Shouliang Wang,Haijiao Long,Lianjie Hou et al.
Shouliang Wang et al.
Mitochondria are dynamic organelles with multiple functions. They participate in necrotic cell death and programmed apoptotic, and are crucial for cell metabolism and survival. Mitophagy serves as a cytoprotective mechanism to remove superf...
CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties [0.03%]
CDK7-YAP-LDHD轴促进D型乳酸消除和铁死亡防御以支持类癌症干细胞特性
Mengzhu Lv,Ying Gong,Xuesong Liu et al.
Mengzhu Lv et al.
Reprogrammed cellular metabolism is essential for maintaining cancer stem cells (CSCs) state. Here, we report that mitochondrial D-lactate catabolism is a necessary initiating oncogenic event during tumorigenesis of esophageal squamous cell...
Metformin escape in prostate cancer by activating the PTGR1 transcriptional program through a novel super-enhancer [0.03%]
二甲双胍通过新型超级增强子激活PTGR1转录程序从而用于前列腺癌的逃逸
Jianheng Ye,Shanghua Cai,Yuanfa Feng et al.
Jianheng Ye et al.
The therapeutic efficacy of metformin in prostate cancer (PCa) appears uncertain based on various clinical trials. Metformin treatment failure may be attributed to the high frequency of transcriptional dysregulation, which leads to drug res...
Envonalkib versus crizotinib for treatment-naive ALK-positive non-small cell lung cancer: a randomized, multicenter, open-label, phase III trial [0.03%]
恩沙替尼对比克唑替尼治疗初治ALK阳性非小细胞肺癌患者：一项随机、开放、多中心III期临床研究
Yunpeng Yang,Jie Min,Nong Yang et al.
Yunpeng Yang et al.
Anaplastic lymphoma kinase (ALK) rearrangements are present in about 5-6% of non-small cell lung cancer (NSCLC) cases and associated with increased risks of central nervous system (CNS) involvement. Envonalkib, a novel ALK inhibitor, demons...
Jie Fu,Xin Zong,Mingliang Jin et al.
Jie Fu et al.
As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions in innate immunity, as well as their structure and ...
High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA [0.03%]
高密度脂蛋白通过长链非编码RNA HDRACA调节血管生成
Zhi-Wei Mo,Yue-Ming Peng,Yi-Xin Zhang et al.
Zhi-Wei Mo et al.
Normal high-density lipoprotein (nHDL) can induce angiogenesis in healthy individuals. However, HDL from patients with coronary artery disease undergoes various modifications, becomes dysfunctional (dHDL), and loses its ability to promote a...
A promising small molecule binding pocket in class B GPCRs: expanding potential for drug development [0.03%]
在B类G蛋白偶联受体中具有药物研发潜力的小分子结合位点的发现
Huan Xiao,Qian Sun,Qiu Sun
Huan Xiao
Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils [0.03%]
慢性肺部细菌感染通过募集促肿瘤MHCIIhi中性粒细胞促进乳腺癌肺转移
Teng Ma,Yu Tang,Taolin Wang et al.
Teng Ma et al.
Breast cancer can metastasize to various organs, including the lungs. The immune microenvironment of the organs to be metastasized plays a crucial role in the metastasis of breast cancer. Infection with pathogens such as viruses and bacteri...
Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics [0.03%]
单细胞转录组解析食管鳞癌新辅助治疗耐药机制的全景图
Yushang Yang,Yanguo Li,Haopeng Yu et al.
Yushang Yang et al.
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications [0.03%]
TET（ten-eleven转位）族蛋白：结构、生物学功能及应用
Xinchao Zhang,Yue Zhang,Chaofu Wang et al.
Xinchao Zhang et al.
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3, can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxycytosine ...