Dietary reprogram of macrophages for cell competition: a promising strategy for malignant cancer control [0.03%]
通过饮食再编程巨噬细胞进行细胞竞争：恶性癌症控制的潜在策略
Jian Chen,Zhaoliang Su,Guangchuan Wang
Jian Chen
RNA modification in cardiovascular disease: implications for therapeutic interventions [0.03%]
心血管病中的RNA修饰及其治疗意义
Cong Wang,Xuyang Hou,Qing Guan et al.
Cong Wang et al.
Cardiovascular disease (CVD) is the leading cause of death in the world, with a high incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable in cell, maintaining cell homeostasis and function by dynamically...
Camrelizumab (a PD-1 inhibitor) plus apatinib (an VEGFR-2 inhibitor) and hepatic artery infusion chemotherapy for hepatocellular carcinoma in Barcelona Clinic Liver Cancer stage C (TRIPLET): a phase II study [0.03%]
卡瑞利珠单抗（PD-1抑制剂）联合阿帕替尼（VEGFR-2抑制剂）和肝动脉灌注化疗治疗巴塞罗那临床肝癌分期C期的肝细胞癌：Ⅱ期研究
Tian-Qi Zhang,Zhi-Jun Geng,Meng-Xuan Zuo et al.
Tian-Qi Zhang et al.
Hepatic arterial infusion chemotherapy (HAIC) using a combination of oxaliplatin, fluorouracil, and leucovorin (FOLFOX) has shown promise for hepatocellular carcinoma (HCC) patients classified under Barcelona Clinic Liver Cancer (BCLC) stag...
Unmasking metabolic dependencies in pancreatic cancer: aberrant polyamine synthesis as a promising new therapeutic target [0.03%]
揭示胰腺癌代谢特征：异常多胺合成作为新的治疗靶点
Gerrit Wolters-Eisfeld,Thilo Hackert,Cenap Güngör
Gerrit Wolters-Eisfeld
Characteristics of premanufacture CD8+T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma [0.03%]
前期CD8⁺T细胞的特征决定了其在弥漫性大B细胞淋巴瘤患者中的CAR-T疗效
Yao Wang,Chuan Tong,Yuting Lu et al.
Yao Wang et al.
Although chimeric antigen receptor (CAR) T cells have become an important treatment option for patients with relapsed/refractory B-cell malignancies, more than 60% of patients with diffuse large B-cell lymphoma (DLBCL) treated with CAR-T ce...
Phase II trial of CDK4/6 inhibitor palbociclib in advanced sarcoma based on mRNA expression of CDK4/ CDKN2A [0.03%]
基于CDK4/CDKN2A的mRNA表达用于评估帕博西尼在软组织肉瘤中疗效的II期临床试验
Javier Martin-Broto,Jeronimo Martinez-Garcia,David S Moura et al.
Javier Martin-Broto et al.
Cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors demonstrated activity in terms of progression-free survival (PFS) in advanced dedifferentiated liposarcoma (DD-LPS), a sarcoma with CDK4 amplification. CDK4 overexpression is by far more ...
Tumor-repopulating cell-derived microparticles elicit cascade amplification of chemotherapy-induced antitumor immunity to boost anti-PD-1 therapy [0.03%]
肿瘤再播种细胞来源的微颗粒通过级联放大化疗诱导的抗肿瘤免疫来增强抗PD-1疗法
Nana Bie,Tuying Yong,Zhaohan Wei et al.
Nana Bie et al.
Immune checkpoint blockade (ICB) therapy, particularly antibodies targeting the programmed death receptor 1 (PD-1) and its ligand (PD-L1), has revolutionized cancer treatment. However, its efficacy as a standalone therapy remains limited. A...
Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase [0.03%]
通过真核起始因子2激酶控制CD4+t细胞以抑制炎症性疾病发生发展
Hao-Yun Peng,Liqing Wang,Jugal Kishore Das et al.
Hao-Yun Peng et al.
CD4+ T cells, particularly IL-17-secreting helper CD4+ T cells, play a central role in the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor 2 Kinase (eEF2K) is pivotal in CD8+ T cells and has important im...
Real-world effectiveness of an intranasal spray A8G6 antibody cocktail in the post-exposure prophylaxis of COVID-19 [0.03%]
针对新冠暴露后预防的鼻用抗体鸡尾酒A8G6的现实世界有效性研究
Xiaosong Li,Pai Peng,Haijun Deng et al.
Xiaosong Li et al.
Previously, we identified an antibody combination A8G6 that showed promising efficacy in COVID-19 animal models and favorable safety profile in preclinical models as well as in a first-in-human trial. To evaluate the real-word efficacy of A...
Controlled Clinical Trial
Signal transduction and targeted therapy. 2023 Oct 23;8(1):403. DOI:10.1038/s41392-023-01656-5 2023
Fe65-engineered neuronal exosomes encapsulating corynoxine-B ameliorate cognition and pathology of Alzheimer's disease [0.03%]
Fe65工程神经外泌体递送 Corynoxine B 改善阿尔茨海默病认知和病理表型
Ashok Iyaswamy,Abhimanyu Thakur,Xin-Jie Guan et al.
Ashok Iyaswamy et al.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the predominant impairment of neurons in the hippocampus and the formation of amyloid plaques, hyperphosphorylated tau protein, and neurofibrillary tangles in the bra...