Gut microbe-derived metabolite indole-3-carboxaldehyde alleviates atherosclerosis [0.03%]
肠道微生物衍生代谢物吲哚-3-甲醛可缓解动脉粥样硬化
Yijing Lu,Wenlong Yang,Zhiyong Qi et al.
Yijing Lu et al.
Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition [0.03%]
无菌无虑：受损皮肤通过IL-24独立于病原识别启动修复过程
Ruben A Ferrer,Marta Torregrossa,Sandra Franz
Ruben A Ferrer
Safeguarding transcriptional memory: a mitotic bookmarking role for chromatin remodelers [0.03%]
染色质重塑酶在分裂过程中守护转录记忆的机制研究
Godwin Sokpor,Huu Phuc Nguyen,Tran Tuoc
Godwin Sokpor
Artificial sweetener sucralose: a possible modulator of autoimmune diseases [0.03%]
人造甜味剂蔗糖素：可能的自身免疫疾病调节因子
Nicolle Kränkel,Ursula Rauch-Kroehnert
Nicolle Kränkel
Ras homolog family member J (RHOJ): a key regulator of chemoresistance associated with epithelial-mesenchymal transition [0.03%]
Rho家族小G蛋白成员J(RHOJ)：与上皮间质转化相关的化疗耐药的关键调节因子
Sijia Liu,Jiang Ren,Long Zhang
Sijia Liu
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease [0.03%]
mTOR（哺乳动物雷帕霉素靶点）信号通路在人类健康和疾病中的多面作用
Vivek Panwar,Aishwarya Singh,Manini Bhatt et al.
Vivek Panwar et al.
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain cellular homeostasis. The mTOR signaling cascade co...
STAT5 promotes PD-L1 expression by facilitating histone lactylation to drive immunosuppression in acute myeloid leukemia [0.03%]
STAT5通过促进组蛋白乳酸化来促进PD-L1表达以驱动急性髓系白血病免疫抑制作用
Ze-Wei Huang,Xue-Ning Zhang,Ling Zhang et al.
Ze-Wei Huang et al.
Immunotherapy is a revolutionized therapeutic strategy for tumor treatment attributing to the rapid development of genomics and immunology, and immune checkpoint inhibitors have successfully achieved responses in numbers of tumor types, inc...
Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study [0.03%]
原发肿瘤与继发肿瘤的基因差异——全基因组对比研究
Lei Zhong,Zhipeng Zhao,Xiaonan Zhang
Lei Zhong
Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions [0.03%]
淋巴结转移在癌症进展中的分子机制、临床意义和治疗干预措施
Haoran Ji,Chuang Hu,Xuhui Yang et al.
Haoran Ji et al.
Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune modulation, and secondary dissemination to distant sites through a series of mechanisms, and it has been proved that lymph node metastasis (LNM) is an essent...
Combined FOLFOX4 with all-trans retinoic acid versus FOLFOX4 with placebo in treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a randomized, double-blind comparative study [0.03%]
联合全反式维甲酸与FOLFOX4对比安慰剂联合FOLFOX4治疗肝细胞癌伴远处转移的疗效：一项随机、双盲临床研究
Juxian Sun,Feifei Mao,Chang Liu et al.
Juxian Sun et al.
The majority of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage. Currently, there are only a few therapeutic methods available for patients with advanced HCC and extrahepatic metastasis (EHM). Systemic chemotherapy, ...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2023 Sep 27;8(1):368. DOI:10.1038/s41392-023-01604-3 2023