Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy [0.03%]
单细胞转录组分析揭示了COVID-19相关儿童脑病的系统性免疫失调
Yi Wang,Laurence Don Wai Luu,Shuang Liu et al.
Yi Wang et al.
Unraveling the molecular mechanisms for COVID-19-associated encephalopathy and its immunopathology is crucial for developing effective treatments. Here, we utilized single-cell transcriptomic analysis and integrated clinical observations an...
Neo-intline: integrated pipeline enables neoantigen design through the in-silico presentation of T-cell epitope [0.03%]
Neo-intline：集成化流程通过T细胞表位的计算机模拟呈递设计新生抗原
Bingyu Li,Ping Jing,Genhui Zheng et al.
Bingyu Li et al.
Neoantigen vaccines are one of the most effective immunotherapies for personalized tumour treatment. The current immunogen design of neoantigen vaccines is usually based on whole-genome sequencing (WGS) and bioinformatics prediction that fo...
Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm [0.03%]
囊液糖蛋白准确区分胰腺粘液性肿瘤的恶性病变
Ming Cui,Ya Hu,Zejian Zhang et al.
Ming Cui et al.
Pancreatic cystic neoplasms (PCNs) are recognized as precursor lesions of pancreatic cancer, with a marked increase in prevalence. Early detection of malignant PCNs is crucial for improving prognosis; however, current diagnostic methods are...
Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling [0.03%]
表观遗传调控的TP53参与前列腺癌的放射抵抗及DNA损伤应答信号通路
Catarina Macedo-Silva,Vera Miranda-Gonçalves,Nuno Tiago Tavares et al.
Catarina Macedo-Silva et al.
External beam radiotherapy (RT) is a leading first-line therapy for prostate cancer (PCa), and, in recent years, significant advances have been accomplished. However, RT resistance can arise and result in long-term recurrence or disease pro...
Activated STING: an ion channel to trigger non-interferon-related functions [0.03%]
激活的STING：一种触发非干扰素相关功能的离子通道
Zhengyu Gao,Bin Wang,Long Zhang
Zhengyu Gao
Cephalopod RNA recoding: linking protein plasticity to thermal adaptation and catalyzing beyond-species protein characterization [0.03%]
头足类动物的RNA重编码：连接蛋白质变异性与热适应性并促进跨物种蛋白表征
Junyi Wang,Guoping Li,Min Wu
Junyi Wang
Correction: Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment [0.03%]
纠正：新型非肽键和非共价小分子3CLpro抑制剂作为COVID-19治疗候选药物的发现
Zhidong Jiang,Bo Feng,Yumin Zhang et al.
Zhidong Jiang et al.
Safety and clinical efficacy of sintilimab (anti-PD-1) in pediatric patients with advanced or recurrent malignancies in a phase I study [0.03%]
特瑞普利单抗（抗PD-1）治疗晚期或复发恶性肿瘤儿童患者的安全性和临床疗效I期研究
Yi Que,Juan Wang,Feifei Sun et al.
Yi Que et al.
The aim of this phase I study is to evaluate, for the first time, the safety and efficacy of sintilimab in pediatric patients diagnosed with advanced or recurrent malignancies. During the dose escalation phase, patients received a single in...
Astrocytes in human central nervous system diseases: a frontier for new therapies [0.03%]
人中枢神经系统疾病中的星形胶质细胞：新疗法的前沿阵地
Alexei Verkhratsky,Arthur Butt,Baoman Li et al.
Alexei Verkhratsky et al.
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS). Astroglia contribute to the pathophysiology of all neurological and neuropsychiatric disorders in w...
Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression [0.03%]
巨噬细胞CARD9通过调节脂联素2表达介导心肌梗死后的的心脏损伤
Yan Liu,Yi-Hui Shao,Jun-Meng Zhang et al.
Yan Liu et al.
Immune cell infiltration in response to myocyte death regulates extracellular matrix remodeling and scar formation after myocardial infarction (MI). Caspase-recruitment domain family member 9 (CARD9) acts as an adapter that mediates the tra...