From the unknown to spotlight: newly identified hormone adjusts hepatic cholesterol synthesis to dietary uptake [0.03%]
从无到有：新发现的激素调控肝脏胆固醇生物合成以适应饮食摄入变化
Yakum Bertrand Nkeh,Resul Gökberk Elgin,Gesine Saher
Yakum Bertrand Nkeh
Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection [0.03%]
优化RNA干扰疗法联合白细胞介素-2信使核糖核酸治疗乙型肝炎病毒感染
Wenjing Zai,Min Yang,Kuan Jiang et al.
Wenjing Zai et al.
This study aimed to develop a pan-genotypic and multifunctional small interfering RNA (siRNA) against hepatitis B virus (HBV) with an efficient delivery system for treating chronic hepatitis B (CHB), and explore combined RNA interference (R...
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets [0.03%]
肿瘤的启动和早期发生：分子机制和干预靶点
Shaosen Zhang,Xinyi Xiao,Yonglin Yi et al.
Shaosen Zhang et al.
Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring clonal advantage as the initial event. However, despite pervasive somatic mutations and clonal expansion in normal tissues, their transformation into...
Penpulimab, an anti-PD-1 antibody, for heavily pretreated metastatic nasopharyngeal carcinoma: a single-arm phase II study [0.03%]
派安普利单抗治疗复发或转移性鼻咽癌患者的II期临床试验
Xiaozhong Chen,Wei Wang,Qingfeng Zou et al.
Xiaozhong Chen et al.
Penpulimab is an anti-programmed cell death-1 (PD-1) IgG1 antibody with no Fc gamma receptor (FcγR) binding activity, and thus theoretically reduced immune-related adverse events (irAEs) while maintaining efficacy. This single-arm, phase I...
Cellular precision modulation of JAK1: tailoring therapies for allergic lung inflammation [0.03%]
细胞内JAK1精准调控：针对过敏性肺部炎症的个体化治疗
Xiaocheng Yan,Siegfried Ussar
Xiaocheng Yan
Lola Zerbib,Sophia Ladraa,Antoine Fraissenon et al.
Lola Zerbib et al.
Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK, an endothelial transmembrane receptor signaling through PIK3CA. Venous malformations are associated with pain, blee...
DNA of neutrophil extracellular traps promote NF-κB-dependent autoimmunity via cGAS/TLR9 in chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病中NETs DNA通过cGAS/TLR9信号通路促进NF-κB依赖性的自身免疫反应
Jun Chen,Tao Wang,Xiaoou Li et al.
Jun Chen et al.
Chronic obstructive pulmonary disease (COPD) is characterised by persistent airway inflammation even after cigarette smoking cessation. Neutrophil extracellular traps (NETs) have been implicated in COPD severity and acute airway inflammatio...
Neoadjuvant camrelizumab (an anti-PD-1 antibody) plus chemotherapy or apatinib (a VEGFR-2 inhibitor) for initially unresectable stage II-III non-small-cell lung cancer: a multicentre, two-arm, phase 2 exploratory study [0.03%]
特瑞普利单抗联合化疗或阿帕替尼对比单纯化疗新辅助治疗可切除II-IIIA期非小细胞肺癌的临床研究
Haoran Xia,Han Zhang,Zheng Ruan et al.
Haoran Xia et al.
This multicentre, two-arm, phase 2 study aimed to explore the efficacy and safety of neoadjuvant camrelizumab plus chemotherapy or apatinib in patients with initially unresectable stage II-III non-small-cell lung cancer (NSCLC). Eligible pa...
Nonconserved epitopes dominate reverse preexisting T cell immunity in COVID-19 convalescents [0.03%]
非保守表位主导COVID-19康复者的既往存在的T细胞免疫反应
Xin Wang,Jie Zhang,Maoshun Liu et al.
Xin Wang et al.
The herd immunity against SARS-CoV-2 is continuously consolidated across the world during the ongoing pandemic. However, the potential function of the nonconserved epitopes in the reverse preexisting cross-reactivity induced by SARS-CoV-2 t...