EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors [0.03%]
EZH2抑制剂促进年轻和成人1型糖尿病供体的β样细胞再生
Keith Al-Hasani,Safiya Naina Marikar,Harikrishnan Kaipananickal et al.
Keith Al-Hasani et al.
β-cells are a type of endocrine cell found in pancreatic islets that synthesize, store and release insulin. In type 1 diabetes (T1D), T-cells of the immune system selectively destroy the insulin-producing β-cells. Destruction of these cel...
Janus-faced Mitofusin 2 (MFN2): mitochondria-endoplasmic reticulum shaping and tethering functions unveiled [0.03%]
双面Mitofusin 2 (MFN2)：揭示线粒体-内质网的形态和连接功能
Camilla Aurora Franchino,Elisa Motori,Matteo Bergami
Camilla Aurora Franchino
Tripartite motif-containing protein 11 (TRIM11): a novel weapon against Alzheimer's disease [0.03%]
含三联基序蛋白11（TRIM11）：对抗阿尔茨海默病的新武器
Yichu Fu,Bi Zhang,Jianfeng Liu
Yichu Fu
Multifunctional nanoparticle-mediated combining therapy for human diseases [0.03%]
用于人类疾病的多功能纳米粒子介导联合疗法
Xiaotong Li,Xiuju Peng,Makhloufi Zoulikha et al.
Xiaotong Li et al.
Combining existing drug therapy is essential in developing new therapeutic agents in disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established in treating extensive hum...
Targeting complement hyperactivation: a novel therapeutic approach for severe pneumonia induced by influenza virus/staphylococcus aureus coinfection [0.03%]
针对补体过度活化：治疗由流感病毒/金黄色葡萄球菌共感染引起的重症肺炎的新疗法
Leili Jia,Haihua Luo,Lizhong Li et al.
Leili Jia et al.
Mpox (formerly monkeypox): pathogenesis, prevention, and treatment [0.03%]
猴痘（以前称为monkeypox）：发病机理、预防与治疗
Junjie Lu,Hui Xing,Chunhua Wang et al.
Junjie Lu et al.
In 2022, a global outbreak of Mpox (formerly monkeypox) occurred in various countries across Europe and America and rapidly spread to more than 100 countries and regions. The World Health Organization declared the outbreak to be a public he...
Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape [0.03%]
CAR分子的吞细胞作用调节CAR-T细胞功能障碍和肿瘤抗原逃逸
You Zhai,Yicong Du,Guanzhang Li et al.
You Zhai et al.
Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid tumors. Although instances of rapid tumor remissions have been observed in animal models and clinical tria...
New insights into the correlations between circulating tumor cells and target organ metastasis [0.03%]
循环肿瘤细胞与靶器官转移之间关联的新见解
Qinru Zhan,Bixia Liu,Xiaohua Situ et al.
Qinru Zhan et al.
Organ-specific metastasis is the primary cause of cancer patient death. The distant metastasis of tumor cells to specific organs depends on both the intrinsic characteristics of the tumor cells and extrinsic factors in their microenvironmen...
Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period [0.03%]
大流行后期开发和批准COVID-19疫苗和疗法的策略
Danyi Ao,Xuemei He,Jian Liu et al.
Danyi Ao et al.
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant casualties and put immense strain on public health systems worldwide, leading to economic recession and social unrest. In response, vario...