Correction: Discovery of novel non-peptidic and non-covalent small-molecule 3CLpro inhibitors as potential candidate for COVID-19 treatment [0.03%]
纠正：新型非肽键和非共价小分子3CLpro抑制剂作为COVID-19治疗候选药物的发现
Zhidong Jiang,Bo Feng,Yumin Zhang et al.
Zhidong Jiang et al.
Safety and clinical efficacy of sintilimab (anti-PD-1) in pediatric patients with advanced or recurrent malignancies in a phase I study [0.03%]
特瑞普利单抗（抗PD-1）治疗晚期或复发恶性肿瘤儿童患者的安全性和临床疗效I期研究
Yi Que,Juan Wang,Feifei Sun et al.
Yi Que et al.
The aim of this phase I study is to evaluate, for the first time, the safety and efficacy of sintilimab in pediatric patients diagnosed with advanced or recurrent malignancies. During the dose escalation phase, patients received a single in...
Astrocytes in human central nervous system diseases: a frontier for new therapies [0.03%]
人中枢神经系统疾病中的星形胶质细胞：新疗法的前沿阵地
Alexei Verkhratsky,Arthur Butt,Baoman Li et al.
Alexei Verkhratsky et al.
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis and defence of the central nervous system (CNS). Astroglia contribute to the pathophysiology of all neurological and neuropsychiatric disorders in w...
Macrophage CARD9 mediates cardiac injury following myocardial infarction through regulation of lipocalin 2 expression [0.03%]
巨噬细胞CARD9通过调节脂联素2表达介导心肌梗死后的的心脏损伤
Yan Liu,Yi-Hui Shao,Jun-Meng Zhang et al.
Yan Liu et al.
Immune cell infiltration in response to myocyte death regulates extracellular matrix remodeling and scar formation after myocardial infarction (MI). Caspase-recruitment domain family member 9 (CARD9) acts as an adapter that mediates the tra...
Longjie Huangfu,Ruiying Li,Yamei Huang et al.
Longjie Huangfu et al.
The interleukin-17 (IL-17) family comprises six members (IL-17A-17F), and recently, all of its related receptors have been discovered. IL-17 was first discovered approximately 30 years ago. Members of this family have various biological fun...
Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L [0.03%]
嗜酸细胞通过组织蛋白酶L促进肺基质破坏和肺气肿发生发展
Xia Xu,Tao Yu,Lingling Dong et al.
Xia Xu et al.
Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema. This implies the potential involvement of eosinophils in the developm...
Starving out brain tumors: a reprogrammed lysine catabolism serves as a novel target for glioblastoma treatment [0.03%]
让脑肿瘤饿死：组氨酸分解代谢重编程作为胶质母细胞瘤治疗的新靶点
Désirée Gül,Oliver H Krämer,Christoph Reinhardt
Désirée Gül
Ectodysplasin A2 receptor-NF-κB-inducing kinase axis: a new player in muscle wasting to cancer cachexia [0.03%]
肌营养不良的新型致病轴： ectodysplasin A2受体-NF-κB诱导激酶在癌症恶病质中的作用
Janusz von Renesse,Peter Mirtschink
Janusz von Renesse
P21-activated kinase 1 (PAK1)-mediated cytoskeleton rearrangement promotes SARS-CoV-2 entry and ACE2 autophagic degradation [0.03%]
P21活化激酶1（PAK1）介导的细胞骨架重组促进SARS-CoV-2入侵和ACE2自噬降解
Ming Liu,Bingtai Lu,Yue Li et al.
Ming Liu et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has had a significant impact on healthcare systems and economies worldwide. The continuous emergence of new viral stra...