Targeting the RAS/RAF/MAPK pathway for cancer therapy: from mechanism to clinical studies [0.03%]
针对RAS/RAF/MAPK通路的肿瘤治疗：从机制研究到临床试验
Md Entaz Bahar,Hyun Joon Kim,Deok Ryong Kim
Md Entaz Bahar
Metastatic dissemination of solid tumors, a leading cause of cancer-related mortality, underscores the urgent need for enhanced insights into the molecular and cellular mechanisms underlying metastasis, chemoresistance, and the mechanistic ...
Simultaneously targeting extracellular vesicle trafficking and TGF-β receptor kinase activity blocks signaling hyperactivation and metastasis [0.03%]
同时靶向细胞外囊泡转运和TGF-β受体激酶活性可抑制信号过度活化和转移
Adilson Fonseca Teixeira,Yanhong Wang,Josephine Iaria et al.
Adilson Fonseca Teixeira et al.
Metastasis is the leading cause of cancer-related deaths. Transforming growth factor beta (TGF-β) signaling drives metastasis and is strongly enhanced during cancer progression. Yet, the use of on-target TGF-β signaling inhibitors in the ...
Durable and enhanced immunity against SARS-CoV-2 elicited by manganese nanoadjuvant formulated subunit vaccine [0.03%]
锰纳米佐剂修饰亚单位疫苗诱导的持久增强型抗SARS-CoV-2免疫反应
Mengyu Guo,Mingjing Cao,Jiufeng Sun et al.
Mengyu Guo et al.
Long-COVID-19: the persisting imprint of SARS-CoV-2 infections on the innate immune system [0.03%]
长期COVID-19：SARS-CoV-2感染对先天性免疫系统的影响
Marianne Boes,Pascal Falter-Braun
Marianne Boes
Host cyclophilin A facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions [0.03%]
宿主环孢菌素A通过与病毒刺突蛋白结合并稳定囊泡上的刺突蛋白来促进新冠病毒的感染
Xiangpeng Sheng,Fang Zhu,Hong Peng et al.
Xiangpeng Sheng et al.
Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages [0.03%]
小胶质细胞谷氨酰胺酶1介导慢性束缚应激诱导的类似抑郁的行为和突触损伤
Huili Chen,Shengyang Fu,Xiangyu Li et al.
Huili Chen et al.
Development of a potent benzonitrile-based inhibitor of glutaminyl-peptide cyclotransferase-like protein (QPCTL) with antitumor efficacy [0.03%]
一种有效的苯腈类谷氨酰胺残基环化酶(QPCT)抑制剂的开发及其抗肿瘤功效
Lei Yu,Pengcheng Zhao,Yaoliang Sun et al.
Lei Yu et al.
Aberrant epithelial cell interaction promotes esophageal squamous-cell carcinoma development and progression [0.03%]
上皮细胞异常相互作用促进食管鳞状细胞癌的发生发展
Liping Chen,Shihao Zhu,Tianyuan Liu et al.
Liping Chen et al.
Epithelial-mesenchymal transition (EMT) and proliferation play important roles in epithelial cancer formation and progression, but what molecules and how they trigger EMT is largely unknown. Here we performed spatial transcriptomic and func...
Ting Fan,Mingna Zhang,Jingxian Yang et al.
Ting Fan et al.
With the development and regulatory approval of immune checkpoint inhibitors and adoptive cell therapies, cancer immunotherapy has undergone a profound transformation over the past decades. Recently, therapeutic cancer vaccines have shown p...
Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis [0.03%]
人类肌萎缩侧索硬化症的生物标志物：周边受体相互作用蛋白激酶1(RIPK1)和IL-8水平升高
Jun Wei,Min Li,Zhi Ye et al.
Jun Wei et al.
Amyotrophic lateral sclerosis (ALS) is a devastating fatal neurodegenerative disease with no cure. Receptor-interacting protein kinase 1 (RIPK1) has been proposed to mediate pathogenesis of ALS. Primidone has been identified as an old drug ...