Beyond the code: the role of histone methylation in cancer resistance and therapy [0.03%]
超越密码：组蛋白甲基化在癌症抗性和治疗中的作用
Daniel Noerenberg,Frederik Damm
Daniel Noerenberg
Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer [0.03%]
用于结直肠癌靶向联合治疗的遗传程序型细胞膜伪装纳米药物
Yun Yang,Qingya Liu,Meng Wang et al.
Yun Yang et al.
Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens, including prolonged circulation in the bloodstream, specific cell recognition and targeting capabilities, and po...
Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein [0.03%]
法尼基转移酶抑制剂lonafarnib通过阻断融合糖蛋白构象变化来抑制呼吸道合胞病毒感染
Qi Yang,Bao Xue,Fengjiang Liu et al.
Qi Yang et al.
Respiratory syncytial virus (RSV) is the major cause of bronchiolitis and pneumonia in young children and the elderly. There are currently no approved RSV-specific therapeutic small molecules available. Using high-throughput antiviral scree...
Correction: Anti-lymphangiogenesis for boosting drug accumulation in tumors [0.03%]
关于抗淋巴管生成作用的更正：增强肿瘤内药物蓄积的效果
Chunling Wang,Junchao Xu,Xiaoyu Cheng et al.
Chunling Wang et al.
Linking IL-10 signaling with lipid metabolic programs in macrophages: dysregulated ceramide homeostasis drives colitis [0.03%]
将IL-10信号与巨噬细胞脂质代谢程序联系起来：失调的神经酰胺稳态导致结肠炎
Imke Atreya,Markus F Neurath
Imke Atreya
Bo Cao,Qixuan Xu,Yajiao Shi et al.
Bo Cao et al.
Pain is estimated to affect more than 20% of the global population, imposing incalculable health and economic burdens. Effective pain management is crucial for individuals suffering from pain. However, the current methods for pain assessmen...
Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes [0.03%]
早期胰岛素治疗对新诊断的2型糖尿病患者心血管事件发生率的现实世界有效性研究
Sihui Luo,Xueying Zheng,Wei Bao et al.
Sihui Luo et al.
Early insulin therapy is capable to achieve glycemic control and restore β-cell function in newly diagnosed type 2 diabetes (T2D), but its effect on cardiovascular outcomes in these patients remains unclear. In this nationwide real-world s...
First-line penpulimab (an anti-PD1 antibody) and anlotinib (an angiogenesis inhibitor) with nab-paclitaxel/gemcitabine (PAAG) in metastatic pancreatic cancer: a prospective, multicentre, biomolecular exploratory, phase II trial [0.03%]
培米单抗（PD-1抗体）和阿帕替尼（血管生成抑制剂）与白蛋白紫杉醇/吉西他滨在转移性胰腺癌中的应用：一项前瞻性多中心生物分子探索Ⅱ期临床试验
Huizi Sha,Fan Tong,Jiayao Ni et al.
Huizi Sha et al.
Metastatic pancreatic cancer (mPC) has a dismal prognosis. Herein, we conducted a prospective, multicentre, single-arm, phase II trial evaluating the efficacy and safety of penpulimab and anlotinib in combination with nab-paclitaxel/gemcita...
Antitumor efficacy and potential mechanism of FAP-targeted radioligand therapy combined with immune checkpoint blockade [0.03%]
特异性FAP放射配体治疗联合免疫点抑制的抗肿瘤效果及潜在机制研究
Liang Zhao,Yizhen Pang,Yangfan Zhou et al.
Liang Zhao et al.
Radiotherapy combined with immune checkpoint blockade holds great promise for synergistic antitumor efficacy. Targeted radionuclide therapy delivers radiation directly to tumor sites. LNC1004 is a fibroblast activation protein (FAP)-targeti...
Macrophages in cardiovascular diseases: molecular mechanisms and therapeutic targets [0.03%]
心血管疾病的巨噬细胞：分子机制和治疗靶点
Runkai Chen,Hongrui Zhang,Botao Tang et al.
Runkai Chen et al.
The immune response holds a pivotal role in cardiovascular disease development. As multifunctional cells of the innate immune system, macrophages play an essential role in initial inflammatory response that occurs following cardiovascular i...