Transcriptional-translational conflict: a novel exploitable tumor suppressive mechanism [0.03%]
转录-翻译冲突：一种新颖的可利用的肿瘤抑制机制
Maria Mudryj,Paramita M Ghosh
Maria Mudryj
Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors [0.03%]
单纯疱疹病毒增效DNA损伤响应抑制剂协同作用杀伤非小细胞肺癌研究
Bopei Cui,Lifang Song,Qian Wang et al.
Bopei Cui et al.
With the continuous in-depth study of the interaction mechanism between viruses and hosts, the virus has become a promising tool in cancer treatment. In fact, many oncolytic viruses with selectivity and effectiveness have been used in cance...
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity [0.03%]
分泌的LRPAP1结合并诱导IFNAR1降解以促进病毒逃避免疫反应
Huangcan Li,Xiong Wang,Yiran Wang et al.
Huangcan Li et al.
The crucial role of interferon (IFN) signaling is well known in the restriction or eradication of pathogen invasion. Viruses take a variety of ways to antagonize host defense through eliminating IFN-signaling intracellularly for decades. Ho...
Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines [0.03%]
基线肠道微生物组和代谢组预测对SARS-CoV-2疫苗的持久免疫反应
Ye Peng,Lin Zhang,Chris K P Mok et al.
Ye Peng et al.
The role of gut microbiota in modulating the durability of COVID-19 vaccine immunity is yet to be characterised. In this cohort study, we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline, 1 month, and...
Priyanka Bhatia,Jared Sterneckert
Priyanka Bhatia
Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2 [0.03%]
羟基羧酸受体HCAR2的正向配体选择性及变构探针依赖性
Lin Cheng,Suyue Sun,Heli Wang et al.
Lin Cheng et al.
Hydroxycarboxylic acid receptor 2 (HCAR2), a member of Class A G-protein-coupled receptor (GPCR) family, plays a pivotal role in anti-lipolytic and anti-inflammatory effects, establishing it as a significant therapeutic target for treating ...
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets [0.03%]
神经退行性疾病的小胶质细胞作用机制及潜在治疗靶点研究进展
Chao Gao,Jingwen Jiang,Yuyan Tan et al.
Chao Gao et al.
Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity. Some identified microglia in ...
Targeting ferroptosis opens new avenues for the development of novel therapeutics [0.03%]
靶向铁死亡开启药物研发新思路
Shumin Sun,Jie Shen,Jianwei Jiang et al.
Shumin Sun et al.
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense against oxidative stress, and abnormal lipid peroxidation. Recent studies have provided compell...
A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir [0.03%]
一种病毒RNA依赖性RNA聚合酶抑制剂VV116可广谱抑制人类冠状病毒且与3CL蛋白酶抑制剂奈玛特韦具有协同作用
Yumin Zhang,Yuan Sun,Yuanchao Xie et al.
Yumin Zhang et al.
During the ongoing pandemic, providing treatment consisting of effective, low-cost oral antiviral drugs at an early stage of SARS-CoV-2 infection has been a priority for controlling COVID-19. Although Paxlovid and molnupiravir have received...
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation [0.03%]
cGAS-STING途径介导的线粒体DNA感应调节眼部表面炎症反应
Weijie Ouyang,Shoubi Wang,Dan Yan et al.
Weijie Ouyang et al.
The innate immune response is the main pathophysiological process of ocular surface diseases exposed to multiple environmental stresses. The epithelium is central to the innate immune response, but whether and how innate immunity is initiat...