B-cell immune checkpoint TIM-1: a potential target for tumour immunotherapy [0.03%]
B细胞免疫检查点TIM-1：肿瘤免疫治疗的潜在靶标
Xinyu Tian,Xiangyun Zheng,Dong Tian
Xinyu Tian
Astragaloside IV derivative HHQ16 ameliorates infarction-induced hypertrophy and heart failure through degradation of lncRNA4012/9456 [0.03%]
Astragaloside IV 衍生物 HHQ16通过降解 lncRNA4012/9456 改善心梗诱导的心室肥大和心力衰竭
Jingjing Wan,Zhen Zhang,Chennan Wu et al.
Jingjing Wan et al.
Reversing ventricular remodeling represents a promising treatment for the post-myocardial infarction (MI) heart failure (HF). Here, we report a novel small molecule HHQ16, an optimized derivative of astragaloside IV, which effectively rever...
From signalling pathways to targeted therapies: unravelling glioblastoma's secrets and harnessing two decades of progress [0.03%]
从信号通路到靶向治疗：揭开胶质母细胞瘤的秘密并利用二十年的研究成果
Brittany Dewdney,Misty R Jenkins,Sarah A Best et al.
Brittany Dewdney et al.
Glioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients alike. Despite advancements in brain cancer resear...
Anti-PD-1 antibody armored γδ T cells enhance anti-tumor efficacy in ovarian cancer [0.03%]
装备抗PD-1抗体的γδT细胞在卵巢癌中的抗癌效果增强效应
Yue Wang,Jingyi Han,Dongdong Wang et al.
Yue Wang et al.
γδ T cells have the unique ability to detect a wide range of tumors with low mutation burdens, making them attractive candidates for CAR-T-cell therapy. Unlike αβ T cells and other immune cells, γδ T cells are superior in MHC non-rest...
Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy [0.03%]
单细胞转录组分析揭示了COVID-19相关儿童脑病的系统性免疫失调
Yi Wang,Laurence Don Wai Luu,Shuang Liu et al.
Yi Wang et al.
Unraveling the molecular mechanisms for COVID-19-associated encephalopathy and its immunopathology is crucial for developing effective treatments. Here, we utilized single-cell transcriptomic analysis and integrated clinical observations an...
Neo-intline: integrated pipeline enables neoantigen design through the in-silico presentation of T-cell epitope [0.03%]
Neo-intline：集成化流程通过T细胞表位的计算机模拟呈递设计新生抗原
Bingyu Li,Ping Jing,Genhui Zheng et al.
Bingyu Li et al.
Neoantigen vaccines are one of the most effective immunotherapies for personalized tumour treatment. The current immunogen design of neoantigen vaccines is usually based on whole-genome sequencing (WGS) and bioinformatics prediction that fo...
Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm [0.03%]
囊液糖蛋白准确区分胰腺粘液性肿瘤的恶性病变
Ming Cui,Ya Hu,Zejian Zhang et al.
Ming Cui et al.
Pancreatic cystic neoplasms (PCNs) are recognized as precursor lesions of pancreatic cancer, with a marked increase in prevalence. Early detection of malignant PCNs is crucial for improving prognosis; however, current diagnostic methods are...
Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling [0.03%]
表观遗传调控的TP53参与前列腺癌的放射抵抗及DNA损伤应答信号通路
Catarina Macedo-Silva,Vera Miranda-Gonçalves,Nuno Tiago Tavares et al.
Catarina Macedo-Silva et al.
External beam radiotherapy (RT) is a leading first-line therapy for prostate cancer (PCa), and, in recent years, significant advances have been accomplished. However, RT resistance can arise and result in long-term recurrence or disease pro...
Activated STING: an ion channel to trigger non-interferon-related functions [0.03%]
激活的STING：一种触发非干扰素相关功能的离子通道
Zhengyu Gao,Bin Wang,Long Zhang
Zhengyu Gao
Cephalopod RNA recoding: linking protein plasticity to thermal adaptation and catalyzing beyond-species protein characterization [0.03%]
头足类动物的RNA重编码：连接蛋白质变异性与热适应性并促进跨物种蛋白表征
Junyi Wang,Guoping Li,Min Wu
Junyi Wang