Drug-microbiota interactions: an emerging priority for precision medicine [0.03%]
药物与微生物组相互作用：精准医疗亟待重视的课题
Qing Zhao,Yao Chen,Weihua Huang et al.
Qing Zhao et al.
Individual variability in drug response (IVDR) can be a major cause of adverse drug reactions (ADRs) and prolonged therapy, resulting in a substantial health and economic burden. Despite extensive research in pharmacogenomics regarding the ...
SARS-CoV-2 spike-specific TFH cells exhibit unique responses in infected and vaccinated individuals [0.03%]
SARS-CoV-2刺突特异性TFH细胞在感染和接种疫苗个体中的独特反应
Rongzhang He,Xingyu Zheng,Jian Zhang et al.
Rongzhang He et al.
Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb) and B cell differentiation are tightly regulated by T follicular help (TFH) cells. However, the longevity and fu...
Bispecific immune molecule PD1-IL2v: a new therapeutic strategy for pancreatic ductal adenocarcinoma [0.03%]
双特异免疫分子PD1-IL2v：胰腺导管腺癌治疗新策略
Yuan Gao,Liqing Yu,Hongming Miao
Yuan Gao
Human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma [0.03%]
TP53突变型弥漫性大B细胞淋巴瘤中人类内源性逆转录病毒的表观遗传学治疗靶点作用
Ying Fang,Mu-Chen Zhang,Yang He et al.
Ying Fang et al.
TP53 mutation (TP53mut) occurs in 10-20% of diffuse large B-cell lymphoma (DLBCL) cases and serves as an unfavorable biomarker of DLBCL progression. It confers resistance to immunochemotherapy, high-dose chemotherapy, autologous stem cell t...
Gut microbe-derived metabolite indole-3-carboxaldehyde alleviates atherosclerosis [0.03%]
肠道微生物衍生代谢物吲哚-3-甲醛可缓解动脉粥样硬化
Yijing Lu,Wenlong Yang,Zhiyong Qi et al.
Yijing Lu et al.
Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition [0.03%]
无菌无虑：受损皮肤通过IL-24独立于病原识别启动修复过程
Ruben A Ferrer,Marta Torregrossa,Sandra Franz
Ruben A Ferrer
Safeguarding transcriptional memory: a mitotic bookmarking role for chromatin remodelers [0.03%]
染色质重塑酶在分裂过程中守护转录记忆的机制研究
Godwin Sokpor,Huu Phuc Nguyen,Tran Tuoc
Godwin Sokpor
Artificial sweetener sucralose: a possible modulator of autoimmune diseases [0.03%]
人造甜味剂蔗糖素：可能的自身免疫疾病调节因子
Nicolle Kränkel,Ursula Rauch-Kroehnert
Nicolle Kränkel
Ras homolog family member J (RHOJ): a key regulator of chemoresistance associated with epithelial-mesenchymal transition [0.03%]
Rho家族小G蛋白成员J(RHOJ)：与上皮间质转化相关的化疗耐药的关键调节因子
Sijia Liu,Jiang Ren,Long Zhang
Sijia Liu
Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease [0.03%]
mTOR（哺乳动物雷帕霉素靶点）信号通路在人类健康和疾病中的多面作用
Vivek Panwar,Aishwarya Singh,Manini Bhatt et al.
Vivek Panwar et al.
The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain cellular homeostasis. The mTOR signaling cascade co...