NAD+ exhaustion by CD38 upregulation contributes to blood pressure elevation and vascular damage in hypertension [0.03%]
CD38上调导致NAD+耗竭介导高血压病血压升高和血管损伤
Yumin Qiu,Shiyue Xu,Xi Chen et al.
Yumin Qiu et al.
Hypertension is characterized by endothelial dysfunction and arterial stiffness, which contribute to the pathogenesis of atherosclerotic cardiovascular diseases. Nicotinamide adenine dinucleotide (NAD+) is an indispensable cofactor in all l...
Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis [0.03%]
罗沙司通过改变大脑铁稳态上调缺氧诱导因子从而减弱药物奖赏作用
Pengju Yan,Ningning Li,Ming Ma et al.
Pengju Yan et al.
Substance use disorder remains a major challenge, with an enduring need to identify and evaluate new, translational targets for effective treatment. Here, we report the upregulation of Hypoxia-inducible factor-1α (HIF-1α) expression by ro...
Teng-Cheong Ha,Michael Morgan,Axel Schambach
Teng-Cheong Ha
Duration of humoral immunity from smallpox vaccination and its cross-reaction with Mpox virus [0.03%]
天花疫苗的体液免疫持续时间和其与Mpox病毒的交叉反应性
Entao Li,Xiaoping Guo,Dongxiang Hong et al.
Entao Li et al.
The ongoing pandemic caused by mpox virus (MPXV) has become an international public health emergency that poses a significant threat to global health. The vaccinia virus Tiantan strain (VTT) was used to vaccinate against smallpox in China 4...
Xingyi Chen,Chaoran Shi,Meihui He et al.
Xingyi Chen et al.
The endoplasmic reticulum (ER) functions as a quality-control organelle for protein homeostasis, or "proteostasis". The protein quality control systems involve ER-associated degradation, protein chaperons, and autophagy. ER stress is activa...
RBFOX2: a key factor in suppressing PDAC metastasis through regulation of alternative splicing events [0.03%]
RBFOX2通过调控可变剪接事件抑制胰腺癌转移
Laura Urbach,Shiv K Singh
Laura Urbach
MDIG-mediated H3K9me3 demethylation upregulates Myc by activating OTX2 and facilitates liver regeneration [0.03%]
MDIG介导的H3K9me3去甲基化通过激活OTX2上调Myc以促进肝再生
Jinpeng Du,Wenwei Liao,Haichuan Wang et al.
Jinpeng Du et al.
The mineral dust-induced gene (MDIG) comprises a conserved JmjC domain and has the ability to demethylate histone H3 lysine 9 trimethylation (H3K9me3). Previous studies have indicated the significance of MDIG in promoting cell proliferation...
Broadly neutralizing antibodies derived from the earliest COVID-19 convalescents protect mice from SARS-CoV-2 variants challenge [0.03%]
从最早的新冠肺炎康复者中获得的广谱中和抗体可保护小鼠免受新冠病毒变种的攻击
Qianyun Liu,Haiyan Zhao,Zhiqiang Li et al.
Qianyun Liu et al.
Coronavirus disease 2019 (COVID-19) was first reported three years ago, when a group of individuals were infected with the original SARS-CoV-2 strain, based on which vaccines were developed. Here, we develop six human monoclonal antibodies ...
Impact of genetic patterns on sorafenib efficacy in patients with FLT3-ITD acute myeloid leukemia undergoing allogeneic hematopoietic stem cell transplantation: a multi-center, cohort study [0.03%]
基因型式对FLT3-ITD阳性急性髓系白血病患者异基因造血干细胞移植后索拉非尼疗效影响的多中心队列研究
Ruoyang Shao,Yu Zhang,Jinping He et al.
Ruoyang Shao et al.
Sorafenib therapy improves overall survival (OS) in patients with FLT3 internal tandem duplication (ITD) acute myeloid leukemia (AML) undergoing allogeneic hematopoietic stem cell transplantation. We explored the efficacy of sorafenib thera...
Skeletal muscle-directed gene therapy: hijacking the fusogenic properties of muscle cells [0.03%]
肌细胞融合特性在骨骼肌定向基因治疗中的应用
Hildegard Büning,Michael Morgan,Axel Schambach
Hildegard Büning