Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets [0.03%]
神经退行性疾病的小胶质细胞作用机制及潜在治疗靶点研究进展
Chao Gao,Jingwen Jiang,Yuyan Tan et al.
Chao Gao et al.
Microglia activation is observed in various neurodegenerative diseases. Recent advances in single-cell technologies have revealed that these reactive microglia were with high spatial and temporal heterogeneity. Some identified microglia in ...
Targeting ferroptosis opens new avenues for the development of novel therapeutics [0.03%]
靶向铁死亡开启药物研发新思路
Shumin Sun,Jie Shen,Jianwei Jiang et al.
Shumin Sun et al.
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense against oxidative stress, and abnormal lipid peroxidation. Recent studies have provided compell...
A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir [0.03%]
一种病毒RNA依赖性RNA聚合酶抑制剂VV116可广谱抑制人类冠状病毒且与3CL蛋白酶抑制剂奈玛特韦具有协同作用
Yumin Zhang,Yuan Sun,Yuanchao Xie et al.
Yumin Zhang et al.
During the ongoing pandemic, providing treatment consisting of effective, low-cost oral antiviral drugs at an early stage of SARS-CoV-2 infection has been a priority for controlling COVID-19. Although Paxlovid and molnupiravir have received...
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation [0.03%]
cGAS-STING途径介导的线粒体DNA感应调节眼部表面炎症反应
Weijie Ouyang,Shoubi Wang,Dan Yan et al.
Weijie Ouyang et al.
The innate immune response is the main pathophysiological process of ocular surface diseases exposed to multiple environmental stresses. The epithelium is central to the innate immune response, but whether and how innate immunity is initiat...
CXXC finger protein 1 (CFP1) bridges the reshaping of genomic H3K4me3 signature to the advancement of lung adenocarcinoma [0.03%]
CXXC指蛋白1(CFP1)通过重塑基因组H3K4me3修饰促进肺腺癌进展
Tao Fan,Chu Xiao,Hengchang Liu et al.
Tao Fan et al.
Histone H3 lysine 4 trimethylation (H3K4me3) is a canonical chromatin modification associated with active gene transcription, playing a pivotal role in regulating various cellular functions. Components of the H3K4me3 methyltransferase compl...
Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys [0.03%]
tau蛋白病促进转基因猴脊髓源性毒性β淀粉样蛋白产生
Zhuchi Tu,Sen Yan,Bofeng Han et al.
Zhuchi Tu et al.
Tauopathy, characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau, and the accumulation of Aβ oligomers, constitute the major pathological hallmarks of Alzheimer's disease. However, the relatio...
Dynamic single-cell mapping unveils Epstein‒Barr virus-imprinted T-cell exhaustion and on-treatment response [0.03%]
动态单细胞鉴定揭示EB病毒印迹T细胞衰竭及治疗反应
Miao-Zhen Qiu,Chaoye Wang,Zhiying Wu et al.
Miao-Zhen Qiu et al.
Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined. This study aimed to finely c...
Gang Zhang,Tianyu Tang,Yinfeng Chen et al.
Gang Zhang et al.
mRNA vaccines have emerged as highly effective strategies in the prophylaxis and treatment of diseases, thanks largely although not totally to their extraordinary performance in recent years against the worldwide plague COVID-19. The huge s...
Cui Yuan,Zhenling Ma,Jiufeng Xie et al.
Cui Yuan et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), showing high infectiousness, resulted in an ongoing pandemic termed coronavirus disease 2019 (COVID-19). COVID-19 cases often experience acute respiratory distress syndrome, whic...
Long-term survival benefit of anti-PD-1 therapy in patients with relapsed or refractory classical Hodgkin lymphoma [0.03%]
抗PD-1治疗复发或难治性经典型霍奇金淋巴瘤患者的长期生存收益
Weiping Liu,Ningjing Lin,Xinqin Feng et al.
Weiping Liu et al.
Anti-programmed cell death-1 (anti-PD-1) therapies have shown a favorable efficacy and good tolerance for relapsed or refractory (r/r) classical Hodgkin lymphoma (cHL). However, there are limited data on long-term outcomes among patients wi...