Targeting strategies for bone diseases: signaling pathways and clinical studies [0.03%]
骨疾病治疗策略：信号传导途径与临床研究
Hao Xu,Wentao Wang,Xin Liu et al.
Hao Xu et al.
Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to targeted drug delivery that emerged in the past decades, ...
Excitatory somatostatin interneurons in the dentate gyrus drive a widespread seizure network in cortical dysplasia [0.03%]
新皮层发育不良中齿状回兴奋性生长抑素阳性中间神经元驱动广泛癫痫网络
Yang Zheng,Cenglin Xu,Jinyi Sun et al.
Yang Zheng et al.
Seizures due to cortical dysplasia are notorious for their poor prognosis even with medications and surgery, likely due to the widespread seizure network. Previous studies have primarily focused on the disruption of dysplastic lesions, rath...
Epidemiological and clinical features of children with the Omicron BA.5.2 subvariant in Guangzhou [0.03%]
广州奥密克戎变异株BA.5.2亚分支儿童病例的流行病学及临床特点
Feng Li,Yinghua He,Xianglong Lan et al.
Feng Li et al.
SYK-mediated epithelial cell state is associated with response to c-Met inhibitors in c-Met-overexpressing lung cancer [0.03%]
SYK介导的上皮细胞状态与c-Met扩增型肺癌小分子抑制剂疗效相关性研究
Ji Zhou,Xu-Chao Zhang,Shan Xue et al.
Ji Zhou et al.
Genomic MET amplification and exon 14 skipping are currently clinically recognized biomarkers for stratifying subsets of non-small cell lung cancer (NSCLC) patients according to the predicted response to c-Met inhibitors (c-Metis), yet the ...
Role of the gut microbiota in anticancer therapy: from molecular mechanisms to clinical applications [0.03%]
肠道菌群在抗癌治疗中的作用：从分子机制到临床应用
Lin-Yong Zhao,Jia-Xin Mei,Gang Yu et al.
Lin-Yong Zhao et al.
In the past period, due to the rapid development of next-generation sequencing technology, accumulating evidence has clarified the complex role of the human microbiota in the development of cancer and the therapeutic response. More importan...
Zaoqu Liu,Qimeng Liang,Yuqing Ren et al.
Zaoqu Liu et al.
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms are linked to innate and adaptive immune dysfunction that accompanies aging (known as immunosenescence). During aging, organisms tend to develop a...
Angiogenic signaling pathways and anti-angiogenic therapy for cancer [0.03%]
癌症的血管生成信号转导途径及抗血管生成功效治疗
Zhen-Ling Liu,Huan-Huan Chen,Li-Li Zheng et al.
Zhen-Ling Liu et al.
Angiogenesis, the formation of new blood vessels, is a complex and dynamic process regulated by various pro- and anti-angiogenic molecules, which plays a crucial role in tumor growth, invasion, and metastasis. With the advances in molecular...
A kidney-brain neural circuit drives progressive kidney damage and heart failure [0.03%]
肾脏-大脑神经回路驱动进行性肾损伤和心力衰竭
Wei Cao,Zhichen Yang,Xiaoting Liu et al.
Wei Cao et al.
Chronic kidney disease (CKD) and heart failure (HF) are highly prevalent, aggravate each other, and account for substantial mortality. However, the mechanisms underlying cardiorenal interaction and the role of kidney afferent nerves and the...
Xu Yan,Xu Liu,Cuihuan Zhao et al.
Xu Yan et al.
Synthetic biology aims to design or assemble existing bioparts or bio-components for useful bioproperties. During the past decades, progresses have been made to build delicate biocircuits, standardized biological building blocks and to deve...
Xia Kang,Yuqi Gao,So-Ichiro Fukada et al.
Xia Kang et al.