Drug tolerant persister cell plasticity in cancer: A revolutionary strategy for more effective anticancer therapies [0.03%]
药物耐受性持久细胞的可塑性与癌症治疗：更有效的抗癌策略革命性方法
Jun He,Zejing Qiu,Jingjing Fan et al.
Jun He et al.
Non-genetic mechanisms have recently emerged as important drivers of anticancer drug resistance. Among these, the drug tolerant persister (DTP) cell phenotype is attracting more and more attention and giving a predominant non-genetic role i...
Gefitinib (an EGFR tyrosine kinase inhibitor) plus anlotinib (an multikinase inhibitor) for untreated, EGFR-mutated, advanced non-small cell lung cancer (FL-ALTER): a multicenter phase III trial [0.03%]
一项评价吉非替尼（表皮生长因子受体酪氨酸激酶抑制剂）联合阿帕替尼（一种多靶点激酶抑制剂）一线治疗携带EGFR突变的晚期非小细胞肺癌患者的有效性和安全性的Ⅲ期临床研究（FL-ALTER）
Hua-Qiang Zhou,Ya-Xiong Zhang,Gang Chen et al.
Hua-Qiang Zhou et al.
Dual inhibition of vascular endothelial growth factor and epidermal growth factor receptor (EGFR) signaling pathways offers the prospect of improving the effectiveness of EFGR-targeted therapy. In this phase 3 study (ClinicalTrial.gov: NCT0...
Current advance of nanotechnology in diagnosis and treatment for malignant tumors [0.03%]
纳米技术在恶性肿瘤诊断和治疗中的最新进展
Bilan Wang,Shiqi Hu,Yan Teng et al.
Bilan Wang et al.
Cancer remains a significant risk to human health. Nanomedicine is a new multidisciplinary field that is garnering a lot of interest and investigation. Nanomedicine shows great potential for cancer diagnosis and treatment. Specifically engi...
Potassium voltage-gated channel subfamily H member 2 (KCNH2) is a promising target for incretin secretagogue therapies [0.03%]
钾电压门控通道亚家族H成员2（KCNH2）是肠降糖素分泌促进疗法的一个颇有前景的作用靶点
Ying-Chao Yuan,Hao Wang,Ze-Ju Jiang et al.
Ying-Chao Yuan et al.
Derived from enteroendocrine cells (EECs), glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are pivotal incretin hormones crucial for blood glucose regulation. Medications of GLP-1 analogs and GLP-1 recepto...
Mark Helm,Marie-Luise Winz
Mark Helm
Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis [0.03%]
乙硫氨酸-S-甲基转移酶1活化剂A通过激活betaine-homocysteine S-methyltransferase 1改善肝脂肪变性疾病
Han Yan,Wenjun Liu,Rui Xiang et al.
Han Yan et al.
Nonalcoholic fatty liver disease (NAFLD) is a serious threat to public health, but its underlying mechanism remains poorly understood. In screening important genes using Gene Importance Calculator (GIC) we developed previously, ribosomal mo...
Single cell whole-genome sequencing of brain cells: age- and cell-type specific mutational profiles [0.03%]
单细胞全基因组测序揭示脑细胞特异的突变特征
Melania Capasso,N Ahmad Aziz
Melania Capasso
LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling [0.03%]
LIM域独有4(LMO4)通过增强IL-21-STAT3信号促进CD8+T细胞的干性及肿瘤排斥作用
Roland C Schelker,Jessica Fioravanti,Fabio Mastrogiovanni et al.
Roland C Schelker et al.
High frequencies of stem-like memory T cells in infusion products correlate with superior patient outcomes across multiple T cell therapy trials. Herein, we analyzed a published CRISPR activation screening to identify transcriptional regula...
Breaking barriers: noncanonical inflammasome executes blood-brain barrier disruption [0.03%]
突破屏障：非经典炎症小体执行血脑屏障破坏功能
Martin Dichgans,Jonas J Neher,Yaw Asare
Martin Dichgans
Jimeng Su,Ying Song,Zhipeng Zhu et al.
Jimeng Su et al.
Multicellular organisms are composed of diverse cell types that must coordinate their behaviors through communication. Cell-cell communication (CCC) is essential for growth, development, differentiation, tissue and organ formation, maintena...