas Hermanns