STAT5 promotes PD-L1 expression by facilitating histone lactylation to drive immunosuppression in acute myeloid leukemia [0.03%]
STAT5通过促进组蛋白乳酸化来促进PD-L1表达以驱动急性髓系白血病免疫抑制作用
Ze-Wei Huang,Xue-Ning Zhang,Ling Zhang et al.
Ze-Wei Huang et al.
Immunotherapy is a revolutionized therapeutic strategy for tumor treatment attributing to the rapid development of genomics and immunology, and immune checkpoint inhibitors have successfully achieved responses in numbers of tumor types, inc...
Genetic differences between primary and metastatic cancer: a pan-cancer whole-genome comparison study [0.03%]
原发肿瘤与继发肿瘤的基因差异——全基因组对比研究
Lei Zhong,Zhipeng Zhao,Xiaonan Zhang
Lei Zhong
Lymph node metastasis in cancer progression: molecular mechanisms, clinical significance and therapeutic interventions [0.03%]
淋巴结转移在癌症进展中的分子机制、临床意义和治疗干预措施
Haoran Ji,Chuang Hu,Xuhui Yang et al.
Haoran Ji et al.
Lymph nodes (LNs) are important hubs for metastatic cell arrest and growth, immune modulation, and secondary dissemination to distant sites through a series of mechanisms, and it has been proved that lymph node metastasis (LNM) is an essent...
Combined FOLFOX4 with all-trans retinoic acid versus FOLFOX4 with placebo in treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a randomized, double-blind comparative study [0.03%]
联合全反式维甲酸与FOLFOX4对比安慰剂联合FOLFOX4治疗肝细胞癌伴远处转移的疗效：一项随机、双盲临床研究
Juxian Sun,Feifei Mao,Chang Liu et al.
Juxian Sun et al.
The majority of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage. Currently, there are only a few therapeutic methods available for patients with advanced HCC and extrahepatic metastasis (EHM). Systemic chemotherapy, ...
Randomized Controlled Trial
Signal transduction and targeted therapy. 2023 Sep 27;8(1):368. DOI:10.1038/s41392-023-01604-3 2023
Transcriptional-translational conflict: a novel exploitable tumor suppressive mechanism [0.03%]
转录-翻译冲突：一种新颖的可利用的肿瘤抑制机制
Maria Mudryj,Paramita M Ghosh
Maria Mudryj
Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors [0.03%]
单纯疱疹病毒增效DNA损伤响应抑制剂协同作用杀伤非小细胞肺癌研究
Bopei Cui,Lifang Song,Qian Wang et al.
Bopei Cui et al.
With the continuous in-depth study of the interaction mechanism between viruses and hosts, the virus has become a promising tool in cancer treatment. In fact, many oncolytic viruses with selectivity and effectiveness have been used in cance...
Secreted LRPAP1 binds and triggers IFNAR1 degradation to facilitate virus evasion from cellular innate immunity [0.03%]
分泌的LRPAP1结合并诱导IFNAR1降解以促进病毒逃避免疫反应
Huangcan Li,Xiong Wang,Yiran Wang et al.
Huangcan Li et al.
The crucial role of interferon (IFN) signaling is well known in the restriction or eradication of pathogen invasion. Viruses take a variety of ways to antagonize host defense through eliminating IFN-signaling intracellularly for decades. Ho...
Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines [0.03%]
基线肠道微生物组和代谢组预测对SARS-CoV-2疫苗的持久免疫反应
Ye Peng,Lin Zhang,Chris K P Mok et al.
Ye Peng et al.
The role of gut microbiota in modulating the durability of COVID-19 vaccine immunity is yet to be characterised. In this cohort study, we collected blood and stool samples of 121 BNT162b2 and 40 CoronaVac vaccinees at baseline, 1 month, and...
Priyanka Bhatia,Jared Sterneckert
Priyanka Bhatia
Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2 [0.03%]
羟基羧酸受体HCAR2的正向配体选择性及变构探针依赖性
Lin Cheng,Suyue Sun,Heli Wang et al.
Lin Cheng et al.
Hydroxycarboxylic acid receptor 2 (HCAR2), a member of Class A G-protein-coupled receptor (GPCR) family, plays a pivotal role in anti-lipolytic and anti-inflammatory effects, establishing it as a significant therapeutic target for treating ...