Zhe-Nan Ling,Yi-Fan Jiang,Jun-Nan Ru et al.
Zhe-Nan Ling et al.
Amino acids are the building blocks of protein synthesis. They are structural elements and energy sources of cells necessary for normal cell growth, differentiation and function. Amino acid metabolism disorders have been linked with a numbe...
RNA binding protein TIAR modulates HBV replication by tipping the balance of pgRNA translation [0.03%]
RNA结合蛋白TIAR通过调节pgRNA的翻译水平来调控HBV复制
Ting Zhang,Huiling Zheng,Danjuan Lu et al.
Ting Zhang et al.
The pregenomic RNA (pgRNA) of hepatitis B virus (HBV) serves not only as a bicistronic message RNA to translate core protein (Cp) and DNA polymerase (Pol), but also as the template for reverse transcriptional replication of viral DNA upon p...
Oit3, a promising hallmark gene for targeting liver sinusoidal endothelial cells [0.03%]
具有潜力作为靶向肝窦状内皮细胞标志物的Oit3基因
Zhi-Wen Li,Bai Ruan,Pei-Jun Yang et al.
Zhi-Wen Li et al.
Liver sinusoidal endothelial cells (LSECs) play a pivotal role in maintaining liver homeostasis and influencing the pathological processes of various liver diseases. However, neither LSEC-specific hallmark genes nor a LSEC promoter-driven C...
CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability [0.03%]
CBX4缺失通过诱导基因组不稳定性促进KrasG12D背景下的肿瘤发生
Fangzhen Chen,Wulei Hou,Xiangtian Yu et al.
Fangzhen Chen et al.
Chromobox protein homolog 4 (CBX4) is a component of the Polycomb group (PcG) multiprotein Polycomb repressive complexes 1 (PRC1), which is participated in several processes including growth, senescence, immunity, and tissue repair. CBX4 ha...
Dun Niu,Yaran Wu,Jiqin Lian
Dun Niu
CircRNAs are a class of single-stranded RNAs with covalently linked head-to-tail topology. In the decades since its initial discovery, their biogenesis, regulation, and function have rapidly disclosed, permitting a better understanding and ...
Temporospatial inhibition of Erk signaling is required for lymphatic valve formation [0.03%]
时空抑制Erk信号通路对形成淋巴管瓣膜是必需的
Yaping Meng,Tong Lv,Junfeng Zhang et al.
Yaping Meng et al.
Intraluminal lymphatic valves (LVs) and lymphovenous valves (LVVs) are critical to ensure the unidirectional flow of lymphatic fluid. Morphological abnormalities in these valves always cause lymph or blood reflux, and result in lymphedema. ...
Targeting copper to combat macrophage-driven inflammation: a potential advanced therapeutic strategy [0.03%]
靶向铜以对抗巨噬细胞驱动的炎症：潜在的先进治疗策略
Ralf Weiskirchen
Ralf Weiskirchen
Qi Li,Wenyuan Qian,Yang Zhang et al.
Qi Li et al.
Genome instability has been identified as one of the enabling hallmarks in cancer. DNA damage response (DDR) network is responsible for maintenance of genome integrity in cells. As cancer cells frequently carry DDR gene deficiencies or suff...
A metabolome atlas of mouse brain on the global metabolic signature dynamics following short-term fasting [0.03%]
小鼠短期饥饿后的脑代谢轮廓及整体代谢标志变化图集
Yaping Shao,Zhenfa Fu,Yanfeng Wang et al.
Yaping Shao et al.
Calorie restriction (CR) or a fasting regimen is considered one of the most potent non-pharmacological interventions to prevent chronic metabolic disorders, ameliorate autoimmune diseases, and attenuate aging. Despite efforts, the mechanism...
Cancer cells evade ferroptosis: sex hormone-driven membrane-bound O-acyltransferase domain-containing 1 and 2 (MBOAT1/2) expression [0.03%]
癌细胞逃逸铁死亡：性激素驱动的膜结合O-酰基转移酶结构域含1和2（MBOAT1/2）表达
Alexia Belavgeni,Wulf Tonnus,Andreas Linkermann
Alexia Belavgeni