CXXC finger protein 1 (CFP1) bridges the reshaping of genomic H3K4me3 signature to the advancement of lung adenocarcinoma [0.03%]
CXXC指蛋白1(CFP1)通过重塑基因组H3K4me3修饰促进肺腺癌进展
Tao Fan,Chu Xiao,Hengchang Liu et al.
Tao Fan et al.
Histone H3 lysine 4 trimethylation (H3K4me3) is a canonical chromatin modification associated with active gene transcription, playing a pivotal role in regulating various cellular functions. Components of the H3K4me3 methyltransferase compl...
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys [0.03%]
tau蛋白病促进转基因猴脊髓源性毒性β淀粉样蛋白产生
Zhuchi Tu,Sen Yan,Bofeng Han et al.
Zhuchi Tu et al.
Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer's disease. However, the relatio...
Dynamic single-cell mapping unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response [0.03%]
动态单细胞鉴定揭示EB病毒印迹T细胞衰竭及治疗反应
Miao-Zhen Qiu,Chaoye Wang,Zhiying Wu et al.
Miao-Zhen Qiu et al.
Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined. This study aimed to finely c...
Gang Zhang,Tianyu Tang,Yinfeng Chen et al.
Gang Zhang et al.
mRNA vaccines have emerged as highly effective strategies in the prophylaxis and treatment of diseases, thanks largely although not totally to their extraordinary performance in recent years against the worldwide plague COVID-19. The huge s...
Cui Yuan,Zhenling Ma,Jiufeng Xie et al.
Cui Yuan et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), showing high infectiousness, resulted in an ongoing pandemic termed coronavirus disease 2019 (COVID-19). COVID-19 cases often experience acute respiratory distress syndrome, whic...
Long-term survival benefit of anti-PD-1 therapy in patients with relapsed or refractory classical Hodgkin lymphoma [0.03%]
抗PD-1治疗复发或难治性经典型霍奇金淋巴瘤患者的长期生存收益
Weiping Liu,Ningjing Lin,Xinqin Feng et al.
Weiping Liu et al.
Anti-programmed cell death-1 (anti-PD-1) therapies have shown a favorable efficacy and good tolerance for relapsed or refractory (r/r) classical Hodgkin lymphoma (cHL). However, there are limited data on long-term outcomes among patients wi...
NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension [0.03%]
CD38上调导致NAD+耗竭介导高血压病血压升高和血管损伤
Yumin Qiu,Shiyue Xu,Xi Chen et al.
Yumin Qiu et al.
Hypertension is characterized by endothelial dysfunction and arterial stiffness, which contribute to the pathogenesis of atherosclerotic cardiovascular diseases. Nicotinamide adenine dinucleotide (NAD+) is an indispensable cofactor in all l...
Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis [0.03%]
罗沙司通过改变大脑铁稳态上调缺氧诱导因子从而减弱药物奖赏作用
Pengju Yan,Ningning Li,Ming Ma et al.
Pengju Yan et al.
Substance use disorder remains a major challenge, with an enduring need to identify and evaluate new, translational targets for effective treatment. Here, we report the upregulation of Hypoxia-inducible factor-1α (HIF-1α) expression by ro...
Teng-Cheong Ha,Michael Morgan,Axel Schambach
Teng-Cheong Ha
Duration of humoral immunity from smallpox vaccination and its cross-reaction with Mpox virus [0.03%]
天花疫苗的体液免疫持续时间和其与Mpox病毒的交叉反应性
Entao Li,Xiaoping Guo,Dongxiang Hong et al.
Entao Li et al.
The ongoing pandemic caused by mpox virus (MPXV) has become an international public health emergency that poses a significant threat to global health. The vaccinia virus Tiantan strain (VTT) was used to vaccinate against smallpox in China 4...