Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment [0.03%]
发现新型非肽类和非共价小分子3CL蛋白酶抑制剂作为COVID-19治疗候选药物
Zhidong Jiang,Bo Feng,Yumin Zhang et al.
Zhidong Jiang et al.
Epigenetic regulation in the tumor microenvironment: molecular mechanisms and therapeutic targets [0.03%]
肿瘤微环境中的表观遗传调控：分子机制和治疗靶点
Jing Yang,Jin Xu,Wei Wang et al.
Jing Yang et al.
Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA methylation, chromatin remodeling, RNA modification, and noncoding RNAs modulate many biological processes that are cruci...
Deciphering dynamic changes of the aging transcriptome with COVID-19 progression and convalescence in the human blood [0.03%]
解析人类血液中随着COVID-19病程发展和康复的衰老转录组的动态变化
Ran Li,Jing Zou,Dongling Pei et al.
Ran Li et al.
Shanze Chen,Abdullah F U H Saeed,Quan Liu et al.
Shanze Chen et al.
Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers. Macrophages possess binary M1/M2 macrophage polar...
Repression of interferon regulatory factor-4 (IRF4) hyperactivation restricts murine lupus [0.03%]
抑制干扰素调节因子-4（IRF4）的过度活化可限制小鼠系统性红斑狼疮的发展
Shijun He,Huihua Ding,Li Chen et al.
Shijun He et al.
SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor [0.03%]
携带ACE2受体的VSV颗粒对SARS-CoV-2的抑制及感染细胞的特异性靶向作用
Fabian Zech,Stefanie Weber,Hanna Dietenberger et al.
Fabian Zech et al.
Radiation-induced tumor immune microenvironments and potential targets for combination therapy [0.03%]
辐射诱发的肿瘤免疫微环境及联合治疗潜在靶点
Siyu Guo,Yihan Yao,Yang Tang et al.
Siyu Guo et al.
As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery....
Relevance of Spike/Estrogen Receptor-α interaction for endothelial-based coagulopathy induced by SARS-CoV-2 [0.03%]
SARS-CoV-2诱导的基于内皮细胞的凝血病与Spike/雌激素受体-α相互作用的相关性研究
Silvia Stella Barbieri,Franca Cattani,Leonardo Sandrini et al.
Silvia Stella Barbieri et al.
Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer [0.03%]
Jak-Stat信号转导通路的进化认知：自身免疫性疾病和癌症中的作用
Chen Xue,Qinfan Yao,Xinyu Gu et al.
Chen Xue et al.
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment. Variou...
FBXW7β loss-of-function enhances FASN-mediated lipogenesis and promotes colorectal cancer growth [0.03%]
FBXW7β失活通过增强FASN介导的脂质合成促进结直肠癌生长
Wenxia Wei,Baifu Qin,Weijie Wen et al.
Wenxia Wei et al.
Continuous de novo fatty acid synthesis is required for the biosynthetic demands of tumor. FBXW7 is a highly mutated gene in CRC, but its biological functions in cancer are not fully characterized. Here, we report that FBXW7β, a FBXW7 isof...