Palmitoylation regulates myelination by modulating the ZDHHC3-Cadm4 axis in the central nervous system [0.03%]
棕榈酰化通过调节ZDHHC3-Cadm4轴调控中枢神经系统的髓鞘形成
Yanli Chang,Jiangli Zhu,Xiaopeng Li et al.
Yanli Chang et al.
The downregulation of Cadm4 (Cell adhesion molecular 4) is a prominent feature in demyelination diseases, yet, the underlying molecular mechanism remains elusive. Here, we reveal that Cadm4 undergoes specific palmitoylation at cysteine-347 ...
A systemic look at pancreatic cancer patients: Predicting metastasis by studying the liver [0.03%]
系统研究胰腺癌病人：通过研究肝脏预测转移现象
Susanne Roth,Christoph Michalski,Jörg D Hoheisel
Susanne Roth
Characterization of ferroptosis-triggered pyroptotic signaling in heart failure [0.03%]
心力衰竭中由铁死亡触发的细胞焦亡信号特征研究
Xukun Bi,Xiaotian Wu,Jiaqi Chen et al.
Xukun Bi et al.
Pressure overload-induced cardiac hypertrophy is a common cause of heart failure (HF), and emerging evidence suggests that excessive oxidized lipids have a detrimental effect on cardiomyocytes. However, the key regulator of lipid toxicity i...
Surufatinib plus toripalimab combined with etoposide and cisplatin as first-line treatment in advanced small-cell lung cancer patients: a phase Ib/II trial [0.03%]
苏瑞替尼联合拓益和依托法普利作为小细胞肺癌一线治疗：一项Ib/II期临床试验
Yaxiong Zhang,Yan Huang,Yunpeng Yang et al.
Yaxiong Zhang et al.
There is still room for improvement in first-line treatment of advanced small cell lung cancer (SCLC). This trial firstly investigated efficacy and safety of antiangiogenic therapy (surufatinib) (200 mg, qd, po) plus anti-PD-1 treatment (to...
GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia [0.03%]
GRP75诱导白色脂肪组织褐变促进癌症恶病质
Xu Chen,Qingnan Wu,Wei Gong et al.
Xu Chen et al.
Cachexia, which affects 50-80% of cancer patients, is a debilitating syndrome that leads to 20% of cancer-related deaths. A key feature of cachexia is adipose tissue atrophy, but how it contributes to the development of cachexia is poorly u...
Pre-metastatic niche: formation, characteristics and therapeutic implication [0.03%]
前转移灶龛：形成、特征及治疗意义
Yuhang Wang,Jiachi Jia,Fuqi Wang et al.
Yuhang Wang et al.
Distant metastasis is a primary cause of mortality and contributes to poor surgical outcomes in cancer patients. Before the development of organ-specific metastasis, the formation of a pre-metastatic niche is pivotal in promoting the spread...
Felipe F Lüttmann,Kee-Pyo Kim,Johnny Kim
Felipe F Lüttmann
Checkpoint blockade therapy in Hodgkin lymphoma: improved response through combination with JAK inhibition [0.03%]
霍奇金淋巴瘤的检查点阻断疗法与JAK抑制联合使用可改善疗效
Marc A Weniger,Ralf Küppers
Marc A Weniger
Understanding genetics, sex and signaling: Implications of sex-dependent APOE4-neutrophil-microglia interactions for Alzheimer's and tauopathies [0.03%]
遗传、性别和信号传导：APOE4-中性粒细胞-小胶质细胞相互作用的性别依赖性对阿尔茨海默病和tau病的影响
Natja Haag,Juliane Bremer,Hans Zempel
Natja Haag
A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation [0.03%]
人类健康与疾病中理解微生物组的系统框架：从基本原则到临床转化
Ziqi Ma,Tao Zuo,Norbert Frey et al.
Ziqi Ma et al.
The human microbiome is a complex and dynamic system that plays important roles in human health and disease. However, there remain limitations and theoretical gaps in our current understanding of the intricate relationship between microbes ...