Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β [0.03%]
新型自噬诱导剂微小隆素H通过靶向磷脂转运蛋白PITPα/β发挥强大的抗肿瘤活性
Hange Yang,Xiaowei Zhang,Cong Wang et al.
Hange Yang et al.
The identification of effective drug targets and the development of bioactive molecules are areas of high need in cancer therapy. The phosphatidylinositol transfer protein alpha/beta isoform (PITPα/β) has been reported to play an essentia...
Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases [0.03%]
转录共激活因子：在信号通路中的新角色及其可能成为疾病的治疗靶点
Priyanka Dey Talukdar,Urmi Chatterji
Priyanka Dey Talukdar
Specific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate synergic interactions between transcription factors and the co-activators. Deregulation of these regulatory molecules i...
Metatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients [0.03%]
重症监护病房中奥密克戎患者机械通气期间人肺微生物群的元转录组分析
Lin Wang,Jia-Bao Cao,Bin-Bin Xia et al.
Lin Wang et al.
The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the disease and fatality is valuable...
Yuqing Mei,Jingjing Wang,Guoji Guo
Yuqing Mei
Yang Yang,Lu Guo,Lin Chen et al.
Yang Yang et al.
Proper subcellular localization is crucial for the functioning of biomacromolecules, including proteins and RNAs. Nuclear transport is a fundamental cellular process that regulates the localization of many macromolecules within the nuclear ...
The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling [0.03%]
一种肿瘤富集小分子格姆博酸酰胺通过靶向WDR1依赖性细胞骨架重塑抑制胶质瘤
Jiaorong Qu,Bojun Qiu,Yuxin Zhang et al.
Jiaorong Qu et al.
Glioma is the most prevalent brain tumor, presenting with limited treatment options, while patients with malignant glioma and glioblastoma (GBM) have poor prognoses. The physical obstacle to drug delivery imposed by the blood‒brain barrier...
Ekaterina Pylaeva,Jadwiga Jablonska
Ekaterina Pylaeva
Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy [0.03%]
溴结构域和末端外结构域蛋白：生物学功能、相关疾病及靶向治疗研究进展
Zhi-Qiang Wang,Zhao-Cong Zhang,Yu-Yang Wu et al.
Zhi-Qiang Wang et al.
BET proteins, which influence gene expression and contribute to the development of cancer, are epigenetic interpreters. Thus, BET inhibitors represent a novel form of epigenetic anticancer treatment. Although preliminary clinical trials hav...